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The N-Glycosylation Of Immunoglobulin G As A Novel Biomarker Of Parkinson’S Disease, Alyce Christine Russell

Theses: Doctorates and Masters

For neurodegenerative diseases, interventions during the early stages of the disease, before significant neurodegeneration has occurred, are associated with an increased probability of slowing or halting the disease process. In order to intervene early, it is essential that an accurate diagnosis is obtained and that disease progression can be monitored. This is particularly relevant for Parkinson’s disease (PD; International Classification of Diseases version 10) because significant neurodegeneration has already occurred by the time the clinical motor symptoms are present. Therefore, the development of translatable, high-throughput biomarkers for large scale population screening is a crucial area of research. Of promise are …

Medical Cannabis In The United States: Policy, Politics And Science, Jelica Grbic

Theses: Doctorates and Masters

Historically, cannabis has been used as a pharmaceutical drug for a variety of conditions including rheumatism, depression, convulsions, and malaria. Since the 1970s, randomised, controlled clinical trials have shown cannabis to be effective in the treatment of debilitating medical conditions including nausea and vomiting resulting from cancer chemotherapy, wasting syndrome associated with HIV/AIDS, and chronic pain. Despite scientific evidence, as of 2011, when the material for this thesis was collected, only 17 states of the United States (U.S.) and the District of Columbia had enacted medical cannabis laws allowing patients with specific medical conditions to use cannabis without being criminally …

Self-Interest Or Self-Inflicted? How The United States Charges Its Service Members For Violating The Laws Of War, Chris Jenks

Faculty Journal Articles and Book Chapters

This chapter explores the aspects of self-interest implicated by the US military prosecuting its own service members who violate the laws of war under different criminal charges than it prosecutes enemy belligerents who commit substantially similar offences. The chapter briefly explains how the US asserts criminal jurisdiction over its service members before turning to how the US military reports violations of the laws of war. It then sets out the US methodology for charging such violations as applied to its service members, and compares this methodology to that applied to those tried by military commissions. The chapter then discusses the …

Robotic Marriage And The Law, Mark Goldfeder, Yosef Razin

Scholarly Works

The United States, and the world at large, is in the midst of a family law revolution that will fundamentally change our very conception of family. Ethical challenges to age-old ideas have prompted people to ask foundational questions, such as how and why our most important personal relationships evolved. In a world where same-sex marriage has been legalized, it is only natural to wonder who marriage may include in the future. This essay explores the question of whether a human and a robot could ever legally marry in the United States. Through a thought experiment, it examines the legal and …

Original Meaning And The Precedent Fallback, Randy J. Kozel

Vanderbilt Law Review

There is longstanding tension between originalism and judicial precedent. With its resolute focus on deciphering the enacted Constitution, the originalist methodology raises questions about whether judges can legitimately defer to their own pronouncements. Numerous scholars have responded by debating whether and when the Constitution's original meaning should yield to contrary precedent. This Article considers the role of judicial precedent not when it conflicts with the Constitution's original meaning but rather when the consultation of text and historical evidence is insufficient to resolve a case. In those situations, deference to precedent can serve as a fallback rule of constitutional adjudication. The …

Letter From The Editor, Garrett Trott

The Christian Librarian

No abstract provided.

Grudge Spending: The Interplay Between Markets And Culture In The Purchase Of Security, Ian Loader, Benjamin J. Goold, Angelica Thumala

All Faculty Publications

In the paper, we use data from an English study of security consumption, and recent work in the cultural sociology of markets, to illustrate the way in which moral and social commitments shape and often constrain decisions about how, or indeed whether, individuals and organizations enter markets for protection. Three main claims are proffered. We suggest, firstly, that the purchase of security commodities is a mundane, non-conspicuous mode of consumption that typically exists outside of the paraphernalia of consumer culture – a form of grudge spending. Secondly, we demonstrate that security consumption is weighed against other commitments that individuals and …

Emergence From Civil Death: The Evolution Of Expungement In West Virginia, Valena Beety, Michael Aloi, Evan Johns

Articles by Maurer Faculty

Ninety-two million Americans have a criminal record—nearly one in three adults. This criminal record can include an arrest that did not lead to a conviction, a conviction for which the person did not serve time in prison, or a conviction for a nonviolent crime. All can have a similar impact on an individual’s job prospects and on local economies. Incarcerating adult Americans costs a combined $68 billion annually at the local, state, and federal levels. The cost of lost wages and lost financial contributions to society by ex-offenders is even higher.

This financially immobilized population of former offenders may be …

Association Between Toxocariasis And Cognitive Function In Young To Middle-Aged Adults, Bruce L. Brown, Lance D. Erickson, Shawn D. Gale, Andrew Berrett, Dawson W. Hedges

Faculty Publications

The ascarid nematodes Toxocara canis (Werner, 1782) and Toxocara cati (Schrank, 1788) may infect humans resulting in toxocariasis. A prior study associated species of Toxocara Stiles, 1905 with cognitive deficits in children. To determine if a similar association between toxocariasis and cognition exists in adults, we analysed a large dataset from the United States’ Center for Disease Control’s National Health and Nutrition Examination Survey. We used linear-regression and multivariate models to examine the association between toxocariasis as assessed by the presence of anti-Toxocara IgG antibodies and three measures of cognitive function – simple reaction time (SRT), symbol-digit substitution (SDS) and …

Modifying Unjust Sentences, E. Lea Johnston

Georgia Law Review

Judicial sentence modification offers a means to address the phenomenon of over-incarcerationas well as the harsh prison conditions that threaten unjust punishment. Indeed, some legislatures have framed states' early release provisions as fulfilling goals of proportionality and just punishment. This Article explores whether the tools available to judges at sentence modification hearings are adequate to respond to the unjust punishment experienced by prisoners. In examining this question, the Article focuses on one population particularly likely to experience disproportionate or inhumane punishment: inmates with serious mental disorders. A deep literature suggests that individuals with serious mental illnesses are especially likely to …

The Sixth Commissioner, Nadelle Grossman

Georgia Law Review

The federal securities laws grant broad rulemaking authority to the Securities and Exchange Commission (SEC). In promulgating rules, the SEC must not only ensure that its rules protect investors and the public interest, but also consider the effects of its rules on efficiency, competition, and capital formation (the ECCF mandate). However, the SEC's rulemaking authority has been frustrated. In two decisions striking down SEC rules, the D.C. Circuit has required the SEC to conduct a quantitative cost-benefit analysis under the ECCF mandate. This contrasts with the SEC's historic practice of qualitatively assessing the effects of its rules. While these D.C. …

Digital Medicine, The Fda, And The First Amendment, Adam Candeub

Georgia Law Review

Digital medicine might transform healthcare more fundamentally than the introduction of anesthesia or germ basis theory of disease. Already, tens of thousands of "medical apps" are available for smartphones. These computer applications can measure blood pressure, pulse, lung function, oxygenation level, sugar level, breathing rate and body temperature-and can even diagnose skin cancer, analyze urine, and take an echocardiogram. In fall 2013, the Federal Drug Administration (FDA) asserted regulatory authority over mobile medical applications and other digital medical services, threatening to chill, if not, destroy this innovation. This Article argues that the FDA stands on firm legal ground regulating medical …

Bank Regulation And Securitization: How The Law Improved Transmission Lines Between Real Estate And Banking Crises, Erik F. Gerding

Georgia Law Review

Financial crises take many forms. Real estate crises can devastate economies.' So too can bank crises. Stock market crashes can precipitate crises of their own. The "subprime crisis" represents the confluence and worst of all three; like three cyclones merging together in warm offshore waters, these three kinds of crises generated even more destructive force when conjoined. The panic that took shape in U.S. real estate and capital markets in 2007 represents another example in a long historical line of intertwined banking and real estate crises. Securitization served as a new coupling rod joining cycles in real estate and banking …

Discoverymania: Plausibility Pleading As Misprescription, Fabio Arcila Jr.

Scholarly Works

In replacing notice pleading with plausibility pleading, the Supreme Court chose to use a pleading solution to address a perceived discovery problem. This dissonance calls into question both the wisdom and legitimacy of the Court’s choice because plausibility pleading is too blunt an instrument to serve the Court’s goals: it is destabilizing because it ignores the interrelationship between discovery and other Federal Rules of Civil Procedure; it is unfairly overinclusive because it impacts all plaintiffs in all federal cases rather than only those in the minority of cases in which discovery is likely to be problematic; and it is unfairly …

Dissolving Condominium, Private Takings, And The Nature Of Property, Douglas C. Harris, Nicole Gilewicz

All Faculty Publications

Condominium enables the subdivision of buildings into multiple private titles. It does so by combining individual titles with an undivided share of common property, a right to participate in governing the property, and an obligation to contribute to its maintenance. The dissolution of condominium breaks apart this package of rights and responsibilities, and results in the termination of the individual titles. Some common law jurisdictions require the unanimous consent of title holders to dissolve condominium, others permit it with a supermajority vote. All jurisdictions allow for non-consensual dissolution, and thus the termination of titles without consent, with a court order. …

Liver Perilipin 5 Expression Worsens Hepatosteatosis But Not Insulin Resistance In High Fat-Fed Mice, Michelle B. Trevino, David Mazur-Hart, Yui Machida, Timothy King, Joseph Nadler, Elena V. Galkina, Arjun Poddar, Sucharita Dutta, Yumi Imai

Mathematics & Statistics Faculty Publications

Perilipin 5 (PLIN5) is a lipid droplet (LD) protein highly expressed in oxidative tissues, including the fasted liver. However, its expression also increases in nonalcoholic fatty liver. To determine whether PLIN5 regulates metabolic phenotypes of hepatosteatosis under nutritional excess, liver targeted overexpression of PLIN5 was achieved using adenoviral vector (Ad-PLIN5) in male C57BL/6J mice fed high-fat diet. Mice treated with adenovirus expressing green fluorescent protein (GFP) (Ad-GFP) served as control. Ad-PLIN5 livers increased LD in the liver section, and liquid chromatography with tandem mass spectrometry revealed increases in lipid classes associated with LD, including triacylglycerol, cholesterol ester, and phospholipid classes, …

When Faith Falls Short: Bankruptcy Decisions Of Churches, Pamela Foohey

Articles by Maurer Faculty

What does a church do when it is about to go bust? Religious organizations, like any business, can experience financial distress. Leaders could try to solve their churches’ financial problems on their own. Perhaps leaders do not view the problems as addressable with law. Or perhaps they do not think, as a moral or spiritual matter, that they should resort to the legal system, such as bankruptcy, to deal with their churches’ inability to pay its debts. Yet about ninety religious organizations seek to reorganize under the Bankruptcy Code every year. This Article relies on interviews with forty-five of these …

Suffolk University Undergraduate Academic Catalog, College Of Arts And Sciences And Sawyer Business School, 2015-2016, Suffolk University

College of Arts and Sciences and Sawyer Business School Academic Catalogs

This catalog contains information for the undergraduate programs in the College of Arts and Sciences and the Sawyer Business School. The catalog is a PDF version of the Suffolk website, so many pages have repeated information and links in the document will not work.

The catalog is keyword searchable by clicking ctrl+f. A-Z course descriptions are also included here as separate PDF files with lists of CAS and SBS courses. Please contact the Archives if you need assistance navigating this catalog or finding information on degree requirements or course descriptions.

Evaporative Techniques For Stormwater Runoff Alleviation, Allison M. Arnold

Graduate Theses, Dissertations, and Problem Reports (ETD)

Current climate changes have led to a projected steady increase in rainfall over the next several decades, notably in the Greater Pittsburgh Area. Even without this predicted increase the urbanization of many regions has altered local natural environments, which in the past stored, shed and evaporated this runoff water effectively, maintaining balance within the water table. These added rainfall forecasts, combined with America’s growing trend to develop and expand the urbanization of our natural earth, has resulted in a growing surplus of stormwater runoff water affecting these cities and their suburbs, leaving many sanitation departments unable to meet the heightened …

Suffolk University Graduate Academic Catalog, College Of Arts And Sciences And Sawyer Business School, 2015-2016, Suffolk University

College of Arts and Sciences and Sawyer Business School Academic Catalogs

This catalog contains information for the graduate programs in the College of Arts and Sciences and the Sawyer Business School. The catalog is a PDF version of the Suffolk website, so many pages have repeated information and links in the document will not work.

The catalog is keyword searchable by clicking ctrl+f. A-Z course descriptions are also included here as separate PDF files with lists of CAS and SBS courses. Please contact the Archives if you need assistance navigating this catalog or finding information on degree requirements or course descriptions.

Modeling Phosphorus Environmental Thresholds On A Watershed Scale, Sara L. Jones

Graduate Theses, Dissertations, and Problem Reports (ETD)

Anthropogenic eutrophication of surface waterways is a major environmental concern as it leads to the decline of aquatic resources and degradation of water. Phosphorus is the most limiting nutrient in freshwater systems and, therefore, an important factor in the control of eutrophication. Identifying the natural P thresholds in soils using the relationship between soil P and potential P losses can help determine areas with a high risk of P loss to waterways via leaching. Twenty-three sites covering a range of land uses were sampled by the USDA-NRCS in the Potomac Watershed in the northeast United States. Four pedons described and …

Collecting Subjectsobjects: The Museum And Victorian Literature 1830-1914, Kayla Kreuger Mckinney

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study argues that the museum wielded enough cultural capital to shape not only the content of literature (which picked up themes like collection, hoarding, display, and organization) but also the formal arrangement of such literature into catalogues, taxonomies, and the dense material-based descriptions for which the Victorian novel is often criticized. The museum, it is shown, is far more central to Victorian thought than has been recognized, and its presence in literature has been misread or overlooked in contemporary criticism. This study also provides a narrative of the Victorian preoccupation with the museual, especially as regards the natural history …

The Influence Of Accelerometer Cut Points On Determining The Percent Of Preschool-Age Children Meeting Physical Activity Guidelines, Anna Elizabeth Scott

Graduate Theses, Dissertations, and Problem Reports (ETD)

Reduced physical activity is thought to be a major contributor to energy imbalance and obesity in children and adolescents. A challenge for researchers is selecting a tool that will accurately measure physical activity, especially in young children. A current tool that is used is an accelerometer. This study had two objectives. The first examined if different sets of accelerometer cut points developed for preschool-age children would produce the same physical activity results when identical raw data were run through them. Through the use of accelerometer data the second objective aimed to determine the percent of children who met the physical …

Igrow: Developing A Curriculum To Increase Gardening Skills, Culinary Competence, And Family Meal Time In Youth And Their Caregiver, Jade Alana White

Graduate Theses, Dissertations, and Problem Reports (ETD)

Objective: To develop a curriculum using evidence based programs to increase gardening skills, cooking competence, and family mealtime for youth (pre and early adolescent years) and their caregiver (dyad pair) using community-based participatory research.

Methods:

Using the Social Cognitive Theory, an inter-disciplinary team (N=3) including child development, nutrition and horticulture expertise: a curriculum was developed by integrating evidence-based curricula from iCook 4-H, Junior Masters Gardener curriculum Health and Nutrition from the Garden and Essential Elements of 4-H Youth Development Programs, with additional resources from USDA’s My Plate, and garden-based recipes. The community based participatory research approach and process was utilized …

Sacred Violence: When Ancient Egyptian Punishment Was Dressed In Ritual Trappings, Kerry Muhlestein

Faculty Publications

Despite gaping holes in our knowledge of ancient Egyptian laws and punishments, the sheer amount of data available for that long-lasting culture dictates that we limit our study of punishments both topically and temporally. This article will investigate the topic of ritual-associated killing from the Old Kingdom through the Libyan era. Earlier phases of Egyptian history yield evidence of ritual killing, such as the retainer burials associated with Early Dynastic kings or the labels of Aha and Djer (fig. 1), that seem to depict ritual slaughter. Whatever the nature of these seeming programs of ritual slaying, we cannot trace a …

The Effect Of Tert-Butylhydroquinone, An Nrf2-Are Signaling Pathway Inducer, On Oxidative Stress-Related Neurodegeneration, Jiahong Sun

Graduate Theses, Dissertations, and Problem Reports (ETD)

Oxidative stress is actively involved in stroke pathogenesis; however, almost all the antioxidants that have been applied into the clinical trials fail to improve ischemic stroke outcomes. We note that most drug candidates have very limited diversity of antioxidative activities. tBHQ is a food additive, which is considered to be safe for human consumption. As both an antioxidant and an Nrf2-ARE signaling pathway inducer, tBHQ can directly eliminate ROS and activates the expression of all the antioxidative genes under Nrf2-ARE regulation. My dissertation investigated the potential clinical application of tBHQ for ischemic stroke treatment by using both in vitro glutamate-induced …

Enhancement Of Rna Splicing By The Nutrient-Regulated Splicing Factor Srsf3, Amanda L. Suchanek

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nutritional status is a powerful regulator of intracellular function. Dietary status can increase or decrease the rate of RNA splicing, thereby affecting gene expression; however, few molecular mechanisms have been identified that are responsible for this type of regulation.;The glucose-6-phosphate dehydrogenase (G6PD) gene has provided a useful tool for the study of nutrient-regulated splicing because accumulation of G6PD mRNA is dependent solely on changes in the rate of mRNA splicing in response to nutritional stimuli, consistent with its enzymatic role of converting dietary energy to fatty acids. Treatment of primary hepatocytes in culture with insulin or feeding a high-carbohydrate, low …

Testing The Relation Between Disgust And Approach-Avoidance Behavior, Ronald Thomas

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Behavioral Immune System (BIS) is a set of psychological processes that evolved to protect individuals from harmful contaminants and pathogens in the environment (Miller & Maner, 2011; Schaller & Duncan, 2007; Tybur, Lieberman, Kurzban, & DeScioli, 2013). The primary mechanism through which the BIS functions is the emotion of disgust, which causes negative physical and affective reactions that encourage avoidance behavior and serve as a deterrent from approaching potentially harmful stimuli (Schaller & Duncan, 2007). Consequently, disgust is proposed to serve a disease-avoidance mechanism. However, relatively little research has empirically tested the link between disgust and general behavioral avoidance …

The Impact Of Choice: Exercise Motivation And Physical Activity In College Students Enrolled In Fitness For Life, Julia Fera Tracy

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Research suggests there is a decline in physical activity (PA) as individuals enter adulthood (Sallis, 2000). Physical activity behaviors that students develop during college years are said to have a long-term impact on adult habits (Keating, Guan, Pinero, & Bridges, 2005). Leslie, Sparling, and Owen (2001) suggest that college campuses are central settings with unseen opportunities to influence young adults' PA patterns. Higher education PA programs can be a mechanism to introduce adults to healthy lifestyles that include PA (Hardin, Andrew, Koo, & Bemiller, 2009).;Purpose: The purpose of this study was to investigate the impact of choice in a …

The Root Of Sustainability: Investigating The Relationship Between Medicinal Plant Conservation And Surface Mining In Appalachia, Jessica B. Turner

Graduate Theses, Dissertations, and Problem Reports (ETD)

Since European colonization, Appalachian culture has been based on resource extraction, such as coal mining, timbering, and Non-Timber Forest Product (NTFP) harvest. Surface mining degrades forest habitat for medicinal plants, especially the habitat for the internationally valuable medicinal herb, American ginseng (Panax quinquefolius L.), and the NTFP culture associated with this plant. The relationship between medicinal plant conservation and surface mining must be studied with a non- traditional, multi-faceted approach: culturally, economically, and ecologically. (1) Using community-based participatory surveys, I determined how ginseng harvesters and non- harvesters in West Virginia communities view the relationship between surface mining and ginseng harvest. …