Digital Commons Network^™

Can Pre-Implantation Biopsies Predict Renal Allograft Function In Pediatric Renal Transplant Recipients?, Jameela A. Kari, Alison L. Ma, Stephanie Dufek, Ismail Mohamed, Nizam Mamode, Neil J. Sebire, Stephen D. Marks

Saudi Medical Journal

Objectives: To determine the utility of pre-implantation renal biopsy (PIB) to predict renal allograft outcomes. Methods: This is a retrospective review of all patients that underwent PIB from January 2003 to December 2011 at the Great Ormond Street Hospital for Children in London, United Kingdom. Thirty-two male patients (56%) aged 1.5-16 years (median: 10.2) at the time of transplantation were included in the study and followed-up for 33 (6-78) months. The results were compared with 33 controls. Results: The PIB showed normal histopathological findings in 13 patients (41%), mild chronic vascular changes in 8 (25%), focal tubular atrophy in one, …

Effectiveness Of Benzocaine In Reducing Deep Cavity Restoration And Post-Extraction Stress In Dental Patients, Khalid H. Al-Samadani, Giath Gazal

Saudi Medical Journal

Objectives: To investigate the effectiveness of topical anesthetic, 20% benzocaine in relieving pain and stress in patients following deep cavity restoration and extraction of teeth under local anesthesia (LA). Methods: A prospective clinical trial was conducted from October 2014 until April 2015 at Taibah University, Al Madinah Al Munawarah, Kingdom of Saudi Arabia. Forty-five patients were included in the 20% benzocaine group, and 46 in the normal saline group. Evaluation of the dental stress was made pre-operatively and immediately post-operative treatment using the visual analogue scale (VAS). Furthermore, discomfort of the injections were recorded by the patients after each treatment …

Improving The Network Scale-Up Estimator: Incorporating Means Of Sums, Recursive Back Estimation, And Sampling Weights, Patrick Habecker, Kirk Dombrowski, Bilal Khan

Department of Sociology: Faculty Publications

Researchers interested in studying populations that are difficult to reach through traditional survey methods can now draw on a range of methods to access these populations. Yet many of these methods are more expensive and difficult to implement than studies using conventional sampling frames and trusted sampling methods. The network scale-up method (NSUM) provides a middle ground for researchers who wish to estimate the size of a hidden population, but lack the resources to conduct a more specialized hidden population study. Through this method it is possible to generate population estimates for a wide variety of groups that are perhaps …

Improving The Odds: Assessing Bait Availability Before Rodent Eradications To Aid In Selecting Bait Application Rates, Madeleine Pott, Alexander S. Wegmann, Richard Griffiths, Araceli Samaniego-Herrera, Richard J. Cuthbert, M. De L. Brooke, William C. Pitt, Are R. Berentsen, Nick D. Holmes, Gregg R. Howald, Karina Ramos-Rendon, James C. Russell

United States Department of Agriculture Wildlife Services: Staff Publications

Rodent eradications undertaken on tropical islands are more likely to fail than eradications undertaken at higher latitudes. We report on 12 independent rodent eradication projects undertaken on tropical islands that utilized the results of an in situ bait availability study prior to eradication to inform, a priori, the bait application rate selected for the eradication. These projects also monitored bait availability during the eradication. The results from our analysis verified the utility of bait availability studies to future rodent eradication campaigns and confirmed the influence of two environmental factors that can affect bait availability over time: precipitation prior to the …

Does Activating The Need To Belong Alter Things Important For Happiness And What Makes Life Complete?, Justus Rui Hao Wee

Dissertations and Theses Collection (Open Access)

Past research on the need to belong in groups has largely examined the circumstances under which individuals go against their personal preferences and conform to group norms. The current research examines how the need to belong may shape the things people view as important for happiness, and what makes their lives complete. Two studies tested the main hypothesis that after activating belongingness needs, participants will be more likely to emphasize the importance of things valued by society (e.g., a lot of money, a successful career, etc.). In Study 1, the need to belong was activated by asking participants to recall …

What The Marriage Equality Cases Tell Us About Voter Id, Ellen D. Katz

Articles

Two years ago, United States u. Windsor tossed out the Defense of Marriage Act ("DOMA"). Thereafter, proponents of marriage equality secured dozens of notable victories in the lower courts, a smattering of setbacks, and last June, the victory they sought in Obergefell v. Hodges. During this same period, opponents of electoral restrictions such as voter identification have seen far less sustained success. Decided the day before Windsor, Shelby County v. Holder scrapped a key provision of the Voting Rights Act ("VRA") while making clear that plaintiffs might still challenge disputed voting regulations under Section 2 of the VRA and the …

Alpha And Omega: When Bullies Run In Packs, Patricia Meglich, Andra Gumbus

WCBT Faculty Publications

While workplace bullying often involves multiple perpetrators, limited research has investigated this important aspect of the phenomenon. In the present study, we explored the perceived severity and comparison of actual behaviors experienced when different perpetrators attack the target. Survey results showed that bullying by one’s supervisor is perceived to be more severe than bullying by a group of coworkers and that coworkers are more likely to bully when the supervisor bullies. When working as a group, bullies focus their attack on the target’s personal life rather than on his or her work life. Implications for research and practice are provided.

The Hour Of Truth: The Conflict In Ukraine–Implications For Europe’S Energy Security And The Lessons For The U.S. Army, Ariel Cohen Dr., Ivan Benovic Mr.

Books, Monographs & Collaborative Studies

Since the breakup of the Soviet Union, a number of gas disputes between Russia and Central and Eastern European countries have unveiled the strategic dependence of Europe on Russian piped gas. The recent Ukrainian crisis demonstrated that Europe has a desperate need to improve the security of its gas supply. The United States is interested in the economic stability and growth of Europe, because the European Union (EU) is its principal and largest economic partner. The United States and the EU enjoy the largest trade and investment relationship in the world, which should not be jeopardized by disruptive, anti-status-quo powers. …

History, Governmental Structure, And Politics: Defining The Scope Of Local Board Of Health Power, Pekham Pal

Fordham Law Review

    Local boards of health often issue regulations that have broad effects that surpass the borders of the city or county to which they apply. Promulgation of such rules by board of health members appointed by the executive branch implicates separation of powers concerns; because such regulations may so extensively burden a locality’s citizens, it may be more appropriate for elected officials to adopt these regulations. Indeed, local businesses or other interested parties often bring suit challenging local board of health actions. Courts apply different analytical methodologies to review these challenges, which often leads to incongruent local health agency discretion for …

Security And Privacy Of Electronic Health Information Systems: Editorial, Elisa Bertino, Robert H. Deng, Xinyi Huang, Jianying Zhou

Research Collection School Of Computing and Information Systems

Digital technologies have dramatically transformed our daily lives by bringing countless conveniences and benefits. As an evolving concept, electronic health information has become the focus of attention in both academia and industry. By leveraging modern digital technologies like the internet and the cloud, electronic health information systems will be a key enabling technology in improving the quality and convenience of patient care, encouraging patient participation in their care, reducing medical errors, improving practice efficiencies, and saving time and cost. The complexity of electronic health information systems, however, raises several new security and privacy issues. It is thus critical to investigate …

Patterns Of Anthropogenic Nutrient Contaminants In The Otter Creek Watershed, Madison County, Kentucky, Elijah D. Wolfe, Walter S. Borowski, Jacob L. Robin

EKU Faculty and Staff Scholarship

We measured nutrient concentrations within the Otter Creek watershed (Madison County, Kentucky) to: (1) discover levels of anthropogenic contaminants affecting the water quality; (2) compare these measurements to a national data set; and (3) identify nutrient sources. The watershed mainly drains rural land characterized by cattle grazing, but also drains the town of Richmond. We sampled throughout the watershed to gain a representative perspective of nutrient levels and specifically targeted localities of suspected anthropogenic nutrient sources. Water samples were passed through a 0.45 mm filter, placed in pre-acidified vials, and measured one to two days after collection. Nutrients – ammonium, …

Huntington’S Disease Cerebrospinal Fluid Seeds Aggregation Of Mutant Huntingtin, Z. Tan, W. Dai, Theo G.M. Van Erp, J. Overman, A. Demuro, M. A. Digman, A. Hatami, R. Albay, Emily M. Sontag, K. T. Potkin, S. Ling, F. Macciardi, W. E. Bunney, J. D. Long, J. S. Paulsen, J. M. Ringman, I. Parker, Charles G. Glabe, L. M. Thompson, W. Chiu, Steven G. Potkin

Biological Sciences Faculty Research and Publications

Huntington’s disease (HD), a progressive neurodegenerative disease, is caused by an expanded CAG triplet repeat producing a mutant huntingtin protein (mHTT) with a polyglutamine-repeat expansion. Onset of symptoms in mutant huntingtin gene-carrying individuals remains unpredictable. We report that synthetic polyglutamine oligomers and cerebrospinal fluid (CSF) from BACHD transgenic rats and from human HD subjects can seed mutant huntingtin aggregation in a cell model and its cell lysate. Our studies demonstrate that seeding requires the mutant huntingtin template and may reflect an underlying prion-like protein propagation mechanism. Light and cryo-electron microscopy show that synthetic seeds nucleate and enhance mutant huntingtin aggregation. …

Neurophysiological Correlates Of The Critical Bandwidth In The Human Auditory System, Grace Ann Bentley

Theses and Dissertations

The critical bandwidth (CBW) is an auditory phenomenon that has been used to study various aspects of auditory processing, including auditory masking, complex tone processing, and loudness perception. Although the psychoacoustic aspects of the CBW have been well studied, the underlying neurophysiology of the CBW has not been as thoroughly examined. The current study examined the neurophysiology of the CBW in young adults, as well as loudness perception in response to the CBW. Auditory stimuli consisting of complex tones of varying bandwidths were presented to 12 individuals (6 male and 6 female, ages 18-26 years). Complex tones were presented around …

The Origins Of Legislation, Ganesh Sitaraman

Vanderbilt Law School Faculty Publications

Although legislation is at the center of legal debates on statutory interpretation, administrative law, and delegation, little is known about how legislation is actually drafted. If scholars pay any attention to Congress at all, they tend to focus on what happens after legislation is introduced, ignoring how the draft came to exist in the first place. In other words, they focus on the legislative process, not the drafting process. The result is that our account of Congress, the legislative process, and the administrative state is impoverished, and debates in statutory interpretation and administrative law are incomplete. This Article seeks to …

How Algorithmic Trading Undermines Efficiency In Capital Markets, Yesha Yadav

Vanderbilt Law School Faculty Publications

This Article argues that the rise of algorithmic trading undermines efficient capital allocation in securities markets. It is a bedrock assumption in theory that securities prices reveal how effectively public companies utilize capital. This conventional wisdom rests on the straightforward premise that prices reflect available information about a security and that investors look to prices to decide where to invest and whether their capital is being productively used. Unsurprisingly, regulation relies pervasively on prices as a proxy for the allocative efficiency of investor capital.

Algorithmic trading weakens the ability of prices to function as a window into allocative efficiency. This …

Predicting Consumer Demand Responses To Carbon Labels, Michael P. Vandenbergh, Sharon A. Shewmake, Abigail Okrent, Lanka Thabrew

Vanderbilt Law School Faculty Publications

Providing carbon footprint labels for all food products is a daunting and potentially infeasible project. Knowing how consumers substitute away from high carbon goods and what they choose as substitutes is essential for understanding which goods are likely to result in meaningful reductions in carbon emissions. This paper proposes a model to systematically estimate how consumers will respond to information from a carbon footprint label. Our model uses consumers' value of their individual carbon footprint with own- and cross-price elasticities of demand data on carbon emissions from life cycle analysis to simulate shifts in consumer demand for 42 food products …

Revitalizing Dormant Commerce Clause Review For Interstate Coordination, Jim Rossi, Alexandra B. Klass

Vanderbilt Law School Faculty Publications

Interstate coordination presents one of the most difficult challenges for American federalism as well as for energy markets and policy. Existing laws vest the approval of large-scale energy infrastructure projects such as interstate oil pipelines and high-voltage, interstate electric transmission lines with state and local levels of government. At the same time, state siting and eminent domain regimes routinely enable and even encourage state regulators to hold out from approving interstate infrastructure projects, hobbling any hope for interstate coordination. This Article analyzes how judicial review under dormant Commerce Clause principles and doctrine can promote better interstate coordination by discouraging regulatory …

Saint Jovan Bigorski - A Macedonian Orthodox Cultic Place, Ruzica Cacanoska, Maya Angelovska-Panova

Occasional Papers on Religion in Eastern Europe

The subject matter of this paper is the socio-historical analysis of the cult1 life of the Saint Jovan (John) Bigorski Monastery. This subject matter will be elaborated by developing a historical frame wherewith the sociological research element will be merged; this element will specifically emphasize the impact of the miraculous icon on the promotion and cultic life of the Saint Jovan Bigorski Monastery.

The Genesis Of 'Hungarism': Bishop Ottokár Prohászka And The Extremist Right In 1920s Hungary, Csaba Fazekas

Occasional Papers on Religion in Eastern Europe

Ottokár Prohászka (1858–1927) was a famous and well-known Hungarian Catholic cleric, starting from 1905, when he became bishop of Székesfehérvár. His life and works often got into the center of discussions, not only among historians and ecclesiastical circles, but also among politicians. At the beginning of the 20th century, Prohászka was also extremely popular with liberals, as his activities represented a promise to renew and modernize Catholicism. Prohászka imagined this modernization on the basis of the social principles of Catholicism, and considered the spread of a “Jewish” mentality, alien to the Hungarian nation, as the fundamental problem.

Growth And Gas Formation By Lactobacillus Wasatchensis, A Novel Obligatory Heterofermentative Nonstarter Lactic Acid Bacterium, In Cheddar-Style Cheese Made Using A Streptococcus Thermophilus Starter, Western Dairy Center, Utah State University, Megan Jane Ostler, Jeff Broadbent, Craig J. Oberg, Donald J. Mcmahon

Nutrition, Dietetics, and Food Sciences Faculty Publications

A novel slow-growing, obligatory heterofermentative, nonstarter lactic acid bacterium (NSLAB) Lactobacillus wasatchensis WDC04 was studied for growth and gas production in Cheddar-style cheese made using Streptococcus thermophilus as the starter culture. Cheesemaking trials were conducted using St. thermophilus alone or in combination with Lb. wasatchensis deliberately added to cheese milk at a level of ~10⁴ cfu/ml. Resulting cheeses were ripened at 6 or 12°C. At d 1, starter streptococcal numbers were similar in both cheeses (~10⁹ cfu/g) and fast-growing NSLAB lactobacilli counts were below detectable levels (<10² cfu/g). As expected, Lactobacillus wasatchensis counts were 3 x 10 …

Drugs For The Indigent: A Proposal To Revise The 340b Drug Pricing Program, Connor J. Baer

William & Mary Law Review

No abstract provided.

2015 Tax Conference Speakers

William & Mary Annual Tax Conference

No abstract provided.

"Deemed" Security Interests In Ucc Article 9: Avoiding Traps For The Unwary, Paul Wangerin

DePaul Business & Commercial Law Journal

No abstract provided.

The Battle Of The Branches: The Impact Of The Judiciary And Title Vi On Desegregation In The American Public School System, Kelsey D. Mccarthy

San Diego Law Review

This Comment analyzes the debate regarding the catalyst for desegregation in the American public school system: judicial intervention or Congress’s legislative action, specifically through implementation of Title VI, which authorized revocation of funds to school districts that did not comply with the desegregation mandate. Part I will summarize the historical events and developments that paved the way to the Supreme Court’s decision in Brown. Part II looks at how the Brown decision alone was not enough to effectuate immediate change in southern schools, despite the court’s order in the second Brown decision, Brown v. Board of Education (Brown II) that …

Teaching Behavior Questionnaire : Verifying Factor Structure And Investigating Depressive Symptoms In Catholic Middle And High Schools., Caroline M. Pittard, Patrick Pössel, Rosamond J. Smith

Faculty and Staff Scholarship

Teaching behavior impacts student psychopathology. This study explored the associations between teaching behavior types and depressive symptoms in students. The Teaching Behavior Questionnaire (TBQ) and the Center for Epidemiological Studies – Depression Scale (CES-D) were completed by 763 middle and 976 high school students from private Catholic schools. In the middle school sample, a confirmatory factor analysis confirmed the four-factor structure of the TBQ previously found in public high schools. As predicted, a two-level hierarchical linear model (HLM) analysis with the high school sample found that only the Negative Teaching Behavior scale of the TBQ was positively related to CES-D …

Challenges In The Pharmacokinetics Of Therapeutic Proteins, Wararat Limothai

Theses and Dissertations (ETD)

Due to the complex structure and complicated disposition pattern of therapeutic macromolecules, their pharmacokinetic interpretation has many challenges. Two of these challenges were investigated in this dissertation: 1) the error of classical bioavailability assessment observed during subcutaneous (SC) administration of therapeutic macromolecules that undergo target-mediated drug disposition (TMDD) and 2) the ontogeny of the neonatal Fc receptor (FcRn) expression along with its effect on the pharmacokinetics of monoclonal antibodies (mAbs) during development.

TMDD often well describes the pharmacokinetics of therapeutic proteins that have high specificity and affinity of binding to their target receptors. The target receptors can be saturated by …

Alcohol And Drug Use Among College Students Attending Public Four-Year Institutions: Implications For Practice And Policy, Marlena Ballard Coco, Frankie Santos Laanan

Faculty and Staff Publications & Presentations

No abstract provided.

Determination Of Nanoparticle Localisation Within Subcellular Organelles In Vitro Using Raman Spectroscopy, Esen Efeoglu, Mark Keating, Jennifer Mcintyre, Alan Casey, Hugh Byrne

Articles

Ease of sample preparation, narrow spectral bandwidth and minimal influence from water are features of Raman spectroscopy which make it a powerful, label-free way to study a wide range of biological structures and phenomena. In this context, given the concerns over their toxicology arising from their increased production and use, evaluation of nanoparticle uptake and localisation in biological systems and determination of the mechanisms of subcellular interaction and trafficking can provide long-term solutions for nanotoxicology, and potential strategies for nanomedicine. In this study, Raman spectroscopy is explored to monitor the sequential trafficking of nanoparticles through subcellular organelles in-vitro and to …

Investigating The Role Of Shape On The Biological Impact Of Gold Nanoparticles In Vitro, Furong Tian, Hugh Byrne, Joao Conde, Tobias Stoeger, Martin Clift,, Alan Casey, Pablo Del Pino, Beatriz Pelaz, Barbara Rothen-Rutishauser,, Giovani Estrada, Jesús De La Fuente

Articles

Aim: To investigate the influence of gold nanoparticle (GNP) geometry on the biochemical response of Calu-3 epithelial cells.

Materials and Methods: Spherical, triangular and hexagonal GNPs were used. The GNP-cell interaction was assessed via atomic absorption spectroscopy (AAS) and transmission electron microscopy (TEM). The biochemical impact of GNPs was determined over 72hrs at [0.0001-1mg/mL].

Results: At 1mg/mL, hexagonal GNPs reduced Calu-3 viability below 60%, showed increased reactive oxygen species production and higher expression of pro-apoptotic markers. A cell mass burden of 1:2:12 as well as number of GNPs per cell (2:1:3) was observed for spherical:triangular:hexagonal GNPs.

Conclusion:

These findings do …

Raman Spectroscopy For Screening And Diagnosis Of Cervical Cancer, Fiona Lyng, Damien Traynor, Ines Rm Ramos, Franck Bonnier, Hugh Byrne

Articles

Cervical cancer is the fourth most common cancer in women worldwide and mainly affects younger women. The mortality associated with cervical cancer can be reduced if this disease is detected at the pre-cancer stage. Current gold standard methods include cytopathology, HPV testing and histopathology but these methods are limited in terms of subjectivity, cost and time. There is an unmet clinical need for new methods to aid clinicians in the early detection of cervical pre-cancer. These methods should be objective, rapid and require minimal sample preparation. Raman spectroscopy is a vibrational spectroscopic technique by which incident radiation is used to …