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2015

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Cotton Injury Due To Soil- Or Foliar-Applied Herbicides: An Assessment Based On The Influences Of Genetic, Agronomic, And Environmental Factors, Brandon William Schrage Dec 2015

Cotton Injury Due To Soil- Or Foliar-Applied Herbicides: An Assessment Based On The Influences Of Genetic, Agronomic, And Environmental Factors, Brandon William Schrage

Graduate Theses and Dissertations

Increasing populations of glyphosate-resistant weeds, such as Palmer amaranth, have prompted growers to pursue alternative means of weed control in cotton. In many cropping systems, this means the utilization of older chemistries and residual herbicides. The goal of this research was to evaluate and understand the agronomic and environmental factors that affect the inconsistent injury often associated with these herbicides as well as determine the impact of Palmer amaranth emergence date on seed production, biomass, and cotton yield. Experiments were conducted in three counties in Arkansas giving a distinct range of climate and soil texture. Injury, biomass, and number of …


Reduction Of Campylobacter Jejuni On Chicken Wingettes By Treatment With Caprylic Acid, Chitosan Or Protective Cultures Of Lactobacillus Spp., Ann Nicole Woo-Ming Dec 2015

Reduction Of Campylobacter Jejuni On Chicken Wingettes By Treatment With Caprylic Acid, Chitosan Or Protective Cultures Of Lactobacillus Spp., Ann Nicole Woo-Ming

Graduate Theses and Dissertations

Poultry is one of the main sources of protein in the United States and in 2014 Americans ate approximately 100 lbs per person. However, consumption of poultry products is strongly associated with foodborne illness from Campylobacter. In the first study, chitosan, caprylic acid and their combination were evaluated as a coating treatment for the reduction of Campylobacter jejuni on poultry products. For the initial screening trials, chitosan of three different molecular weights (15-50 kDa, 190-310 kDa and 400-600 kDa) was evaluated at three concentrations (0.5%, 1.0%, 2.0%) and separately, caprylic acid was tested at 0.5%, 1.0% and 2.0% using chicken …


Defining The Potassium Nutritional Requirements And Distribution Among Plant Parts Of Representative Soybean Cultivars From Different Maturity Groups, Md. Rasel Parvej Dec 2015

Defining The Potassium Nutritional Requirements And Distribution Among Plant Parts Of Representative Soybean Cultivars From Different Maturity Groups, Md. Rasel Parvej

Graduate Theses and Dissertations

The potassium (K) requirement of soybean [Glycine max (L.) Merr.] was investigated to determine whether cultivar sensitivity to K deficiency was affected by growth habit (determinate or indeterminate) and how cultivars from each growth habit accumulate and distribute K among plant structures. We also diagnosed K deficiency across reproductive growth stages (R2-6) using trifoliolate leaf- and petiole-K concentrations and at harvest (R8) using seed-K concentration. Soybean responded similarly to K deficiency in terms of yield, selected yield components, and seed-K concentration, regardless of growth habit. The yield loss from K deficiency was greatest on the middle to upper nodes of …


Extraction, Purification And Characterization Of A Pure Peptide From Soybean To Demonstrate Anti-Proliferation Activity On Human Cancer Cells And Test The Ability Of Soy Peptide Fractions In Reducing The Activity Of Angiotensin-I Converting Enzyme, Srinivas Jairam Rayaprolu Dec 2015

Extraction, Purification And Characterization Of A Pure Peptide From Soybean To Demonstrate Anti-Proliferation Activity On Human Cancer Cells And Test The Ability Of Soy Peptide Fractions In Reducing The Activity Of Angiotensin-I Converting Enzyme, Srinivas Jairam Rayaprolu

Graduate Theses and Dissertations

Proteins are of major interest for nutritional value, functionality and sensory characteristics in foods, and biological activity as health-promoting ingredients. A large number of potential biological activities are encrypted within the primary structures of animal and plant proteins. This research has been based on utilizing a legume by-product, soybean meal, to obtain value-added protein products. Forty four Arkansas grown soybean lines were subjected to analysis for protein and amino acid (profile) content to select lines that have high protein attributes. Three soybean lines, R95-1705 (high yielding, non-transgenic and high protein), N98-445A and S03-543CR (bred for high oleic acid - monounsaturated …


Leptin Regulates The Expression Of Autophagy-Related Genes In Chickens, Peter Olawale Ishola Dec 2015

Leptin Regulates The Expression Of Autophagy-Related Genes In Chickens, Peter Olawale Ishola

Graduate Theses and Dissertations

Autophagy or cellular self-digestion, a lysosomal degradation pathway that is conserved from yeast to human, plays a key role in recycling cellular constituents, including damaged organelles. It also plays a pivotal role in the adaptation of cells to a plethora of distinct stressors including starvation. Autophagy has been extensively studied in mammals and yeast, but little is known in avian species. Thus, the major objective of the present study was to determine the effects of leptin on autophagy-related genes in chicken hypothalamus, muscle and liver. Leptin is an adipocytokine that is mostly produced by white adipose cells in mammals (as …


Stink Bugs: Spatial Distribution, Pecan Phenological Susceptibility And Sampling Program, Brian Cowell Dec 2015

Stink Bugs: Spatial Distribution, Pecan Phenological Susceptibility And Sampling Program, Brian Cowell

Graduate Theses and Dissertations

An effective management program for stink bugs (SBs) in pecan groves requires knowledge of: stages of the pecans susceptible to SB damage; strata of the tree with SB damaged nuts; a practical SB monitoring method; and, effects of landscapes contributing SBs into pecan groves.

Stink bugs produced feeding punctures in pecan shucks at all phenological stages. Pecans punctured before the dough stage drop from the tree. Kernel damage occurs in the pecans’ dough stage, whereas mature pecans are not damaged.

The pecans collected from the whole tree using the tree shaker had significantly less punctures than the pecans collected from …


Swat Model Simulation Of Bioenergy Crop Impacts On Water Quality In Cache River Watershed, Eeshan Kumar Dec 2015

Swat Model Simulation Of Bioenergy Crop Impacts On Water Quality In Cache River Watershed, Eeshan Kumar

Graduate Theses and Dissertations

Energy security through increased biofuel production is one of the components of the Energy Independence and Security Act (EISA) 2007. As per EISA 2007 mandate, appropriate independent research institutes are required to assess concerns to natural biodiversity due to biofuel production and report it to the Congress through the Environment Protection Agency (EPA). Planners, researchers, and agencies concerned with environmental regulations, ideally, would like to have location-specific information about the impacts for developing appropriate management interventions. This study examines long-term impacts on water quality in response to targeted (i.e. marginal lands) production of biofuel crops by setting up two SWAT …


A Comparison Of Athletic Identity And Career Maturity Of Female Student-Athletes At Different Levels Of Competition, Simeon Hinsey Dec 2015

A Comparison Of Athletic Identity And Career Maturity Of Female Student-Athletes At Different Levels Of Competition, Simeon Hinsey

Graduate Theses and Dissertations

This study explored the relationship between the athletic identity and career maturity of women’s basketball student-athletes. Differences in athletic identity and career maturity were also investigated based on a women’s basketball student-athlete’s level of competition, race, year in school, socioeconomic status, and professional athletic career aspirations. In order to examine the relationship between these variables, a convenience sample of 209 women’s basketball student-athletes from NCAA Division I (n = 62), NCAA Division II (n = 40), NCAA Division III (n = 50), and NAIA (n = 57) institutions located in the southeastern region of the United States participated in the …


On The Evolutionary Origins Of Religious Belief, Robert Duane Howard Dec 2015

On The Evolutionary Origins Of Religious Belief, Robert Duane Howard

Graduate Theses and Dissertations

Religious belief is a byproduct of evolutionarily designed cognitive mechanisms. The ubiquity of religious belief and experience across human cultures is explained by our common human psychology; our domain-specific cognitive mechanisms give rise, collectively, to the phenomenon of byproduct religious belief/experience. In this thesis, I will examine what I call religion-generating cognitive mechanisms, and I will argue that byproduct raw god-beliefs are developed by cultures into refined god-beliefs. These refined god-beliefs are co-opted by evolutionary processes and are cultural adaptations. My conception of “religious belief” in terms of raw and refined god-beliefs allows a disambiguation of the term “religion,” and …


Hydrology-Biology Response Relationships In The Ozark Highlands, Dustin Thomas Lynch Dec 2015

Hydrology-Biology Response Relationships In The Ozark Highlands, Dustin Thomas Lynch

Graduate Theses and Dissertations

I examined flow-ecology relationships among stream communities in the Ozark Highlands, USA. I sampled fish, crayfish, and benthic macroinvertebrates during two consecutive summers, including a drought year (2012) and a flood year (2013). Biological response variables related to community structure were assessed via two different statistical methods: an Information Theoretic approach relating response variables to a priori selected predictor variables incorporating hydrology, habitat, geomorphology, and water quality, and canonical ordination using forward selection to relate these same response variables to a large assortment of hydrologic metrics. In addition to assessing metrics related to predicted natural flow, flow alteration at gaged …


Wireless Monitoring Of Driver's Pulse Rate And Temperature Using Hand Gloves Approach, Rohith Reddy Narala Dec 2015

Wireless Monitoring Of Driver's Pulse Rate And Temperature Using Hand Gloves Approach, Rohith Reddy Narala

Graduate Theses and Dissertations

There is growing concern about dangers correlated with driving, for people with known cardiovascular diseases. However, the association between having a chronic cardiovascular disease and being involved in a motor vehicle crash remains controversial. This study aims to monitor people with known medical emergencies or other medical conditions while driving [1]. It also helps the co-passengers to be cautious while the person is driving with an abnormal health condition. Designed it to be convenient and also can be easily adaptable by the end user.

The proposed project focuses on a wearable sensor glove that equipped with a pulse rate sensor, …


Composition Of Four Selected Arkansas-Grown Non-Gmo Soybean Cultivars And The Development Of High Protein Beverage Using A Selected Soybean Protein Hydrolysate, Quyen Tran Phuong Nguyen Dec 2015

Composition Of Four Selected Arkansas-Grown Non-Gmo Soybean Cultivars And The Development Of High Protein Beverage Using A Selected Soybean Protein Hydrolysate, Quyen Tran Phuong Nguyen

Graduate Theses and Dissertations

Protein beverages made with non-genetically modified (non-GM) ingredients have been in demand due to the increasing consumers’ interest in healthy eating habit. Beverages formulated with non-GM soy protein are rare in the United States market since 93% soybeans planted in U.S (2013) are labeled as GM. This study aimed to develop protein hydrolysate beverages using one cultivar among the four Arkansas grown non-GM soybean cultivars including Osage, R95-1705, R08-4004 and R05-4969. R08-4004 was selected since it had the highest amounts of the three branched amino acids including Phenylalanine (51.4 mg/g), Leucine (74.9 mg/g), and Isoleucine (49.7 mg/g) with lowest amount …


A Descriptive Case Study Of Individuals With Presumed Ocular Histoplasmosis Syndrome Utilizing A Facebook Support Group, Lisa Aimee Thompson Dec 2015

A Descriptive Case Study Of Individuals With Presumed Ocular Histoplasmosis Syndrome Utilizing A Facebook Support Group, Lisa Aimee Thompson

Graduate Theses and Dissertations

This dissertation describes the experiences of people diagnosed with presumed ocular histoplasmosis syndrome as they participate in an online peer-support group on Facebook. This is a descriptive case study of factors related to adjustment, treatment, emotional distress, access to services, and online peer support. Participants were interviewed and observed, and documents were collected to describe this phenomenon.


Broiler Breeder Mating Behavior And The Effects Of Pre-Incubation Embryo Integrity Modifications On Broiler Performance, Emily Kathryn Lhamon Dec 2015

Broiler Breeder Mating Behavior And The Effects Of Pre-Incubation Embryo Integrity Modifications On Broiler Performance, Emily Kathryn Lhamon

Graduate Theses and Dissertations

Modern broiler breeders have been observed displaying significantly less mating behaviors than their ancestral fowl. Effective mating behavior translates into fertile hatching eggs that ultimately become broilers processed for market. The poultry industry has made significant changes in genetics, environment, housing, and diets of commercial poultry. However, there are some concessions made in genetic selection and streamlined management to produce larger, fast-growing, efficient birds. Aggression in broiler breeder males is believed to be a sign of high fertility. However, highly aggressive males pose a threat to the welfare of their flock mates, and may also impede frequency of mating and …


Responses Of Two Strains Of Broilers To Diets Varying In Essential Amino Acid Density And Energy Levels, Tyler James Clark Dec 2015

Responses Of Two Strains Of Broilers To Diets Varying In Essential Amino Acid Density And Energy Levels, Tyler James Clark

Graduate Theses and Dissertations

The responses of two different commercial strains of broilers to diets varying in overall amino acid levels and metabolizable energy levels were observed. Amino acid levels used were 80%, 90%, 100%, 110%, 120%, and 130% of Ross recommended minimum digestable levels of essential amino acids. Energy levels used were either below or above Ross recommended metabolizable energy levels. Diets were fed for 56 days. The two strains were a fast growing broiler strain and a slower growing broiler strain. A selection of birds from each pen was processed at 35, 43, and 56 days of age. Average body weights, cumulative …


Factors Affecting The Sustainability Of Public-Private Collaborations At The Municipal Level: The Case Of Motorcycle Rallies, Anne Burgin Diallo Dec 2015

Factors Affecting The Sustainability Of Public-Private Collaborations At The Municipal Level: The Case Of Motorcycle Rallies, Anne Burgin Diallo

Graduate Theses and Dissertations

Urban public-private collaborations promoting large-scale tourist events are increasingly common. The incentive to collaborate, for urban policy-makers, is the perception of the opportunity for economic development, and yet little is known about factors contributing to the sustainability of such urban cross-sector collaborations. The dissertation accomplishes three objectives. First, it combines resource dependence theory (RDT) and goal congruence theory (GCT) to extend our understanding of how collaborating organizations align their respective organizational goals and manage their interdependencies in complex, urban, inter-sectoral, environments. This is accomplished through use of complementary factors from each theory. Second, using qualitative methods, the research applies RDT …


An Evaluation Of The Validity Of A Script-Driven Imagery Procedure Among Traumatic Event Exposed Adolescents, Emily Renae Mischel Dec 2015

An Evaluation Of The Validity Of A Script-Driven Imagery Procedure Among Traumatic Event Exposed Adolescents, Emily Renae Mischel

Graduate Theses and Dissertations

Extensive research suggests script-driven imagery procedures employed with traumatic event-exposed adults produce reliable reactions that map onto contemporary models of posttraumatic stress, including increased physiological (Carson et al., 2000; Orr et al., 1998; Ramón et al., 2006) and negative affective (Pitman et al., 1987) responses to trauma scripts. Therefore, such procedures can be utilized in a controlled, laboratory-based setting, supporting mechanism-oriented research designed to better understand the nature, correlates, and consequences of traumatization and posttraumatic stress symptoms (PTSS). Unfortunately, only one study has begun to evaluate the validity of script-driven imagery procedures for use with youth, making further investigation of …


The Validity Of Urine Color Self-Assessment As An Index Of Hydration In Males, Daniel Layne Nixon Dec 2015

The Validity Of Urine Color Self-Assessment As An Index Of Hydration In Males, Daniel Layne Nixon

Graduate Theses and Dissertations

While water intake is so important, there are few practical hydration assessment techniques for the general population to use on a daily basis. The present study examined the accuracy of self-assessed urine color (Ucol) as a potential hydration assessment tool. Male college aged subjects provided a urine sample into a custom built urinal (n=76; 1.79±0.76 m, 83.9±16.0 kg). The urinal contained a picture of the 1-8 color scale and a light and dark urine color scale. Subjects were asked to give their urine color estimation as a whole number integer and to estimate if their urine was light or dark. …


Microbial Safety, Shelf Life Stability, Quality Preservation, And Consumer Acceptance Of Vacuum-Infused, Irradiated Chicken Breast Meat Treated With Natural Plant Extracts And Organic Acids, Kenneth Franklin Over Dec 2015

Microbial Safety, Shelf Life Stability, Quality Preservation, And Consumer Acceptance Of Vacuum-Infused, Irradiated Chicken Breast Meat Treated With Natural Plant Extracts And Organic Acids, Kenneth Franklin Over

Graduate Theses and Dissertations

Contamination of poultry products with food borne pathogens is a consistently recurring problem in the United States and the world. Recalls associated with chicken contamination are responsible for considerable economic losses to the poultry industry. Many decontamination steps are currently in place to reduce the likelihood of contaminated products reaching the consumer, but despite these safeguards, contamination events are still uncomfortably frequent. Irradiation is a safe and effective means of ensuring the safety of both ready-to-cook and ready-to-eat poultry but is not utilized in the United States. This is due, in part, to certain irradiation dose-dependent quality characteristic defects associated …


Image Processing And Visualization Of Terahertz Pulsed Imaging Of Breast Cancer Tumors, Yuhao Wu Dec 2015

Image Processing And Visualization Of Terahertz Pulsed Imaging Of Breast Cancer Tumors, Yuhao Wu

Graduate Theses and Dissertations

Terahertz imaging technology has grown substantially in recent years. With new advances made in the generation, manipulation, and detection of terahertz radiation, terahertz imaging has found its application as inspection tools in a wide range of areas including biomedicine, materials science, and aerospace industries. In the field of medical imaging, terahertz (THz) has emerged as a new imaging modality due to some fundamental physical properties of the THz wave. THz imaging has been used to examine various biological structures, and THz tomography has been developed to probe the 3D structures of those samples.

THz pulsed imaging (TPI) is one of …


A Simulation Platform For Accurate Prediction Of In-Bin Drying And Storage Of Rough Rice, Houmin Zhong Dec 2015

A Simulation Platform For Accurate Prediction Of In-Bin Drying And Storage Of Rough Rice, Houmin Zhong

Graduate Theses and Dissertations

Natural air (NA), in-bin drying and storage of rough rice generally maintains high grain quality, but the associated slow movement and occasional stagnation of the drying front during the process may result in problems of rice quality reduction, mold growth, and mycotoxin development, especially for rough rice in the top layers of the bin. Using modeling techniques to simulate in-bin rough rice drying in typically-encountered field scenarios may provide a tool for rapidly predicting the grain condition as drying progresses. The objectives for this study were to (1) investigate accurate models for predicting equilibrium moisture content (EMC) of rough rice …


Portion Size Communication By Means Of Package Design, Tami J. Strickland Dec 2015

Portion Size Communication By Means Of Package Design, Tami J. Strickland

Graduate Theses and Dissertations

This qualitative study assessed consumers’ current methods of determining portion sizing of chicken products and examined their perceptions of how effectively three package designs communicate portion size. Everett M. Rogers’ Diffusion of Innovations (DI) Theory analyzes the characteristics of the consumer of the innovation (adopter) and the impact these characteristics have on adopting new innovations. The innovation in this study will be the prototype packaging. Focusing on Rogers’ adopter characteristics and defined proprietary consumer segmentation characteristics, this study will be pivotal for future package design projects targeting nutrition education.

Focus group questions were scrutinized through a pilot study and revised …


Effects Of Gender And School Size On Mathematics And Science Achievement For Students In Western Arkansas, Jason Edward Moore Dec 2015

Effects Of Gender And School Size On Mathematics And Science Achievement For Students In Western Arkansas, Jason Edward Moore

College of Education Dissertations

The purpose of this dissertation was to research the effects of gender and school size on mathematics and science achievement for schools in western Arkansas. Related research revealed historical performance gaps in mathematics and science achievement between males and females, but also showed that those gaps have closed over the past few decades. However, the research also showed that there is still a large gap in the number of males and females working in Science, Technology, Engineering, and Mathematics (STEM) careers. This study also investigated this trend within western Arkansas to determine whether the gender gap in STEM is caused …


Genetic Factors Influencing B-Type Natriuretic Peptide-Mediated Production Of Cyclic Guanosine Monophosphate And Blood Pressure Effects In Heart Failure Patients, David E. Lanfear, Jia Li, Raza Abbas, Ruicong She, Badri Padhukasahasram, Ramesh C. Gupta, David Langholz, W Hw Tang, Keoki L. Williams, Hani N. Sabbah, Sheryl L. Chow Dec 2015

Genetic Factors Influencing B-Type Natriuretic Peptide-Mediated Production Of Cyclic Guanosine Monophosphate And Blood Pressure Effects In Heart Failure Patients, David E. Lanfear, Jia Li, Raza Abbas, Ruicong She, Badri Padhukasahasram, Ramesh C. Gupta, David Langholz, W Hw Tang, Keoki L. Williams, Hani N. Sabbah, Sheryl L. Chow

Cardiology Articles

Natriuretic peptides (NPs) represent a critical pathway in heart failure (HF). We explored genetic determinants of pharmacodynamic effects of B-type NP (BNP) and changes in plasma cyclic guanosine monophosphate (cGMP) and blood pressure (BP). HF patients (n = 135) received recombinant human BNP (nesiritide) at standard doses, and plasma cGMP levels were measured at baseline and during infusion. We tested the association of 119 single nucleotide polymorphisms (SNPs) in 4 candidate genes (NPR1, NPR2, NPR3, and membrane metallo-endopeptidase (MME)) with the change in cGMP and BP. Gene-based testing for association of genetic variation with endpoints was significant only for MME. …


Integrated Dual Disorder Treatment: Co-Occurring Evidence-Based Practice Implementation, Alteration, And Fidelity Over Time, Jennifer Harrison Dec 2015

Integrated Dual Disorder Treatment: Co-Occurring Evidence-Based Practice Implementation, Alteration, And Fidelity Over Time, Jennifer Harrison

Dissertations

Individuals with co-occurring illnesses are at risk for poor outcomes related to criminal justice, hospitalization, housing, and employment. High fidelity evidence-based practice models, including Integrated Dual Disorder Treatment (IDDT), are associated with significant improvements in outcomes. Although IDDT has been well-researched in small scale clinical trials, the implementation, alteration, and sustainability in real world applications over time has not been well-researched or understood. Initially, a descriptive analysis of a secondary dataset including the full population of 68 IDDT fidelity teams from 2006–2012 evaluated by the Michigan Fidelity and Assessment Team (MiFAST) in one state was completed. IDDT fidelity significantly improved …


Effects Of Gunnison Sage-Grouse Habitat Treatment Efforts On Associated Avifauna And Vegetation Structure, Paul Lukacs, Amy Seglund, Steve Boyle Dec 2015

Effects Of Gunnison Sage-Grouse Habitat Treatment Efforts On Associated Avifauna And Vegetation Structure, Paul Lukacs, Amy Seglund, Steve Boyle

Wildlife Biology Faculty Publications

Conservation efforts over the last 20 years for the Gunnison Sage-Grouse (Centrocercus minimus) have involved extensive habitat manipulations done predominantly to improve brood rearing habitat for the grouse. However, the effects of Gunnison Sage-Grouse habitat treatments on sympatric avifauna and responses of vegetation to manipulations are rarely measured, and if they are, it is immediately following treatment implementation. This study examined the concept of umbrella species management by retrospectively comparing density and occupancy of eight sagebrush associated songbird species and six measures of vegetation in treated and control sites. Our results suggested that songbird densities and occupancy changed …


Makenzie Petzel Honors Portfolio, Makenzie Jo Petzel Dec 2015

Makenzie Petzel Honors Portfolio, Makenzie Jo Petzel

Honors Capstone Portfolios

Makenzie Petzel's honors portfolio captured in December 2015.


Anna Rice Honors Portfolio, Anna Grace Rice Dec 2015

Anna Rice Honors Portfolio, Anna Grace Rice

Honors Capstone Portfolios

Anna Rice's honors portfolio captured in December 2015.


Applying The Philosophies Of The Beacon Model, Michael P. Raisch Dec 2015

Applying The Philosophies Of The Beacon Model, Michael P. Raisch

Creativity and Change Leadership Graduate Student Master's Projects

The purpose of this project is to apply all the knowledge and skills learned from a master’s degree in Creative Studies at Buffalo State college combined with personal experience in order to share perspective on what a “Beacon” is and how its core values are the foundation for enriching your life as well as the lives of those around you and how it all relates to Creativity. Furthermore, this project applies the concepts from the Beacon model more deeply through supporting philosophies and how the Halloween holiday naturally serves as a Beacon. There is a relationship due to the fact …


Methylseleninic Acid Promotes Antitumour Effects Via Nuclear Foxo3a Translocation Through Akt Inhibition, Míriam Tarrado-Castellarnau, Roldán Cortés, Miriam Zanuy, Josep Tarragó-Celada, Ibrahim H. Polat, Richard Hill, Teresa W-M Fan, Wolfgang Link, Marta Cascante Dec 2015

Methylseleninic Acid Promotes Antitumour Effects Via Nuclear Foxo3a Translocation Through Akt Inhibition, Míriam Tarrado-Castellarnau, Roldán Cortés, Miriam Zanuy, Josep Tarragó-Celada, Ibrahim H. Polat, Richard Hill, Teresa W-M Fan, Wolfgang Link, Marta Cascante

Toxicology and Cancer Biology Faculty Publications

Selenium supplement has been shown in clinical trials to reduce the risk of different cancers including lung carcinoma. Previous studies reported that the antiproliferative and pro-apoptotic activities of methylseleninic acid (MSA) in cancer cells could be mediated by inhibition of the PI3K pathway. A better understanding of the downstream cellular targets of MSA will provide information on its mechanism of action and will help to optimize its use in combination therapies with PI3K inhibitors. For this study, the effects of MSA on viability, cell cycle, metabolism, apoptosis, protein and mRNA expression, and reactive oxygen species production were analysed in A549 …