Digital Commons Network^™

Phenotypic Assays For Reactive Gliosis: Towards Multicellular Polypharmacology For Spinal Cord Injury, Samuel Robert Beckerman

Open Access Dissertations

Following traumatic central nervous system (CNS) injury, most severed axons fail to regenerate beyond the glial scar. This results in persistent deficits, including paralysis. Regenerative failure is due to neuron-intrinsic and extrinsic factors (i.e. CNS glial cells). Astrocytes are interesting extrinsic factors because they are a major constituent of the glial scar. After injury, astrocyte phenotypes change in a process called reactive gliosis. Reactive astrocytes are characterized by expansion of their glial fibrillary acid protein (GFAP) cytoskeleton and increased expression of axon-growth inhibitory chondroitin sulfate proteoglycans (CSPGs). As there are no FDA-approved drugs that enhance regeneration or functional recovery, there …

A Polyglot Approach To Bioinformatics Data Integration: A Phylogenetic Analysis Of Hiv-1, Steven Reisman, Thomas Hatzopoulos, Konstantin Laufer, George K. Thiruvathukal, Catherine Putonti

Bioinformatics Faculty Publications

As sequencing technologies continue to drop in price and increase in throughput, new challenges emerge for the management and accessibility of genomic sequence data. We have developed a pipeline for facilitating the storage, retrieval, and subsequent analysis of molecular data, integrating both sequence and metadata. Taking a polyglot approach involving multiple languages, libraries, and persistence mechanisms, sequence data can be aggregated from publicly available and local repositories. Data are exposed in the form of a RESTful web service, formatted for easy querying, and retrieved for downstream analyses. As a proof of concept, we have developed a resource for annotated HIV-1 …

Overview Of Influenza And Pneumococcal Vaccines, Krista Brooks

Faculty Articles & Research

No abstract provided.

October 24, 2015 (Pages 6259-6390), Pennsylvania Legislative Reference Bureau

Volume 45 (2015)

No abstract provided.

Microrna Circulating In The Early Aftermath Of Motor Vehicle Collision Predict Persistent Pain Development And Suggest A Role For Microrna In Sex-Specific Pain Differences., Sarah D. Linnstaedt, Margaret G. Walker, Joel S. Parker, Eunice Yeh, Robert L. Sons, Erin Zimny, Christopher A. Lewandowski, Phyllis L. Hendry, Kathia Damiron, Claire Pearson, Marc-Anthony Velilla, Brian J. O'Neil, Jeffrey Jones, Robert Swor, Robert Domeier, Scott Hammond, Samuel A. Mclean

Emergency Medicine Articles

BACKGROUND: Molecular mediators influencing the transition from acute to persistent musculoskeletal pain following common stress exposures such as motor vehicle collision (MVC) remain poorly understood. In this exploratory, proof of concept study, we compared circulating microRNA (miRNA) expression profiles in the early aftermath of MVC among individuals who did and did not subsequently develop persistent pain. Blood RNA samples were obtained from African American individuals (n = 53) who presented to the emergency department after MVC and were discharged to home after evaluation. The presence or absence of severe pain in the axial region, the most common and morbid region …

Differentiated Effects Of The Multimodal Antidepressant Vortioxetine On Sleep Architecture: Part 2, Pharmacological Interactions In Rodents Suggest A Role Of Serotonin-3 Receptor Antagonism, Steven C. Leiser, Deborah Iglesias-Bregna, Ligia Westrich, Alan Pehrson, Connie Sanchez

Department of Psychology Faculty Scholarship and Creative Works

Antidepressants often disrupt sleep. Vortioxetine, a multimodal antidepressant acting through serotonin (5-HT) transporter (SERT) inhibition, 5-HT 5-HTand 5-HTreceptor antagonism, 5-HTreceptor partial agonism, and 5-HTreceptor agonism, had fewer incidences of sleep-related adverse events reported in depressed patients. In the accompanying paper a polysomnographic electroencephalography (sleep-EEG) study of vortioxetine and paroxetine in healthy subjects indicated that at low/intermediate levels of SERT occupancy, vortioxetine affected rapid eye movement (REM) sleep differently than paroxetine. Here we investigated clinically meaningful doses (80-90% SERT occupancy) of vortioxetine and paroxetine on sleep-EEG in rats to further elucidate the serotoninergic receptor mechanisms mediating this difference. Cortical EEG, electromyography …

Optimizing Merlot For Optimal Ict Literacy, Lesley S. Farmer

SJSU Open Access Conference

Today's students need to locate, use and share information in myriad formats; they need to be ICT (information and communication technology) literacy. The CSU system has started an ICT Literacy Initiative to build out the MERLOT collection of ICT literacy learning objects, and to help faculty integrate ICT literacy into their curricula. This session explains ICT literacy, especially in terms of new standards. Attendees will find out how MERLOT supports ICT literacy, and how they can join and contribute to the ICT literacy community.

Steroid Receptor Isoform Expression In Drosophila Nociceptor Neurons Is Required For Normal Dendritic Arbor And Sensitivity, Aidan L. Mcparland, Taylor L. Follansbee, Gwendolyn D. Vesenka, Alexandra E. Panaitiu, Geoffrey K. Ganter

Biology Student Publications

Steroid hormones organize many aspects of development, including that of the nervous system. Steroids also play neuromodulatory and other activational roles, including regulation of sensitivity to painful stimuli in mammals. In Drosophila, ecdysteroids are the only steroid hormones, and therefore the fly represents a simplified model system in which to explore mechanisms of steroid neuromodulation of nociception. In this report, we present evidence that ecdysteroids, acting through two isoforms of their nuclear ecdysone receptor (EcR), modulate sensitivity to noxious thermal and mechanical stimuli in the fly larva. We show that EcRA and EcRB1 are expressed by third instar larvae in …

The Echo: October 23, 2015, Taylor University

2015-2016 (Volume 103)

Lacrosse at a crossroads – Upland update – Top five news events of the week – Late night for Taylor – In The Loop – Around The World – Democratic candidates unveiled – Road to Ohio – Stylish Staff – Grandma Gracie – O-Group heartbreak – Echograms #TaylorU -- #TaylorU’s Top Tweets – Journeying from Taylor to L.A. – Quartet returns – Hotel for spies – Marriage isn’t for everyone – Does anyone really care? – My real self – Trojans subdue Saints – Weekly Preview – Cross country moves up – Trojans’ big guns fizzle in shootout – Athlete …

An Analysis Of Fertilizer Markets In Bric Countries, Robert Lloyd

Administrative Issues Journal

Over the previous decade the collection of countries known as the BRIC nations has worked together to advance social and economic agendas. These four nations represent unique challenges and immense opportunities for MNC’s searching to expand their business into these countries. This paper reviews these opportunities and challenges in the context of the fertilizer industry and provides an overall outlook for this international market. Recommendations are provided for how an international business might succeed in each of the BRIC nations.

Criss Chronicles, Volume 6, Issue 1

Criss Chronicles Newsletter

This edition of Criss Chronicles features From the Dean's Desk, The Information Exchange, Conversation with Melinda Kozel, Focus on Resources: Women: Transnational Networks, From the Archives: The Fine Arts Press Collection at the Criss Library, Copyright Corner, and an Events Calendar.

Theaflavin-3, 3'-Digallate Decreases Human Ovarian Carcinoma Ovcar-3 Cell-Induced Angiogenesis Via Akt And Notch-1 Pathways, Not Via Mapk Pathways, Ying Gao, Gary O. Rankin, Youying Tu, Yi Charlie Chen

Biochemistry and Microbiology

Theaflavin-3, 3'-digallate (TF3) is a black tea polyphenol produced from polymerization and oxidization of the green tea ployphenols epicatechin gallate and (-)-epigallocatechin-3-gallate (EGCG) during fermentation of fresh tea leaves. TF3 has been reported to have anticancer properties. However, the effect of TF3 on tumor angiogenesis and the underlying mechanisms are not clear. In the present study, TF3 was verified to inhibit tumor angiogenesis. Compared with EGCG, TF3 was more potent. TF3 inhibited human ovarian carcinoma OVCAR-3 cell-induced angiogenesis in human umbilical vein endothelial cell model and in chick chorioallantoic membrane model. TF3 reduced tumor angiogenesis by downregulating HIF-1α and VEGF. …

The Bison, October 23, 2015

The Bison Newspapers

No abstract provided.

Champions Of Healthcare Awards 2015 Program, Pcom Office Of Diversity And Community Relations

Diversity and Inclusion

Invitation and Program for Georgia Campus' 2015 Champions of Healthcare Awards.

Keynote Speaker: Barbara Ross-Lee, DO, FACOFP, New York Institute of Technology Vice President for Health Sciences and Medical Affairs

Awardees: Colleen D. Heer; Jeffrey K. Seiple, MBA, LFD, LE; Srujana Rayalam, BVSc, MVSc, PHD; Shu Zhu, MD, PhD; Mark D. Darrow, MD FACP; Nathan M. Polite, DO; Jennifer L. Gooch, PhD; Brittany Melvin (MS/Biomed ’16); Carly Duncan (PharmD ’16); Thuy Le (DO ‘17); Senator Renee Unterman; Hannah Southerland (PharmD ’19)

Volume 8 - Issue 1: La Créole - A Journal Of Creole History & Genealogy, Dr. Ronald Dorris, Fatima Shaik, Mary Gehhman

La Créole - A Journal of Creole History & Genealogy

The Louisiana Creole Research Association, Inc., known as LA Creole, was founded on August 21, 2004 as a New Orleans-based, non-profit family research and educational organization. Its purpose is to assist Creoles of Color in researching their ancestry, to educate the general public about Creole history and culture, and to celebrate the contributions and legacy of a unique, sometimes forgotten people. La Créole, the Association’s journal is published annually.

Hdl In Sepsis - Risk Factor And Therapeutic Approach, Emily E. Morin, Ling Guo, Anna Schwendeman, Xiang-An Li

Pediatrics Faculty Publications

High-density lipoprotein (HDL) is a key component of circulating blood and plays essential roles in regulation of vascular endothelial function and immunity. Clinical data demonstrate that HDL levels drop by 40-70% in septic patients, which is associated with a poor prognosis. Experimental studies using Apolipoprotein A-I (ApoAI) null mice showed that HDL deficient mice are susceptible to septic death, and overexpressing ApoAI in mice to increase HDL levels protects against septic death. These clinical and animal studies support our hypothesis that a decrease in HDL level is a risk factor for sepsis, and raising circulating HDL levels may provide an …

Light Suppression Of Nitrate Reductase Activity In Seedling And Young Plant Tissues, Mark A. Schoenbeck, Bikash Shrestha, Melanie F. Mccormick, Timothy D. Kellner, Claudia M. Rauter

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

Light is often reported to enhance plant nitrate reductase (NR) activity; we have identified a context in which light strongly suppresses NR activity. In vitro NR activity measurements of laboratory-grown seedlings showed strong suppression of nitrate-induced NR activity in cotyledon, hypocotyl, and root tissues of Ipomoea hederacea (L.) Jacquin; robust NR activity accumulated in nitrate-induced tissues in the dark, but was absent or significantly reduced in tissues exposed to light during the incubation. The suppressive mechanism appears to act at a point after nitrate perception; tissues pre-incubated with nitrate in the light were potentiated and developed NR activity more rapidly …

Size Does Matter: Crocodile Mothers React More To The Voice Of Smaller Offspring, T. Chabert, A. Colin, T. Aubin, V. Shacks, S. L. Bourquin, R. M. Elsey, J. G. Acosta, N. Mathevon

Publications and Research

Parental care is widespread in Archosaurs (birds, crocodilians, dinosaurs and pterosaurs), and this group provides a useful model for the evolution of parent-offspring interactions. While offspring signalling has been well-studied in birds, the modulation of parental care in crocodilians remains an open question. Here we show that acoustic communication has a key role in the dynamics of crocodilian’ mother-offspring relationships. We found embedded information about the emitter’s size in juvenile calls of several species, and experimentally demonstrated that Nile crocodile mothers breeding in the wild are less receptive to the calls of larger juveniles. Using synthetized sounds, we further showed …

Mechanosensitive Channel Msl8 Regulates Osmotic Forces During Pollen Hydration And Germination, Eric S. Hamilton, Gregory S. Jensen, Grigory Maksaev, Andrew Katims, Ashley M. Sherp, Elizabeth S. Haswell

Biology Faculty Research

Pollen grains undergo dramatic changes in cellular water potential as they deliver the male germ line to female gametes, and it has been proposed that mechanosensitive ion channels may sense the resulting mechanical stress. Here, we identify and characterize MscS-like 8 (MSL8), a pollen-specific, membrane tension–gated ion channel required for pollen to survive the hypoosmotic shock of rehydration and for full male fertility. MSL8 negatively regulates pollen germination but is required for cellular integrity during germination and tube growth. MSL8 thus senses and responds to changes in membrane tension associated with pollen hydration and germination. These data further suggest that …

How Overqualification Impacts Job Attitudes And Well-Being: The Unique Roles Of Perceptions And Reality, Marijana L. Arvan

USF Tampa Graduate Theses and Dissertations

The recent global economic downturn has stimulated a growing interest among scholars in how employees interpret and respond to the circumstance of being overqualified. However, the overqualification literature has been hindered by uncertainty regarding the extent to which employees’ perceptions of being overqualified are based in reality. The present study sought to address this concern by proposing and testing a theoretical model of objective overqualification, perceived overqualification, job satisfaction, and well-being using a cross-sectional sample of full-time employees who had recently graduated from college. Additionally, the present study investigated cognitive ability, achievement striving, and trait negative affectivity as potential moderators …

Ensemble Concerts: Normal West High School Wind Ensemble And Isu Wind Symphony, October 23, 2015, Lisa Preston Conductor, Martin H. Seggelke Conductor

School of Music Programs

Center for the Performing Arts
October 23, 2015
Friday Evening
8:00 p.m.

Gardner-Webb Yesterday And Today, Chelsea Sydnor

GWU-Today

In Back to the Future Part II (1989), Marty McFly and Emmett ‘Doc’ Brown travel 30 years forward in time to October 21, 2015. In honor of yesterday’s “Back to the Future Day,” we’re giving you a glimpse of what Gardner-Webb was like in 1955 and 1985, two of the other time periods featured in the iconic film trilogy.

The Setonian, October 22, 2015, Seton Hall University

2015

No abstract provided.

Defining Adolescence, Alexa C. Curtis

Journal of Adolescent and Family Health

Chronologic definitions of adolescence and adolescent sub-stages vary throughout the literature. Definitions for adolescence are important because they inform the construction and implementation of adolescent research and program development. This article identifies commonly used chronologic parameters for adolescence, explores the developmental theory contributing to the understanding of adolescent chronology and posits a developmentally consistent definition of this critical transitional phase as: “early adolescence” 11-13 years, “adolescence” 14-17 years, and “young adulthood” 18-25 years. Keywords: adolescent, development, chronologic definitions, research

The Tiger Vol. 109 Issue 43 2015-10-22, Clemson University

Tiger Newspapers 2015

No abstract provided.

The Potential For A Blood Test For Scabies, Larry G. Arlian, Hermann Feldmeier, Majorie S. Morgan

Biological Sciences Faculty Publications

Scabies, caused by the mite S. scabiei that burrows in the skin of humans, is a contagious skin disease that affects millions of people worldwide. It is a significant public health burden in economically disadvantaged populations, and outbreaks are common in nursing homes, daycare facilities, schools and workplaces in developed countries. It causes significant morbidity, and in chronic cases, associated bacterial infections can lead to renal and cardiac diseases. Scabies is very difficult to diagnose by the usual skin scrape test, and a presumptive diagnosis is often made based on clinical signs such as rash and itch that can …

Connexin26 Gap Junction Mediates Mirna Intercellular Genetic Communication In The Cochlea And Is Required For Inner Ear Development, Yan Zhu, Liang Zong, Ling Mei, Hong-Bo Zhao

Otolaryngology--Head & Neck Surgery Faculty Publications

Organ development requires well-established intercellular communication to coordinate cell proliferations and differentiations. MicroRNAs (miRNAs) are small, non-coding RNAs that can broadly regulate gene expression and play a critical role in the organ development. In this study, we found that miRNAs could pass through gap junctions between native cochlear supporting cells to play a role in the cochlear development. Connexin26 (Cx26) and Cx30 are predominant isoforms and co-express in the cochlea. Cx26 deficiency but not Cx30 deficiency can cause cochlear developmental disorders. We found that associated with Cx26 deletion induced the cochlear developmental disorders, deletion of Cx26 but not Cx30 disrupted …

Improving Healthspan Via Changes In Gut Microbiota And Fermentation, Michael J. Keenan, Maria L. Marco, Donald K. Ingram, Roy J. Martin

Faculty Publications

Dietary resistant starch impact on intestinal microbiome and improving healthspan is the topic of this review. In the elderly population, dietary fiber intake is lower than recommended. Dietary resistant starch as a source of fiber produces a profound change in gut microbiota and fermentation in animal models of aging. Dietary resistant starch has the potential for improving healthspan in the elderly through multiple mechanisms as follows: (1) enhancing gut microbiota profile and production of short-chain fatty acids, (2) improving gut barrier function, (3) increasing gut peptides that are important in glucose homeostasis and lipid metabolism, and (4) mimicking many of …

Migration In The Social Stage Of Dictyostelium Discoideum Amoebae Impacts Competition, Chandra N. Jack, Neil J. Buttery, Boahemaa Adu-Oppong, Michael Powers, Christopher R.L. Thompson, David Queller, Joan E. Strassmann

Biology Faculty Research

Interaction conditions can change the balance of cooperation and conflict in multicellular groups. After aggregating together, cells of the social amoeba Dictyostelium discoideum may migrate as a group (known as a slug) to a new location. We consider this migration stage as an arena for social competition and conflict because the cells in the slug may not be from a genetically homogeneous population. In this study, we examined the interplay of two seemingly diametric actions, the solitary action of kin recognition and the collective action of slug migration in D. discoideum, to more fully understand the effects of social competition …

Bayle's 'Rorarius,' Leibniz, And Animal Souls, Richard Fry

SIUE Faculty Research, Scholarship, and Creative Activity

Bayle produces a set of three criteria to evaluate views of non-human animal souls. These criteria arise from Bayle’s interaction with the extant Modern views on the topic and are meant to capture features that any successful view will have. Bayle criticizes Leibniz’s view of animal souls at length for its reliance on the theory of pre-established harmony, entering into a long exchange with Leibniz on the topic, but Bayle never explicitly applies his criteria. This leads some (including Leibniz) to conclude that Bayle thinks Leibniz’s view satisfies the criteria. I argue in this paper that Leibniz’s view properly satisfies …