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2015-December-22-Etsu Partners With Peace Corps To Offer New Academic Program, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Acculturation And Alcohol Drinking Behavior Among Chinese International University Students In The Midwest, Shuangshuang Cai

College of Education and Human Sciences: Dissertations, Theses, and Student Research

The purpose of this study was to explore the relationship between alcohol consumption and acculturation among Chinese international university students in the Midwestern part of the United States. A sample of 91 students from a university in the Midwest participated in the study. All were Chinese and included undergraduate and graduate students. Measures used included the General Ethnicity Questionnaire–Chinese Version (Abridged); the General Ethnicity Questionnaire–American Version (Abridged); the Alcohol Expectancy Questionnaire (AEQ-3); the Alcohol Use Questionnaire, consisting of two subscales, drinking frequency and drinking quantity; and a demographic form created by the author. Results indicated that older Chinese international students …

Small-Scale Projects And Their Potential For Urban Regeneration: Experiences From Eastern Germany, Christina Götz, Ian Cooper, Krassimira Paskaleva-Shapira

Economic and Business Review

The notion that urban living is composed of multiple, interacting aspects instead of only depending on the condition of buildings is widely known. However, once urban renewal is considered, talk automatically turns to large-scale rebuilding projects. To date, there has been little knowledge exchange about projects that take place on the local level, tackling the socio-cultural dimension of urban life. While not destroying, but transforming, what already exists into something socially valuable, such projects open up a set of opportunities for the urban community. This paper draws upon German case studies to propose a definition for such projects and to …

Formal Modeling And Verification Of Delay-Insensitive Circuits, Hoon Park

Dissertations and Theses

Einstein's relativity theory tells us that the notion of simultaneity can only be approximated for events distributed over space. As a result, the use of asynchronous techniques is unavoidable in systems larger than a certain physical size. Traditional design techniques that use global clocks face this barrier of scale already within the space of a modern microprocessor chip. The most common response by the chip industry for overcoming this barrier is to use Globally Asynchronous Locally Synchronous (GALS) design techniques. The circuits investigated in this thesis can be viewed as examples of GALS design. To make such designs trustworthy it …

Mechanisms Of Adaptation In The Newly Invasive Species Brachypodium Sylvaticum (Hudson) Beauv., Gina Lola Marchini

Dissertations and Theses

It is common knowledge that invasive species cause worldwide ecological and economic damage, and are nearly impossible to eradicate. However, upon introduction to a novel environment, alien species should be the underdogs: They are present in small numbers, possess low genetic diversity, and have not adapted to the climate and competitors present in the new habitat. So, how are alien species able to invade an environment occupied by native species that have already adapted to the local environment? To discover some answers to this apparent paradox I conducted four ecological genetic studies that utilized the invasive species Brachypodium sylvaticum (Hudson) …

Reliability And Validity Of Neurobehavioral Function On The Psychology Experimental Building Language Test Battery In Young Adults, Brian J. Piper, Shane Mueller, Alexander R. Geerken, Kyle L. Dixon, Gregory Kroliczak, Reid H. Olsen, Jeremy K. Miller

Michigan Tech Publications, Part 1

Background. The Psychology Experiment Building Language (PEBL) software consists of over one-hundred computerized tests based on classic and novel cognitive neuropsychology and behavioral neurology measures. Although the PEBL tests are becoming more widely utilized, there is currently very limited information about the psychometric properties of these measures.

Methods. Study I examined inter-relationships among nine PEBL tests including indices of motor-function (Pursuit Rotor and Dexterity), attention (Test of Attentional Vigilance and Time-Wall), working memory (Digit Span Forward), and executive-function (PEBL Trail Making Test, Berg/Wisconsin Card Sorting Test, Iowa Gambling Test, and Mental Rotation) in a normative sample (N = 189, …

State V. Votroubek Respondent's Brief Dckt. 43104

Not Reported

No abstract provided.

State V. Freeman Respondent's Brief Dckt. 43116

Not Reported

No abstract provided.

State V. Barrett Respondent's Brief Dckt. 43235

Not Reported

No abstract provided.

State V. Talley Appellant's Brief Dckt. 43349

Not Reported

No abstract provided.

Pvt1 Exon 9: A Potential Biomarker Of Aggressive Prostate Cancer?, Adeodat Ilboudo, Jyoti Chouhan, Brian K. Mcneil, Joseph R. Osborne, Olorunseun O. Ogunwobi

Publications and Research

Prostate cancer (PCa) is the most commonly diagnosed cancer as well as the greatest source of cancer-related mortality in males of African ancestry (MoAA). Interestingly, this has been shown to be associated with single nucleotide polymorphisms around regions 2 and 3 of the 8q24 human chromosomal region. The non-protein coding gene locus Plasmacytoma Variant Translocation 1 (PVT1) is located at 8q24 and is overexpressed in PCa and, therefore, is also a candidate biomarker to explain the well-known disparity in this group. PVT1 has at least 12 exons that make separate transcripts which may have different functions, all of which are …

Results Of A Community Randomized Study Of A Faith-Based Education Program To Improve Clinical Trial Participation Among African Americans, Paula M. Frew, Jay T. Schamel, Kelli A. O'Connell, Laura A. Randall, Sahithi Boggavarapu

Environmental & Global Health Faculty Research

This is a report of a cluster randomized clinical trial evaluating the effectiveness of a church-based educational intervention aimed at improving African Americans’ (AA) participation in clinical trials. Two hundred and twenty-one AA subjects ages ≥50 years from six predominantly AA churches were randomized to intervention or control condition. The intervention included three educational sessions about clinical trials and health disparities; control participants completed questionnaires. Primary endpoints of the study were differences in individual subjects' intentions to obtain clinical trial information and intention to join a clinical trial, as determined by 10 point scale items at baseline, three and six …

Period-1 Encodes An Atp-Dependent Rna Helicase That Influences Nutritional Compensation Of The Neurospora Circadian Clock, Jillian M. Emerson, Bradley M. Bartholomai, Carol S. Ringelberg, Scott E. Baker, Jennifer Loros, Jay Dunlap

Dartmouth Scholarship

Mutants in the period-1 (prd-1) gene, characterized by a recessive allele, display a reduced growth rate and period lengthening of the developmental cycle controlled by the circadian clock. We refined the genetic location of prd-1 and used whole genome sequencing to find the mutation defining it, confirming the identity of prd-1 by rescuing the mutant circadian phenotype via transformation. PRD-1 is an RNA helicase whose orthologs, DDX5 [DEAD (Asp-Glu-Ala-Asp) Box Helicase 5] and DDX17 in humans and DBP2 (Dead Box Protein 2) in yeast, are implicated in various processes, including transcriptional regulation, elongation, and termination, ribosome biogenesis, and mRNA decay. …

Fungal Melanin: What Do We Know About Structure?, Joshua D. Nosanchuk, Ruth E. Stark, Arturo Casadevall

Publications and Research

The production of melanin significantly enhances the virulence of many important human pathogenic fungi. Despite fungal melanin’s importance in human disease, as well as melanin’s contribution to the ability of fungi to survive in diverse hostile environments, the structure of melanin remains unsolved. Nevertheless, ongoing research efforts have progressively revealed several notable structural characteristics of this enigmatic pigment, which will be the focus of this review. These compositional and organizational insights could further our ability to develop novel therapeutic approaches to combat fungal disease and enhance our understanding of how melanin is inserted into the cell wall.

Youth: The Motor Of Redevelopment In Mid-Sized Post-Industrial Towns, Naja Marot

Economic and Business Review

This article builds on the results of a transnational project to reveal the importance of the youth in the redevelopment process of a post-industrial region. The introduction to the region and to collaborative planning is elaborated on the basis of two surveys performed in the Zasavje region and its central town of Trbovlje, in which the youth evaluated the state of the region and gave proposals for future development. The discussion focuses on the challenges and added value of the collaborative process for the development of the region and is then generalised to similar areas across Central Europe.

Hot Spot Mutation In Tp53 (R248q) Causes Oncogenic Gain-Of-Function Phenotypes In A Breast Cancer Cell Line Derived From An African American Patient, Nataly Shtraizent, Hiroshi Matsui, Alla Polotskaia, Jill Bargonetti

Publications and Research

African American (AA) breast cancer patients often have triple negative breast cancer (TNBC) that contains mutations in the TP53 gene. The point mutations at amino acid residues R273 and R248 both result in oncogenic gain-of-function (GOF) phenotypes. Expression of mutant p53 (mtp53) R273H associates with increased cell elasticity, survival under serum deprivation conditions, and increased Poly (ADP ribose) polymerase 1 (PARP1) on the chromatin in the AA-derived TNBC breast cancer cell line MDA-MB-468. We hypothesized that GOF mtp53 R248Q expression could stimulate a similar phenotype in the AA-derived TNBC cell line HCC70. To test this hypothesis we depleted the R248Q …

Gliopathy Of Demyelinating And Non-Demyelinating Strains Of Mouse Hepatitis Virus., Lawrence C. Kenyon, Kaushiki Biswas, Kenneth S Shindler, Manasi Nabar, Marjorie Stout, Susan T Hingley, Judith B Grinspan, Jayasri Das Sarma

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Demyelination in the central nervous system induced by neurovirulent strains of Mouse Hepatitis Virus (MHV) is mediated by the viral spike glycoprotein, but it is not clear whether the mechanism of this disease pathology involves direct viral infection of oligodendrocytes. Detailed studies of glial cell tropism of MHV are presented, demonstrating that direct MHV infection of oligodendrocytes differs between demyelinating (RSA59) and non-demyelinating (RSMHV2) viral strains both in vitro and in vivo. Our results indicate that direct injury of mature oligodendrocytes is an important mechanism of virus-induced demyelination. In vivo, RSA59 infection was identified in spinal cord gray and white …

Tbx2 Represses Pten In Rhabdomyosarcoma And Skeletal Muscle., B Zhu, M Zhang, E M Williams, C Keller, A Mansoor, J K Davie

Articles

Rhabdomyosarcoma (RMS) is the most frequent soft tissue sarcoma in children that shares many features of developing skeletal muscle. TBX2, a T-box family member, is highly upregulated in tumor cells of both major RMS subtypes where it functions as an oncogene. TBX2 is a repressor that is often overexpressed in cancer cells and functions in bypassing cell growth control, including the repression of the cell cycle regulators p14 and p21. We have found that TBX2 directly represses the tumor-suppressor phosphatase and tensin homolog (PTEN) in both RMS and normal muscle. Exogenous expression of TBX2 in normal muscle cells downregulates PTEN, …

Dead Broets Society: Masculinity In Walt Whitman’S War Verse, Anika N. Jensen

The Gettysburg Compiler: On the Front Lines of History

There are two images of masculinity in Walt Whitman’s Drum-Taps, his collection of wartime poetry: one, the strong, hardened soldier, the image of manliness, and the other the boyish, rosy-cheeked recruit. Whitman’s sexuality, while not the Victorian social norm, was no secret, and he wrote openly of the hospitalized soldiers during his time as a Union nurse with admiration, affection, and love. Some critics, such as Thomas Wentworth Higginson, castigated Whitman’s queer themes to be overwhelming, distractingly sensual, and "unmanly," while others, like William Sloane Kennedy, dissented, arguing instead that the overt sexuality present in Whitman’s work was precisely …

Prion Protein Gene Sequence And Chronic Wasting Disease Susceptibility In White-Tailed Deer (Odocoileus Virginianus), Adam L. Brandt, Amy C. Kelly, Michelle L. Green, Paul Shelton, Jan Novakofski, Nohra E. Mateus-Pinilla

Faculty Creative and Scholarly Works

The sequence of the prion protein gene (PRNP) affects susceptibility to spongiform encephalopathies, or prion diseases in many species. In white-tailed deer, both coding and non-coding single nucleotide polymorphisms have been identified in this gene that correlate to chronic wasting disease (CWD) susceptibility. Previous studies examined individual nucleotide or amino acid mutations; here we examine all nucleotide polymorphisms and their combined effects on CWD. A 626 bp region of PRNP was examined from 703 free-ranging white-tailed deer. Deer were sampled between 2002 and 2010 by hunter harvest or government culling in Illinois and Wisconsin. Fourteen variable nucleotide positions …

Exploring The Relationship Between Commuting Stress, Job Strain And Safety Behaviors While Commuting: The Dual Role Of Work-Related Rumination, Katrina A. Burch

Master's Theses

For those who commute to and from work on a daily basis, this is an activity that requires attention to both what one is doing and the environment, in order for the commute to be done safely. Although research has shown that work can spill over into home and other non-work domains, very little attention has been paid to the impact that work may have on the transition time between one’s work and home domains. The present study sought to examine the impact of daily commuting stress and end-of-day job strain on the safety of one’s commute through the experience …

2015-12 Library Impact Statement For Hdf 318 Health And Wealth, Joanna Burkhardt

Collection Development Reports and Documents

Library Impact Statement submitted in response to new course proposal for HDF 318 Health and Wealth. This class was supported with no need for additional resources. Responding library faculty: Joanna Burkhardt. Requesting faculty: Nilton Proto.

Summer-Long Grazing Of High Vs. Low Endophyte (Neotyphodium Coenophialum)-Infected Tall Fescue By Growing Beef Steers Results In Distinct Temporal Blood Analyte Response Patterns, With Poor Correlation To Serum Prolactin Levels, Joshua J. Jackson, Merlin D. Lindemann, James A. Boling, James C. Matthews

Animal and Food Sciences Faculty Publications

Previously, we reported the effects of fescue toxicosis on developing Angus-cross steer growth, carcass, hepatic mRNA, and protein expression profiles of selected serum proteins, and blood clinical and chemical profiles, after summer-long grazing (85 days) of high endophyte (HE)- vs. low endophyte (LE)-infected fescue pastures. We now report the temporal development of acute, intermediate, and chronic responses of biochemical and clinical blood analytes determined at specified time intervals (period 1, day 0–36; period 2, day 37–58; and period 3, day 59–85). Throughout the trial, the alkaloid concentrations of the HE forage was consistently 19–25 times greater (P ≤ 0.002) …

The Murray Ledger And Times, December 21, 2015, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

What's Happening: December 21, 2015, Maine Medical Center

What's Happening

No abstract provided.

Timothy Fletcher V. Perry Phelps

2015 Decisions

USDC for the District of Delaware

Board Of Directors Of Sapphire V. George Simpson

2015 Decisions

USDC for the District Court of the Virgin Islands

Lorenzo Sims V. Wexford Health Sources Inc

2015 Decisions

USDC for the Western District of Pennsylvania

Development Of Self-Adjuvanted Self-Assembling Protein Nanoparticles For Use As Vaccine Candidates, Christopher P. Karch

Doctoral Dissertations

Nanotechnology and nanoparticles are one type of vaccine delivery system. Potentially, the most exciting nanoparticle for vaccine development is our Self-Assembling Protein Nanoparticles (SAPNs). Based off of coiled-coil oligomerization domains, SAPNs self-assemble into particles that are about the size and shape of small icosahedral viruses. Studies have demonstrated that SAPNs are effective vaccine candidates, inducing immune responses as well as protection for malaria, toxoplasmosis, influenza, and SARS. While effective, one missing component for SAPNs is the presence of an immunopotentiator. We have sought to resolve this problem by generating Self-Adjuvanted SAPNs. These SAPNs contain a small concentration of flagellin, a …

Answering Concussion's Crucial Questions, Staff

Browse All News

No abstract provided.