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Sex-Dependent Role Of Interleukin-1 Signaling In Emotional And Cognitive Behaviors In Mice: Phenotyping Male And Female Il1-R1 Null Mutant Mice, Jennifer Anne Johnson

Dissertations, Theses, and Capstone Projects

IL1-R1 null mutant mice (IL1-R1 KO) have reduced signaling in the interleukin-1 (IL-1) pathway, making them a convenient model for testing the importance of IL-1 in either the development or maintenance of mouse behaviors. Prior research has revealed impaired cognitive and emotional processes in adult male IL1-R1 KO mice, including impaired spatial learning and memory and decreased anxiety with associated impairments in hippocampal cell proliferation and signal transmission. The current studies explored the neuroanatomy and behavioral phenotype of both male and female IL1-R1 KO mice. An array of behavioral tests was administered, including retesting at an older age for cognitive …

The Role Of The Vta Nmda Receptors, Vta Da Cells And Vta Terminal Regions In Reward-Related Learning, Karen Kest

Dissertations, Theses, and Capstone Projects

Reward-related learning occurs when an initially neutral stimulus acquires the capacity to elicit responses similar to an unconditioned stimulus (US) with which it is associated, in which case the stimulus now functions as a conditioned stimulus (CS). The mechanisms whereby stimuli come to function as CSs are not fully understood and comprise the theme of this dissertation. We have previously proposed that coincident signals from an unconditioned and the eventual conditioned stimulus (US and CS) signals on dopamine (DA) cells of the ventral tegmental area (VTA) leads to strengthening of CS synapses, allowing the CS to acquire the ability to …

Deception As Forgery: The Role Of Reference Information In Honesty And Deceit, Timothy John Luke

Dissertations, Theses, and Capstone Projects

Using concepts derived from cybernetics, self-presentation theory, and research on human self-regulation, I develop a cybernetic perspective of deception and self-presentation. In this perspective, human communication, both honest and deceptive, is controlled by feedback mechanisms. I report two studies designed to test the basic prediction derived from the cybernetic framework that deceivers are able to better emulate truth-tellers when they have access to relevant reference information about the way truth-tellers behave. Each study manipulated liars' and truth-tellers' access to reference information in a different manner. In Study 1, some participants viewed video recordings of people being interviewed in a manner …

Studies Toward A General Synthesis Of Poly-Substituted Alpha-Hydroxytropolones, Christine Marie Meck

Dissertations, Theses, and Capstone Projects

Chapter 1: This chapter gives a brief history of α-hydroxytropolones, how they were discovered and unique properties of these substrates. Included is a background on the bioactivity of these substrates in cellular targets such as bacteria, fungi, parasites, tumors and toxicity, as well as their ability to inhibit various metallo-based enzymes. Structure activity relationships studies are reviewed on important metalloenzymes HIV-Reverse Transcriptase (RT) and Inositol monophosphatase (IMPase). Finally the chapter finishes with a synthetic overview of α-hydroxytropolones including natural product targets such as puberulic acid, puberulonic acid, β-thujaplicinol, and β-hydroxytropolone.

Chapter 2: A brief review on β-hydroxy-γ-pyrone based oxidopyrylium cycloadditions …

Biophysical Characterization Of A De Novo Elastin, Kelly Nicole Greenland

Dissertations, Theses, and Capstone Projects

Natural human elastin is found in tissue such as the lungs, arteries, and skin. This protein is formed at birth with no mechanism present to repair or supplement the initial quantity formed. As a result, the functionality and durability of elastin's elasticity is critically important. To date, the mechanics of this ability to stretch and recoil is not fully understood. This study utilizes de novo protein design to create a small library of simplistic versions of elastin-like proteins, demonstrate the elastin-like proteins, maintain elastin's functionality, and inquire into its structure using solution nuclear magnetic resonance (NMR).

Elastin is formed from …

Art As Communication: Employing Gricean Principles Of Communication As A Model For Art Appreciation, Melissa June Dolese

Dissertations, Theses, and Capstone Projects

Abstract

How and why artworks elicit varied preferences and judgments among different individuals remains a topic with many unresolved issues. For instance, individuals with little artistic experience tend to show little appreciation for abstract art, even though such works often show a highly skilled organization of visual elements. A key aspect of a positive aesthetic experience concerns the ability of viewers to construct meaning. I propose that viewers attempt to make meaning of artworks due to a sense that art is a communicative process. Here I attempt an application of one intentionalist model of communication, the Gricean framework, to visual …

The Inconstancy Of Bodies: Yvonne Meier's Works, 1985 ' 2012, Lindsey Ann Drury

Dissertations, Theses, and Capstone Projects

What is ability? And conversely, what is disability? This research on the dancer and choreographer Yvonne Meier theorizes that her more than 30-year career has challenged the oft perceived polarities between function and dysfunction, utility and futility through the physical actions of dance performances. As she developed as a dancer and choreographer, Meier engaged in forms of movement training that pledged to expand her ability by unearthing the hidden causes and effects of actions. And yet, she created works which foregrounded the very gaps in knowledge between acts, their intentions, and effects. The fundamental disability expressed through Meier's works is …

Getting Out Of The Ghetto: Harm Reduction, Drug User Health, And The Transformation Of Social Policy In New York, Rachel Faulkner-Gurstein

Dissertations, Theses, and Capstone Projects

This dissertation is a qualitative study of the emergence and evolution of harm reduction drug policies in New York City. It examines harm reduction as a case of the institutionalization of a public health policy movement. Harm reduction seeks to treat the medical and social consequences of drug use without requiring abstinence. The dissertation examines the process by which harm reduction has managed, in the words of one informant, to 'get out of the ghetto' and become increasingly integrated into New York's public health establishment. Harm reduction has undergone three stages of institutionalization. It began as an activist policy movement. …

Pseudomonas Bacteriophage Phi6 As A Model For Virus Emergence, Brian Elwood Ford

Dissertations, Theses, and Capstone Projects

The Pseudomonas bacteriophage Φ6 has a long and well-established history as a model organism. Here we describe a set of experiments to extend this model system to concepts previously unclaimed. Chapter 1 presents a brief background of the ecology of viruses that infect microorganisms. Chapter 2 examines genetic mutations allowing for host range expansion. Chapter 3 presents a novel paired strain assay to study how a non genetic host-acquired factor affects fitness of these enveloped viruses on subsequent hosts. Chapter 4 is an extension of this system to include how the bacteria host is affected in virus-host coevolution.

On The Biology, Behavior, And Conservation Of The Chambered Nautilus, Nautilus Sp., Gregory Jeff Barord

Dissertations, Theses, and Capstone Projects

Chambered nautiluses are unique molluscs that differ from their closest relatives, octopus, squid, and cuttlefish, in many ways. Most obvious, nautiluses possess the ancestral trait of an external shell; a shell that has protected them for hundreds of millions of year but is dooming them today. Although nautiloids have survived all five mass extinction events, the lineage is under siege in the current 'sixth mass extinction'. Unregulated, unmanaged, and ongoing nautilus fisheries, particularly in the Philippines and Indonesia, have been depleting populations in a matter of years, some to local extinction, to supply a worldwide demand for the ornamental shell. …

Cuckolds And Codpieces: Early Modern Anxieties In Male Potency, Doris Barkin

Dissertations, Theses, and Capstone Projects

My dissertation is an exploration of male potency through a close examination of the tropes of the cuckold and the codpiece as presented in English dramatic works of the early modern period: I examine codpiece and cuckoldry discourses side by side, to see how one informs the other, and to perceive to what extent masculinity is affected and communicated by these discourses. My purpose here is to explore early modern views of masculinity, marriage, and sexuality through various theoretical frameworks, from Freud to Foucault.

My study argues that while the codpiece may emphasize or articulate sexual power and virility, that …

The Relationship Between A Norm Referenced Measure Of Theory Of Mind And Preschoolers' Social Skills In The Classroom, Sarah Ellen Birch

Dissertations, Theses, and Capstone Projects

This study sought to examine the effect of Theory of Mind (ToM) performance as measured by a norm-referenced assessment on the social skills of a multicultural group of preschool students. This study extends the current research in this area. Most previous studies examined the relationship among ToM, other social cognitive skills and social skills using participants from predominately Caucasian middle class families (Slaughter et al., 2015). Additionally, earlier research relied primarily on homemade measures of such skills (Cassidy et al., 2003; Disendruck & Ben-Eliyahu, 2006; McAlister & Peterson, 2013; Watson et al., 1999; Walker, 2005).

Participants included 67 children between …

Social-Ecological Resilience In The Viking-Age To Early-Medieval Faroe Islands, Seth Brewington

Dissertations, Theses, and Capstone Projects

This dissertation aims to evaluate the development and maintenance of social-ecological resilience during the settlement-period (ca. 9th through 11th centuries CE) in the Faroe Islands. In particular, the core objectives include the identification of the key social and natural variables involved, the examination of how these variables contributed to overall resilience, and the investigation of the initiation of the Faroese domestic economy.

This research focuses primarily on an analysis of the 9th through 13th century archaeofaunal assemblage from the site of Undir Junkarinsfløtti, located on the island of Sandoy. This analysis represents the first detailed study of the Faroese settlement-period …

The Role Of Perineuronal Nets In Regulating Barrel Cortex Physiology, Philip Chu

Dissertations, Theses, and Capstone Projects

The ability of the brain to adapt to changing environmental conditions is regulated by genetic and environmental factors. One component of the brain extracellular matrix, a scaffold of proteins and proteoglycans, tightly ensheaths the soma and proximal processes of neurons. These Perineuronal nets (PNNs) play protective and structural roles in the brain, but also regulate plasticity and behavior. Their developmental expression is highly attenuated following sensory deprivation, or pharmacological silencing of neuronal activity. Thus, PNNs contribute to the activity dependent regulation of plasticity in the brain. Although PNNs are relatively ubiquitous in the neocortex, little is known about the degree …

/N/:/R/ Correspondences In Albanian Dialects: Understanding The N>R Sound Change, Katie Albany

Dissertations, Theses, and Capstone Projects

The Albanian language is an Indo-European language that constitutes a separate branch in the Indo-European language family. There are two major dialects, Geg and Tosk, spoken in present day Albania that are mutually intelligible. There are morpho-syntactic differences between the two dialects and shared words provide evidence for a number of sound changes applying in certain contexts in Tosk. The focus of this paper is n > r sound change in Tosk applying to the nasal /n/ in an intervocalic position followed by an unstressed vowel. The lenition rule has been prolific diachronically, but stopped applying some time between the 13 …

Intimate Relationships: Reality And Normativity, Jason V. Altilio

Dissertations, Theses, and Capstone Projects

Close interpersonal relationships are a part of everyone's life at some point. For most people these relationships are actually prominent parts of their everyday lives. As such, it is important to figure out whether and how they fit into different normative theories of ethics. Relationships like those that exist as romantic couples, close friendships, and parent-child relationships share certain features with other close interpersonal relationships that I define as 'intimate relationships' in this dissertation. Intimate relationships are those that exist between people when they wish one another well, act for one another, do so mutually, treat one another as ends …

Assessing Theory Of Mind In Children With Autism Spectrum Disorder And Children With Typical Development, Sarita Austin

Dissertations, Theses, and Capstone Projects

Theory of mind (ToM) is the cognitive mechanism that allows a person to make inferences about other person's beliefs/knowledge. To date, a sizable portion of the research in ToM skills has involved assessment using false-belief tasks (FBT). FBT tasks are designed to examine people's actions in order to determine whether their beliefs/knowledge take into account other person's beliefs/knowledge. The current study used an alternative behavioral task to FBT with children with autism spectrum disorder (ASD) and young typically developing (TD) children. To date, a simple ToM task that has minimal linguistic and memory requirements has not been used with young …

Distribution Of Indigenous Strains Of Atoxigenic And Toxigenic Aspergillus Flavus And Aspergillus Parasiticus In Maize And Peanuts Agro-Ecological Zones Of Kenya, Daniel O. Okun, Fathiya M. Khamis, Geoffrey M. Muluvi, Joseph J. Ngeranwa, Fidelis O. Ombura, Moses O. Yongo, Eucharia U. Kenya

All Peer-Reviewed Publications

Background: Grains of important food and export crops in Africa are susceptible to contamination by toxin-producing moulds. Aflatoxins are mycotoxins associated with liver damage and cancer in humans and animals. These toxic substances are produced by fungi (such as Aspergillus flavus and Aspergillus parasiticus) in food and feed exposed to poor conditions during crop cultivation, storage or processing of harvest. The presence of aflatoxins in especially maize and peanuts in Kenya is of great concern. Recent developments in the application of atoxigenic strains of these fungi as biological control agents against toxigenic strains could be a solution to the problem. …

Semantic Models As Knowledge Repositories For Data Modellers In The Financial Industry, Gary Thompson

Dissertations

Data modellers working in the financial industry are expected to use both technical and business knowledge to transform data into the information required to meet regulatory reporting requirements. This dissertation explores the role that semantic models such as ontologies and concept maps can play in the acquisition of financial and regulatory concepts by data modellers. While there is widespread use of semantic models in the financial industry to specify how information is exchanged between IT systems, there is limited use of these models as knowledge repositories. The objective of this research is to evaluate the use of a semantic model …

The Guardian, September 30, 2015, Wright State University Student Body

The Guardian Student Newspaper

Twelve page issue of The Guardian, the official student-run newspaper for Wright State University. The Guardian has been published regularly since March of 1965.

Augusto Antonio Aguila. The Heart Of Need And Other Stories. Manila: University Of Santo Tomas Publishing House, 2013. 164 Pages., Charlene B. Diaz

Perspectives in the Arts and Humanities Asia

Excerpt: The fairy tale is the antithesis of the realist story. Realism strives for verisimilitude. It seeks out the everyday and the ordinary and portrays “life as it is.” In the last two decades, even the fairytale has been subject to revisioning, with people more interested in finding out what happens after “happily ever after.” The ten short stories that comprise the collection The Heart of Need and Other Stories by Augusto Antonio Aguila are realist stories of the most disenchanted kind. In Aguila’s gritty urban Manila landscape, the most his characters can hope for is getting by and coming …

A Novel And Domain-Specific Document Clustering And Topic Aggregation Toolset For A News Organisation, Claire Mcmahon

Dissertations

Large collections of documents are becoming increasingly common in the news gathering industry. A review of the literature shows there is a growing interest in datadriven journalism and specifically that the journalism profession needs better tools to understand and develop actionable knowledge from large document sets. On a daily basis, journalists are tasked with searching a diverse range of document sets including news gathering services, emails, freedom of information requests, court records, government reports, press releases and many other types of generally unstructured documents. Document clustering techniques can help address problems of understanding the ever expanding quantities of documents available …

Serving The Story, Howard Schaap

Faculty Work Comprehensive List

"The kinds of stories we tell about ourselves matter, and the story patterns that control and direct our lives are powerful forces."

Posting about using our life stories for service to the church from In All Things - an online hub committed to the claim that the life, death, and resurrection of Jesus Christ has implications for the entire world.

http://inallthings.org/serving-the-story/

The Role Of Dependence In Alcohol Reinforcement: Neurobehavioral Mechanisms, Michal Atzram

Dissertations, Theses, and Capstone Projects

The motivation to consume alcohol is complex, though physiological dependence has long been implicated in alcohol reinforcement and alcoholism. The research presented here was conducted to examine the role of alcohol dependence on voluntary alcohol consumption and preference, the validity of the Lieber-DeCarli (LD) liquid diet as a procedure to induce dependence, and the effect of alcohol administration on dopamine and endocannabinoids. While the LD diet has been used extensively to induce alcohol toxicity and teratogenic effects, there has not been research that has examined its use in the development of dependence and alcohol reinforcement. This research utilized varying periods …

Basic Cable: A Reluctant American Perspective On The Arab Spring Through Revolutionary Art, Philip Ayoub

Dissertations, Theses, and Capstone Projects

Supported by a critical component that traces back the Egyptian revolution of 2011 to its roots in the post-Nasser era when the Supreme Council of the Armed Forces assumed nearly complete political and economic control over the country, this novella, based in New York City, looks at the crisis through an American lens. As the story progresses the protagonist learns that the conditions which precipitated the events in Egypt can be viewed at once as both a product of American capitalism and Egyptian complicity, as well as act as a mirror, albeit on a magnified scale, of the changing socio-economic …

Developmental Coordination Disorder: The Relationship Between Gait And Attention With Possible Implications For Early Identification And Intervention, Yocheved Bensinger-Brody

Dissertations, Theses, and Capstone Projects

The aim of this research was to evaluate how increased levels of challenge to attentional capacity would affect the motor planning and coordination in the gait of children at risk of Developmental Coordination Disorder (DCD) across developmental ages. The study incorporated a dual task paradigm requiring both motor and attention performance, with the primary hypothesis that children who are at risk of DCD across different ages (3- to 8 yrs.-of-age) would demonstrate an alteration in their motor strategies if they were simultaneously engaging in an attention task. A secondary hypothesis of this study was that there is an underlying deficit …

Effects Of Reproductive Experiences On Age-Related Neural And Behavioral Changes In Female Rats, Saranna Belgrave

Dissertations, Theses, and Capstone Projects

The experiences of motherhood, pregnancy, birth and postnatal care, are associated with neural and behavioral changes. Female rats undergoing multiple bouts of motherhood (multiparous) have been shown in some, but not all studies, to have a dampened HPA axis stress response, changes in some hormone levels and better performance on spatial memory tasks compared to age matched females who have not given birth (nulliparous). Moreover, some of these changes extend into old age, approximately 24 months old. Thus, parous rats provide a unique, physiological model in which to investigate neural and hormonal factors that may contribute to cognitive decline and …

Reconsidering Organicism In Milton Babbitt's Music And Thought, Zachary Bernstein

Dissertations, Theses, and Capstone Projects

This dissertation makes two related but distinct claims. The first explores the influence of organicism, particularly in the hierarchical formulation developed by Heinrich Schenker, on Milton Babbitt's thought. This influence is shown to inform Babbitt's writings on a range of issues, guiding his analyses, his view of music cognition, and his understanding of the tonal and twelve-tone systems, including his own compositional twelve-tone techniques. Analysis of Babbitt's compositions, however, reveals several complications with the organicist model: there are a number of pieces and situations that conflict with the expectations of hierarchical organicism. As a result, this dissertation advocates for a …

Knowledge Discovery And Prediction Modeling Of Protein-Drug Binding Kinetic By Integrating Machine Learning, Normal Mode Analysis And Molecular Dynamics Simulation, See Hong Chiu

Dissertations, Theses, and Capstone Projects

One of the unaddressed challenges in drug discovery is that drug potency measured by protein-ligand binding affinity, such as IC₅₀ and K_d in vitro, is not correlated with drug activity in vivo. Computational modeling is playing an increasing role in designing efficient therapeutics. However, existing computational methods for the high-throughput study of protein-ligand interactions (PLI) mainly focus on the prediction of the binding affinity. This is the combined effect of association (k_on) and dissociation (k_off) rate constants. Few works have been produced to predict koff or its reciprocal, residence time, which is a key …

Wh-Question Processing In Children With Cochlear Implants, Zarabeth Waldman Deluca

Dissertations, Theses, and Capstone Projects

Children with cochlear implants (CIs) have exhibited difficulty accurately answering and producing wh-questions. The syntactic construction of wh-questions include syntactic movement, whereby the wh-question phrase that replaces the subject or object noun is fronted to the beginning of the sentence. This leaves a syntactic gap at the subject or object's original location, to be filled by the listener during immediate language processing. One view is that this syntactic gap is resolved by retaining that filler concept in working memory (WM), until it can be reintegrated into the wh-question. However, the CI population is also notable for WM deficits, which may …