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2015

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Calmodulin Methyltransferase Is Required For Growth, Muscle Strength, Somatosensory Development And Brain Function, Sitvanit Haziza, Roberta Magnani, Dima Lan, Omer Keinan, Ann Saada, Eli Hershkovitz, Nurit Yanay, Yoram Cohen, Yoram Nevo, Robert L. Houtz, Val C. Sheffield, Hava Golan, Ruti Parvari Aug 2015

Calmodulin Methyltransferase Is Required For Growth, Muscle Strength, Somatosensory Development And Brain Function, Sitvanit Haziza, Roberta Magnani, Dima Lan, Omer Keinan, Ann Saada, Eli Hershkovitz, Nurit Yanay, Yoram Cohen, Yoram Nevo, Robert L. Houtz, Val C. Sheffield, Hava Golan, Ruti Parvari

Horticulture Faculty Publications

Calmodulin lysine methyl transferase (CaM KMT) is ubiquitously expressed and highly conserved from plants to vertebrates. CaM is frequently trimethylated at Lys-115, however, the role of CaM methylation in vertebrates has not been studied. CaM KMT was found to be homozygously deleted in the 2P21 deletion syndrome that includes 4 genes. These patients present with cystinuria, severe intellectual disabilities, hypotonia, mitochondrial disease and facial dysmorphism. Two siblings with deletion of three of the genes included in the 2P21 deletion syndrome presented with cystinuria, hypotonia, a mild/moderate mental retardation and a respiratory chain complex IV deficiency. To be able to attribute …

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Drug Developed From Uab Research Sharply Lowers Cholesterol In Animal Tests, Jeff Hansen Aug 2015

Drug Developed From Uab Research Sharply Lowers Cholesterol In Animal Tests, Jeff Hansen

Browse All News

No abstract provided.

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Damage/Danger Associated Molecular Patterns (Damps) Modulate Chlamydia Pecorum And C. Trachomatis Serovar E Inclusion Development In Vitro, Cory Ann Leonard, Robert V. Schoborg, Nicole Borel Aug 2015

Damage/Danger Associated Molecular Patterns (Damps) Modulate Chlamydia Pecorum And C. Trachomatis Serovar E Inclusion Development In Vitro, Cory Ann Leonard, Robert V. Schoborg, Nicole Borel

ETSU Faculty Works

Persistence, more recently termed the chlamydial stress response, is a viable but non-infectious state constituting a divergence from the characteristic chlamydial biphasic developmental cycle. Damage/danger associated molecular patterns (DAMPs) are normal intracellular components or metabolites that, when released from cells, signal cellular damage/ lysis. Purine metabolite DAMPs, including extracellular ATP and adenosine, inhibit chlamydial development in a species-specific manner. Viral co-infection has been shown to reversibly abrogate Chlamydia inclusion development, suggesting persistence/chlamydial stress. Because viral infection can cause host cell DAMP release, we hypothesized DAMPs may influence chlamydial development. Therefore, we examined the effect of extracellular ATP, adenosine, and cyclic …

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An Implantable Device To Regulate Urination Through Deep Brain Stimulation, Jesse E. Bucksot, Muhammad A. Arafat, Pedro Irazoqui Aug 2015

An Implantable Device To Regulate Urination Through Deep Brain Stimulation, Jesse E. Bucksot, Muhammad A. Arafat, Pedro Irazoqui

The Summer Undergraduate Research Fellowship (SURF) Symposium

Urinary Incontinence (UI) is a disease in which patients lose control of their bladder. It is particularly common in elderly women having a prevalence of as much as 30% to 50% [1]. Many of these patients are left without successful treatment. A recent study has shown a new option for treatment that consists of deep brain stimulation (DBS) at a site known as the periaqueductal gray (PAG) [2, 3]. To test the effectiveness of this treatment, chronic stimulation of the PAG should be used in animals to see if it can reliably prevent micturition in the long term. A device …

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Simulating Low-Frequency Sonic Pulsations To Achieve Thrombolysis, Joseph C. Muskat, Matthew C. Pharris, Charles F. Babbs Aug 2015

Simulating Low-Frequency Sonic Pulsations To Achieve Thrombolysis, Joseph C. Muskat, Matthew C. Pharris, Charles F. Babbs

The Summer Undergraduate Research Fellowship (SURF) Symposium

Cardiovascular thrombosis may result in critical ischemia to a range of anatomical regions, constituting a leading cause of death in the United States. Current invasive treatments for such arterial blockages often yield blood clot recurrence, resulting in repeated hospitalization of patients. This research aims to show how internally introduced pressure oscillations may be used to initiate thrombolysis. We present a novel computational model for determining the resonant frequency and corresponding deformation of an idealized thrombus. Sinusoidal pressure differences across the thrombus induce axial displacements of frequency dependent amplitude. The maximum peak displacement occurs at a resonant frequency of 73 Hz …

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Crack Propagation Simulation Tool, Shuhui Tang, Kiettipong Banlusan Aug 2015

Crack Propagation Simulation Tool, Shuhui Tang, Kiettipong Banlusan

The Summer Undergraduate Research Fellowship (SURF) Symposium

Fortuitous crack propagation rendering unexpected material failure is ubiquitous in many cases. For example, ships in World War II collapsed because of crack propagations and contemporary it can be even encountered inside the Boeing 737 fuselage. This leads to the essence of conducting research on the factors that affect the ductility of the material. An experimental study like tensile test is not fastidious enough to control the temperature and stress around crack tip and it is not able to give atomic level details such as how the crack propagates and the bonds break when the materials are subjected to the …

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Bioengineered Cell Niche For Skeletal Muscle Regeneration, Nicole M. Whittern, Naagarajan Narayanan, Chunhui Jiang, Owen Jones, Jay Gilbert, Michael Whittern, Shihuan Kuang, Meng Deng Aug 2015

Bioengineered Cell Niche For Skeletal Muscle Regeneration, Nicole M. Whittern, Naagarajan Narayanan, Chunhui Jiang, Owen Jones, Jay Gilbert, Michael Whittern, Shihuan Kuang, Meng Deng

The Summer Undergraduate Research Fellowship (SURF) Symposium

Skeletal muscles can self-repair minor strains, lacerations, and contusions; however, in cases of volumetric muscle lossand muscle degenerative diseases, tissue fails to regenerate. Current cell-based therapies, such as myoblast transplantation, have significant drawbacks of low survival rates and engraftment efficacy, mainly due to the absence of supportive cell microenvironment. Scaffolds that mimic the natural cell microenvironment provide a robust platform to support cell adhesion, migration, proliferation, and differentiation. Electrospinning is a versatile technology platform used for fabricating the fiber scaffold that mimics the extracellular matrix. Thus, we aim to reconstitute the cell microenvironment through development of aligned fiber scaffolds by …

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Long-Term Tillage System Impacts On Soil Erodibility, Julianne R. Chechanover, Dennis C. Flanagan Aug 2015

Long-Term Tillage System Impacts On Soil Erodibility, Julianne R. Chechanover, Dennis C. Flanagan

The Summer Undergraduate Research Fellowship (SURF) Symposium

Conservation tillage practices, such as no-till agriculture, have the potential of reducing the erodibility of a soil compared to conventional agricultural practices. This research sought to determine whether long-term agricultural practices affect the baseline erodibility properties of a soil. Two soils from Throckmorton-Purdue Agricultural Center in Tippecanoe County, Indiana were used during this experiment. One soil was treated with a long-term conventional tillage (fall chisel, spring disk) system and the other soil was treated with a long-term no-till system. The soils’ interrill erodibility, and rill erodibility and critical hydraulic shear stress were measured under a rainfall simulator using soil boxes …

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Recovery Of Nutrients From Animal And Human Wastes, Nathaniel E. Kallmyer, Zhe Sun, Kaitlin Harris, Zhi Zhou, Ernest R. Blatchley Iii Aug 2015

Recovery Of Nutrients From Animal And Human Wastes, Nathaniel E. Kallmyer, Zhe Sun, Kaitlin Harris, Zhi Zhou, Ernest R. Blatchley Iii

The Summer Undergraduate Research Fellowship (SURF) Symposium

Removal of nitrogen- and phosphorus-containing molecules from wastewater is necessary to prevent excessive growth of algae and resulting chemical changes to bodies of water. Of wastewater components, urine contains relatively high concentrations of nitrogen and phosphorus, the majority of which is ultimately present as ammonia and phosphate. Separation and stabilization of these nutrients may also allow for their reuse as fertilizer. Before the nutrients may be stored, they must be stabilized. At least a portion of ammonia-N must be converted to nonvolatile nitrogen. This may be achieved by using ammonia- and nitrite-oxidizing bacteria (AOB and NOB, respectively) to convert ammonia …

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Effect Of Aging Time And Retail Displaying Period With A Short-Term Temperature Abuse On Color Stability Of Two Beef Muscles, Derico Setyabrata, Hyun-Wook Kim, Yuan H. Brad Kim Aug 2015

Effect Of Aging Time And Retail Displaying Period With A Short-Term Temperature Abuse On Color Stability Of Two Beef Muscles, Derico Setyabrata, Hyun-Wook Kim, Yuan H. Brad Kim

The Summer Undergraduate Research Fellowship (SURF) Symposium

Meat color and tenderness are two most important quality factors affecting consumers’ decision on meat purchasing. Post-mortem meat aging has been widely practiced to improve palatability attributes, but could be adversely related to meat color. In particular, temperature abuse during aging or retail display can negatively affect the color stability of aged meat. The objective of this study was to determine the effect of aging time and short-term temperature abuse during display on color stability of two beef muscles (M. longissimus dorsi, LD and semitendinosus, ST). LD and ST muscles were separated from three beef carcasses, vacuum-packaged …

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Viewing The Extracellular Matrix: An Imaging Method For Tissue Engineering, Michael Drakopoulos, Sarah Calve Aug 2015

Viewing The Extracellular Matrix: An Imaging Method For Tissue Engineering, Michael Drakopoulos, Sarah Calve

The Summer Undergraduate Research Fellowship (SURF) Symposium

The field of regenerative medicine seeks to create replacement tissues and organs, both to repair deficiencies in biological function and to treat structural damage caused by injury. Scaffoldings mimicking extracellular matrix (ECM), the structure to which cells attach to form tissues, have been developed from synthetic polymers and also been prepared by decellularizing adult tissue. However, the structure of ECM undergoes significant remodeling during natural tissue repair, suggesting that ECM-replacement constructs that mirror developing tissues may promote better regeneration than those modeled on adult tissues. This work investigated the effectiveness of a method of viewing the extracellular matrix of developing …

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Detecting Genomic Regions Responsible For Resistance In Arabidopsis, Valeria Cancino, Anjali Iyer-Pascuzzi, Rucha Karve Aug 2015

Detecting Genomic Regions Responsible For Resistance In Arabidopsis, Valeria Cancino, Anjali Iyer-Pascuzzi, Rucha Karve

The Summer Undergraduate Research Fellowship (SURF) Symposium

Ralstonia solanacearum is a soil-borne plant root colonizing pathogen and the casual agent of bacterial wilt (BW) disease. BW leads to severe yield loss in a wide variety of agricultural commodity crops, such as tomato, banana, and pepper. In this study, we look at the plant-pathogen interaction between Ralstonia solanacearum and various ecotypes of Arabidopsis thaliana with the goal of finding resistant ecotypes. To identify resistant ecotypes, seeds are first sterilized and left to soak in the dark. Then the seeds are plated on agar media, transferred to a growth chamber, and allowed to grow for 5 days. On day …

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Evaluation Of Two Non-Destructive Methods For Estimating Biomass In A Prairie, Arnoldas Pivorius, Laura Ploughe, Jeff Dukes Aug 2015

Evaluation Of Two Non-Destructive Methods For Estimating Biomass In A Prairie, Arnoldas Pivorius, Laura Ploughe, Jeff Dukes

The Summer Undergraduate Research Fellowship (SURF) Symposium

The estimation of above ground biomass is important in managing natural resources, like assessing habitat conditions. Direct, destructive measurements by clipping, drying, and weighing plant matter is time consuming and labor intensive. It is of interest to develop non-invasive methods to complement or replace direct vegetation harvest. Two non-invasive methods were evaluated, light penetration and visual obstruction, in the Purdue Wildlife Area prairie. Light penetration in the grassland plots were measured using a Decagon light stick (LP-80), 5 cm from the ground and above the plants. Estimation of visual obstruction was done using a Robel pole, which focuses on the …

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Seasonality Of Forensically Relevant Diptera In Northwestern Indiana, Sarah M. Stanley, Trevor Stamper Aug 2015

Seasonality Of Forensically Relevant Diptera In Northwestern Indiana, Sarah M. Stanley, Trevor Stamper

The Summer Undergraduate Research Fellowship (SURF) Symposium

Minimum postmortem interval (mPMI) estimations are critical to solving cases of equivocal death and the accuracy of these predictions can depend on the understanding of necrophagous fly successional patterns. In order to better understand the successional patterns of necrophagous flies, it is important to know the seasonality of forensically relevant fly species—that is, the baseline pattern of their presence and absence in relation to annually cyclic environmental factors. Since many environmental factors play a role in insect seasonality, it is possible that some of these factors can be summed to create an index that represents seasonality in a simpler form. …

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Proteoglycan Mimic Of The Glycocalyx To Treat Endothelial Dysfunction, Victoria Messerschmidt, Alyssa Panitch, James R. Wodicka Aug 2015

Proteoglycan Mimic Of The Glycocalyx To Treat Endothelial Dysfunction, Victoria Messerschmidt, Alyssa Panitch, James R. Wodicka

The Summer Undergraduate Research Fellowship (SURF) Symposium

Patients with kidney failure usually undergo hemodialysis, a process by which toxins produced by the body are filtered from the blood, in order to survive. The preferred form for vascular access is called an arteriovenousfistula (AVF), a surgically created connection between an artery and vein that is utilized to undergo dialysis. However, AVFs have a failure rate of 50-60%. One of the contributions to AVF failure is endothelial cell dysfunction and loss of glycocalyx, which allows neutrophils and other native cells into the media of the vessel, which causes an inflammatory response. Our lab addresses endothelial dysfunction by mimicking the …

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Behavioral Outputs Of Fragile-X Autistic Mice Exposed To Open-Field, Randomized, Short-Term Visual Stimuli, Nicholas M. Dicola, Alexander A. Chubykin Aug 2015

Behavioral Outputs Of Fragile-X Autistic Mice Exposed To Open-Field, Randomized, Short-Term Visual Stimuli, Nicholas M. Dicola, Alexander A. Chubykin

The Summer Undergraduate Research Fellowship (SURF) Symposium

Animal models of different neurological disorders are required for studying the pathophysiology of these diseases, and for potential development of pharmacological and behavioral treatments. The scientific community often uses mouse models for behavior studies due to their powerful genetic tools and low cost. However, subjective measurement techniques are often used when analyzing mice for behavioral traits which often results in discrepancies in results. An automated tracking software would aim to eliminate these discrepancies and subjective analysis. This lab has developed a software program which offered an ability to automatically collect open-field behavioral data with simultaneous on-line analysis. Python, an open …

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Nanomechanics Simulation Toolkit - Dislocations Make Or Break Materials, Michael N. Sakano, Alejandro Strachan, David Johnson, Mitchell Wood Aug 2015

Nanomechanics Simulation Toolkit - Dislocations Make Or Break Materials, Michael N. Sakano, Alejandro Strachan, David Johnson, Mitchell Wood

The Summer Undergraduate Research Fellowship (SURF) Symposium

The goal of computational material science is to improve existing materials and design new ones through mathematical calculations. In particular, molecular dynamic simulations can allow for visualization of dislocations in a material, along with its resulting behavior when under stress. For example, plastic deformation and strain hardening result from the movement, multiplication and interaction of dislocations within the crystal structure. A simulation tool to study these phenomena was developed for the nanoHUB web resource as a part of the Network for Computational Nanotechnology at Purdue University and targets audiences ranging from undergraduate students to researchers. We created a user-friendly environment …

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Harnessing Notch Signaling For Biomaterial Scaffold-Based Bone Regeneration, Helena P. Lysandrou, Chunhui Jiang, Naagarajan Narayanan, Shihuan Kuang, Meng Deng Aug 2015

Harnessing Notch Signaling For Biomaterial Scaffold-Based Bone Regeneration, Helena P. Lysandrou, Chunhui Jiang, Naagarajan Narayanan, Shihuan Kuang, Meng Deng

The Summer Undergraduate Research Fellowship (SURF) Symposium

Bone fracture has recently become prevalent, especially with an increasingly aging population. Current bone grafts procedures, including autografts and allografts, are hindered by multiple factors, such as limited supplies and inconsistent bone healing. Scaffold-based bone tissue engineering emerges as a prospective strategy to aid in bone regeneration through delivery of growth factors such as bone morphogenic proteins (BMPs). However, the use of BMPs suffers from several drawbacks such as protein instability and immunogenicity. Therefore, there exists a great need for the development of novel therapies to promote bone healing. Notch signaling, a pathway critical for cell-fate determination has been shown …

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Chemical Modification Of Uniform Soils And Soils With High/Low Plasticity Index, Xuanchi Li, Fei Tao, Antonio Bobet Aug 2015

Chemical Modification Of Uniform Soils And Soils With High/Low Plasticity Index, Xuanchi Li, Fei Tao, Antonio Bobet

The Summer Undergraduate Research Fellowship (SURF) Symposium

Lime and/or cement are used to treat weak subgrade soils during construction of highways. These chemicals are mixed with the soil to improve its workability, compactability and engineering properties. INDOT (Indiana Department of Transportation) has been using chemical modification of native soils for the past 20 years. In fact, 90% of current subgrade is treated, typically with quick lime, lime byproducts or cement. For pavement design, it is customary to not include any improvement of the subgrade for the design of the pavement layers. Recent research completed through JTRP (Joint Transportation Research Program) recommends a higher stiffness modulus for chemically …

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Captive Breeding Protocols And Their Impact On Genetic Diversity In White-Footed Mice (Peromyscus Leucopus): Implications For Threatened And Endangered Species, Maureen C. Lamb, Janna R. Willoughby, J. Andrew Dewoody Aug 2015

Captive Breeding Protocols And Their Impact On Genetic Diversity In White-Footed Mice (Peromyscus Leucopus): Implications For Threatened And Endangered Species, Maureen C. Lamb, Janna R. Willoughby, J. Andrew Dewoody

The Summer Undergraduate Research Fellowship (SURF) Symposium

Captive breeding protocols used in zoos often are aimed at increasing population sizes and retaining genetic diversity of endangered species. However, captive breeding causes genetic adaptation to captivity that can lead to an overall decrease in genetic diversity and reduce chances of a successful reintroduction to the wild. In this study, we assess how 3 different breeding protocols—random mating, preferential breeding of individuals with the lowest mean kinship scores, and selection for docility—affect the variability of mitochondrial DNA in white-footed mice (Peromyscus leucopus). We used mice that were captured from the wild but were mated for up to …

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Former Intern ‘Pays It Forward’ For Current Student, Kim Hill Aug 2015

Former Intern ‘Pays It Forward’ For Current Student, Kim Hill

News and Events (Discontinued Series)

No abstract provided.

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Aubuchon '16 Researches Impulse Control In Dogs, Kim Hill Aug 2015

Aubuchon '16 Researches Impulse Control In Dogs, Kim Hill

News and Events (Discontinued Series)

No abstract provided.

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Chateaubriand And His Influence On The Early French Romantics' Perspective On Nature, Kyra Kalina Sanchez Clapper Aug 2015

Chateaubriand And His Influence On The Early French Romantics' Perspective On Nature, Kyra Kalina Sanchez Clapper

Electronic Theses and Dissertations Archive

This work analyzes Chateaubriand's writings on America and compares them to Rousseau's philosophical writings on nature. In doing so, Iargue that Chateaubriand showed an exception interest in nature without human intervention - unlike Rousseau, who had an anthropomorphic approach to nature. By emphasizing Chateaubriand's nonanthropomorphic approach to nature, this paper rejects the monolithic view of FrenchRomanticism and contributes a deeper understanding of this important trend eighteenth century onwards.In order to arrive at a global picture of Chateaubriand's idea of nature, the primary source I will analyze are Chateaubriand's Atala, Voyage en Amerique, and Memoires d'outre-tombe and Rousseau's Discours sur l'origine …

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Civil Rights Act; Section 1981; Title Vii; Reverse Discrimination; Equal Protection; Mcdonald V. Santa Fe Trail Transp. Co., Caroline Williams Aug 2015

Civil Rights Act; Section 1981; Title Vii; Reverse Discrimination; Equal Protection; Mcdonald V. Santa Fe Trail Transp. Co., Caroline Williams

Akron Law Review

No abstract provided.

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Civil Rights Act; Section 1981; Title Vii; Reverse Discrimination; Equal Protection; Mcdonald V. Santa Fe Trail Transp. Co., Caroline Williams Aug 2015

Civil Rights Act; Section 1981; Title Vii; Reverse Discrimination; Equal Protection; Mcdonald V. Santa Fe Trail Transp. Co., Caroline Williams

Akron Law Review

THE UNITED STATES SUPREME COURT in McDonald v. Santa Fe Trail Transportation Co.' held that Title VIP prohibits racial discrimination by both employers and unions against white persons upon the same standards as it prohibits racial discrimination against nonwhites. The Court further held that Section 19811 is applicable to racial discrimination in private employment against white persons as well as nonwhites.

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A Hypothetical: Quinlan Under Ohio Law, Wendy C. Gerzog Aug 2015

A Hypothetical: Quinlan Under Ohio Law, Wendy C. Gerzog

Akron Law Review

WITH THE DECISION by all of the respondents in In re Quinlan not to appeal their case to the United States Supreme Court, the people in this country will have to wait for a definitive statement of law on a person's right to die and on a guardian's standing to assert that right for his ward. Because of the dearth of precedent in this area, each state court that is faced with the prospect of reviewing a case like Quinlan will have to grapple with its own constitutional and statutory schemes in order to make a determination of these difficult …

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A Hypothetical: Quinlan Under Ohio Law, Wendy C. Gerzog Aug 2015

A Hypothetical: Quinlan Under Ohio Law, Wendy C. Gerzog

Akron Law Review

WITH THE DECISION by all of the respondents in In re Quinlan1 not to appeal their case to the United States Supreme Court,2 the people in this country will have to wait for a definitive statement of law on a person's right to die and on a guardian's standing to assert that right for his ward. Because of the dearth of precedent in this area, each state court that is faced with the prospect of reviewing a case like Quinlan will have to grapple with its own constitutional and statutory schemes in order to make a determination of these difficult …

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Burglary Insurance Policies; Reasonable Expectations; Unconscionability; Application Of Implied Warranty Of Fitness; C & J Fertilizer, Inc. V. Allied Mutual Ins. Co., Janice Gui Aug 2015

Burglary Insurance Policies; Reasonable Expectations; Unconscionability; Application Of Implied Warranty Of Fitness; C & J Fertilizer, Inc. V. Allied Mutual Ins. Co., Janice Gui

Akron Law Review

THE IOWA SUPREME COURT handed down a landmark decision in C & I Fertilizer, Inc. v. Allied Mutual Ins. Co.', in holding that insurance policies carry implied warranties that they are fit for their intended use. The impetus for this decision was a clause in a burglary and robbery policy which defined "burglary" as . . . the felonious abstraction of insured property . . . from within the premises by a person making felonious entry therein by actual force and violence, of which force and violence there are visible marks made by tools, explosives, electricity or chemicals upon, or …

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Open-Source Photometric System For Enzymatic Nitrate Quantification, Ben T. Wittbrodt, D. A. Squires, J. Walbeck, E. Campbell, W. H. Campbell, Joshua M. Pearce Aug 2015

Open-Source Photometric System For Enzymatic Nitrate Quantification, Ben T. Wittbrodt, D. A. Squires, J. Walbeck, E. Campbell, W. H. Campbell, Joshua M. Pearce

Department of Materials Science and Engineering Publications

Nitrate, the most oxidized form of nitrogen, is regulated to protect people and animals from harmful levels as there is a large over abundance due to anthropogenic factors. Widespread field testing for nitrate could begin to address the nitrate pollution problem, however, the Cadmium Reduction Method, the leading certified method to detect and quantify nitrate, demands the use of a toxic heavy metal. An alternative, the recently proposed Environmental Protection Agency Nitrate Reductase Nitrate-Nitrogen Analysis Method, eliminates this problem but requires an expensive proprietary spectrophotometer. The development of an inexpensive portable, handheld photometer will greatly expedite field nitrate analysis to …

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2015 August 5 -- Agenda And Attachments Aug 2015

2015 August 5 -- Agenda And Attachments

Agendas and Minutes

No abstract provided.

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