Digital Commons Network^™

Silibinin-Mediated Metabolic Reprogramming Attenuates Pancreatic Cancer-Induced Cachexia And Tumor Growth., Surendra K. Shukla, Aneesha Dasgupta, Kamiya Mehla, Venugopal Gunda, Enza Vernucci, Joshua J. Souchek, Gennifer Goode, Ryan King, Anusha Mishra, Ibha Rai, Sangeetha Nagarajan, Nina V. Chaika, Fang Yu, Surendra K. Shukla

Journal Articles: Eppley Institute

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related deaths in the US. Cancer-associated cachexia is present in up to 80% of PDAC patients and is associated with aggressive disease and poor prognosis. In the present studies we evaluated an anti-cancer natural product silibinin for its effectiveness in targeting pancreatic cancer aggressiveness and the cachectic properties of pancreatic cancer cells and tumors. Our results demonstrate that silibinin inhibits pancreatic cancer cell growth in a dose-dependent manner and reduces glycolytic activity of cancer cells. Our LC-MS/MS based metabolomics data demonstrates that silibinin treatment induces global metabolic reprogramming in pancreatic …

Exploring Strategies For Effective Advocacy: The Lived Experience Of Leaders Of Pakistani Non-Governmental Organizations, Rubina F. Bhatti

Dissertations

Non-governmental Organizations (NGOs) have increasingly been recognized as influential players in world politics and international development. Despite limited financial resources and having to rely on volunteers who often lack formal training, NGOs’ advocacy work has often been highly effective. Since the beginning of the 1990s, it has resulted in both the formulation of new policies and the cancellation or modification of existing ones.

Advocacy work by NGOs is especially important in countries like Pakistan because deep-rooted injustices and discrimination are unlikely to change without pressure from NGOs. This study investigated the strategies used by five NGO leaders for effective advocacy …

Reprogramming To Pluripotency Using Small Molecule Compounds, Brittany E. Greenberg

Theses and Dissertations (ETD)

The generation of induced pluripotent stem cells (iPSCs) through the use of small molecule compounds has evolved as a potential cellular reprogramming strategy. Individually, specific small molecule compounds have previously been shown to replace reprogramming transcription factors or enhance the efficiency of cellular reprogramming. More recently, a combination of small molecule compounds can replace all of the reprogramming factors. In this review, we describe in detail the generation of chemically induced pluripotent stem cells using small molecule inhibitors and activators that target either downstream protein kinases or modify chromatin structure to promote somatic cell reprogramming. In addition, epigenetic modulating small …

Burden, Depressive Symptoms, And Perceived Health In Male Caregivers Of Persons With End Stage Renal Disease, Loretta Alexia Williams

Theses and Dissertations (ETD)

Introduction: Men are increasingly assuming the role of caregiver to individuals with chronic illnesses. The debilitating effects of ESRD cause many of those diagnosed with the disease to require assistance from family caregivers. Caregiver literature well reports that caregivers experience mental and physical health effects related to this role. However, research involving the experiences of male caregivers of individuals with ESRD is understudied. These studies use the background and contextual as well as primary and secondary domains of the Stress Process Model to determine the levels of and explore the experiences associated with caregiver burden, depressive symptoms, and perceived health …

Development Of Oral Vaccines Against Lyme Disease, Rita Raquel Dos Anjos De Carvalho E Melo

Theses and Dissertations (ETD)

Lyme Disease, caused by the spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States and Europe. If left untreated, it can lead to permanent damage to the nervous and musculoskeletal systems. In some cases, patients that receive the recommended antibiotic therapy develop a debilitating health condition associated with substantial health care costs. Despite current preventive measures, the incidence and the geographic distribution of Lyme Disease continues to increase. Recent estimates from CDC suggest that the true number of cases of Lyme Disease in the US is approximately 300,000 per year. Yet, there is currently no vaccine …

Optimization Of Lead Spectinamide Compounds As Novel Anti-Tuberculosis Agents With A Pharmacometric Approach, Ashit Rasendu Trivedi

Theses and Dissertations (ETD)

In an effort to combat the global Tuberculosis pandemic, Dr.Richard E. Lee and his group at St.Jude Children’s Research Hospital designed a novel series of anti-tuberculosis agents, spectinamides – semi-synthetic analogs of spectinomycin. Spectinamides are a potent inhibitor of mycobacterial ribosomes and overcome efflux mediated drug resistance in M. tb. Spectinamides have shown an excellent in vitro activity, which makes them well suited for further lead optimization and preclinical development. We hypothesized that through pharmacokinetic (PK) and pharmacodynamics (PD) model-based dosing optimization studies, we could strategically guide the selection and refinement of more potent and effective anti-TB spectinamides. Biopharmaceutical in …

Medicaid Discontinuity Among Adults With Cardiovascular Disease Or High Risk Conditions: Associations With Medication Adherence And Health Care Utilization, Kiraat Divyang Munshi

Theses and Dissertations (ETD)

BACKGROUND: Medicaid coverage among adults is often characterized by discontinuity – loss of Medicaid coverage, and churning, or entering and exiting Medicaid – over short durations. Little is known about the impact of having discontinuous Medicaid coverage on access to care, preventive care, pharmacotherapy, primary care, and hospitalizations, among non-elderly adults with cardiovascular disease (CVD) or high-risk conditions.

OBJECTIVES: This dissertation employed a three empirical research papers approach to pursue the following aims: (1) characterize the adult subpopulations with CVD or conditions placing them at high risk for CVD who lack continuous Medicaid coverage, and examine the characteristics associated with …

Functional Analysis Of Genomic Variation And Impact On Molecular And Higher Order Phenotypes, Ashutosh Kumar Pandey

Theses and Dissertations (ETD)

Reverse genetics methods, particularly the production of gene knockouts and knockins, have revolutionized the understanding of gene function. High throughput sequencing now makes it practical to exploit reverse genetics to simultaneously study functions of thousands of normal sequence variants and spontaneous mutations that segregate in intercross and backcross progeny generated by mating completely sequenced parental lines. To evaluate this new reverse genetic method we resequenced the genome of one of the oldest inbred strains of mice—DBA/2J—the father of the large family of BXD recombinant inbred strains. We analyzed ~100X wholegenome sequence data for the DBA/2J strain, relative to C57BL/6J, the …

Development And Evaluation Of Amphotericin B Loaded Iron Oxide Nanoparticles For Targeted Drug Delivery To Systemic Fungal Infections, Pavan Balabathula

Theses and Dissertations (ETD)

A targeted nanotheronostic drug delivery system to diagnose and treat life threatening invasive fungal infections (IFIs) such as cryptococcal meningitis was designed, developed, characterized, and evaluated. To address the development processes, first, iron oxide nanoparticles (IONP) (34-40 nm) coated with bovine serum albumin (BSA), loaded and targeted with amphotericin B (AMB) (AMB-IONP) was formulated by applying a layer by layer approach. Several designs (A, B, C, D, & E) of AMB-IONP were developed and their physicochemical properties such as drug loading with HPLC method, particle size, poly dispersity index (PDI), and ζ-potential using dynamic light scattering (DLS) technique, morphology with …

Genetic Control Of Survival And Weight Loss During Pneumonic Burkholderia Pseudomallei (Bp) Infection, Felicia D. Emery

Theses and Dissertations (ETD)

Burkholderia pseudomallei (Bp) is a saprophytic, gram-negative aerobe and the causative agent of the disease melioidosis. Melioidosis is an infectious disease that occurs in humans and animals and is prevalent in Southeast Asia, northern Australia and other tropical areas. Transmission occurs through direct contact with the organism via ingestion, inhalation, or through open wounds and skin abrasions. Clinical presentation is extremely variable and can range from acute septicemia with bacterial dissemination to distant sites, to an isolated pulmonary infection. Treatment of melioidosis can be problematic because it is often difficult to diagnose and Bp is resistant to a diverse group …

Applying Molecular And Phenotypic Tools To Characterize Flesh Texture And Acidity Traits In The Arkansas Peach Breeding Program And Understanding The Crispy Texture In The Arkansas Blackberry Breeding Program, Alejandra Andrea Salgado Rojas

Graduate Theses and Dissertations

Quantitative trait loci (QTL) utilizing a pedigree-based analysis (PBA) approach was performed in the peach breeding program for the first time. The pedigree consisted of seven-F1 populations, their parents, ancestors, and cultivars. Flesh firmness and titratable acidity (TA) were examined in 2011, 2012, and 2013. For TA, a consistent and strong QTL was identified on the proximal end of linkage group (LG) 5 of the peach genome. For flesh firmness, two QTLs were located on LG 4. The first QTL was located on the chromosomal region where the slow-melting flesh (SMF) DNA test was identified, and the second QTL was …

Detection Of Trace Metals (Ai, V, Cr, Mn, Co, Ni, Cu, U, Ba, Zn,As, Mo, Cd) In The Houston Ship Channel Water By Inductively Coupled Plasma Mass Spectroscopy (Icp-Ms), Boingoc Thi Dang

Theses (Pre-2016)

The Houston Ship Channel is one of the nation busiest seaports. The channel has been transporting goods to the sea since 1836. The oil and gas industry has started to emerge in Texas, leading to the building and construction of numerous refineries around the ship channel (Port of Houston, 2012). The basis of this research was to investigate the concentration of trace metals in the Ship Channel of Houston. Houston is known for its oil and gas refineries and also the heavy metals that might be discharged through waste associated with surrounding industries. The Ship Channel has a large amount …

In Your Region December 2015, Department Of Primary Industries And Regional Development, Western Australia

Newsletters

No abstract provided.

Effects Of 12-Month, 2000iu/Day Vitamin D Supplementation On Treatment Naïve And Vitamin D Deficient Saudi Type 2 Diabetic Patients, Abdulaziz M. Al-Othman, Nasser M. Al-Daghri, Shaun B. Sabico

Saudi Medical Journal

Objectives: To determine whether 12-month, 2000IU/day vitamin D supplementation cardiometabolically improves treatment naïve type 2 diabetes mellitus (T2DM) Saudi patients with vitamin D deficiency. Methods: This 12-month interventional study was conducted at primary health centers in 5 different residential areas in Riyadh, Saudi Arabia between January 2013 and January 2014. Forty-five Saudi T2DM patients were enrolled. Baseline anthropometrics, glycemic, and lipid profiles were measured and repeated after 6 and 12 months. All subjects were provided with 2000IU vitamin D supplements for one year. Results: Vitamin D deficiency at baseline was 46.7%, 31.8% after 6 months, and 35.6% after 12 months, …

What’S Wrong With Peg?, Charles J. Higgins

Finance Faculty Works

PEG is a newer investment ratio measure of a security’s PE ratio divided by the firm’s growth rate as a percentage. It is examined and contrasted with other investment valuation measures. PEG is shown to be problematic in terms of its units of measure, in what it purports to appropriately determine, and it is non monotonic for relatively profitable firms and is only slightly indicative of correct security selection for relatively unprofitable firms.

The Application And Adaptation Of Psychological First Aid: The Filipino Psychologists' Experience After Typhoon Haiyan, Ma. Regina Hechanova, Bernice Vania Navarro Landoy, Pia Anna P. Ramos, Niel Steve M. Kintanar

Psychology Department Faculty Publications

This study examined the experiences, adaptations, observations, and insights on the use of Psychological First Aid (PFA) in the Philippines. Nineteen PFA providers who were trained in the basics of PFA from three major cities in the Philippines took part in this study. Respondents' knowledge about PFA was consistent with the core principles of promoting a sense of safety, calm, self-and community efficacy, connectedness, and instilling a sense of hope. The delivery of PFA was adapted to the Filipino culture through the use of local counseling models, a group-based setup , and the use of mindfulness and relaxation techniques. The …

Vicarious Trauma And Natural Disasters: A Transcendental Phenomenological Analysis Of The Experiences Of Families Of Typhoon Haiyan Survivors, Arvin Jeremy N. Tan, Andrew O. Jardeleza, Florian Antoinette P. Sta Maria, Mendiola Teng-Calleja

Psychology Department Faculty Publications

Using transcendental phenomenology, we examined the experience of vicarious trauma in the context of natural disasters. We specifically looked at the narratives of domestic migrants whose family members were Typhoon Haiyan survivors. Findings show that the survivors’ families experienced painful and intrusive psychological distress. The gravity of the pain and loss experienced by the participants was relative to the amount of pain, loss, or damage sustained by the subject of their attachment. Vicarious trauma was experienced as a void-filling phenomenon occupying the emotional space created by the physical distance of the participants from their families experiencing the disaster. This phenomenon …

The Color Of The Year: A Textual Analysis Of Pantone’S Color Communication Techniques Through The Application Of Barthes’ Semiotic, Kyung Lee

Masters Theses

This research analyzes the content of Pantone’s color of the year in 2000, 2002, 2009, 2014 and 2015 utilizing Barthes’ semiological system from a communication perspective. This study scrutinizes the announcement of Pantone’s color of the year as well as its color story to discover the purpose and the effectiveness of the verbalized nomination. The result reveals the significance of the semantic nature, which directs individuals’ viewpoint and creates a new connotation to alter their preconception. Also, Pantone’s color of 2014, Radiant Orchid, verified that the consolidation of the visual image and verbal content can maximize the influences that the …

The War On Drugs: An Analysis Of The Rhetoric According To Richard Weaver’S Theory Of Ultimate Terms, Cristina Peniche

Masters Theses

The language associated with President Nixon’s ‘war on drugs’ has sparked considerable debate in the political struggle against narcotics' abuse and crime, as well as within scholarly research. There is a language associated with the debate and it reflects the primary considerations of policy makers- economics, criminal behavior, and morality. The present study discusses these qualities as well as the rhetorical ideas of Richard Weaver, specifically his theory of ultimate terms. Then, discussions within research show the discontent that scholars bear towards narcotics'-related language. Specifically, there is concern that the rhetoric may stigmatize certain populations and hinder better outcomes. As …

How Is Academic Motivation In Children Influenced By Emotional Regulation?, Rosanna Pengelly

The Plymouth Student Scientist

Children’s academic achievement is influenced by motivation. Motivation, in turn, is affected by emotional regulation and children’s reactions to poor or high achievement. This study investigated academic motivation to gain an understanding of the attributions (effort, ability, difficulty and luck) made by children on their achievements in a maths test among 25 SEN children (i.e., children with emotional, behavioural and social difficulties) and 44 mainstream children. SEN children made more attributions to effort whereas mainstream children made more attributions to ability. Emotional regulation was measured using the Emotion Regulation Questionnaire (ERQ). Emotional reappraisal (i.e., reinterpreting the meaning of emotional stimuli) …

Exposure To Predator Kairomones Influences Egg Number And Size In Littorina Littorea, Jessica Raynor, Simon Rundle

The Plymouth Student Scientist

Predator kairomones play an important role in intertidal ecosystems, but knowledge on their potential role in influencing maternal effects is lacking. The aim of this study was to test whether egg production by female Littorina littorea was influenced by short-term exposure to predator kairomones before egg laying. Laboratory populations were exposed to predator cues from the intertidal crab Carcinus maenas for nine days, and egg number, egg size, and survivorship of the offspring were measured and compared with those from reference populations. Snails exposed to predator cues produced significantly more eggs, which were also significantly smaller than those produced from …

Plymouth Undergraduate Research In Mathematics, Tom Heinzl, Tom Mccourt

The Plymouth Student Scientist

Guest editorial from lectures in Physics and Pure Mathematics.

The Acute Effect Of High-Intensity Interval Training Versus Moderate-Intensity Continuous Training On Postprandial Blood Glucose Regulation, Katharina Gross

The Plymouth Student Scientist

Blood glucose control is central to the prevention and treatment of type 2 diabetes (T2D). Regular physical activity can improve glucose tolerance but many people lack the time to exercise. High-intensity interval training requires much less time commitment and results in similar or superior physiological adaptations over prolonged endurance training. However, few studies have directly compared the effects of both training strategies and a control condition on postprandial blood glucose concentration in a standardized manner. This study aims to investigate the acute effect of a single session of high-intensity interval training (HIIT) compared to a single session of moderate-intensity continuous …

Are Children's False Memories Driven By Conceptual Or Perceptual Factors?, Alexandra Hodgson

The Plymouth Student Scientist

Using the Deese/Roediger-McDermott (DRM) paradigm we examined the effects of perceptual (distinctiveness) and conceptual (backward associative strength) factors on the generation of false memories in 5 and 7-year-old children. Participants were randomly assigned to either the perceptually similar (just black or white pictures) or dissimilar condition (alternating black and white with colour pictures). For both conditions, these pictures were also high or low in backward associative strength. We hypothesised that false memories would be influenced by age, perceptual similarity and conceptual factors interacting. Results showed that true memories increased with age. False memories in 5 year olds not only extended …

The Efficacy Of Levodopa+Ddc Inhibitor+Entacapone Versus Levodopa+Ddc Inhibitor+Placebo In Parkinson's Disease: An Intervention Review, Jennifer Harrison

The Plymouth Student Scientist

Parkinson's disease (PD) has many possible treatment options. The main therapy uses a drug called levodopa. However after prolonged use, this drug begins to wear off and becomes less effective. Therefore additional drugs are needed to help ensure the patient is comfortable and to aid the relief of symptoms that can often occur. The addition of the COMT inhibitor, entacapone, aims to reduce motor symptoms and smooth out fluctuations that can sometimes be experienced with levodopa therapy. These can include bradykinesia, which is slowness of movement and help to control the resting tremor that is often associated with PD. The …

You Can't Tickle Yourself...Or Can You? The Effect Of A Hypnotic Suggestion On Sensory Attenuation Phenomenon, Shamsideen Yusuf

The Plymouth Student Scientist

The internal motor simulation mechanism is widely believed to generate anticipatory sensory outcomes on the basis of the efferent copy of the motor commands. What is currently unknown is whether the motor prediction mechanism can integrate non-motor inputs such as a hypnotic suggestion in generating sensory predictions. Seventy-two undergraduate students (M=12, F=60) were recruited via Plymouth University participation pool, to undergo a randomised hypnotic suggestion (IV) of either an alien- hand or an alien-foot. The participants were asked to apply tactile stimulation to their left palm (DV) before and after the suggestion and report the tickling sensations. The results revealed …

Building An Aging Advocacy Network: Findings From The New Hampshire Senior Leadership Series, Susan Fox, Laura K. Davie, Alison C. Rataj

Institute on Disability

Public policy related to senior issues has not kept pace with the changes called for by an aging population. Advocacy is an important part of the policy landscape as it promotes a united effort to create change and encourage legislative action. Effective advocacy helps inform and educate policy makers, allows individuals to have their voices heard, builds stronger communities, and allows people to live more fulfilling lives. However, policy makers are inundated with causes to support, and it is easy for certain populations or causes to be lost in this process. This has been especially true for advocacy efforts around …

Sports Information And Sports Media In High Schools, Meredith R. Shaul

Masters Essays

No abstract provided.

The Impact Of Judaism On Social Reform, Meghan Conner

Verbum

In lieu of an abstract, below is the essay's first paragraph.

Judaism marked the beginning of a revolutionary idea that laid the groundwork for social reform: humans have the ability and therefore the responsibility to stop injustices in the world. The Jews were the first to decide that it was their responsibility as the Chosen People to fight against inequality in the world. This mentality revolutionized social reform and brought it into existence as a way for human beings to positively shape their world. The ideas laid by the Jews continued to impact people for centuries and are especially relevant …

Massachusetts Community Mediation Center Grant Program: Fiscal Year 2015 Report & Evaluation, Massachusetts Office Of Public Collaboration, University Of Massachusetts Boston

Massachusetts Office of Public Collaboration Publications

The Massachusetts Office of Public Collaboration (MOPC, originally known as the Massachusetts Office of Dispute Resolution), the statutory state dispute resolution agency and an applied research center of the McCormack Graduate School at the University of Massachusetts Boston, has administered the Community Mediation Center Grant Program (the CMC Grant Program or grant program) under G.L. Ch. 75, §47 since July 2012. The grant program provides state operational funding to qualified community mediation centers. The program goal is to advance the mission of community mediation as a cost-effective public service that increases access to justice for Massachusetts citizens, particularly for low …