Digital Commons Network^™

Active Yap Promotes Pancreatic Cancer Cell Motility, Invasion And Tumorigenesis In A Mitotic Phosphorylation-Dependent Manner Through Lpar3., Shuping Yang, Lin Zhang, Vinee Purohit, Surendra K. Shukla, Xingcheng Chen, Fang Yu, Kai Fu, Yuanhong Chen, Joyce C. Solheim, Surendra K. Shukla, Wei Song, Jixin Dong

Journal Articles: Eppley Institute

The transcriptional co-activator Yes-associated protein, YAP, is a main effector in the Hippo tumor suppressor pathway. We recently defined a mechanism for positive regulation of YAP through CDK1-mediated mitotic phosphorylation. Here, we show that active YAP promotes pancreatic cancer cell migration, invasion and anchorage-independent growth in a mitotic phosphorylation-dependent manner. Mitotic phosphorylation is essential for YAP-driven tumorigenesis in animals. YAP reduction significantly impairs cell migration and invasion. Immunohistochemistry shows significant upregulation and nuclear localization of YAP in metastases when compared with primary tumors and normal tissue in human. Mitotic phosphorylation of YAP controls a unique transcriptional program in pancreatic cells. …

Hiv-1-Tat Protein Inhibits Sc35-Mediated Tau Exon 10 Inclusion Through Up-Regulation Of Dyrk1a Kinase, Ferdous Kadri, Marco Pacifici, Anna Wilk, Amanda Parker-Struckhoff, Luis Del Valle, Kurt F. Hauser, Pamela E. Knapp, Christopher Parsons, Duane Jeansonne, Adam Lassak, Francesca Peruzzi

School of Medicine Faculty Publications

The HIV-1 transactivator protein Tat is implicated in the neuronal damage that contributes to neurocognitive impairment affecting people living with HIV/AIDS. Aberrant splicing of TAU exon 10 results in tauopathies characterized by alterations in the proportion of TAU isoforms containing three (3R) or four (4R) microtubule-binding repeats. The splicing factor SC35/SRSF2 binds to nuclear RNA and facilitates the incorporation of exon 10 in the TAU molecule. Here, we utilized clinical samples, an animal model, and neuronal cell cultures and found that Tat promotes TAU 3R up-regulation through increased levels of phosphorylated SC35, which is retained in nuclear speckles. This mechanism …

Volume 113, Number 9 – Tuesday, November 3, 2015, Saint Mary's College Of California

The Collegian

No abstract provided.

Spartan Daily, November 3, 2015, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 145, Issue 30

The George-Anne, Georgia Southern University

The George-Anne

• Daily
• News
• Puzzles
• Special Project
• Features
• Sports

Basal Salivary Oxytocin And Skin To Skin Contact Among Lactating Mothers Of Premature Infants, Jessica Marie Gordon

USF Tampa Graduate Theses and Dissertations

This dissertation research explored mechanisms of human milk (HM) expulsion by describing the effects of skin to skin contact (SSC) on maternal basal oxytocin (OT) secretion among 20 premature mothers with hospitalized premature infants. This one-group, repeated measures design consisted of: 1) daily SSC with covariant data via self-report diary and 2) maternal salivary OT with and without SSC at 4 time points were collected over a 7 day time frame. Results indicate that mean levels of basal OT increase over time (M 234 pg/ml, SD 108 pg/ml time point 1; M 257 pg/ml, SD 125 pg/ml time point 3). …

Growing Christmas Trees, John R. Seifert

Historical Documents of the Purdue Cooperative Extension Service Archive

No abstract provided.

The Off-Board String On The Medieval Fiddle, Linda Marie Zaerr

Performance Practice Review

Drawing on explicit descriptions, iconographic representations, and contemporary narrative, this essay analyzes playing techniques and repertories plausible for one type of medieval fiddle and suggests that notions of historical fiddle performance may need to expand to accommodate the aesthetics and techniques implied by the off-board fiddle.

While it has been widely assumed that the left thumb was used to pluck the laterally divergent string described by Jerome of Moravia, the complete body of evidence suggests an alternative interpretation: the thumb can be used to stop this off-board string, extending the melodic range of the instrument down to a step below …

Rwu Faculty Member Andrew Rhyne Named Finalist In Wildlife Crime Tech Challenge, Public Affairs, Roger Williams University

Featured News Story

Rhyne is a contender for the People’s Choice Award and a $500,000 grand prize for creating real-time data analytics platform to enhance the detection of illegal wildlife trade.

Volume 51 - Issue 08 - Monday, November 2, 2015, Rose Thorn Staff

The Rose Thorn Archive

The Rose Thorn, Rose-Hulman's independent student newspaper.

A Novel Plant Cell Culture Platform For Semicontinous Production Of Recombinant Proteins: Butyrylcholinesterase As A Case Study, Jasmine Corbin, Bryce Hashimoto, Kalimuthu Karuppanan, Raymond Rodriguez, Somen Nandi, Brian Roberts, Amy Noe, Karen Mcdonald

Integrated Continuous Biomanufacturing II

In this paper we describe a novel biomanufacturing production platform that utilizes transgenic rice cell suspension cultures for efficient semicontinuous cell culture (SCC) production of recombinant proteins. The production platform utilizes a metabolically regulated promoter, a secretion signal peptide that enables secretion out of the cell for ease of recovery/purification, coupled with an efficient semicontinuous operational strategy that allows independent optimization of growth and production phases. In addition, long term operation (up several months¹) is possible by maintaining viable biomass within the bioreactor, thereby reducing the need for long seed trains, as well as minimizing turn-around time, CIP …

Optimal Control Of A Continuous Bioreactor For Maximized Beta-Carotene Production, Nazmul Karim, Jonathan Raftery, Xinghua Pan

Integrated Continuous Biomanufacturing II

Carotenes such as β-carotene have a positive impact in human health as a precursor of vitamin A. Structural complexity of these compounds makes their chemical synthesis a difficult endeavor, facilitating the need for their biological production. Continuous operation can be used in these processes to allow for increased cell viability through the mitigation of substrate and product inhibition, thereby increasing the productivity of the carotenoid product. This work looks to examine the operating conditions necessary to achieve the maximum production of the desired carotenoid products when produced via continuous operation. First, a two-level parameter estimation method is utilized to develop …

Mathematical Modeling Of A Bioreactor Producing Epo-Hr Operating In Perfusion Mode, Osman Fernandez, Raydel Alvarez, Ernesto Chico, Adolfo Castillo, Julio Dustet

Integrated Continuous Biomanufacturing II

The interest in use perfusion mode has increased in the last years, due to an increased awareness of perfusion advantages, some general improvement in equipment reliability, and a broadening of operational skills in the biomanufacturing industry. However, mathematical modeling of bioreactors in continuous mode with cell retention (perfusion mode) with concomitant cell bleeding is still emerging, because this scheme has a few applications in global biotechnology industry. The case of study was industrial fermentation process of CHO cells producing EPO-hr. The model involves a total of 7 equations and 19 variables. In order to fix the degrees of freedom were …

The Tiger Vol. 109 Issue 46 2015-11-02, Clemson University

Tiger Newspapers 2015

No abstract provided.

Current, November 02, 2015, University Of Missouri-St. Louis

Current (2010s)

No abstract provided.

Engineers Without Borders | College Of Engineering, Usu College Of Engineering

College of Engineering News

Nov. 2, 2015 – Members of the Engineers Without Borders Team Mexico have been working with residents in the community of La Salitrera, Mexico for several years to help eliminate arsenic from water supplies using an improved design on a classic tool – the bio-sand water filter.

The Murray Ledger And Times, November 2, 2015, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

82-Year-Old Atmore Resident Active Again After Cutting-Edge Valve-In-Valve Procedure, Tyler Greer

Browse All News

No abstract provided.

Pharmacology: The Pharmacodynamics Of Nutrients And Nutrient Interactions In Biological Functions, M. Hasan Mohajeri, Gunter P. Eckert, James R. Pauly, Christopher M. Butt

Pharmaceutical Sciences Faculty Publications

No abstract provided.

Vol. 49, No. 10 (November 2, 2015)

Indiana Law Annotated

No abstract provided.

Daily Eastern News: November 02, 2015, Eastern Illinois University

November

No abstract provided.

Long Non Coding Rna Malat1 Promotes Tumor Growth And Metastasis By Inducing Epithelial-Mesenchymal Transition In Oral Squamous Cell Carcinoma, Xuan Zhou, Su Liu, Guoshuai Cai, Lingping Kong, Tingting Zhang, Yu Ren, Yansheng Wu, Mei Mei, Lun Zhang, Xudong Wang

Dartmouth Scholarship

The prognosis of advanced oral squamous cell carcinoma (OSCC) patients remains dismal, and a better understanding of the underlying mechanisms is critical for identifying effective targets with therapeutic potential to improve the survival of patients with OSCC. This study aims to clarify the clinical and biological significance of metastasis-associated long non-coding RNA, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in OSCC. We found that MALAT1 is overexpressed in OSCC tissues compared to normal oral mucosa by real-time PCR. MALAT1 served as a new prognostic factor in OSCC patients. When knockdown by small interfering RNA (siRNA) in OSCC cell lines TSCCA and …

November 2, 2015

The Gavel Gazette

No abstract provided.

Rising To China's Challenge In The Pacific Rim: Reforming The Foreign Corrupt Practices Act To Further The Trans-Pacific Partnership, Michael B. Runnels

Seattle University Law Review

It is a commonly held myth that the rise of U.S. global economic hegemony rests upon a free trade philosophy. On the contrary, protectionist trade policies were central to galvanizing American industrialization. This misconception lies at the heart of why the trade liberalization policies enforced under the U.S.-led Bretton Woods institutions, the World Bank and the International Monetary Fund (IMF), brought ruinous results to many poor countries. The subsequent decline in credibility of these institutions challenges their continued relevance and opens a space for powerful nations to fashion alternative rules of trade. China is a member of the IMF but …

Sialylation Of Igg Fc Domain Impairs Complement-Dependent Cytotoxicity., Isaak Quast, Christian W Keller, Michael A Maurer, John P Giddens, Björn Tackenberg, Lai-Xi Wang, Christian Münz, Falk Nimmerjahn, Marinos Dalakas, Jan D Lünemann

Department of Neurology Faculty Papers

IgG molecules exert both pro- and antiinflammatory effector functions based on the composition of the fragment crystallizable (Fc) domain glycan. Sialylated IgG Fc domains have antiinflammatory properties that are attributed to their ability to increase the activation threshold of innate effector cells to immune complexes by stimulating the upregulation of the inhibitory Fcγ receptor IIB (FcγRIIB). Here, we report that IgG Fc sialylation of human monoclonal IgG1 molecules impairs their efficacy to induce complement-mediated cytotoxicity (CDC). Fc sialylation of a CD20-targeting antibody had no impact on antibody-dependent cellular cytotoxicity and did not change the affinity of the antibody for activating …

Tinnitus And Trauma, Marc A. Fagelson

ETSU Faculty Works

Trauma-provoked tinnitus challenges patients and clinicians. Effects of trauma may exacerbate tinnitus, and patients with both tinnitus and posttraumatic stress disorder rate distress levels as higher than patients who experience only one or the other. This presentation will highlight links between tinnitus and trauma histories relevant to clinical audiologists.

Atrazine Exposure And Reproductive Dysfunction Through The Hypothalamus-Pituitary-Gonadal (Hpg) Axis, Sara Wirbisky, Jennifer L. Freeman

School of Health Sciences Faculty Publications

Endocrine disrupting chemicals (EDC) are exogenous agents that alter endogenous hormone signaling pathways. These chemicals target the neuroendocrine system which is composed of organs throughout the body that work alongside the central nervous system to regulate biological processes. Of primary importance is the hypothalamic-pituitary-gonadal (HPG) axis which is vital for maintaining proper reproductive function. Atrazine (2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine) is a pre-emergent herbicide used to prevent the growth of weeds on various crops. This herbicide is reported to widely contaminate potable water supplies everywhere it is applied. As such, the European Union banned the use of atrazine in 2004. Currently the United States …

Evading Miller, Robert S. Chang, David A. Perez, Luke M. Rona, Christopher M. Schafbuch

Seattle University Law Review

Miller v. Alabama appeared to strengthen constitutional protections for juvenile sentencing that the United States Supreme Court recognized in Roper v. Simmons and Graham v. Florida. In Roper, the Court held that executing a person for a crime committed as a juvenile is unconstitutional under the Eighth Amendment. In Graham, the Court held that sentencing a person to life without parole for a nonhomicide offense committed as a juvenile is unconstitutional under the Eighth Amendment. In Miller, the Court held that a mandatory sentence of life without parole for a homicide offense committed by a juvenile is also unconstitutional under …

Mmu: 11/02/15–11/08/15, Student Bar Association

Monday Morning Update

The Monday Morning Update, or MMU as it is referred to by students, is a weekly email newsletter of news, events, and opportunities of special interest to Notre Dame Law School students.

Emergent Insect And Neotropical Migratory Bird Interactions And Responses To Habitat, Hydrology, And Progressive Urbanization In The Tampa Bay Region, Nathaniel Lee Goddard

USF Tampa Graduate Theses and Dissertations

The growing human population threatens the many of the earth’s biological systems. In the last 600 years extinction rates risen from 1 extinction per million species per year (E/MSY) in the 1400’s to 50 E/MSY today. During this time period 1.5% of all known birds have gone extinct, because they could not adapt quickly enough to human mediated changes. The goal of this dissertation was to determine how urbanization and anthropogenic services needed to support urban areas impact cypress dome wetland aquatic insect and migratory bird populations that depend on them. In Central Florida cypress dome hydroperiods are driven by …