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2015

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Sestrin2, A Regulator Of Thermogenesis And Mitohormesis In Brown Adipose Tissue, Seung-Hyun Ro, Ian Semple, Allison Ho, Hwan-Woo Park, Jun Hee Lee Jan 2015

Sestrin2, A Regulator Of Thermogenesis And Mitohormesis In Brown Adipose Tissue, Seung-Hyun Ro, Ian Semple, Allison Ho, Hwan-Woo Park, Jun Hee Lee

Department of Biochemistry: Faculty Publications

Sestrin2 is a stress-inducible protein that functions as an antioxidant and inhibitor of mTOR complex 1. In a recent study, we found that Sestrin2 overexpression in brown adipocytes interfered with normal metabolism by reducing mitochondrial respiration through the suppression of uncoupling protein 1 (UCP1) expression. The metabolic effects of Sestrin2 in brown adipocytes were dependent on its antioxidant activity, and chemical antioxidants produced similar effects in inhibiting UCP1-dependent thermogenesis. These observations suggest that low levels of reactive oxygen species (ROS) in brown adipocytes can actually be beneficial and necessary for proper metabolic homeostasis. In addition, considering that Sestrins are ROS …

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Moving Foward?: Problematic Ideologies In Twenty-First Century Fairy Tale Films, Alyson Kilmer Jan 2015

Moving Foward?: Problematic Ideologies In Twenty-First Century Fairy Tale Films, Alyson Kilmer

All Master's Theses

Fairy tales, as a reflection of our values and belief systems, are crucial in shaping and maintaining cultural ideologies. In the twenty-first century, cinematic fairy tales have the unique position of representing such values in an expansive and expeditious manner. Audiences must therefore be critically conscious of the messages promoted by these tales. An analysis of the five most popular contemporary fairy tale films, Disney’s Princess and the Frog (2009), Tangled (2010), Universal’s Snow White and the Huntsman (2012), and Disney’s Frozen (2013) and Maleficent (2014), revealed minimal attempts to propitiate critical audiences in regard to changing cultural values, but …

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My Family, My Identity: An Ethnohistorical Exploration Of A Multiethnic Family, Sarah Oosahwee-Voss Jan 2015

My Family, My Identity: An Ethnohistorical Exploration Of A Multiethnic Family, Sarah Oosahwee-Voss

All Master's Theses

This thesis focuses on family identity in a time when multiethnic couples are increasing in population. How will this populace choose to define who they are? The purpose of this thesis is to focus on a multiethnic family, specifically one with different tribal heritages, and explore how their identity was formed over time and maintained through various times in their history. Multiple ethnographic methods were utilized in tandem to collect the information. A framework was then created to determine the main themes found throughout the history and information compiled in order to define the core values within their family identity. …

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Elk And Deer Hunters In Washington State: Affiliations And Ethical Behavior, Isa O. Harrison Jan 2015

Elk And Deer Hunters In Washington State: Affiliations And Ethical Behavior, Isa O. Harrison

All Master's Theses

Elk and deer are particularly challenging natural resources to manage due to their mobility and the impacts of other species and humans both direct and indirect. A man-made lack of natural predators has created a need for hunting in order to control the population expansions of herds. Such efforts face two major problems: mobility makes herds difficult to accurately quantify and hunting laws are challenging to enforce. Policies regarding the annual take and type of hunting have been based on the assumption that the primary factor motivating hunters is harvesting more animals. However, this study has found that the primary …

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Will Neuroscience Redefine Mental Injury?: Disability Benefit Law, Mental Health Parity Law, And Disability Discrimination Law, Stacey A. Tovino Jan 2015

Will Neuroscience Redefine Mental Injury?: Disability Benefit Law, Mental Health Parity Law, And Disability Discrimination Law, Stacey A. Tovino

Faculty Articles

No abstract provided.

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Type I Interferons Link Viral Infection To Enhanced Epithelial Turnover And Repair, Lulu Sun, Hiroyuki Miyoshi, Sofia Origanti, Timothy J. Nice, Alexandra C. Barger, Nicholas A. Manieri, Leslie A. Fogel, Anthony R. French, David Piwnica-Worms, Helen Piwnica-Worms, Herbert W. Virgin, Deborah J. Lenschow, Thaddeus S. Stappenbeck Jan 2015

Type I Interferons Link Viral Infection To Enhanced Epithelial Turnover And Repair, Lulu Sun, Hiroyuki Miyoshi, Sofia Origanti, Timothy J. Nice, Alexandra C. Barger, Nicholas A. Manieri, Leslie A. Fogel, Anthony R. French, David Piwnica-Worms, Helen Piwnica-Worms, Herbert W. Virgin, Deborah J. Lenschow, Thaddeus S. Stappenbeck

Biological Sciences Faculty Research and Publications

The host immune system functions constantly to maintain chronic commensal and pathogenic organisms in check. The consequences of these immune responses on host physiology are as yet unexplored, and may have long-term implications in health and disease. We show that chronic viral infection increases epithelial turnover in multiple tissues, and the antiviral cytokines type I interferons (IFNs) mediate this response. Using a murine model with persistently elevated type I IFNs in the absence of exogenous viral infection, the Irgm1−/− mouse, we demonstrate that type I IFNs act through nonepithelial cells, including macrophages, to promote increased epithelial turnover and wound …

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Introductory Editorial: Water Microbiology, Patrick J. Mcnamara, Mark J. Krzmarzick Jan 2015

Introductory Editorial: Water Microbiology, Patrick J. Mcnamara, Mark J. Krzmarzick

Civil and Environmental Engineering Faculty Research and Publications

No abstract provided.

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Panel: "Academic Collaborations In International Settings: Equity And Quality In Education Through Stem Education", Csusb - Latino Education And Advocacy Days (Lead) Jan 2015

Panel: "Academic Collaborations In International Settings: Equity And Quality In Education Through Stem Education", Csusb - Latino Education And Advocacy Days (Lead)

Latino Education and Advocacy Days (LEAD) Video Recordings

No abstract provided.

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Influence Of Saltwater Intrusion, Climate, And Development On The Ground Water Supply Of San Juan Island, Scott Joel Adolphson Jan 2015

Influence Of Saltwater Intrusion, Climate, And Development On The Ground Water Supply Of San Juan Island, Scott Joel Adolphson

All Master's Theses

Freshwater availability is a serious resource concern, due to the needs of its increasing population. This issue is especially critical in coastal regions, both due to supplying the growing number of people migrating to these areas and the higher potential for saltwater intrusion into groundwater supplies as water demands increase. This study assessed the degree of saltwater intrusion on San Juan Island, Washington, including its extent, contributing factors and the implication for the water resource availability. Results indicate that saltwater intrusion levels have not increased significantly in the study area, yet the size of the area threatened has increased. Saltwater …

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The Politics Of Narrative: Law And The Representation Of Mexican Criminality, Deborah Weissman Jan 2015

The Politics Of Narrative: Law And The Representation Of Mexican Criminality, Deborah Weissman

Fordham International Law Journal

No abstract provided.

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Making The Case For Antiestablishmentarianism: The Church And State In Norway, Julia L. Ernst Jan 2015

Making The Case For Antiestablishmentarianism: The Church And State In Norway, Julia L. Ernst

Fordham International Law Journal

No abstract provided.

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Justice Among The Ashes: How Government Compensation Facilities Can Bring Justice To Disaster Victims, Lindy Rouillard-Labbé Jan 2015

Justice Among The Ashes: How Government Compensation Facilities Can Bring Justice To Disaster Victims, Lindy Rouillard-Labbé

Fordham International Law Journal

No abstract provided.

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Windows Into Changing Worldviews: A Critical Cartographic Analysis Of Four Influential World Maps From The 13th To The 21st Century, Elizabeth E. Wicks Jan 2015

Windows Into Changing Worldviews: A Critical Cartographic Analysis Of Four Influential World Maps From The 13th To The 21st Century, Elizabeth E. Wicks

Honors Theses

It is an inherent part of human nature to seek knowledge of the world around us. As knowledge of the world grew, so did the need for its visual representation — thus came the introduction of the map into society. The map is a technology that allows us to see an expansive view of the world around us and to understand our own place in the world. In the past, displaying a full view of the world was more of a challenge — many regions remained unexplored or undiscovered. The mapmaker was given the task of representing both known and …

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Spatial Variation Of Bacterial Communities On The Leaves Of Southern Magnolia Trees, Heather L. Valdin Jan 2015

Spatial Variation Of Bacterial Communities On The Leaves Of Southern Magnolia Trees, Heather L. Valdin

Honors Theses

Bacteria are found in almost all environments on earth, including on the surface of other living things. Bacteria that exist on the leaves of plants (the phyllosphere) are of interest because of the potentially harsh nature of the environment they inhabit, and of applied interest. Although there has been a substantial amount of research in phyllosphere microbiology, few studies have examined the effect of spatial variation on phyllosphere community composition. This project investigated the effect of spatial variation on the bacterial communities living on the surface of Magnolia grandiflora leaves. Following DNA extraction, next generation sequencing of 16S rRNA gene …

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A Visualization Tool For Survey Responses And A Unifying Interface Redesign, Iva Cramer Jan 2015

A Visualization Tool For Survey Responses And A Unifying Interface Redesign, Iva Cramer

Honors Theses

As an intern for financial software company FNC, Inc. during the summer of 2014, my fellow interns and I began an innovation project for creating and analyzing surveys for better client feedback methods. I have continued this project even after the internship, and this thesis covers that continuation: the visualization of survey responses and the redesign of the page on which they are contained. The project detailed here was to revamp the survey statistics page with a coherent layout that matches the rest of the site in addition to overhauling the actual graphs and charts for aesthetic and accuracy.

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Ramped Soapbox, Alyssa Marie Radtke Jan 2015

Ramped Soapbox, Alyssa Marie Radtke

Honors Theses

This is a collection of mostly autobiographical disability poetry.

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The Effect Of A Neurotoxic Dose Of Methamphetamine On Attention And Response Learning In The Rat, Anja Kremer Jan 2015

The Effect Of A Neurotoxic Dose Of Methamphetamine On Attention And Response Learning In The Rat, Anja Kremer

Honors Theses

High doses of methamphetamine (neurotoxic doses) have been shown to have an effect on both attention and response learning. In previous literature, meth rats were found to have higher reaction times, and therefore, it has been concluded that meth may cause a deficit in response learning. Our study, using modal initiation time as a measure of response learning, found no effects of methamphetamine or training condition on mode. Studies have also shown positively skewed reaction time distributions, which have been defined as attentional lapses. Our experiment used DevMode to measure these lapses. Although meth did not, training condition did have …

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Secondary Metabolites Isolated From Perovskia Atriplicifolia And Their In Vitro Binding Affinity For Human Opioid And Cannabinoid Receptors, Ashli Fitzpatrick Jan 2015

Secondary Metabolites Isolated From Perovskia Atriplicifolia And Their In Vitro Binding Affinity For Human Opioid And Cannabinoid Receptors, Ashli Fitzpatrick

Honors Theses

Plants and their natural products have been utilized for thousands of years in the treatment of many human diseases. Because of their structural diversity, natural products are ideal lead compounds for drug development. In this thesis, the natural products of the plant Perovskia atriplicifolia were investigated, specifically their in vitro binding affinity to receptors in opioid and cannabinoid classes. Extracts that demonstrated good selective opioid and cannabinoid receptor binding were subjected to bioassay-guided fractionation. Four active compounds were identified from the crude extract in Perovskia atriplicifolia: 1) 5-hydroxy-3',4',6,7-tetramethoxy flavone, 2) 5,7-dihydroxy-3',4',6,-trimethoxy flavone, 3) 5-hydroxy-4',6,7-trimethoxy flavone, and 4) 5,7-dihydroxy-4',6,-dimethoxy flavone. Each …

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Marketing For Entrepreneurs: How To Promote One's Own Craft, Teresa Hendrix Jan 2015

Marketing For Entrepreneurs: How To Promote One's Own Craft, Teresa Hendrix

Honors Theses

This thesis seeks to serve as an alternative, cost efficient resource to those creative entrepreneurial ventures with a product (or service) that needs both people to consume it and a profit eventually sufficient to support its creators. By excluding excess details unrelated to promotion, and supplementing with specific, anecdotal advice directly from interviews with successful small business owners, this thesis aims to provide a plethora of marketing techniques that an entrepreneur can test before facing the daunting cost of an agency. Based on an extensive bibliography of primary and secondary sources*, this thesis explores three common components that manifest themselves …

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Exploration Of Cannabinoid And Opioid Agents From Plants Used In Traditional Medicine, John Fitzpatrick Jan 2015

Exploration Of Cannabinoid And Opioid Agents From Plants Used In Traditional Medicine, John Fitzpatrick

Honors Theses

Ten plants, with known medicinal uses, were gathered to study for their possible production of secondary metabolites that act as opioid and cannabinoid agents. All plants were subjected to in vitro bioassays testing for their affinity for the opioid and cannabinoid receptors. Banisteriopsis caapi extracts displayed the greatest affinity for both opioid and cannabinoid receptors. B. caapi extracts underwent column fractionation yielding fractions that were subjected to further in vitro studies. We discovered that the ethanolic extract of this plant (foliage) binds to all three opioid receptors (µ, κ and δ) and cannabinoid receptors (CB1 and CB2) with values ranging …

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Societal Dysfunction: The Floundering Policies Of Rehabilitation And Incarceration For Non-Violent Alcohol And Drug Offenders In The United States Of America, Josh Horton Jan 2015

Societal Dysfunction: The Floundering Policies Of Rehabilitation And Incarceration For Non-Violent Alcohol And Drug Offenders In The United States Of America, Josh Horton

Honors Theses

No abstract provided.

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Learning Shakespeare Shouldn't Hurt: An Engaging 4-Week Othello Curriculum For 9th Graders, Amelia Kucic , '16 Jan 2015

Learning Shakespeare Shouldn't Hurt: An Engaging 4-Week Othello Curriculum For 9th Graders, Amelia Kucic , '16

Senior Theses, Projects, and Awards

Shakespearean literature is an essential component of American literature and cultural consciousness, discusses material that is highly relevant to modern adolescents, and presents an ideal platform for creative learning across multiple intelligences. However, intimidated students are often reluctant to engage with this material. This Othello curriculum draws on progressive educational theory, strategies for teaching literacy to English Language Learners and Special Education students, and existing creative methods of teaching Shakespeare to circumvent this intimidation and engage 9th graders with Othello through the exploration of relevant themes, utilization of students' natural propensity for creative expression, and development of traditional English literacy …

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Autonomy Of The Student: Maintaining Ballet's Relevance As An Art Form Through Pedagogy, Daniel Cho , '15 Jan 2015

Autonomy Of The Student: Maintaining Ballet's Relevance As An Art Form Through Pedagogy, Daniel Cho , '15

Senior Theses, Projects, and Awards

No abstract provided.

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Week 3: Resting, Calvin University Jan 2015

Week 3: Resting, Calvin University

Campus Ministries Resources

No abstract provided.

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The Cost Of Workplace Bullying In Irish Universities, Patrick Pearse Rockett Jan 2015

The Cost Of Workplace Bullying In Irish Universities, Patrick Pearse Rockett

Walden Dissertations and Doctoral Studies

Employees who demean and degrade coworkers cost organizations billions of dollars every year. Workplace bullying is a business problem that affects up to 15% of employees, and little empirical research is available to establish the extent of bullying in academia. Bullies flourish in decentralized structures, and universities can be particularly susceptible to bullying behavior because of their decentralized structures of teaching and research that promote the growth of microclimates in segregated silos, from laboratories to small departments. The purpose of this multiple-case, census sample study was to explore the cost-reduction strategies that university human resource (HR) leaders use to manage …

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X-Dimer Mutations And Their Effects On The Folding Stability And Assembly Of Ecad12 At The K14-D138 Interface, Martha Kaitlyn Coghlan Jan 2015

X-Dimer Mutations And Their Effects On The Folding Stability And Assembly Of Ecad12 At The K14-D138 Interface, Martha Kaitlyn Coghlan

Honors Theses

Classical cadherins were first identified by their function in mediating calcium-dependent cellular adhesion and constitute a large family of cellular adhesion receptor proteins whose differential binding is central to the development and maintenance of tissue architecture. The interface underlying the binding interaction reveals that all classical cadherins share a common adhesive interface in which the portion of the β-A strand closest to the N-terminus is swapped between EC1 domains of the adhesive partner protomers. A second dimeric configuration, known as the 'X-dimer', is the face-to-face association of two protomers in which their orientation is dictated by three symmetrical noncovalent interactions …

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In Vino Veritas: A Comparison Of Organic Winemaking And Attitudes Towards Organic Wine In Four Global Regions, Mary Sloan Merkel Jan 2015

In Vino Veritas: A Comparison Of Organic Winemaking And Attitudes Towards Organic Wine In Four Global Regions, Mary Sloan Merkel

Honors Theses

Organic winemaking is a very high value adding activity for the economy, but the industry has seen different levels of growth throughout the world. It is unclear whether organic winemaking is a viable long-term activity in prominent winemaking regions. This thesis looks at the regulations dealing with organic winemaking and attitudes towards organic wine in four major wine producing areas in the world: the United States, Italy, Argentina, and New Zealand. This thesis uses an extensive literature review of existing studies and papers dealing with organic wine, as well as government regulations and private standards to determine the current practices …

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Honestly, Woman, You Call Yourself Our Mother?: Mothers And Witches In Harry Potter, Mary-Eileen Rankin Rankin Jan 2015

Honestly, Woman, You Call Yourself Our Mother?: Mothers And Witches In Harry Potter, Mary-Eileen Rankin Rankin

Honors Theses

This thesis aims to analyze the importance of maternal nurture and the witches as mothers trope in the Harry Potter series. This nurture is traditional as well as perverse and appears in characters besides the adult women. Rowling creates characters who appeal to paradigms of the Early Modern bad mother witch who harmed children among other accusations associated with female sexuality and motherhood. Additionally, Rowling challenges the negative stereotype of associating witches and bad mothering by presenting witches as good mothers. The power of maternal nurture in the series is best seen through the good mothers. This theme plays such …

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Understanding The Implications Of Climate Change For Birds Of The Family Phasianidae: Incorporating Fleshy Structures Into Models Of Heat Dissipation Capacity, Megan L. Smith Jan 2015

Understanding The Implications Of Climate Change For Birds Of The Family Phasianidae: Incorporating Fleshy Structures Into Models Of Heat Dissipation Capacity, Megan L. Smith

Honors Theses

Though widespread acceptance of global warming has generated a plethora of studies evaluating the potential responses of species to increased temperatures, until recently, species and genus-specific studies were not common and for many taxa such studies have yet to be completed. One particularly understudied group in this regard is the avian order Galliformes. In this study, I focus on the tribe Phasianidae. Furthermore, most studies evaluating the potential range changes of species in response to a changing climate fail to account for the ability of organisms to adapt to the changing climatic conditions, either via plastic adaptations or genetic adaptations. …

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The Effects Of Acoustic Signals On The Endocrine Physiology Of Female Green Treefrogs, Hyla Cinerea, Melissa Paige Dent Jan 2015

The Effects Of Acoustic Signals On The Endocrine Physiology Of Female Green Treefrogs, Hyla Cinerea, Melissa Paige Dent

Honors Theses

The vocalizations of male H. cinerea stimulate cortisol production in male receivers during close-range interactions. In many vertebrate species, males and females possess similar sensory neuroendocrine pathways, suggesting that acoustic signals may also stimulate CORT production in females. Males of this species would potentially benefit from stimulating CORT production in females because elevated CORT levels significantly decrease the strength of female preferences for energetically costly calls (i.e., calls produced at rapid rates). The primary objective of my honors research was to assess how the acoustic signals produced by male green treefrogs, Hyla cinerea, influence the endocrine physiology of female signal …

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