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A Simple Method For Discovering Druggable, Specific Glycosaminoglycan-Protein Systems. Elucidation Of Key Principles From Heparin/Heparan Sulfate-Binding Proteins, Aurijit Sarkar, Umesh R. Desai

Psychology Publications

Glycosaminoglycans (GAGs) affect human physiology and pathology by modulating more than 500 proteins. GAG-protein interactions are generally assumed to be ionic and nonspecific, but specific interactions do exist. Here, we present a simple method to identify the GAG-binding site (GBS) on proteins that in turn helps predict high specific GAG–protein systems. Contrary to contemporary thinking, we found that the electrostatic potential at basic arginine and lysine residues neither identifies the GBS consistently, nor its specificity. GBSs are better identified by considering the potential at neutral hydrogen bond donors such as asparagine or glutamine sidechains. Our studies also reveal that an …

A Simple Method For Discovering Druggable, Specific Glycosaminoglycan-Protein Systems. Elucidation Of Key Principles From Heparin/Heparan Sulfate-Binding Proteins, Aurijit Sarkar, Umesh R. Desai

Medicinal Chemistry Publications

Glycosaminoglycans (GAGs) affect human physiology and pathology by modulating more than 500 proteins. GAG-protein interactions are generally assumed to be ionic and nonspecific, but specific interactions do exist. Here, we present a simple method to identify the GAG-binding site (GBS) on proteins that in turn helps predict high specific GAG–protein systems. Contrary to contemporary thinking, we found that the electrostatic potential at basic arginine and lysine residues neither identifies the GBS consistently, nor its specificity. GBSs are better identified by considering the potential at neutral hydrogen bond donors such as asparagine or glutamine sidechains. Our studies also reveal that an …

Heterosexual Men In Homosexual Encounter, Laurence L. Garcia, Ma. Mayla Imelda M. Lapa, Christine Joy J. Bandala

CNU Journal of Higher Education

Sexuality is an important aspect of being human. Sex as an expression of sexuality is a biologically important means to ensure the continuation of the human race. However, sexuality has social ramifications. The experience of the heterosexual man in engaging in homosexual sex is a social taboo, thus, is not at all talked about in contrast to the homosexual man’s experience. It is therefore the primary aim of this study to analyze the underlying reasons why heterosexual men engage in sex with other men. The study used deductive approach to theory development to create a theory that would explain the …

Avs Corner, January 2015, Allison Millican, Casey Wheeler, Emily Cook, Jennifer Lantzer, Karen Taylor, Megan Kelley, Tina Rowland, Johanna Johnson

AVS Corner

No abstract provided.

Assessment Of A Metaviromic Dataset Generated From Nearshore Lake Michigan, Siobhan C. Watkins, Neil Kuehnle, C Anthony Ruggeri, Kema Malki, Katherine Bruder, Jinan Elayyan, Kristina Damisch, Naushin Vahora, Paul O'Malley, Brianne Ruggles-Sage, Zachary Romer, Catherine Putonti

Bioinformatics Faculty Publications

Bacteriophages are powerful ecosystem engineers. They drive bacterial mortality rates and genetic diversity, and affect microbially mediated biogeochemical processes on a global scale. This has been demonstrated in marine environments; however, phage communities have been less studied in freshwaters, despite representing a potentially more diverse environment. Lake Michigan is one of the largest bodies of freshwater on the planet, yet to date the diversity of its phages has yet to be examined. Here, we present a composite survey of viral ecology in the nearshore waters of Lake Michigan. Sequence analysis was performed using a web server previously used to analyse …

2015 Program, Belmont University

Humanities Symposium Programs

No abstract provided.

Composition, Taxonomy And Functional Diversity Of The Oropharynx Microbiome In Individuals With Schizophrenia And Controls., Eduardo Castro-Nallar, Matthew L Bendall, Marcos Pérez-Losada, Sarven Sabuncyan, Emily G Severance, Faith B Dickerson, Jennifer R Schroeder, Robert H Yolken, Keith A Crandall

Computational Biology Institute

The role of the human microbiome in schizophrenia remains largely unexplored. The microbiome has been shown to alter brain development and modulate behavior and cognition in animals through gut-brain connections, and research in humans suggests that it may be a modulating factor in many disorders. This study reports findings from a shotgun metagenomic analysis of the oropharyngeal microbiome in 16 individuals with schizophrenia and 16 controls. High-level differences were evident at both the phylum and genus levels, with Proteobacteria, Firmicutes, Bacteroidetes, and Actinobacteria dominating both schizophrenia patients and controls, and Ascomycota being more abundant in schizophrenia patients than controls. Controls …

Madness In Arthur Schnitzler’S Therese: Chronik Eines Frauenlebens, Janek Jakubisin

Theses & ETDs

This thesis explores the presence and function of madness in Arthur Schnitzler’s Therese: Chronik eines Frauenlebens. Applying the theories regarding madness in Michel Foucault’s History of Madness, I argue that madness is a social construct and elucidate the ways in which it is constructed by the characters and society in the novel. In the first chapter, I investigate the madness of Fabiani, who is the protagonist’s (Therese’s) father and illustrate how Fabiani’s madness is constructed by the military in a fashion which parallels the historical constructions of madness identified by Foucault. The second chapter focuses on Therese and analyzes how …

Simple, Not Easy: A Solution To Metabolic Syndrome, Forrester White

Theses & ETDs

Metabolic Syndrome is a cluster of physiological factors that greatly increase the risk of developing type 2 diabetes and cardiovascular disease. In order to promote public health through the prevention and reduction of Metabolic Syndrome the following questions were asked: What is a likely mechanism that leads to the manifestation of Metabolic Syndrome and which mode of exercise best prevents and reverses these abnormalities? Metabolic Syndrome is likely the result of behavioral factors, including overconsumption and sedentarism, which induce an adaptive insulin resistant mechanism to become protracted leading to compensatory hyperinsulinemia and clinical manifestations of Metabolic Syndrome. A combination of …

Bioh 463.80: Tutoring Human Anatomy And Physiology Ii - Honors, Laurie A. Minns

University of Montana Course Syllabi

No abstract provided.

Gonzaga University Factbook 2015-16, Institutional Research, Gonzaga University

Institutional Research

The Gonzaga University Factbook contains information on student enrollments, demographic profiles, admissions statistics, majors, retention and graduation rates, degree completions, faculty information, and more. It is updated annually with the most current and commonly-needed information about Gonzaga University.

The Effect Of High-Fidelity Cardiopulmonary Resuscitation ({Cpr}) Simulation On Athletic Training Student Knowledge, Confidence, Emotions, And Experiences, Kristin Tivener, Donna Gloe

College of Health and Human Services

No abstract provided.

Comparative Proteomics Of Mouse Tears And Saliva: Evidence From Large Protein Families For Functional Adaptation, Robert C. Karn, Christina M. Laukaitis

Scholarship and Professional Work - LAS

We produced a tear proteome of the genome mouse, C57BL/6, that contained 139 different protein identifications: 110 from a two-dimensional (2D) gel with subsequent trypsin digestion, 19 from a one-dimensional (1D) gel with subsequent trypsin digestion and ten from a 1D gel with subsequent Asp-N digestion. We compared this tear proteome with a C57BL/6 mouse saliva proteome produced previously. Sixteen of the 139 tear proteins are shared between the two proteomes, including six proteins that combat microbial growth. Among the 123 other tear proteins, were members of four large protein families that have no counterparts in humans: Androgen-binding proteins (ABPs) …

Differential Expression Of Proteins Involved In Vldl Trafficking Causes Reduced Vldl Secretion In Male Ames Dwarf Mice, Faisal Ahmed Moinuddin

Electronic Theses and Dissertations

Cardiovascular diseases (CVDs) have been recorded as the number one cause of death worldwide, accounting for 32% of total deaths annually. More than two-thirds of all CVD cases are associated with atherosclerosis, which is the accumulation of fats and other substances causing plaque formation in the interior walls of major arteries. This leads to narrowing of the lumen and hardening of the arteries, ultimately resulting in angina, heart attack and/or stroke. Studies have shown that the pathogenesis of atherosclerosis and associated CVDs is strongly linked to elevated secretion of liver-specific lipoproteins called very-low-density-lipoprotein (VLDL). VLDLs are crucial lipoproteins responsible for …

An Investigation Of Physiological Measures In A Marketing Decision Task, Nelson Lerma

Electronic Theses and Dissertations

The objective of the present study was to understand the use of physiological measures as an alternative to traditional market research tools, such as self-reporting measures and focus groups. For centuries, corporations and researchers have relied almost exclusively on traditional measures to gain insights into consumer behavior. Oftentimes, traditional methods have failed to accurately predict consumer demand, and this has prompted corporations to explore alternative methods that will accurately forecast future sales. One the most promising alternative methods currently being investigated is the use of physiological measures as an indication of consumer preference. This field, also referred to as neuromarketing, …

Bio 2220 : Anatomy And Physiology Ii, Biological Sciences

Approved Course Proposals

No abstract provided.

Religious Discourse And Interdisciplinarity In Sport Studies, Zachary T. Smith

The Hilltop Review

Religious and theological explorations of leisure have remained few and far between, as religious studies perceive sport and game related studies as trivial, and as leisure theorists find social scientific methods more compelling. And yet, religious traditions and thinkers have been offering accounts and ethics of leisure activities for thousands of years, and anthropological evidence suggests the origination of sport and game play arose in the context of religious cult activity (Huizinga, 1949; Guttmann, 2007). Further, contemporary research has indicated that religion plays an important role in structuring the thought and behavior of religious persons towards their leisure (Waller, 2009) …

The Effects Of Passive, Active, And Beta-Alanine Supplemented Recovery On Blood Lactate During Anaerobic Exercise, Tracey Hampshire

Kinesiology Student Research - Archive

INTRODUCTION: It is widely shown through experimentation and knowledge of human physiology that an active recovery following high-intensity exercise removes lactic acid (BLa) more quickly than passive recovery. Some research suggests that Beta-Alanine (BA) supplementation can decrease BLa levels following supramaximal exercise. PURPOSE: The purpose of this research was to assess whether passive, active, or Beta-Alanine supplemented recovery is more effective at lowering blood lactate accumulation following supramaximal anaerobic exercise. METHODS: Five male (M, 21.2 ±1.48 yrs, 178.25 ±6.36 cm, 85.59 ±10.30 kg) and three female subjects (F, 22 ±1.73 yrs, 164.23 ±1.50 cm, 70.9 ±12.56 kgs) at UTA volunteered …

Am Ceremonial Script, April 26, 2015, Eastern Michigan University

Commencement Programs and Materials

No abstract provided.

Regulation Of Tie2 Extracellular Complex Formation In Angiogenesis, Annamarie Dalton

Theses and Dissertations

Pathological angiogenesis is an essential component of tumor growth, development, and metastasis for which few effective therapeutic options exist. Though many cancer therapies target the function of cell surface receptors, mechanisms regulating membrane receptor crosstalk remain unclear. Two important families of receptors in angiogenesis, the Ties and Integrins, respond to the extracellular environment via outside-in and, in the case of Integrins, also inside- out signaling. Recent reports showed that the endothelial specific tyrosine kinase receptor, Tie2, forms complexes with two of the endothelial Integrin heterodimers, α₅β₁ and α_Vβ₃, providing a convenient mechanism for …

Cyber Security And Management Within The Government, Brandon Larsen

Senior Seminars

No abstract provided.

Hbsi Automation Using The Kinect 2, Zachary Edward Moore

Open Access Theses

This research focused on classifying Human-Biometric Sensor Interaction errors in real-time. The Kinect 2 was used as a measuring device to track the position and movements of the subject through a simulated border control environment. Knowing, in detail, the state of the subject ensures that the human element of the HBSI model is analyzed accurately. A network connection was established with the iris device to know the state of the sensor and biometric system elements of the model. Information such as detection rate, extraction rate, quality, capture type, and more metrics was available for use in classifying HBSI errors. A …

Accidental Opioid Overdose Fatalities In Western Australia, 2008-2012: A Case For More Targeted Intervention, Natalie J. Castalanelli

Theses : Honours

While there are current opioid overdose prevention strategies in Western Australia, these strategies are targeted at illicit opioid users and rely on bystander presence to intervene. The aim of the current study was to identify disparities between current overdose prevention strategies and the actual circumstances surrounding opioid related fatalities, to inform the development of best-practice opioid overdose prevention strategies for Western Australia. To do this, coronial files were drawn from the National Coronial Information System for accidental illicit opioid related fatalities (N = 329) and accidental prescription opioid related fatalities (N = 126) for the years 2008 to 2012. Each …

The Role Of Nkcc2a On The Nervous System Activity, Kavya Annu

Browse all Theses and Dissertations

The NKCC2A is a splice variant of the Na+K+2Cl- co-transporter 2 (Slc12a1), which is abundantly expressed in macula densa and in the apical membrane of the tubular cells in the kidney. Most of our knowledge regarding NKCC2 function is limited to the kidney, the organ where NKCC2 is abundantly expressed. However, recent studies have demonstrated that NKCC2 is also expressed in extra-renal tissues. This study was designed to determine if NKCC2A, a splice variant of NKCC2 has an impact on behavior and nervous system activity of mice. To these ends, we used mice (wild type, WT), lacking a single or …

Identification Of The Domain(S) In Protein Disulfide Isomerase Required For Binding And Disassembly Of The Cholera Holotoxin, Laura Herndon

HIM 1990-2015

Cholera, caused by the secretion of cholera toxin (CT) by Vibrio cholerae within the intestinal lumen, triggers massive secretory diarrhea which may lead to life-threatening dehydration. CT is an AB5-type protein toxin that is comprised of an enzymatically active A1 chain, an A2 linker, and a cell-binding B pentamer. Once secreted, the CT holotoxin moves from the cell surface to the endoplasmic reticulum (ER) of a host target cell. To cause intoxication, CTA1 must be displaced from CTA2/CTB5 in the ER and is then transferred to the cytosol where it induces a diarrheal response by stimulating the efflux of chloride …

Bioh 462.01: Principles Of Medical Physiology, Laurie A. Minns

University of Montana Course Syllabi

No abstract provided.

Bioh 424.80: Human Form And Function Teaching Assistant Ii - Honors, Heather D. Labbe

University of Montana Course Syllabi

No abstract provided.

Assessment Of Pain: Knowledge, Attitudes, And Practices Of Health Care Providers In Almadinah Almunawwarah, Saudi Arabia, Khalid W. Al-Quliti, Majed S. Alamri

Neurosciences

Objective: To present data on knowledge and attitudes toward pain assessment among health care providers in Almadinah Almunawwarah, Saudi Arabia. Methods: This exploratory study required at least 100 participants to attain an effect size of 0.2 or larger. A convenience sample was recruited from the major hospitals in Almadinah Almunawwarah, Saudi Arabia; King Fahad Hospital, Ohud Hospital, Alansar Hospital, Almeqat Hospital, and the Maternity Hospital. Data collection occurred between January and April 2014. Knowledge of pain assessment was examined by administering the Knowledge and Attitudes Survey Regarding Pain. Results: Data from 105 participants was collected. Seventy-three participants scored 44% or …

Bulletin Of Yale University School Of Nursing 2015-2016, Yale School Of Nursing

Yale School of Nursing Bulletins and Catalogues

Series 111, Number 15

September 5, 2015

Altitude Exposure At 1800 M Increases Haemoglobin Mass In Distance Runners, Laura A. Gravican-Lewis, Iona Halliday, Chris R. Abbiss, Philo U. Saunders, Christopher P.J. Gore

Research outputs 2014 to 2021

The influence of low natural altitudes (< 2000 m) on erythropoietic adaptation is currently unclear, with current recommendations indicating that such low altitudes may be insufficient to stimulate significant increases in haemoglobin mass (Hb_mass). As such, the purpose of this study was to determine the influence of 3 weeks of live high, train high exposure (LHTH) at low natural altitude (i.e. 1800 m) on Hb_mass, red blood cell count and iron profile. A total of 16 elite or well-trained runners were assigned into either a LHTH (n = 8) or CONTROL (n = 8) group. Venous blood samples were drawn prior to, at 2 weeks and at 3 weeks following exposure. Hb_mass was measured in duplicate prior to exposure and at 2 …