Digital Commons Network^™

Zirconium-89: Radiochemistry And Ligand Development Toward Improved Pet Applications, Melissa Ann Deri

Dissertations, Theses, and Capstone Projects

Antibodies are attractive targeting vectors for positron emission tomography (PET) based imaging agents due to their high affinity and selectivity to a variety of biological targets. Creating such imaging agents requires a radionuclide with suitable decay characteristics. This role has been filled by zirconium-89 which has a 78.41 h half-life that ideally matches the multi-day biological half-life of IgG antibodies.

However, the use of a radiometal necessitates the use of a bifunctional chelator to bind the metal and conjugate to the antibody. For ⁸⁹Zr this has been the purview of various derivatives of desferrioxamine B (DFO); however, the observed …

Diversity And Phylogeography Of Anurans Of The Highlands Of Ethiopia, Xenia Freilich

Dissertations, Theses, and Capstone Projects

Located in Eastern Africa, Ethiopia is a country of unique geological features, among them the largest continuous Afro-alpine zone in Africa and the Great Rift Valley (GRV). The GRV formation began ~20 mya; it is a fault system that splits the central Ethiopian dome in two separate highland systems (Baker et al., 1972, Chorowicz, 2005). In spite of the general assumption that the GRV has played a major role in shaping the biodiversity of the country, its influence has not been fully investigated, as only a handful of studies have addressed its impact on the phylogeographic and evolutionary history of …

Three Potential Mediators Of The Effects Of Child Abuse And Neglect On Smoking In Middle Adulthood, Miriam Ghirmay

Dissertations, Theses, and Capstone Projects

The purpose of the current study was fourfold: (1) to determine whether individuals with histories of child abuse and neglect have higher rates of current cigarette smoking in middle adulthood compared with matched controls; (2) to examine whether individuals with histories of abuse and/or neglect are at increased risk for higher rates of current psychopathology (anxiety or depression), negative coping, and past year traumas and victimization experiences in adulthood compared with matched controls; (3) to determine whether current psychopathology, negative coping, and past year traumas and victimization experiences mediate the relationship between child maltreatment and current smoking; and (4) to …

A Man To Preserve Or Reform The Nation: Masculinity As Political Rhetoric In English Novels During The Revolution Controversy, Janne Burger Gillespie

Dissertations, Theses, and Capstone Projects

The English literary responses to the French Revolution have been given thorough critical attention as has the Revolution's impact on women writers and femininity. However, the Revolution's impact on and engagement with standards of manliness have been left relatively unexplored. This dissertation examines how a critique of masculinity is positioned in the space of contemporary political considerations in the quarter-century following the French Revolution. Thus, this dissertation argues that there is a dialectical engagement between masculinity and political views in late eighteenth-century and early nineteenth-century English novels such as Maria Edgeworth's Belinda and Leonora, Charlotte Smith's Emmeline and Desmond …

Eye Tracking And Performance Evaluation: Automatic Detection Of User Outcomes, Allen V.R. Harper

Dissertations, Theses, and Capstone Projects

While evaluating user task performance with eye tracking has been examined within the field of Human-Computer Interaction (HCI), previous research has generally utilized eye tracking to understand how users perform a task. This dissertation defines a new paradigm by which eye-tracking research can be used in HCI: to predict whether users will be successful at a task, using a pattern classification model trained on their eye-tracking data.

This dissertation describes the experimental framework and it demonstrates (through laboratory experiments and machine-learning modeling) the feasibility and limits of predicting user outcomes based solely on eye movement patterns. Utilizing an online learning …

Expanding The Structural Biologist's Tool Chest By Chemical And Biocompatible Modification Of Peptides: From Characterizing Marine Snail Toxins To Outphoxing Tryptophan, Alexander Grigoryan

Dissertations, Theses, and Capstone Projects

This dissertation focuses on expanding chemical derivatization methodologies of peptides with the ultimate goal of studying proteins that are not amenable to traditional high-resolution structural techniques. The first project, conducted in the laboratory of Dr. Mandë Holford, uses improved synthetic and chemical derivatization methods to access and characterize peptidic natural products from venomous marine snails belonging to the family Terebridae. Closely related to Conus snails, the Terebridae also produce disulfide-rich peptide toxins (teretoxins) that are potent and specific agonists of ion channels and receptors of the central nervous system. Teretoxins are underexplored relative to Conus toxins, and represent a …

Population Genomics Of White-Footed Mice (Peromyscus Leucopus) In New York City, Stephen Edward Harris

Dissertations, Theses, and Capstone Projects

Urbanization significantly alters natural ecosystems. New York City (NYC) is one of the oldest and most urbanized cities in North America, but still maintains substantial populations of some native wildlife. The white-footed mouse, Peromyscus leucopus, is a common resident of NYC's forest fragments, and isolated populations may adapt in response to novel urban ecosystems. Using pooled transcriptome-wide RNAseq data, individually barcoded transcriptome-wide RNAseq data, and genome-wide RADseq data, I found genetic differentiation between urban and rural P. leucopus populations and evidence suggestive of local adaptation. I compared genome and transcriptome-wide SNP data in P. leucopus from relatively large urban …

Is Cue-Based Memory Retrieval 'Good-Enough'?: Agreement, Comprehension, And Implicit Prosody In Native And Bilingual Speakers Of English, Elizabeth Pratt

Dissertations, Theses, and Capstone Projects

This dissertation focuses on structural and prosodic effects during reading, examining their influence on agreement processing and comprehension in native English (L1) and Spanish-English bilingual (L2) speakers. I consolidate research from three distinct areas of inquiry'cognitive processing models, development of reading fluency, and L1/L2 processing strategies'and outline a cohesive and comprehensive processing model that can be applied to speakers regardless of language profile. This model is characterized by three critical components: a cognitive model of memory retrieval, a processing paradigm that outlines how resources may be deployed online, and the role of factors such as prosody in parsing decisions.

The …

Learning Functional Prepositions, John Stewart

Dissertations, Theses, and Capstone Projects

In first language acquisition, what does it mean for a grammatical category to have been acquired, and what are the mechanisms by which children learn functional categories in general? In the context of prepositions (Ps), if the lexical/functional divide cuts through the P category, as has been suggested in the theoretical literature, then constructivist accounts of language acquisition would predict that children develop adult-like competence with the more abstract units, functional Ps, at a slower rate compared to their acquisition of lexical Ps. Nativists instead assume that the features of functional P are made available by Universal Grammar (UG), and …

The Anchor, Volume 129.05: September 30, 2015, Hope College

The Anchor: 2015

The Anchor began in 1887 and was first issued weekly in 1914. Covering national and campus news alike, Hope College’s student-run newspaper has grown over the years to encompass over two-dozen editors, reporters, and staff. For much of The Anchor's history, the latest issue was distributed across campus each Wednesday throughout the academic school year (with few exceptions). In recent years The Anchor moved to monthly print issues and a more frequently updated website. The Anchor is now published in print twice per academic semester. Occasionally, the volume and/or issue numbering is irregular.

Tragedy, History, And Ecstasy: Concerning Nietzsche’S “Untimely” Ideas On Authentic Selfhood, Marc Oliver D. Pasco

Perspectives in the Arts and Humanities Asia

This paper proposes that there exists a specific philosophical connection between Nietzsche’s thoughts on tragedy in Birth of Tragedy and his thoughts on history in “On the Uses and Disadvantages of History for Life.” The paper hopes to enrich one’s appreciation of Nietzsche’s early ideas on authentic selfhood by showing the relation between Dionysiac ecstasy and unhistorical consciousness. A postscript in the last part of the paper examines Philippine folk religiosity within the framework of the aforementioned connection between Dionysiac ecstasy and unhistorical consciousness.

The Winonan, Winona State University

The Winonan - 2010s

No abstract provided.

Persons As Self-Consciously Concerned Beings, Benjamin Abelson

Dissertations, Theses, and Capstone Projects

This dissertation is an analysis of the concept of a person. According to this analysis, persons are beings capable of being responsible for their actions, which requires possession of the capacities for self-consciousness, in the sense of critical awareness of one's first-order desires and beliefs and concern, meaning emotional investment in the satisfaction of one's desires and truth of one's beliefs. The persistence of a person over time requires uninterrupted maintenance of those capacities. This view is in conflict with the more popular account of persistence in terms of the continuity of distinctive psychological states. Furthermore, this account of personhood …

Incipient Speciation In Freshwater Fish Species From Two Isolated Watersheds, Paula Gore Miller

Dissertations, Theses, and Capstone Projects

The process of speciation occurs as a result of restricted gene flow between segments of an interbreeding population occupying different geographic areas. This separation may result in isolated populations which undergo genetic and phenotypic changes. The Wisconsin glacial period, which ended approximately 17,500 years ago, dramatically altered the geography of North America. The glacier covered almost the entire North America as it advanced. Areas that were not covered with ice provided suitable habitats (refugia) for relict species that were previously widespread in the northern section of the continent. As the ice sheet retreated, animals and plants were able to return …

The Insulin/Igf Signaling Regulator Cytohesin/Grp-1 Modulates Sensitivity To Excitotoxicity In C. Elegans, Nazila Tehrani

Dissertations, Theses, and Capstone Projects

Excitotoxicity is a form of neurodegeneration that serves as the main underlying cause of brain damage in stroke/brain ischemia, and a contributing factor in a range of neurological diseases such as Epilepsy, ALS, Alzheimer, and Huntington's disease. In excitotoxicity, over-activation of glutamate receptors causes necrotic neuronal cell death. In spite of intense study of excitotoxicity, the molecular mechanisms that lead from glutamate receptor activation to necrotic death remain a mystery. Aging neurons are known to be more vulnerable to excitotoxicity and less likely to recover, but the underlying reasons for the increased cellular vulnerability are unknown. To gain insight into …

Variability, Stability, And Flexibility In The Speech Kinematics And Acoustics Of Adults Who Do And Do Not Stutter, Eric S. Jackson

Dissertations, Theses, and Capstone Projects

It is well known that people who do and do not stutter produce speech differently, at least some of the time, even when perceived as fluent. One way that investigators have assessed these differences is by measuring variability, or the inconsistency of repeated speech movements. Variability in speech has typically been quantified using linear analysis techniques (e.g., measures of central tendency), and results have indicated that people who stutter produce speech that is (sometimes) characterized by increased variability. However, variability is a complex phenomenon, one that cannot be assessed by linear methods alone. This dissertation employs linear and nonlinear analysis …

The Ecology Of Winter Flounder From An Otolith Perspective, George William Jackman

Dissertations, Theses, and Capstone Projects

In this dissertation, sagittal otoliths were used as a lens to examine latent life history patterns in winter flounder (Pseudopleuronectes americanus) and also as a means of interpreting the species' relationship to their abiotic and biotic environment. Otoliths provide a unique and powerful perspective into the lives of the telost fishes, because they permanently record the spatial and temporal histories through sequential growth patterns from conception to capture. The patterns of growth and dormancy in the otolith are regulated by endogenous and exogenous rhythms, and as the otolith grows, trace elements are absorbed from the ambient environment and …

Musical Regularity And Rhythmic Patterns: A Quantitative Analysis Of Birdsong Structure, Eathan Ezra Janney

Dissertations, Theses, and Capstone Projects

Birdsong is a complex, learned behavior that, like music, has meaningful units at multiple timescales. Birds perform by constructing extended presentations of their phrase repertoire. Each bird's repertoire is built from small units, such as syllables, or groups of syllables with characteristic pitch, rhythm, and timbre. Like a musician each bird has its unique structure of performance that communicates its individual identity. Also contained within a bird's performance, is information about its group identity and species identity. Like a musician's performance, a bird's singing affects the behavioral state of listeners'birds perform to attract mates and defend territory.

Subjectively, many can …

Cultural Evolution In Natural Populations: A Quantitative Bioacoustic Analysis, Chenghui Ju

Dissertations, Theses, and Capstone Projects

Bird song is a powerful model system in behavioral biology, especially for learning and cultural evolution. Understanding the origins and maintenance of vocal diversity in nature is fundamentally important to acoustic biology. Here, we propose a large-scale, integrative population analysis of nearly 2000 songs of the house finch (Haemorhous mexicanus) (190 individuals) collected in western Long Island of New York during an interval of 37 years (between 1975 and 2012) to explore cultural change of bird songs. Generally, I have three aims in this study. In the chapter 1, to facilitate acoustic analysis for field recordings with ambient noise, of …

Whistles Of Sympatric Species Of Bottlenose Dolphins (Tursiops Truncatus) And Spotted Dolphins (Stenella Frontalis) In The Bahamas: Acoustic Characteristics And Contextual Use, Jennifer Daisy Kaplan

Dissertations, Theses, and Capstone Projects

Bottlenose and spotted dolphins in the Bahamas frequently interact in social, socio-sexual, and aggressive encounters, and whistles are thought to play a key role in their communication. Concurrent vocal and behavioral recordings of wild sympatric species of Atlantic spotted dolphins (Stenella frontalis) and Atlantic bottlenose dolphins (Tursiops truncatus) were collected from three Bahamas populations, and the acoustic parameters, structure, and contextual use of their whistles were analyzed. The mean acoustic parameters of spotted dolphins in the Bimini and White Sand Ridge Bahamas populations were higher in frequency than those of bottlenose dolphins, but bottlenose dolphins produced whistles that had higher …

Olfaction As The Paradigm For Perceptual Philosophy, Andreas Keller

Dissertations, Theses, and Capstone Projects

Plato wrote that smell is of a "half-formed nature" and that not much can be said about it, and Kant identified smell as the "most ungrateful" and "most dispensable" of the senses. Because contemporary philosophers share this distaste for smell perception, olfaction is often dismissed or ignored in philosophical accounts of perception. Instead, contemporary philosophy of perception is based almost exclusively on visual perception. The goal of this dissertation is to show that this focus on a single modality distorts our understanding of what perception is.

I am not the first to realize the potential of opening up perceptual philosophy …

Communication, Labor, And Communicative Labor, Rachel Mckinney

Dissertations, Theses, and Capstone Projects

This project looks at the work we do to understand, to be understood, and to act on the basis of such understanding. Communicative labor is an important and under-theorized aspect of communication, and one that significantly impacts our epistemic, social and political lives. In this dissertation I take such labor as my object of analysis, and show how it bears on speakers and contexts.

First I provide an analysis of labor suitable for characterizing unwaged, immaterial and reproductive labor, and argue that such an analysis helps make sense of language systems ' the common pool resource systems that allow speakers …

The 'In-Group Advantage' For Perceiving Emotion Across Demographic Groups And Communication Channels, Thomas Myers

Dissertations, Theses, and Capstone Projects

The ability to perceive emotions in others is critical to successful social interaction. While much research has been conducted on some of the factors affecting emotion perception, other areas have received relatively little attention and, thus, are not well understood. There is growing evidence to suggest that various demographic factors, as well as their interactions, impact the accuracy of emotion perception. The impact of these factors seems to vary as a function of the particular channel (e.g., facial, prosodic, and lexical) through which emotions are perceived and may even be influenced by the presence of an 'in-group advantage' (IGA; Elfenbein …

Music In Poetry And Poetry In Music: Tumanian's Anush, Beata Asmik Navratil

Dissertations, Theses, and Capstone Projects

The poem Anush by the Armenian poet Hovhannes Tumanian (1869-1923) is rooted in traditional Armenian music. Tumanian's poem reflects a number of manifestations thereof: (1) It borrows in its style from Armenian lyrical songs (such as lalik and khagh), from the parerg style (the traditional dance-song), and from the voghb style (laments such as funeral laments, bayati, and tragic odes). (2) Ashug style of storytelling/singing as a main form of conveying the storyline and emotions of protagonists are present. (3) Dancing and music making during Armenian traditional rituals -- in particular, the Hambarsum celebration (Feast of Christ's Ascension), …

Explorations In Advancing Microalgae Productivity, Peter Neofotis

Dissertations, Theses, and Capstone Projects

This thesis is part of an effort to advance microalgae cultivation for biofuel and high value products. The first chapters describe a large scale screening effort in which novel strains that hold great promise in large outdoor cultivation systems were isolated. Among these are strains of Scenedesmus obliquus, Borodinellopsis texensis, Chlorella sorokiniana, Ankistrodesmus, Coelastrella, and a previously uncharacterized species in the Chlamydomonadales. These species are characterized in terms of their phylogenetic relationship, biomass productivity, and, for some, lipid and carotenoid profiles under growth and stress conditions. Also discussed in regards to growth metabolism and oil …

The Role Of Posterior Parietal Cortex In Episodic Memory Retrieval: Transcranial Direct Current Stimulation Studies (Tdcs), Denise Pergolizzi

Dissertations, Theses, and Capstone Projects

Neuroimaging studies of recognition memory have shown that greater activity in the lateral posterior parietal cortex (PPC) correlates with successful recognition in a variety of paradigms, but experimental techniques that manipulate brain activity are necessary to determine the specific contribution of the PPC in episodic memory retrieval. Transcranial Direct Current Stimulation (tDCS) is a non-invasive technique that can be used to manipulate cortical excitability. The collection of experiments that comprise this dissertation use tDCS to determine: 1) whether or not the lateral PPC is causally involved in episodic retrieval, and 2) whether the lateral PPC has a direct role in …

The Architecture Of Nineteenth-Century Cuban Sugar Mills: Creole Power And African Resistance In Late Colonial Cuba, Lorena Tezanos Toral

Dissertations, Theses, and Capstone Projects

By the mid-nineteenth century, Cuba had become the world's leading sugar producer, providing about a third of the world's supply. As a result, sugar mills dominated the Cuban countryside, each one growing into a micro-town, with housing complexes (mansions for owners and slave barracks or bohios for workers), industrial facilities (mills and boiler houses), and adjoining buildings (kitchens, infirmaries, etc.), all organized around a central, open space, known as a batey. Owned by the Creole elite (New World offspring of Spanish settlers) and worked by African slaves, sugar mills became places of enslavement and subjugation as well as contact, …

The Effect Of Retention Interval On Temporal Control Of Responding In Rats On The Peak Interval Procedure, Catherine Tsiris

Dissertations, Theses, and Capstone Projects

A considerable body of literature on time perception has investigated the effects of short intratrial retention intervals (RI) in the seconds range, on temporal performance, however there is a dearth of research examining the effects of long, intersession RIs (hours to days range) on timing. The present study examined the effect of two different RI durations (2 days and 70 days) on time estimates in subjects on the peak interval procedure. Twenty-four rats, eight per group, were exposed to one of three conditions. The experimental group was trained at 5 months and tested after a 70-day RI. One control group …

Documents From The September 30, 2015 Meeting Of The Associated Students Of The University Of Montana (Asum), University Of Montana--Missoula. Associated Students

Senate Meeting Agendas and Minutes, 2007-Present

Agenda, meeting minutes, and roll call tally sheet from the September 30, 2015 meeting of the Associated Students of the University of Montana (ASUM). The following resolutions were discussed during the meeting:

SB10-15/16-Resolution Amending Office Hour Bylaws

SB11-15/16-Resolution to Reconstitute Columbus Day as Indigenous Peoples' Day

Senescent Changes In Orientation, Frequency, And 3-D Slant And Shape Perception, Danny Tam

Dissertations, Theses, and Capstone Projects

The ability to perceive the 3-Dimensional world is effortless despite the fact that the input to the visual system is 2-Dimensional. Attempts to derive biologically plausible models of shape from texture have focused on how changes in orientation and spatial frequency information are processed based on the response properties of primary visual cortex (V1) neurons. However, the relative contributions of orientation and spatial frequency information in detecting slant and shape from 3-D surfaces are not well understood. Additionally, in senescence, changes in optical components of the eye result in reduced frequency sensitivity, but whether concurrent neurophysiological changes affect the ability …