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The Search, The Jackson Laboratory

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No abstract provided.

Delimiting Species And Varieties Of Cycladenia Humilis (Apocynaceae), Holly Kathryn Brabazon

Student Works

Taxonomic delimitation of rare species is vital for accurate assessments of diversity and for their conservation. Cycladenia humilis, the sole species of Cycladenia, is an enigmatic perennial widely dispersed across the western United States. Within this species there are three currently recognized varieties: C. humilis var. humilis in Northern California, C. humilis var. venusta in Southern California, and C. humilis var. jonesii in Utah and Northern Arizona. Some populations occur geographically in areas between the typical distribution of each variety and the presently accepted taxonomy inadequately addresses these populations. Using five nDNA regions, we seek to clarify relationships between current …

Montana Business Quarterly, Summer 2015, University Of Montana--Missoula. Bureau Of Business And Economic Research

Montana Business Quarterly, 1949-2021

This is an academic publication produced by the Bureau of Business and Economic Research (BBER) at the University of Montana’s College of Business. This is volume 53, number 2.

The Effects Of Antiepileptic Inducers In Neuropsychopharmacology, A Neglected Issue. Part Ii: Pharmacological Issues And Further Understanding, Jose De Leon

Psychiatry Faculty Publications

The literature on inducers in epilepsy and bipolar disorder is seriously contaminated by false negative findings. Part II of this comprehensive review on antiepileptic drug (AED) inducers provides clinicians with further educational material about the complexity of interpreting AED drug-drug interactions.

The basic pharmacology of induction is reviewed including the cytochrome P450 (CYP) isoenzymes, the Uridine Diphosphate Glucuronosyltransferases (UGTs), and P-glycoprotein (P-gp). CYP2B6 and CYP3A4 are very sensitive to induction. CYP1A2 is moderately sensitive while CYP2C9 and CYP2C19 are only mildly sensitive. CYP2D6 cannot be induced by medications. Induction of UGT and P-gp are poorly understood. The induction of metabolic …

Transportation Network Companies: How Should South Carolina Adjust Its Regulatory Framework, Emily Dobson

South Carolina Law Review

No abstract provided.

First Choice, July 2015, Wusf Public Media

First Choice Monthly Newsletter

The July 2015 issue of WUSF's newsletter "First Choice."

Thriving In The Cold: Glacial Expansion And Post-Glacial Contraction Of A Temperate Terrestrial Salamander (Plethodon Serratus), Catherine E. Newman, Christopher C. Austin

Faculty Publications

© 2015 Newman, Austin. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The dynamic geologic history of the southeastern United States has played a major role in shaping the geographic distributions of amphibians in the region. In the phylogeographic literature, the predominant pattern of distribution shifts through time of temperate species is one of contraction during glacial maxima and persistence in refugia. However, the diverse biology and ecology of amphibian species suggest that a …

Evaluation Of Anti-Migraine Drugs In An In Vivo Rat Model Of Chronic Migraine, Shannon Nicole Stiles

Graduate Theses/Dissertations

Approximately 2% of the US population is affected by chronic migraine (CM). CM is a recurring, neurological disorder characterized by painful headache, along with autonomic, gastrointestinal, and other somatic symptoms. Prolonged sensitization of the trigeminal system, which is implicated in CM, is comprised of peripheral primary trigeminal ganglion neurons that provide sensory innervation of the head and face and second order neurons in the spinal trigeminal nucleus (STN). The goal of my study was to evaluate anti-migraine drugs for their ability to inhibit ongoing peripheral and central sensitization of trigeminal nociceptors. An in vivo animal model was used to determine …

Investigation Of Nocifensive And Cellular Effects Of Dihydroergotamine In A Model Of Chronic Migraine, Jennifer Elise Denson

Graduate Theses/Dissertations

The goal of my study was to investigate the nocifensive behavioral and cellular effects of dihydroergotamine (DHE) and sumatriptan in a model of sustained trigeminal activation. Trigeminal nerves provide sensory innervation to the head and face and their activation has been implicated in migraine pathology. The most commonly prescribed medications for migraine treatment are the triptan class of drugs. However, triptans are not an effective therapy for all migraine patients and some develop triptan resistance. Ergot-derivatives, including DHE, could be a potential alternative for this subpopulation of patients. To cause activation of the trigeminal system, adult male Sprague Dawley rats …

The Utilization Of Polymerase Chain Reaction, Dna Barcoding And Bioinformatics In Identifying Plant Species, Lindee J. Triplett, Ryan Foo, Ronald W. Strohmeyer (Mentor)

Idaho Conference on Undergraduate Research

Bioinformatics and DNA barcoding is a process used to identify plants, animals, and fungi. DNA barcoding in plants utilizes a key variable region in the genome, the RuBisCo large subunit (RbcL) on Chloroplast DNA. Once the DNA is extracted, Polymerase Chain Reaction (PCR) amplifies that region and that sample is sent off for sequencing. Bioinformatics and DNA barcoding helps taxonomists determine the sequence of the RbcL gene as well as obtain a unique barcode that can be used to identify plants. Several plant species from our local campus were sequenced and identified using the previously described methods.

Velaglucerase Alfa (Vpriv) Enzyme Replacement Therapy In Patients With Gaucher Disease: Long-Term Data From Phase Iii Clinical Trials, Derralynn A. Hughes, Derlis Gonzalez, Elena A. Lukina, Atul Mehta, Madhulika Kabra, Deborah Elstein, Isaac Kisinovsky, Pilar Giraldo, Ashish Bavdekar, Thomas N. Hangartner, Nan Wang, Eric Crombez, Ari Zimran

Biomedical, Industrial & Human Factors Engineering Faculty Publications

Type 1 Gaucher disease is an inherited lysosomal enzyme deficiency with variable age of symptom onset. Common presenting signs include thrombocytopenia, anemia, hepatosplenomegaly, bone abnormalities, and, additionally in children, growth failure. Fifty-seven patients aged 3–62 years at the baseline of two phase III trials for velaglucerase alfa treatment were enrolled in the single extension study. In the extension, they received every-other-week velaglucerase alfa intravenous infusions for 1.2–4.8 years at 60 U/kg, although 10 patients experienced dose reduction. No patient experienced a drug-related serious adverse event or withdrew due to an adverse event. One patient died following a convulsion that was …

The Accelerator, Volume 8 Issue 15, Summer 2015, Christa Santos

The Accelerator

No abstract provided.

Husbands Who Drug And Rape Their Wives: The Injustice Of The Marital Exemption In Ohio’S Sexual Offenses, Patricia J. Falk

Law Faculty Articles and Essays

This article argues that Ohio's marital rape exemption fails to vindicate the sexual autonomy and physical integrity of all persons in the state to be free from non-consensual sexual conduct. This protection from unwanted, non-consensual sexual violation should be afforded to Ohioans regardless of the victim's marital relationship to the perpetrator. Furthermore, the state's sexual offense provisions are plagued with inconsistencies and illogical distinctions with respect to the marital immunity. Ohio's partially abolished marital exemption cannot be justified under any coherent theory of justice, appears to survive merely due to inertia, and certainly does not serve the best interests of …

Placental Dna Methylation Related To Both Infant Toenail Mercury And Adverse Neurobehavioral Outcomes, Jennifer Zeynab Joukhadar Maccani, Devin C. Koestler, Barry Lester, E Andres Houseman, David A. Armstrong, Karl T. Kelsey, Carmen J. Marsit

Dartmouth Scholarship

Background:

Prenatal mercury (Hg) exposure is associated with adverse child neurobehavioral outcomes. Because Hg can interfere with placental functioning and cross the placenta to target the fetal brain, prenatal Hg exposure can inhibit fetal growth and development directly and indirectly.

Objectives:

We examined potential associations between prenatal Hg exposure assessed through infant toenail Hg, placental DNA methylation changes, and newborn neurobehavioral outcomes.

Methods:

The methylation status of > 485,000 CpG loci was interrogated in 192 placental samples using Illumina’s Infinium HumanMethylation450 BeadArray. Hg concentrations were analyzed in toenail clippings from a subset of 41 infants; neurobehavior was assessed using the NICU …

Modeling Of Epizootics On Four Genera Of Arabian Gulf Corals, John Alexander Kluge

HCNSO Student Theses and Dissertations

Coral colonies, from a reef near Abu Dhabi, United Arab Emirates (UAE), were counted and assessed for condition using photo-transects. An epidemic model, used to track how a communicable disease moves through a population, was constructed to help predict the future condition of this coral reef. In situ data from a disease outbreak that occurred in September 2011 provided a baseline for the model. Coral Populations of Porites, Platygyra, Acropora and Dipsastrea were modelled using condition categories that included Healthy, Black Band Disease Infected, Cyanobacteria Infected, Recovered, Recruits or Dead. Results from the modelling indicate that populations of Platygyra and …

The Spinnaker Summer 2015, University Of North Florida

Spinnaker

Student newspaper for the UNF community. Date: Summer 2015

Analytical Approaches In Investigating The Kinetics Of Water-Molecule Complexes In Tropospheric Reactions, William J. Keeton

Theses and Dissertations

Ozone is a heavily monitored pollutant. Ozone is not directly emitted into the atmosphere, but rather the product of chemical reactions. Ground level ozone occurs when nitrogen oxides (NOx) and volatile organic compounds (VOCs) react with each other in the presence of sunlight. The primary precursors of ozone are anthropogenically emitted, and as a result, tropospheric ozone has cost millions of dollars in damages and has hurt the health of countless people. This dissertation is a collection of work that aims to provide insight into atmospheric reactions that result in tropospheric ozone and the instrumentation to study such reactions. While …

Louisiana Agriculture Summer, 2015, Lsu Agcenter

Louisiana Agriculture

No abstract provided.

Phylogenetics, Divergence Times And Diversification From Three Genomic Partitions In Monocots, Kate L. Hertweck, Michael S. Kinney, Stephanie A. Stuart, Olivier Maurin, Sarah Mathews, Mark W. Chase, Maria A. Gandolfo, J. Chris Pires

Faculty Publications

© 2015 The Authors. Resolution of evolutionary relationships among some monocot orders remains problematic despite the application of various taxon and molecular locus sampling strategies. In this study we sequenced and analysed a fragment of the low-copy, nuclear phytochrome C (PHYC) gene and combined these data with a previous multigene data set (four plastid, one mitochondrial, two nuclear ribosomal loci) to determine if adding this marker improved resolution and support of relationships among major lineages of monocots. Our results indicate the addition of PHYC to the multigene dataset increases support along the backbone of the monocot tree, although relationships among …

Ocean Acidification Research In The 'Post-Genomic' Era: Roadmaps From The Purple Sea Urchin Strongylocentrotus Purpuratus, Tyler G. Evans, Jacqueline L. Padilla-Gamiño, Morgan W. Kelly, Melissa H. Pespeni, Francis Chan, Bruce A. Menge, Brian Gaylord, Tessa M. Hill, Ann D. Russell, Stephen R. Palumbi, Eric Sanford, Gretchen E. Hofmann

Faculty Publications

© 2015 Elsevier Inc. Advances in nucleic acid sequencing technology are removing obstacles that historically prevented use of genomics within ocean change biology. As one of the first marine calcifiers to have its genome sequenced, purple sea urchins (Strongylocentrotus purpuratus) have been the subject of early research exploring genomic responses to ocean acidification, work that points to future experiments and illustrates the value of expanding genomic resources to other marine organisms in this new 'post-genomic' era. This review presents case studies of S. purpuratus demonstrating the ability of genomic experiments to address major knowledge gaps within ocean acidification. Ocean acidification …

Automatic Video Self Modeling For Voice Disorder, Ju Shen, Changpeng Ti, Anusha Raghunathan, Sen-Ching S. Cheung, Rita Patel

Computer Science Faculty Publications

Video self modeling (VSM) is a behavioral intervention technique in which a learner models a target behavior by watching a video of him- or herself. In the field of speech language pathology, the approach of VSM has been successfully used for treatment of language in children with Autism and in individuals with fluency disorder of stuttering. Technical challenges remain in creating VSM contents that depict previously unseen behaviors. In this paper, we propose a novel system that synthesizes new video sequences for VSM treatment of patients with voice disorders. Starting with a video recording of a voice-disorder patient, the proposed …

Wooster Magazine: Summer 2015, Karol Crosbie

Wooster Magazine: 2011-2020

The summer 2015 issue of the Wooster magazine covers several different cases. It recaps the beginning of Interim President S. Gloria Nugent’s leadership in the College, details the sustainable budget initiative positions for Wooster’s future, and announces the retirement of Hayden Schilling with quotes from Michael Ruttinger ’05, Megan Prichard ’07, John D. Faust ’86, Keith Beckett, and Megan Thomas ’08. The issue also recaps Wooster’s biggest fundraising day ever (the five big gifts), archaeology conference contingents, and Black and Gold Weekend. During Black and Gold Weekend, Nancy Roha Meislahn ’65 spoke about her 50th reunion and was pictured with …

Today - July 2015, Loma Linda University Health

TODAY

Inside this issue:

-- Thousands experience Loma Linda University Health at 60th General Conference Session
-- Empowering teachers: EXSEED trains K-12 educators in the art of teaching STEM
-- LLUMC Murrieta named 'Most Wired' by American Hospital Association for second consecutive year
-- Twins overcome insurmountable odds to celebrate first berthday
-- Worldwide delegates from General Conference session tour Loma Linda University Health campus
-- The importance of child health care spans across continents
-- Memory of Cancer Center patients lives on
-- Why go on a mission trip?
-- President's Award recipients represent that University's best
-- Ralph Lee …

Dualism And Doctrine, Dov Fox, Alex Stein

Indiana Law Journal

What kinds of harm among those that tortfeasors inflict are worthy of compensation? Which forms of self-incriminating evidence are privileged against government compulsion? What sorts of facts constitute a criminal defendant’s intent? Existing doctrine pins the answer to all of these questions on whether the injury, facts, or evidence at stake are “mental” or “physical.” The assumption that operations of the mind are meaningfully distinct from those of the body animates fundamental rules in our law.

A tort victim cannot recover for mental harm on its own because the law presumes that he is able to unfeel any suffering arising …

Intractable Delay And The Need To Amend The Petition Provisions Of The Fdca, Diana R. H. Winters

Indiana Law Journal

Private party oversight has proven to be ineffective at countering inaction by the Food and Drug Administration (FDA). Inaction when regulation is warranted can put the public at continued and increasing risk of harm, but the failure of private enforcement to compel action reverberates beyond this harm to the interests of individuals. It also diminishes the transparency of agency decision making, lessens the opportunity for public participation, and reduces the interaction between the institutions that oversee agencies. Moreover, the benefits afforded to the administrative process by judicial review are weakened.

This Article analyzes two examples of FDA inertia and compares …

Using Visual Data Mining In Highway Traffic Safety Analysis And Decision Making, Yao-Te Tsai, Huw D. Smith, Stephen M. Swartz, Fadel M. Megahed

Journal of Transportation Management

An ongoing, two-fold challenge involves extracting useful information from the massive amounts of highway crash data and explaining complicated statistical models to inform the public about highway safety. Highway safety is critical to the trucking industry and highway funding policy. One method to analyze complex data is through the application of visual data mining tools. In this paper, we address the following three questions: a) what existing data visualization tools can assist with highway safety theory development and in policy-making?; b) can visual data mining uncover unknown relationships to inform the development of theory or practice? and c) can a …

The Virtues Of Bright Lines: Self-Determination, Secession, And External Intervention, Brad R. Roth

Law Faculty Research Publications

The United Nations Charter-based international order sought to reconcile the selfdetermination of peoples with the inviolability of state boundaries by presuming sovereign states to be manifestations of the self-determination of the entirety of their territorial populations. This presumption, albeit notionally rebuttable, traditionally prevailed even where states could only by a feat of ideological imagination be characterized as "possessed of a government representing the whole people belonging to the territory without distinction." But the international reaction to fragmentation in the former Yugoslaviaregarding both the initial "dissolution" and the subsequent struggle over Kosovo-called into question the rigid doctrines of the past and …

Prostate Cancer Education In The African American Community: Implcations For Community-Based Health Communication Strategies, Barry Charles Hill

Open Access Theses

This paper examines the social milieu of African American barbershops by exploring health discussions and information transfer between barbers and barbershop clients. This paper examines associations between peer helper and health promotion intervention variables, and peer helper intervention effectiveness in increasing knowledge and health discussion frequency. Study findings suggest barbers with higher education are significantly more effective as peer helpers in discussing health topics more frequently (OR 4.64; CI 1.00 - 21.49) and in increasing client knowledge (β 0.94; CI 0.26 - 1.63). Additionally, barbershop health educational materials were significantly associated with increased barber health discussion (OR 4.13; CI 1.32 …

Susceptibility Of Parkinson’S Disease Following Mild Blast Traumatic Brain Injury, Glen Howel Galicia Acosta

Open Access Theses

Blast injury-induced neurotrauma (BINT) is steadily increasing in prevalence due to escalated terror activity and constitutes the signature injury associated with current military conflicts. BINT produces significant neurological deficiencies and there is a growing concern that the injury may produce long-term consequences that affect the resilience and the performance of soldiers. One of the potential consequences is an increased susceptibility to Parkinson's disease (PD). A vital goal aimed at curtailing the post-deployment long-term consequences of blast injury-induced neurotrauma is to further our knowledge of pathogenic mechanisms responsible for the escalation of post injury diseases. The purpose of this project is …

Book Review - Chattahoochee River User's Guide, Maryska S. Connolly-Brown

Georgia Library Quarterly

No abstract provided.