Digital Commons Network^™

The Unique N- And C-Terminal Domains Of Metallothionein-3 Influence The Growth And Differentiation Of Breast Cancer Cells, Brent Jeffrey Voels

Theses and Dissertations

Toxic insult from the heavy metal cadmium is known to induce the expression of metallothioneins (MT) which are cysteine-rich heavy metal binding proteins six to seven kilodaltons in size. Previous research demonstrates that over-expression of MT-3 occurs in the majority of breast cancers and is associated with poor patient outcome. Furthermore, MT-3 has been shown to inhibit the growth of breast cancer and prostate cancer cell lines. Studies have shown that the MT-3 protein contains 7 additional amino acids that are not present in any other member of the MT gene family, a 6 amino acid C-terminal sequence and a …

Characterization Of Kraft Alkali Lignin And Products Of Its Thermal Degradation By Fractional Pyrolysis Methods, Keith Michael Voeller

Theses and Dissertations

At present, methods addressing the characterization of lignin and its decomposition products are limited. Typical approaches reported various spectroscopic, chromatographic and thermal methods. None of the methods is ideal for different reasons. In this study, a novel thermal carbon analysis (TCA) was developed providing essential mass balance data complementary to liquid-liquid extraction (LLE) prior to separation and identification by gas chromatography and mass spectrometry (GC-MS) as well as thermal desorption-pyrolysis-gas chromatography-mass spectrometry (TD-Py-GC-MS) to fully characterize lignin and its degradation products from hydrothermal treatment in subcritical water conditions.

The TCA method enabled a quantitative thermal evolution profile through TD and …

How Shared Experiences Impact Teachers Who Remain In American Indian Elementary Schools More Than Five Years, Rae Marie Wilkie-Villebrun

Theses and Dissertations

This qualitative study examined shared experiences of teachers who remain at American Indian schools teaching for five years or more in an attempt to help administrators understand what factors impact a teacher’s decision to stay. Teachers, regardless of their race or gender, who have worked at an American Indian school for five years or longer, were interviewed. The teachers were recruited to participate in this study through their superintendent/principals and personal contacts. The theoretical framework used to guide this study was a social support model studied by LaRocco, House, and French in 1980. They examined the effect of perceived social …

The Future Of Polyamorous Marriage Lessons From The Marriage Equality Struggle, Hadar Aviram, Gwendolyn Leachman

Faculty Scholarship

No abstract provided.

Are Private Prisons To Blame For Mass Incarceration And Its Evils? Prison Conditions, Neoliberalism, And Public Choice, Hadar Aviram

Faculty Scholarship

No abstract provided.

Troubled Waters Diana Nyad And The Birth Of The Global Rules Of Marathon Swimming, Hadar Aviram

Faculty Scholarship

No abstract provided.

Restoring Community Dignity Following Police Misconduct Reforming The Criminal Injustice System: Essay, John Felipe Acevedo

Essays, Reviews, and Shorter Works

No abstract provided.

Free Speech Paternalism And Free Speech Exceptionalism: Pervasive Distrust Of Government And The Contemporary First Amendment Book Reviews And Responses, Ronald J. Krotoszynski Jr.

Essays, Reviews, and Shorter Works

No abstract provided.

Manufacturing Optimization Of Non-Traditional Pasta Products, Elena De La Peña

Plant Sciences

A study was conducted to determine the effect of including non-traditional ingredients on the flow and agglomeration properties of flour formulations, the rheological behavior of pasta dough, and the physical and cooked quality of the spaghetti. The effect of including non-traditional ingredients on the chemical changes that occurred in pasta during pasta making and cooking was also investigated. The formulations used were semolina 100% (S), whole wheat flour 100% (WW), semolina-whole wheat flour (49:51) (SWW), semolina-flaxseed flour (90:10), whole wheat flour-flaxseed flour (90:10), and semolina-whole wheat flour-flaxseed flour (39:51:10). Flaxseed flour was incorporated as fine (FF) or coarse (CF) particles. …

Patent Demands And Initial Public Offerings, Robin Feldman, Evan Frondorf

Faculty Scholarship

Quantitative analysis of patent behavior is critical, as congressional and regulatory agencies consider the impact of patent trolling on modern markets. Anecdotal evidence has suggested that “non-practicing entities,” also known as “patent trolls,” specifically target companies for lawsuits, licensing demands, or other monetization activity as firms approach or complete major funding events, such as their initial public offering (IPO). To test this narrative, we survey in-house legal staff at companies that have recently gone public about their exposure to patent demands surrounding their first round of venture capital funding and their IPO. The study is one of the first attempts …

Merit-Based Sentencing Reductions: Moving Forward On Specifics, And Some Critique Of The New Model Penal Code, Rory Little

Faculty Scholarship

No abstract provided.

Toward A More Perfect Union?: The Dangers Of Conflating Progress And Equality, Leo P. Martinez

Faculty Scholarship

No abstract provided.

Politics Of Nonenforcement, Zachary S. Price

Faculty Scholarship

No abstract provided.

Institutionalized Disruption: The Rise Of The Reformer Startup, Abraham Cable

Faculty Scholarship

No abstract provided.

Do Patent Licensing Demands Mean Innovation?, Robin Feldman, Mark A. Lemley

Faculty Scholarship

No abstract provided.

A Genuine Civil Justice Crisis?, Richard L. Marcus

Faculty Scholarship

No abstract provided.

The Role Of Law And Lawyers For Disaster Victims: A Uc Hastings-Waseda Symposium On The Legal Aftermath Of The Fukushima Daiichi Nuclear Power Station Disaster – Introduction To The Symposium Issue, Setsuo Miyazawa

Faculty Scholarship

No abstract provided.

How (Not) To Regulate Assisted Reproductive Technology: Lessons From "Octomom", Radhika Rao

Faculty Scholarship

No abstract provided.

Responding To The Childhood Vaccination Crisis: Legal Frameworks And Tools In The Context Of Parental Vaccine Refusal, Dorit Rubenstein Reiss, Lois A. Weithorn

Faculty Scholarship

No abstract provided.

Forward, Contract Law Present And Future: A Symposium To Honor Professor Charles L. Knapp On Fifty Years Of Teaching Law, H.G. Prince

Faculty Scholarship

No abstract provided.

Empowering Law Students To Overcome Extreme Public Speaking Anxiety: Why Just Be It Works And Just Do It Doesn't, Heidi K. Brown

Articles & Chapters

For law students experiencing extreme public speaking anxiety, which can manifest from variations of introversion, shyness, social anxiety, or social phobia, the Socratic method of intellectual discourse — either in the classroom or in the first-year oral argument experience — can trigger such a high level of apprehension that it may threaten even an otherwise strong student’s confidence in his or her future as an attorney. Extreme public speaking anxiety can pose a serious impediment to processing and comprehending legal concepts, and engaging with professors, classmates, and substantive material. Unless the anxious law student takes steps to address the roots …

Non-Transferrin-Bound Iron Is Associated With Biomarkers Of Oxidative Stress, Inflammation And Endothelial Dysfunction In Type 2 Diabetes, Husam Aljwaid, Desley L. White, Keith J. Collard, A. John Moody, Jonathan H. Pinkney

School of Health Professions

No abstract provided.

Implementation Science: A Reappraisal Of Our Journal Mission And Scope, Robbie Foy, Anne Sales, Michel Wensing, Gregory A. Aarons, Signe Flottorp, Bridie Kent, Susan Michie, D O’Connor, Anne Rogers, Nick Sevdalis, Sharon Straus, Paul Wilson

School of Nursing and Midwifery

No abstract provided.

Nurses' Perceptions Of Using An Evidence-Based Care Bundle For Initial Emergency Nursing Management Of Patients With Severe Traumatic Brain Injury: A Qualitative Study, Jintana Damkliang, Julie Considine, Bridie Kent, Maryann Street

School of Nursing and Midwifery

No abstract provided.

The Effectiveness Of Psychosocial Intervention For Individuals With Cleft Lip And/Or Palate., Alyson Norman, Martin Persson, Nicola Stock, Nichola Rumsey, Jonathan Sandy, Andrea Waylen, Zoe Edwards, Vanessa Hammond, Lucy Partridge, Andy Ness

School of Psychology

OBJECTIVE: The aim of this review was to assess the effectiveness of different psychological interventions for children and adults with cleft lip and/or palate and their parents. DESIGN: We searched six databases including MEDLINE and EMBASE to June 2013 and checked bibliographies. We included research that evaluated any psychological intervention in studies in which at least 90% of the participants had cleft lip and/or palate or were parents of those with cleft lip and/or palate. Studies containing less than 90% were excluded unless they reported results separately for those with cleft lip and/or palate, or raw data were available upon …

Developing Students’ Energy Literacy In Higher Education, D Cotton, W Miller, J Winter, I Bailey, S Sterling

School of Geography, Earth and Environmental Sciences

No abstract provided.

Determining Riverine Sediment Storage Mechanisms Of Biologically Reactive Phosphorus In Situ Using Dgt, Emily E. Burns, Sean Comber, William Blake, Rupert Goddard, Laurence Couldrick

School of Geography, Earth and Environmental Sciences

No abstract provided.

A Qualitative Study Of The Impact Of Severe Asthma And Its Treatment Showing That Treatment Burden Is Neglected In Existing Asthma Assessment Scales., Michael E. Hyland, Ben Whalley, Rupert C. Jones, Matthew Masoli

School of Psychology

BACKGROUND: People with severe asthma experience significant respiratory symptoms and suffer adverse effects of oral corticosteroids (OCS), including disturbed mood and physical symptoms. OCS impacts on health-related quality of life (HRQoL) have not been quantified. Asthma HRQoL scales are valid as outcome measures for patients requiring OCS only if they assess the deficits imposed by OCS. AIMS: The aim of this study was to compare the burden of disease and treatment in patients with severe asthma with items in eight asthma-specific HRQoL scales. METHODS: Twenty-three patients with severe asthma recruited from a severe asthma clinic were interviewed about the impact …

Refractory Depression: Mechanisms And Evaluation Of Radically Open Dialectical Behaviour Therapy (Ro-Dbt) [Reframed]: Protocol For Randomised Trial, T. R. Lynch, B. Whalley, R. J. Hempel, S. Byford, P Clarke, S Clarke, D. Kingdon, H. O'Mahen, I. T. Russell, J. Shearer, M. Stanton, M. Swales, A. Watkins, B. Remington

School of Psychology

IntroductionOnly 30–40% of depressed patients treated with medication achieve full remission. Studies that change medication or augment it by psychotherapy achieve only limited benefits, in part because current treatments are not designed for chronic and complex patients. Previous trials have excluded high-risk patients and those with comorbid personality disorder. Radically Open Dialectical Behaviour Therapy (RO-DBT) is a novel, transdiagnostic treatment for disorders of emotional over-control. The REFRAMED trial aims to evaluate the effectiveness and cost-effectiveness of RO-DBT for patients with treatment-resistant depression.Methods and analysisREFRAMED is a multicentre randomised controlled trial, comparing 7 months of individual and group RO-DBT treatment with …

Polymorphisms Near Tbx5 And Gdf7 Are Associated With Increased Risk For Barrett’S Esophagus, Claire Palles, Laura Chegwidden, Xinzhong Li, John M. Findlay, Garry Farnham, Giner F Castro, Maikel P. Peppelenbosch, Michal Kovac, Claire L. Adams, Hans Prenen, Sarah Briggs, Rebecca Harrison, Scott Sanders, David Macdonald, Chris Haigh, Art Tucker, Sharon Love, Manoj Nanji, John Decaestecker, David Ferry, Barrie Rathbone, Julie Hapeshi, Hugh Barr, Paul Moayyedi, Peter Watson, Barbara Zietek, Neera Maroo, Laura Gay, Tim Underwood, Lisa Boulter, Hugh Mcmurtry, David Monk, Praful Patel, Krish Ragunath, Dulaimi D Al, Iain Murray, Konrad Koss, Andrew Veitch, Nigel Trudgill, Chuka Nwokolo, Bjorn Rembacken, Paul Atherfold, Elaine Elaine Green, Yeng Ang, Ernst J. Kuipers, Wu Chow, Stuart Paterson, Sudarshan Kadri, Ian Beales, Charles Grimley, Paul Mullins, Conrad Beckett, Mark Farrant, Andrew Dixon, Sean Kelly, Matthew Johnson, Shahjehan Wajed, Anjan Dhar, Elinor Sawyer, Rebecca Roylance, Lynn Onstad, Marilie D. Gammon, Douglas A. Corley, Nicholas J. Shaheen, Nigel C. Bird, Laura J. Hardie, Brian J. Reid, Weimin Ye, Geoffrey Liu, Yvonne Romero, Leslie Bernstein, Anna H. Wu, Alan G. Casson, Rebecca Fitzgerald, David C. Whiteman, Harvey A. Risch, David M. Levine, Tom L. Vaughan, Auke P. Verhaar, Den Brande J Van, Eelke L. Toxopeus, Manon C. Spaander, Bas P.L. Wijnhoven, Der Laan Ljw Van, Kausilia Krishnadath, Cisca Wijmenga, Gosia Trynka, Ross Mcmanus, John V. Reynolds, J O’Sullivan, Padraic Macmathuna

Peninsula Medical School

No abstract provided.