Digital Commons Network^™

Filling The D.C. Circuit Vacancies, Carl W. Tobias

Indiana Law Journal

Partisanship undermines judicial nominations to the U.S. Court of Appeals for the District of Columbia Circuit. With three of eleven judgeships vacant during Barack Obama’s first term, he was the only President in a half century not to appoint a jurist to the nation’s second-most important court. Confirming accomplished nominees, thus, became imperative for the circuit’s prompt, economical, and fair case disposition. In 2013, Obama submitted excellent candidates. Patricia Millett had argued thirty-two Supreme Court appeals; Cornelia Pillard successfully litigated numerous path-breaking matters; and Robert Wilkins had served on the D.C. District bench for three years. The purportedly shrinking tribunal …

No Ordinary Fish Tale: Working Toward A Transnational Solution To The Cod Crisis In The Gulf Of Maine, Michael Ruderman

Indiana Law Journal

In response to a National Oceanic and Atmospheric Administration (NOAA) survey that showed “record-low levels of abundance” of groundfish in the Gulf of Maine (“Gulf”), local fisherman Brian Pearce asserted: “It concerns [me] that what [NOAA is] saying and what we [the local fishermen] are seeing is such a contrast . . . . Who sees more fish in the ocean than the fishermen?” Despite Mr. Pearce’s skepticism, the state of the cod fishery in the Gulf of Maine—home to “critical” and “legendary" fishing grounds in Canadian and American territories—is, in fact, dire. According to the NOAA survey, conducted in …

Clinical Application Of Electrocardiographic Imaging In Patients With Ischemic Cardiomyopathy, Early Repolarization Syndrome And Brugada Syndrome, Junjie Zhang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Electrocardiographic Imaging (ECGI) is a noninvasive modality for human application in both research and clinical settings. It is an important tool for investigation of abnormal electrophysiological (EP) substrates and arrhythmias in patients. Multi-channel body surface potential recordings and the patient-specific heart-torso geometry from ECG gated computed tomography are processed by ECGI algorithms to reconstruct epicardial potentials, electrograms and patterns of activation and repolarization. ECGI is able to continuously generate high-resolution, panoramic EP maps of the entire heart on a beat-by-beat basis, which cannot be achieved with invasive catheter mapping.

ECGI was applied in ischemic cardiomyopathy patients to characterize the abnormal …

Investigation Of 89zr-Siderophores As Molecular Imaging Agents For Positron Emission Tomography Imaging Of Bacterial Infections, Nora C. M. Goscinski

Arts & Sciences Graduate Student Theses and Dissertations

Siderophores are small molecules synthesized by bacteria to harvest Fe³⁺ from their environment. In infection scenarios, their production can increase infection virulence by increasing the ability of bacteria to obtain Fe³⁺ and therefore grow more rapidly. The selective uptake of siderophores in vivo in multi-bacteria environments indicates that this class of molecules has a potential use as selective imaging agents. In this work, DFO-NCS and a library of trihydroxamate siderophores were evaluated as vehicles to deliver ⁸⁹Zr selectively to bacteria for Positron Emission Tomography (PET) imaging of bacterial infections. Productive work with radiometals involves thorough knowledge of …

Functional Consequences Of Cantu Syndrome Associated Mutations In The Atp Sensitive Potassium Channel, Paige Cooper

Arts & Sciences Graduate Student Theses and Dissertations

ATP-sensitive potassium (KATP) channels are composed of inward-rectifying potassium channel pore-forming subunits (Kir6.1 and Kir6.2, encoded by KCNJ8 and KCNJ11, respectively) and regulatory sulfonylurea receptor subunits (SUR1 and SUR2, encoded by ABCC8 and ABCC9, respectively). These channels couple metabolism to excitability in multiple tissues. Mutations in ABCC9 have been linked to Cantú syndrome (CS), a multi-organ disease characterized by congenital hypertrichosis, distinct facial features, osteochondrodysplasia, and cardiac defects. Additionally, two ABCC9 mutation-negative patients, exhibiting clinical hallmarks of CS, have been identified as having KCNJ8 mutations. This body of work is focused on determining the functional consequences and molecular mechanisms of …

Endogenous Protection In Subarachnoid Hemorrhage, Eric Milner

Arts & Sciences Graduate Student Theses and Dissertations

Vasospasm-induced delayed cerebral ischemia (DCI) remains a major source of morbidity in patients with aneurysmal subarachnoid hemorrhage (SAH). Moreover, cognitive dysfunction is the primary driver of poor long-term outcome in SAH survivors; modeling such deficits preclinically is thus key for mechanistic and translational investigation. We hypothesized that activating innate neurovascular protective mechanisms by conditioning may represent a novel therapeutic approach against SAH-induced DCI, short-term, neurological deficits, and long-term neurocognitive deficits; and, secondarily, that the neurovascular protection it provides is mediated by endothelial nitric oxide synthase (eNOS) and hypoxia-inducible factor 1α (HIF-1α).In Experiment 1, wild-type C57BL/6 mice were subjected to hypoxic …

The Mechanism And Regulation Of Mammalian Photoreceptor Dark Adaptation, Yunlu Xue

Arts & Sciences Graduate Student Theses and Dissertations

The visual perception of vertebrates begins in rod and cone photoreceptors. Both photoreceptors require visual pigments to detect light. At the first step of light detection, a chromophore molecule (i.e. 11-cis retinal), which is conjugated to the visual pigment in photoreceptor outer segment, absorbs a photon. Photoisomerization of the chromophore activates the visual pigment, triggers the phototransduction cascade, and produces electrical signals. After photoisomerization, the chromophore is ultimately converted to all-trans retinol, which must be recycled to regenerate the visual pigment. This visual pigment regeneration process is called the visual cycle. It is the rate-limiting step of the photoreceptor dark …

Wildland Fire Deficit And Surplus In The Western United States, 1984-2012, Sean A. Parks, Carol Miller, Marc-Andrè Parisien, Lisa M. Holsinger, Solomon Z. Dobrowski, John Abatzoglou

Forest Management Faculty Publications

Wildland fire is an important disturbance agent in the western US and globally. However, the natural role of fire has been disrupted in many regions due to the influence of human activities, which have the potential to either exclude or promote fire, resulting in a "fire deficit" or "fire surplus," respectively. In this study, we developed a model of expected area burned for the western US as a function of climate from 1984 to 2012. We then quantified departures from expected area burned to identify geographic regions with fire deficit or surplus. We developed our model of area burned as …

Focus Group Report On The Teaching Resources Collection, Tamar Brown, Marilyn Geller, Anne-Marie Mulligan, Kate Thornhill, Jaime Wimmer

Library Reports

The Lesley University Libraries’ Assessment Workgroup conducted focus group interviews with faculty and students in order to plan for the future development of the library's Teaching Resources Collection, which includes K-8 curriculum materials and the Evelyn M. Finnegan Collection of high-quality children's literature. We spoke with a total of seven faculty members and two students, a very small sample, but our conversations did offer the library a starting point for thinking about how to improve the visibility of the collection, the space in which it is housed, and patron ability to access the materials. Focus group participants gave feedback on …

Intravacuolar Membranes Regulate Cd8 T Cell Recognition Of Membrane-Bound Toxoplasma Gondii Protective Antigen, Jodie Lopez, Amina Bittame, Céline Massera, Virginie Vasseur, Gregory Effantin, Anne Valat, Celia Buaillon, Sophie Allart, Barbara A. Fox, Leah M. Rommereim, David J. Bzik

Dartmouth Scholarship

Apicomplexa parasites such as Toxoplasma gondii target effectors to and across the boundary of their parasitophorous vacuole (PV), resulting in host cell subversion and potential presentation by MHC class I molecules for CD8 T cell recognition. The host-parasite interface comprises the PV limiting membrane and a highly curved, membranous intravacuolar network (IVN) of uncertain function. Here, using a cell-free minimal system, we dissect how membrane tubules are shaped by the parasite effectors GRA2 and GRA6. We show that membrane association regulates access of the GRA6 protective antigen to the MHC I pathway in infected cells. Although insertion of GRA6 in …

Engineering A Healthier Watershed: Middle School Students Use Engineering Design To Lessen The Impact Of Their Campus' Impervious Surfaces On Their Local Watershed, Elizabeth Claire Gardner

Dissertations and Theses

It is important that students understand not only how their local watershed functions, but also how it is being impacted by impervious surfaces. Additionally, students need experience exploring the scientific and engineering practices that are necessary for a strong STEM background. With this knowledge students can be empowered to tackle this real and local problem using engineering design, a powerful practice gaining momentum and clarity through its prominence in the recent Framework for K-12 Science Education. Twenty classes of suburban sixth-graders participated in a new five-week Watershed Engineering Design Unit taught by their regular science teachers. Students engaged in scientific …

Using Landsat Tm Imagery To Monitor Vegetation Change Following Flow Restoration To The Lower Owens River, California, Lesley Crandell Bross

Dissertations and Theses

Rehabilitating river corridors to restore valuable riparian habitat consumes significant resources from both governments and private companies. Given these considerable expenditures, it is important to monitor the progress of such projects. This study evaluated the utility of using Landsat Thematic Mapper remotely-sensed data from 2002 and 2009 to monitor vegetation change induced by instream flow restoration to the Lower Owens River in central California. This study compared the results of an unsupervised classification with an NDVI threshold classification to appraise the resources required and effectiveness of each analysis method. The results were inspected by creating standard remote sensing accuracy error …

Isn’T Citizen Science A Hoot? A Case-Study Exploring The Effectiveness Of Citizen Science As An Instrument To Teach The Nature Of Science Through A Local Nocturnal Owl-Monitoring Project, Tess Marie Kreofsky

Dissertations and Theses

Citizen science projects present a distinctive opportunity for professional and volunteer scientists to coordinate their efforts to gather unique sets of data that can benefit the scientific and local communities. These projects are assumed to be an effective educational tool to teach nature of science (NOS) to participants (Brossard, Lewenstein, Bonney, 2005). This case study evaluates the effectiveness of participation in a citizen science project as a way to learn about NOS. Through enhancement of the Tryon Creek Owl Monitoring Project the researcher reviewed the characteristics of a citizen science project that were thought to be necessary to impact the …

Genocide In German South West Africa & The Herero Reparations Movement, Melanie Bracht

Senior Theses

During my spring 2015 Semester at Sea voyage, the ship docked in Walvis Bay, Namibia for five days. Prior to the voyage, I knew nothing about Namibia’s history. I was surprised to learn of its treacherous past and the role Germany played in shaping its political and economic condition. I took a tour of the Himba settlement, driving hours across the barren, dry land to a small circle of huts. Women cover their skin with red clay and continue the tradition of sauna bathes, never bathing in water in their entire lives. The Himba culture was captivating and it was …

Somali Stories: A Development Of A Story-Based Esl Literacy Tool For Use With Older Adult Somali Women, Susan Renee Marshall

School of Education and Leadership Student Capstone Theses and Dissertations

The focus of this study is on incorporating what was learned through research to develop a curriculum resource. The primary research question addressed in this project is how educators can incorporate stories from older adult Somali women into English language instruction to improve these students’ English language writing skills. Key influences include my experience as an ESL educator and my strong interest in stories, including their use in education. The study has a curriculum development design. A curriculum resource, in the form of a story-based literacy tool designed to teach English language literacy skills to older Somali women, was developed. …

Shatranj, Anushka J. Mehrotra

Honors Theses

Shatranj contains the prologue and first five chapters of an in-progress novel completed as an Honors Thesis in Creative Writing. The story is set in Mumbai, India and tells the story of a fictional assassin company called the Fireflies. The story is told through the perspectives of multiple characters; Ishan, the protagonist, a new recruit to the group; Rhea a former Firefly who left the group and joined a group of other Firefly deserters; Tahiliani, one of the heads of the group; and Akash, a senior member of the Fireflies who desperately wants to prove himself and replace Tahiliani as …

Burns's Politics 'In Another View': Late 1792/Early 1793, Robert P. Irvine

Studies in Scottish Literature

Presents a reconsideration of Burns's political views in 1792-1793, examining in detail the original performance context of his poem "The Rights of Woman," in the Dumfries Theatre in November 1792, and the political context of his song "Why should na poor people mow," as first sent in letters to Robert Cleghorn in December 1792 and to Robert Graham of Fintry in January 1793, arguing that such "political" poems might be read less in terms of French or metropolitan revolutionary politics than in terms of major cultural and social changes in the Scottish community and networks to which Burns belonged.

Sir Walter Scott's The Monastery And The Representation Of Religious Belief, Chad T. May

Studies in Scottish Literature

Examines Sir Walter Scott's novel The Monastery, written while he was also working on his better-known medieval novel Ivanhoe, and discusses its representation of the historical religious transition of Scotland from a Catholic to a Protestant country; focuses especially on Scott's treatment of the supernatural, in the figure of the White Lady, and argues that Scott uses her to allow representation of a personal religious experience or religious vision that otherwise fitted uneasily with his generally secular project for historical representation in fiction; and concludes by briefly sketching the significance of this atypical, transitional novel for understanding religious …

Indigenous Women, Water Justice And Zaagidowin (Love), Deborah Mcgregor

Articles & Book Chapters

I would like to open by saying Chi-miigwech (a big thank-you) to those Elders/Grandmothers who have shared their stories and teachings with me over the years. Some have since passed on and I hope that through my words, their love and generosity will continue the process of healing the people and waters upon which they so integrally depend.

The paper which follows contains many references to notions of love, mutual respect, and responsibility towards the natural world, and water in particular. These ideas may seem a little tenuous for a serious paper on a critical environmental justice issue, but concepts …

Free Mate Choice Enhances Conservation Breeding In The Endangered Giant Panda, Meghan S. Martin-Wintle, David J. Shepherdson, Guiquan Zhang, Hemin Zhang, Desheng Li, Xiaoping Zhou, Rengui Li, Ronald R. Swaisgood

Biology Faculty Publications and Presentations

Conservation breeding programmes have become an increasingly important tool to save endangered species, yet despite the allocation of significant resources, efforts to create self-sustaining populations have met with limited success. The iconic giant panda (Ailuropoda melanoleuca) embodies the struggles associated with ex situ species conservation. Here we show that behavioural mate preferences in giant pandas predict reproductive outcomes. Giant pandas paired with preferred partners have significantly higher copulation and birth rates. Reproductive rates increase further when both partners show mutual preference for one another. If managers were to incorporate mate preferences more fully into breeding management, the production of giant …

Nucleus Accumbens Deep Brain Stimulation In A Rat Model Of Binge Eating, W. T. Doucette, J. Y. Khokhar, A. I. Green

Dartmouth Scholarship

Binge eating (BE) is a difficult-to-treat behavior with high relapse rates, thus complicating several disorders including obesity. In this study, we tested the effects of high-frequency deep brain stimulation (DBS) in a rodent model of BE. We hypothesized that BE rats receiving high-frequency DBS in the nucleus accumbens (NAc) core would have reduced binge sizes compared with sham stimulation in both a 'chronic BE' model as well as in a 'relapse to chronic BE' model. Male Sprague-Dawley rats (N=18) were implanted with stimulating electrodes in bilateral NAc core, and they received either active stimulation (N=12) or sham stimulation (N=6) for …

The Tohono O'Odham Nation And The United States-Mexico Border, Peter Heidepriem

American Indian Law Journal

No abstract provided.

Where Is The Warfare? The Impact Of Sola Scriptura On Science And Religion Dialogue, William James Richardson

Senior Theses

I have two aims with the publication of this thesis. The first is to contribute to the recent scholarly work that seeks to discredit the popular, yet fallacious, warfare model of science and religion. A nuanced investigation shows that the warfare evident in popular discourse cannot easily be attributed to a conflict between the essence of science and religion. Rather “science” and “religion” are interpreted as something else entirely. The New Atheists equate science with scientism, and religion is often associated with the Biblical inerrantism of many Protestant Christians. Both ideologies are grounded in an empiricist epistemological framework founded by …

Measurement, Modeling, And Mitigation Of Lead Impacts From General Aviation, Stephen Neil Feinberg

McKelvey School of Engineering Graduate Student Theses & Dissertations

Airborne lead (Pb) has been regulated as a criteria pollutant by the United States Environmental Protection Agency (EPA) since the Clean Air Act and its amendments in the 1970s. During the 1970s, atmospheric Pb emissions were dominated by the combustion of leaded automobile fuel and metals manufacturing. Over time, those emissions have decreased greatly and according to the EPA the largest emitter of Pb today is piston-engine aircraft. Additionally, in 2008 the EPA reduced the National Ambient Air Quality Standard (NAAQS) for Pb by an order of magnitude. These combined factors served as the impetus for further study of general …

Segmentation And Strain Mapping Of A Beating Heart, Kenna Middleton

McKelvey School of Engineering Graduate Student Theses & Dissertations

Conventional methods of estimating deformation optically often compare image intensities before and after deformation to help estimate the strain fields. However, these current meth ods often introduce undesirable error that propagates through the system, growing larger through each strain calculation. These errors create false, concentrated regions of strain throughout the image. Additionally, gathering and evaluating images in three- and four dimensional space creates even more difficulty for conventional methods. Here, by imple menting new techniques of gathering four-dimensional ultrasound data sets and calculating deformation fields with traditional errors reduced three-fold, four-dimensional images were evaluated to create a novel visualization tool …

Relating Neural Dynamics To Olfactory Coding And Behavior, Chao Li

McKelvey School of Engineering Graduate Student Theses & Dissertations

Sensory stimuli often evoke temporal patterns of spiking activity across a population of neurons in the early processing stages. What features of these spatiotemporal responses encode behaviorally relevant information, and how dynamic processing of sensory signals facilitates information processing are fundamental problems in sensory neuroscience that remain to be understood. In this thesis, I have investigated these issues using a relatively simple invertebrate model (locusts; Schistocerca americana).

In locusts, odorants are transduced into electrical signals by olfactory sensory neurons in the antenna and are subsequently relayed to the downstream neural circuit in the antennal lobe (analogous to the olfactory bulb …

Molecularly Targeted Nanoparticles For Modulation Of Inflammatory Mediators In Atherosclerosis, Rohun Udatta Palekar

McKelvey School of Engineering Graduate Student Theses & Dissertations

The enzyme thrombin has been demonstrated through experimental and clinical studies to play a crucial role in mediating both inflammation and thrombosis in atherosclerosis. The cellular effects of thrombin in promoting atherosclerosis involve the activation of signaling pathways that result in the secretion of a host of various chemokines, cytokines, cell adhesion molecules, etc. that promote vascular inflammation. Due in part to thrombin and other pro-atherogenic molecules, this prolonged inflammatory state in atherosclerosis results in the deterioration of the endothelium, increasing the risk of focal thrombosis. Current treatment strategies to address the role of thrombin in atherosclerosis, despite efficacy of …

Lysosomal Rnaset2 Is Required For Metabolic Stress-Mediated Ros Generation And Cell Death, George Caputa

Arts & Sciences Graduate Student Theses and Dissertations

Ectopic lipid deposition in non-adipose tissues is a hallmark of metabolic diseases, such as obesity and diabetes, and associated with cell dysfunction, cell death, and organ dysfunction. However, the molecular mechanisms linking excess free fatty acid to cell death are poorly understood. In order to identify genes critical for lipotoxicity, our lab performed a genetic screen in Chinese hamster ovary cells and isolated mutants that were resistant to lipotoxic death. In one of the lines, mutant 2B1, an allele encoding RNASET2, a ribonuclease of the T2 family, was disrupted by proviral insertion. We found that RNASET2 is induced during lipotoxicity …

Characterizing The Role Of Sialylated Milk Glycans And The Infant Gut Microbiota In Growth And Metabolism, Mark Richard Charbonneau

Arts & Sciences Graduate Student Theses and Dissertations

Undernutrition is a pressing and pervasive global health problem. The pathogenesis of this disease remains unclear, but epidemiologic studies indicate that it is not due to food insecurity alone. Moreover, current therapeutic interventions have limited efficacy in preventing or ameliorating the long-term sequelae of undernutrition, including stunting and cognitive deficits. Recent culture-independent studies have demonstrated that the normal postnatal pattern of gut microbiota development is disrupted in children with undernutrition, leading to the proposal that perturbations in gut microbiota development impairs healthy growth of the host. Human breast milk contains a diverse repertoire of free and conjugated human milk oligosaccharides …

Behavioral And Fmri-Based Characterization Of Cognitive Processes Supporting Learning And Retrieval Of Memory For Words In Young Adults, Binyam Nardos

Arts & Sciences Graduate Student Theses and Dissertations

A novel word is rarely defined explicitly during the first encounter. With repeated exposure, a decontextualized meaning of the word is integrated into semantic memory. With the overarching goal of characterizing the functional neuroanatomy of semantic processing in young adults, we employed a contextual word learning paradigm, creating novel synonyms for common animal/artifact nouns that, along with additional real words, served as stimuli for the lexical-decision based functional MRI (fMRI) experiment. Young adults (n=28) were given two types of word learning training administered in multiple sessions spread out over three days. The first type of training provided perceptual form-only training …