Digital Commons Network^™

Endoplasmic Reticulum Stress And Ethanol Neurotoxicity, Fanmuyi Yang, Jia Luo

Pharmacology and Nutritional Sciences Faculty Publications

Ethanol abuse affects virtually all organ systems and the central nervous system (CNS) is particularly vulnerable to excessive ethanol exposure. Ethanol exposure causes profound damages to both the adult and developing brain. Prenatal ethanol exposure induces fetal alcohol spectrum disorders (FASD) which is associated with mental retardation and other behavioral deficits. A number of potential mechanisms have been proposed for ethanol-induced brain damage; these include the promotion of neuroinflammation, interference with signaling by neurotrophic factors, induction of oxidative stress, modulation of retinoid acid signaling, and thiamine deficiency. The endoplasmic reticulum (ER) regulates posttranslational protein processing and transport. The accumulation of …

Rethinking Chutes: Incentives, Investment, And Innovation, Simone M. Sepe, Charles K. Whitehead

Cornell Law Faculty Publications

Eighty-two percent of public firms have golden parachutes (or “chutes”) under which CEOs and senior officers may be paid tens of millions of dollars upon their employer’s change in control. What justifies such extraordinary payouts?

Much of the conventional analysis views chutes as excessive compensation granted by captured boards, focusing on the payouts that occur following a takeover. Those explanations, if they ever were complete, miss the mark today. This Article demonstrates, theoretically and empirically, that chutes are less relevant to a firm during a takeover than they are before a takeover, particularly in relation to firms that invest in …

Chronic Systemic Immune Dysfunction In African-Americans With Small Vessel-Type Ischemic Stroke, Candice M. Brown, Cheryl D. Bushnell, Gregory P. Samsa, Larry B. Goldstein, Carol A. Colton

Neurology Faculty Publications

The incidence of small vessel-type (lacunar) ischemic strokes is greater in African-Americans compared to whites. The chronic inflammatory changes that result from lacunar stroke are poorly understood. To elucidate these changes, we measured serum inflammatory and thrombotic biomarkers in African-Americans at least 6 weeks post-stroke compared to control individuals. Cases were African-Americans with lacunar stroke (n = 30), and controls were age-matched African-Americans with no history of stroke or other major neurologic disease (n = 37). Blood was obtained > 6 weeks post-stroke and was analyzed for inflammatory biomarkers. Freshly isolated peripheral blood mononuclear cells were stimulated with lipopolysaccharide …

A Clinical Trial To Validate Event-Related Potential Markers Of Alzheimer's Disease In Outpatient Settings, Marco Cecchi, Dennis K. Moore, Carl H. Sadowsky, Paul R. Solomon, P. Murali Doraiswamy, Charles D. Smith, Gregory A. Jicha, Andrew E. Budson, Steven E. Arnold, Kalford C. Fadem

Neurology Faculty Publications

INTRODUCTION: We investigated whether event-related potentials (ERP) collected in outpatient settings and analyzed with standardized methods can provide a sensitive and reliable measure of the cognitive deficits associated with early Alzheimer's disease (AD).

METHODS: A total of 103 subjects with probable mild AD and 101 healthy controls were recruited at seven clinical study sites. Subjects were tested using an auditory oddball ERP paradigm.

RESULTS: Subjects with mild AD showed lower amplitude and increased latency for ERP features associated with attention, working memory, and executive function. These subjects also had decreased accuracy and longer reaction time in the target detection task …

Evaluating Positive Behavior Interventions And Supports (Pbis) : Examining Teachers' Perceptions Of Managing Student Conduct And Student Achievement In Pbis And Non-Pbis Schools., Carla Marie Soeder-Kolodey

Electronic Theses and Dissertations

This capstone investigated the impact of the implementation of positive behavior interventions and supports (PBIS) in schools across Kentucky on teachers’ perceptions of student behavior and on student academic achievement scores, using a causal comparative design. Schools in Kentucky were selected at random according to school type: elementary, middle, and high school. Special schools, or schools serving populations overlapping into multiple categories, were eliminated from the study. Schools were then identified by their level of implementation of PBIS: Control represented the schools that had not received any training in PBIS, PBIS represented schools that had started the implementation of PBIS, …

Assessing The Water Quality Benefits Of Green Infrastructure Stormwater Control Measures., Sam Abdollahian

Electronic Theses and Dissertations

Permeable pavements systems and tree boxes are a common type of Green Infrastructure (GI) Stormwater Control Measures (SCMs) that are often used for mitigating the stormwater runoff. In this study two permeable pavement systems and a tree box installed along parking lanes of an urban street in Louisville, KY, were investigated to evaluate their performance on improving stormwater runoff quality. The water quality monitoring was accomplished by analysis of samples collected from stormwater runoff and the captured stormwater volume at the bottom of the permeable pavements’ sub-base reservoir and by a drain gauge (lysimeter) installed in the tree box. Pollutants …

Development Of A Vascularized, Induced Pluripotent Stem Cell-Derived Liver-Tissue Mimic For Therapeutic Applications., Venkat Madhav Ramakrishnan

Electronic Theses and Dissertations

This dissertation describes the incorporation of several technologies (stem cells, gene therapy, tissue engineering and regenerative medicine) into a single project that aims to produce a liver-tissue mimic for therapeutic applications. The liver is arguably one of the most complex organs in the body. In addition to its remarkable capacity to regenerate, it performs a host of vital functions. As a result, its impairment has widespread systemic consequences. The work described herein focused on the liver in the context of cardiovascular disease and used the heritable disorder Familial Hypercholesterolemia (FH) as a clinical disease model. As (a) the only definitive …

The Relevance Of Client-Healthcare Provider Communication To The Appraisal Of Illness Uncertainty In Women With Fibromyalgia Syndrome., Melody Dawn Reibel

Electronic Theses and Dissertations

Illness uncertainty and impaired client-healthcare provider (HCP) communication are critical healthcare problems for women with fibromyalgia syndrome (FMS). However, the relationship between illness uncertainty and client-HCP communication has not been previously examined. The purposes of this dissertation were to (a) gain a deeper understanding of the lived experiences of women with FMS, (b) to examine the relationships among client-HCP communication, illness uncertainty, helplessness, and subjective well-being (SWB) in women with FMS, and (c) evaluate the psychometric properties of the patient-HCP communication scale (PHCPCS) in women with FMS. A mixed-methods design enhanced validity of the findings. The qualitative pilot study showed …

Circulating Angiogenic Stem Cells In Diabetes., Nagma Zafar

Electronic Theses and Dissertations

Circulating angiogenic stem cells (CACs) are rare cells found in peripheral blood that have been shown to contribute to endothelial repair and new blood vessel formation. These cells could be biomarkers and/or therapeutic targets for the assessment and prevention of cardiovascular disease (CVD), which is the leading cause of mortality globally and in the United States. Diabetes is an independent risk factor for CVD, and there are inconsistent reports on the role of CACs in diabetic vasculopathy. To study this further we tested the hypothesis that diabetes depletes circulating levels of CACs, due to hyperglycemia or insulin resistance and that …

A Phenomenological Study Of Anticipated Intimacy And Sexual Expression Needs Of Aging Male And Female Baby Boomers., Charles Shawn Oak

Electronic Theses and Dissertations

The purpose of this study was to understand the phenomenon of how heterosexual Baby Boomers define and understand intimacy, sexual expression, along expectations and desires relating to their respective expressions across the lifespan through their individual experiences and reflections. A set of guiding questions were used in a hermeneutic phenomenological qualitative research design. Data was gathered from thirteen subjects (n=13) using the Rappaport Time Line (RTL) that was used to develop individualized semi-structured interviews and follow-up interviews that were professionally transcribed. These were coded to identify emergent themes. Results of the study provided insight into the phenomenon of how heterosexual …

A Plant-Made Cholera Toxin B Subunit Enhances Mucosal Wound Healing And Protects Against Ulcerative Colitis And Colon Cancer., Keegan J Baldauf

Electronic Theses and Dissertations

This dissertation describes the previously unidentified effects of a plant-produced recombinant cholera toxin B subunit (CTBp) on the gastrointestinal (GI) tract and its ability to protect against inflammation in a mouse model of colonic injury and ulcerative colitis (UC). To comprehensively analyze CTBp’s impacts on the GI tract, we employed global analysis methodologies based on multi-color flow cytometry to analyze immune cell populations in GI and systemic lymphatic compartments, gene expression microarray to decipher transcript-level changes in the colon and small intestine, and 16S rRNA sequencing to characterize fecal microbiota. Based on a drastic shift observed in the immune cell …

Immunomodulation Of Myeloid-Derived Suppressor Cells By Particulate B-Glucan In Cancer., Sabrin Husein Albeituni

Electronic Theses and Dissertations

Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells that promote tumor progression. In this study, we investigated the effect of dectin-1 stimulation by yeast-derived particulate β-glucan in MDSC function and differentiation in cancer. In vivo treatment of mice bearing lewis lung carcinoma and mammary cell carcinoma with particulate β-glucan decreased tumor weight and splenomegaly, and reduced the accumulation of polymorphonuclear-MDSC (PMN-MDSC) but not monocytic-MDSC (M-MDSC) in the spleen and tumor. In addition, particulate β-glucan differentially modulated the function of different MDSC subsets; it enhanced PMN-MDSC respiratory burst and apoptosis, and induced the differentiation of M-MDSC into …

Evaluation Of Liver Transplant Prioritization Methods For Hepatocellular Carcinoma Patients Using Multistate Models., Sarah Katharine Alver

Electronic Theses and Dissertations

The Model for End Stage Liver Disease (MELD), used for prioritizing liver transplantation, predicts mortality from liver disease. Patients with hepatocellular carcinoma (HCC) risk disease progression not reflected in their MELD score. Exception scores prioritize HCC patients higher than their MELD scores, but advantage them over non-HCC patients. To address this, a delay of six months for using exception scores has been implemented, and alternative HCC-specific scores have been developed. Using multistate models, this study projects waitlist dropout and transplant probabilities under the delay and under two alternative scores. The delay improves equity between HCC and non-HCC patients for the …

The Pedagogy Of Medical Humanities : Using Literature And The Visual Arts To Help Future Caregivers Maintain Their Compassion And Resilience., Lisa Higgins Shugoll

Electronic Theses and Dissertations

This dissertation argues that medical humanities education for students considering careers in healthcare should begin at the general undergraduate level and should have two primary objectives, (1) providing tools that will help students foster therapeutic, compassionate relationships with their patients, and (2) providing strategies that will help students maintain healthy habits of mind that afford resilience against compassion fatigue. I assert that in order for students to practice compassion for themselves and others three core objectives must be met. (1) Students must be exposed to the fundamentals of bioethics in order to understand the virtue of compassion itself, (2) they …

Trapped In The Tiebout Model : The Impact Of Federal Affordable Housing Programs On Migration Of Wealthier Residents., Yu-Chih Lin

Electronic Theses and Dissertations

Housing mobility programs have been implemented in America since the 1990s to solve poverty concentration and to improve the economic self-sufficiency of low-income families through housing subsidies. This policy was based on the assumption that mixed-income neighborhoods provide better resources and opportunities to low-income families so that program participants who relocate to low-poverty neighborhoods improve their economic status. Currently, few studies examine the effectiveness of housing mobility programs under a decentralized fiscal system. Specifically, the migration of program participants may stimulate Tiebout’s vote-with-feet mechanisms and may limit the duration of the newly-created mixed-income environment, leaving poverty concentration and poverty unsolved. …

A Culturally-Sensitive Model Of The Development Of Child Anxiety., Jenny Marie Petrie

Electronic Theses and Dissertations

Explanatory models significantly enhance the understanding of etiological influences that place children at risk for anxiety, yet little is known about processes that promote resilient outcomes in children. While contextual factors influence risk and protective processes, cultural constructs have not been incorporated into existing models of anxiety and the role of culture remains obscure. The current study proposes a culturally sensitive model for understanding the etiological and mitigating processes underlying anxious symptoms in ethnic minority youth, and preliminarily tests basic components of the proposed model within a non-clinical community sample of 49 African American (AA) parent-child dyads who completed self-report …

A Comparative Analysis Of Data Collection Systems Used In Radiography Educational Programs And The Role Mobile Electronic Devices Play, Robin S. Garner

Electronic Theses and Dissertations

Each radiography program has a system to collect important data from didactic and clinical settings in order to accurately assess the progress and success of students, provide the needed student intervention, and provide accreditation agencies with appropriate documentation that demonstrates student success in reaching program learning outcomes. The purpose of this research study was to determine the method of data collection and documentation used by radiography programs to evaluate student progress and to examine if MEDs play a role in evaluating and documenting student skills at the point of care.

The majority of radiography programs in this study were using …

Breeding Bird Census To Compare Long-Term Changes In The Avifauna Of The Spruce-Fir Forest On Mount Guyot, Great Smoky Mountains National Park 1967-2015, Kevin C. Brooks

Electronic Theses and Dissertations

The high-elevation forests of the Southern Appalachian Mountains have been impacted and rearranged by a tiny introduced pest from Europe, known as the Balsam Woolly Adelgid (Adelges piceaea), creating a concern for conservation. Breeding bird censuses, along with botanical surveys, have been conducted periodically on an established 60-acre plot since 1967 on the virgin forested slopes of Mount Guyot, Great Smoky Mountains National Park, with the last census being completed in 2015. Breeding bird populations are shown to rise and fall in response to the forest’s changes over the last 48 years. Comparisons are made between all studies in order …

Commencement Program 2015 December: College Of Liberal Arts, The University Of Texas At Arlington

Commencement Programs, Photos, and Video

No abstract provided.

Current Status And Long-Term Trends In Water Quality And Living Resources In The Virginia Tributaries And Chesapeake Bay Mainstem From 1985 Through 2014, Daniel M. Dauer, Todd A. Egerton, John R. Donat, Michael F. Lane, Suzanne C. Doughten, Cindy Johnson, Monika Arora

Status and Trends for Virginia Chesapeake Bay

The period prior to the implementation of the Chesapeake Bay Monitoring Program was characterized by a marked decline in the water quality of the Chesapeake Bay. The disappearance of submerged aquatic vegetation in certain regions of the Bay, declines in the abundance of some commercially and recreationally important species, increases in the incidence of low dissolved oxygen events, changes in the Bay's food web, and other ecological problems have been related to the deteriorating water quality (e.g. USEPA, 1982,1983;Officer et al.,1984; Orth and Moore, 1984). The results of concerted research efforts in the late 1970s and early 1980s stimulated the …

Stewards Of Place: The Role Of Dialogue And Deliberation In Strengthening Colleges And Universities, Windy Y. Lawrence, Zach Justus, Leah A. Murray, Barbara A. Brown

eJournal of Public Affairs

In 2014, the American Association of State Colleges and Universities (AASCU) produced a sequel monograph, Stewards of Place II, which followed up on and extended the learnings about community engagement from the preceding report— Stepping Forward as Stewards of Place—published over a decade earlier. This article examines some of AASCU’s learnings over the past 10 years about the important role of colleges and universities as stewards of place. Specifically, the authors contend that dialogue and deliberation are key approaches for strengthening the position of colleges and universities as stewards of place. The article defines dialogue and deliberation, discusses five main …

Latina/O First Generation College Students And College Adjustment: An Examination Of Family Support Processes, Patricia R. Cerda-Lizarraga

College of Education and Human Sciences: Dissertations, Theses, and Student Research

First generation Latina/o college students are at a higher risk for not completing their college degrees when compared to other ethnic minorities due to added barriers and challenges of being the first to go to college. Researchers reported that poor college adjustment is one of the factors contributing to the lack of college completion among Latina/o college students. A few studies exist on the role that family support has on the college adjustment of Latina/o students and these yielded mixed findings. The central role of the family among Latina/o students and their support during the college adjustment period merits attention. …

Mechanisms By Which Dietary Ellagic Acid Attenuates Obesity And Obesity-Mediated Metabolic Complications, Inhae Kang

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Ellagic acid (EA) is a polyphenol found in various fruits and plants, such as berries, pomegranates, muscadine grapes, nuts and bark of oak tree. EA has been known to exhibit anti-inflammatory and anti-proliferative effects in various types of cancer. However, little is known about the effects of EA on obesity. Herein, 1) the lipid-lowering role of EA was identified in primary human adipose stem cells (hASCs) and human hepatoma Huh7 cells; 2) the molecular mechanisms by which EA attenuates adipogenesis by epigenetic modification were identified; 3) the effects of EA on high fat and high sucrose-mediated obesity was …

Network Support Variation For Black Women In The United States: A Mobility Study Of Immigrant And Non-Immigrant Black Women, Lesa Annette Johnson

Department of Sociology: Dissertations, Theses, and Student Research

Connections between socioeconomic status, social capital, and social support have been quite prominent in sociological research. However, such research still largely ignores the experiences of recently arrived African immigrants, particularly those who arrive as refugees. Black immigrants who arrived in the United States since 1965 have included an increasing number of refugees from war-torn, sub-Saharan African countries, such as the recently independent South Sudan. The numbers of women in these refugee roles has steadily increased since 1990. Black refugee women, many with children, bring diverse forms of social capital that influence their social networks and economic mobility, distinguishing them from …

An Evaluation And Exploration Of Nutrition Education In Elementary Schools, Elisha M. Hall

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Childhood obesity is a significant problem in the United States. Obese children suffer from a variety of physical, emotional, and social consequences. To curb or reduce this problem, school-based nutrition education interventions have become more common. However, little research has been conducted concerning nutrition-related socioeconomic disparities in behavior change constructs for low and high income children, which is integral to forming appropriate theory-based interventions and allocating resources appropriately. Research into classroom teachers’ perspectives is also an area in need of strengthening to better inform interventions. Finally, the School Enrichment Kit Program (SEKP), a current interactive, classroom-based, nutrition and physical activity …

Assessing The Sociocultural Impact Of Special Events In The Context Of Germanfest In Nebraska, Usa, Yanli Wang

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

The present study examined the sociocultural impact of special events based on the cultural festival of GermanFest in Syracuse, Nebraska. A total of 143 (71.5%) local residents responded to the self-administered survey. The dimensions of the sociocultural impact, the important reasons for celebrating the festival, the relationship among festival stakeholders, the levels of community involvement, and the improvement of the quality of life in the community as impacts of the festival and demographic information were investigated separately.

The Festival Social Impact Attitude Scale (FSIAS) was utilized to identify the dimensions of the sociocultural impact of GermanFest. Three dimensions were identified …

Pre- And Post-Season Physical And Cognitive Testing Of College Athletes Susceptible To The Effects Of Concussion, Audrey Berning, Elsa Klump, Hannah Burkhart, Jeneca Thomas, Stephanie Cahill

Student-Faculty Research - College of Physical Therapy

No abstract provided.

Alaska State Trooper Critical Incident Response Team And Peer Support Program Development, Cari Miller

Student Projects for Graduate Degrees

Law enforcement officers experience enormous job-related stress burdens in comparison to other career fields. Officers routinely encounter stressful situations from sources specific to their occupation, particularly their frequent exposure to dangerous situations, violence, and witnessing human suffering and depravity. Negative effects of occupational stress are exhibited in physical, physiological, emotional, and psychological changes. Law enforcement stress management programs are developed to provide resources to offset the negative effects, provide positive coping strategies to reduce stress, and increase the officer’s quality of life. This project developed program documents, policies, and procedures for the Critical Incident Response Team (CIRT) and Peer Support …

Physical Assessment Of Children With Fasd: Evidence Based Practice, Tabitha Waller

Student Projects for Graduate Degrees

Fetal Alcohol Spectrum Disorder (FASD) is the leading preventable cause of developmental delay worldwide. Early diagnosis and intervention are vital to the prevention of secondary disabilities for those with FASD. Current diagnostic guidelines fail to identify the many physical malformations associated with prenatal alcohol exposure and recommendations for diagnostic differentials vary between guidelines. A critical appraisal of the literature and review of current guidelines was conducted to create an evidence-based physical anomaly checklist and differential diagnostic table. The critical appraisal consisted of 27 articles and resulted in 85 physical anomalies associated with prenatal alcohol exposure. The review of current guidelines …

Needs Assessment For A Patient Centered Medical Home Model Of Care At The Providence Alaska Cancer Center, Jeremy Rosiecki

Student Projects for Graduate Degrees

In order to better understand the needs of cancer patients and allocate resources, the Providence Alaska Cancer Center requested a needs assessment for an oncology focused patient centered medical home (PCMH). A PCMH allows for coordinated and comprehensive care through the use of a teamwork model that centers on the primary care physician. The Providence Alaska Cancer Center staff randomly selected the records of 200 cancer patients between 2010 and 2011, using the cancer tumor registry. Data were analyzed to answer four specific questions that addressed the 1) presence of a Primary Care Physician (PCP), 2) number and type of …