Digital Commons Network^™

Temporal Localization Of Insulin-Like Growth Factor 1 (Igf1) Positive Cells In Developing Hypothyroid Brain, Shelby Anne Kline

All Graduate Theses, Dissertations, and Other Capstone Projects

Hypothyroidism has been known to result in numerous neuroanatomical defects in the developing brain. To investigate further into the mechanism in which these defects are obtained, local brain insulin-like growth factor 1 (Igf1) was investigated in relation to the hypothyroid brain. There are many similarities between hypothyroidism and the Igf1 deficient brain. Additionally, TH (thyroid hormone) is known to interact with Igf1. Therefore, the purpose of this study was to investigate the effect of induced congenital hypothyroidism on the temporal expression of Igf1-positive cells in the brain. To investigate the relationship between TH and Igf1 in the brain, we inhibited …

Fracture, Gretchen R. Heisler

Undergraduate Honors Thesis Projects

Gothic/horror novella taking place in 1950s Western Pennsylvania.

Letter From The Dean, Michael Vayda

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

No abstract provided.

Nutrient Competition Between Algae And Juncus Effusus In The Lake Fayetteville Artificial Spiral Wetland, Toryn Jones, Thad Scott

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

There is insufficient research focusing exclusively on how nutrient competition between algae and wetland macrophytes affects the growth of these species. This study examined the relationship between nutrient concentrations (N and P), algal concentrations, and the growth of Juncus effusus. Juncus effusus growth in the Lake Fayetteville artificial spiral wetland was monitored over a four month period during the prime growing season. Eighteen plants were taken from the wetland and replanted in 1 of 6 treatments: plant-only, algae-only, combined, plant-only +supplement, algaeonly +supplement, or combined +supplement. The algae and combined environments received an inoculation of algae, and the +supplement treatments …

Conjugated Linoleic Acid-Rich Chocolate Paste Production And Characterization, Sarah Mayfield, Davy Van De Walle, Claudia Delbaere, Sara Shinn, Andrew Proctor, Koen Dewettinck, Ashok Patel

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

Conjugated linoleic acid (CLA) is an 18-carbon fatty acid with multiple health benefits, including anti-obesity and anti-carcinogenic properties. CLA-rich soy oil (CLARSO) can be produced through a heterogeneous catalysis process, and this oil was previously used to produce CLA-rich margarines and shortenings. The objective of this study was to produce CLA-rich chocolate pastes by replacing a portion of the fat with CLARSO and compare the rheological (flow), textural, and thermal properties of these pastes to controls made with either soy oil or traditional fats. CLARSO was used to prepare pastes. Rheology, firmness, and thermal behavior of the pastes were determined. …

Novel Delivery Systems For Iron Replenishment, Naresh Modepalli

Electronic Theses and Dissertations

Iron is an integral part of hemoglobin and essential for the production of red blood cells. Iron deficiency and the resulting anemia are major nutritional deficiency disorders. The majority of patient populations suffering from iron deficiency anemia (IDA) are women of child bearing age and children of all ages. Iron deficiency is a complication of various other chronic conditions. Oral iron salts or colloidal parenteral iron formulations are treatment options for iron replenishment since several decades, but they are associated with severe side effects along with other patient noncompliance issues. Transdermal delivery of iron could be a potential alternative to …

High Quality Human 3d Body Modeling, Tracking And Application, Qing Zhang

Theses and Dissertations--Computer Science

Geometric reconstruction of dynamic objects is a fundamental task of computer vision and graphics, and modeling human body of high fidelity is considered to be a core of this problem. Traditional human shape and motion capture techniques require an array of surrounding cameras or subjects wear reflective markers, resulting in a limitation of working space and portability. In this dissertation, a complete process is designed from geometric modeling detailed 3D human full body and capturing shape dynamics over time using a flexible setup to guiding clothes/person re-targeting with such data-driven models. As the mechanical movement of human body can be …

Connecting The Dots: Jewish Mysticism, Ritual Murder, And The Trial Of Mendel Beilis, Robert Weinberg

History Faculty Works

No abstract provided.

Is The Bay Delta Conservation Plan Adequately Funded?, Vincent Vu

UC Law Environmental Journal

No abstract provided.

Mississippi Asl Project, James Corey Blount

Electronic Theses and Dissertations

American Sign Language (ASL) is a manual language used by many deaf people in the United States and Canada. For much of its existence, ASL was believed to be a system of rudimentary gestures and signs based on the English language. However, studies that analyzed the linguistic properties of this signed ‘mode’ (Stokoe, 1960) legitimized that it was a language independent of spoken language, with its own system of principles and elements to construct meaningful utterances. Like any language, ASL is influenced by the social demographics of its users. Social demographics such as ethnicity, geographic location, age, gender, and socioeconomic …

Cultural Change In The Ancient Mediterranean And Near Eastern World: A Study Of Interactions Between The Egyptian Empire And Its Neighbors, Benjamin Rideout

Honors Theses and Capstones

No abstract provided.

Iconografía, Estereotipos Y Manipulación Fotográfica De La Belleza Femenina, M. Mar Martínez-Oña, Ana M. Muñoz Muñoz

Artículos científicos

Se estudian las tendencias en investigación que se han desarrollado en relación con la iconografía, estereotipos y el concepto de belleza femenina. El objetivo es proponer una mirada unificadora sobre la imagen de las mujeres, su iconografía, estereotipos y belleza. Temas que se interrelacionan a través de una misma dicotomía positiva y negativa, presente en la representación de las mujeres a lo largo de la Historia. Actualmente reflejada en el mercado publicitario con la imagen de la mujer ama de casa en contraposición con la mujer objeto de deseo, vida privada y pública. Para ello, se revisa la bibliografía más …

Análisis Iconográfico Del Mito De Lilith En La Publicidad, M. Mar Martínez-Oña, Ana M. Muñoz Muñoz

Artículos científicos

La cultura occidental, mantiene un imaginario femenino condicionado por la creación androcéntrica, que encasilla a las mujeres bajo diversos estereotipos conceptuales de maldad o bondad, entre ellos, aquel que ejemplifica la maldad en sí, el mito de Lilith.Metodología: A partir de una lectura y posterior análisis iconográfico se identifican y clasifican las diferentes iconografías, nueve en total, que presentan este mito. Tras este primer análisis se cuantifica en qué sectores comerciales aparece el antiguo mito y cómo se representa. Resultados y conclusiones: Siendo los sectores comerciales de perfumes, audiovisual y moda los que más utilizan la imagen de Lilith. La …

Reanimating Ghost Editions, Reorienting The Early American Novel, Karen A. Weyler, Michelle Burnham

English

What are the origins of the American novel? Does it begin with the imagination, when Europeans first began dreaming of life in the New World?1 Does it begin with Daniel Defoe’s adventurers, Robinson Crusoe and Moll Flanders, and their literary progeny? Or does the novel need a material presence in the soil of the New World? Does it begin in 1789, with William Hill Brown’s The Power of Sympathy?—which Isaiah Thomas, with shrewd prescience, marketed as the “first American novel.” Or does it begin even earlier, in 1742, with Benjamin Franklin’s first American edition of Samuel Richardson’s sentimental novel Pamela, …

Annual Economic Report For 2013, Central Bank Of Nigeria (Cbn)

Documents

CBN draft report analyzing the Nigerian economy in 2013

Identity: Societal And Legal Ramifications With Special Focus On Transsexuals, Dr. Nancie Palmer Ph.D, Acsw/Lmsw, Charlene L. Smith M.A., J.D., Llm, Tova Verchow J.D. Candidate, 2015, Jennifer Dale J.D. Candidate, 2015

Nova Law Review

The law is stuck on binary or categorical approaches.2 One is either

this or that—heterosexual or homosexual; male or female; black or white;

and the list can go on and on.3 This article posits that this approach should

not be the way in which we categorize people’s personhood

Nova Law Review Full Issue

Nova Law Review

No abstract provided.

Syndecan2 Controls Vascular Smooth Muscle Development And Cytoskeletal Dynamics, Deepak Atri

Yale Medicine Thesis Digital Library

Syndecan2 is a member of the Syndecan family of transmembrane proteoglycans, expressed broadly in mammals. Syndecan2, along with Syndecan4, is expressed in the vasculature of mouse and man. Global deletion of Syndecan2 in mice does not affect viability and fertility of mice. However, it does result in defects in vascular smooth muscle cell coverage of the dermal vasculature of the mouse embryo.

We here report that lineage specific deletion of Syndecan2 in vascular smooth muscle results in delayed development of vascular smooth muscle coverage in the developing retinal vasculature. Postnatally, mice that lack Sdc2 in vascular smooth muscle mice exhibit …

Medicine@Yale October/November 2015 Volume 11, Issue 2, Yale School Of Medicine Office Of Communications

Medicine@Yale - development newsletter

Medicine@Yale : advancing biomedical science, education and health care was a print and online newsletter which published news about academics, research and philanthropy for alumni, donors, faculty, students and the general public. It was initially published 6 times a year and then changed to a quarterly schedule. The first issue came out June/Jul. 2005. The final issue was published in May/June 2022, vol. 17, issue 1. Published by Yale School of Medicine, Office of Communications.

Isolated Wetland Commons And The Constitution, Blake Hudson, Michael Hardig

Journal Articles

Isolated wetlands provide great ecological and economic value to the United States. While some states provide protection for isolated wetlands, a great many do not. These wetlands are also left outside the ambit of federal wetland regulatory protections under the Clean Water Act, with its murky jurisdictional reach. Notwithstanding jurisdictional questions under current federal statutes, the U.S. Supreme Court has gone so far as to call into question the constitutionality of federal isolated wetland regulation. This Article makes a normative argument that, in the absence of state or local programs providing holistic isolated wetland protection, federal action is needed. The …

The Ubiquitin Ligase Siah2 Regulates Obesity-Induced Adipose Tissue Inflammation, Gail Kilroy, Lauren E. Carter, Susan Newman, David H. Burk, Justin Manuel, Andreas Möller, David D. Bowtell, Randall L. Mynatt, Sujoy Ghosh, Z. Elizabeth Floyd

Faculty Publications

© 2015 The Obesity Society. Objective Chronic, low-grade adipose tissue inflammation associated with adipocyte hypertrophy is an important link in the relationship between obesity and insulin resistance. Although ubiquitin ligases regulate inflammatory processes, the role of these enzymes in metabolically driven adipose tissue inflammation is relatively unexplored. Herein, the effect of the ubiquitin ligase Siah2 on obesity-related adipose tissue inflammation was examined. Methods Wild-type and Siah2KO mice were fed a low- or high-fat diet for 16 weeks. Indirect calorimetry, body composition, and glucose and insulin tolerance were assayed along with glucose and insulin levels. Gene and protein expression, immunohistochemistry, adipocyte …

Reciprocal Osmotic Challenges Reveal Mechanisms Of Divergence In Phenotypic Plasticity In The Killifish Fundulus Heteroclitus, Reid S. Brennan, Fernando Galvez, Andrew Whitehead

Faculty Publications

© 2015. Published by The Company of Biologists Ltd. The killifish Fundulus heteroclitus is an estuarine species with broad physiological plasticity, enabling acclimation to diverse stressors. Previous work suggests that freshwater populations expanded their physiology to accommodate low salinity environments; however, it is unknown whether this compromises their tolerance to high salinity.We used a comparative approach to investigate the mechanisms of a derived freshwater phenotype and the fate of an ancestral euryhaline phenotype after invasion of a freshwater environment. We compared physiological and transcriptomic responses to high-and low-salinity stress in fresh and brackish water populations and found an enhanced plasticity …

Are New Sodium Targets In The National School Lunch Program Feasible And Are They Necessary?, Yaneve Shemesh

PCOM Biomedical Studies Student Scholarship

In many societies, high salt intake is a continuing issue in adults, and is of growing concern in children due to the prevalence of processed foods. In response, the USDA has set three targets for sodium in meals offered in the National School Lunch Program (NSLP), and the National School Breakfast Program (NSBP). This 8-year goal is meant to decrease overall sodium levels in both meal programs. However, many associated with school nutrition ask if there is significant evidence to show what effect sodium plays on children’s health, and thus determine if these targets are necessary or achievable. In addressing …

Enhanced Cgmp-Dependent Signaling In Astrocytes: Novel Therapeutic Target In Alzheimer's Disease, Nyema M. Woart

PCOM Biomedical Studies Student Scholarship

Over five million Americans suffer from Alzheimer’s Disease (AD), with an expected 34% increase in the incidence in this disease over the next decade. Unfortunately, there is no cure for AD. Recent studies have indicated that drugs which increase the levels of cyclic guanosine-3’5’-monophosphate (cGMP) may help preserve learning and memory in AD and enhance cognition in the aging brain; however, the mechanism(s) of how cGMP exerts this beneficial effect is unknown. The present findings now suggest that elevation of cGMP in astrocytes depresses inhibitory potassium currents in these cells to stimulate their protective influence on neuronal activity. Cellular currents …

Use Of Swine Small Intestine Submucosa As A Dermal Suture, Paige E. Black

PCOM Biomedical Studies Student Scholarship

The purpose of this preliminary study is to determine if swine small intestine submucosa (SIS) can be used to create a suture that will perform comparably to commercially available chromic gut sutures when placed into a wound in rat dermis. This study is part of an ongoing collaboration that has explored SIS as a biologic scaffold in various tissues and surgical procedures. In this study, eight Sprague-dawley rats were divided into two groups, each receiving a full thickness skin wound between the scapula, made by a 5mm biopsy punch. The wound was then closed with commercially available chromic gut suture, …

Inducible Depletion Of Satellite Cells In Adult, Sedentary Mice Impairs Muscle Regenerative Capacity Without Affecting Sarcopenia, Christopher S. Fry, Jonah D. Lee, Jyothi Mula, Tyler J. Kirby, Janna R. Jackson, Fujun Liu, Lin Yang, Christopher L. Mendias, Esther E. Dupont-Versteegden, John J. Mccarthy, Charlotte A. Peterson

Physical Therapy Faculty Publications

A key determinant of geriatric frailty is sarcopenia, the age-associated loss of skeletal muscle mass and strength. Although the etiology of sarcopenia is unknown, the correlation during aging between the loss of activity of satellite cells, which are endogenous muscle stem cells, and impaired muscle regenerative capacity has led to the hypothesis that the loss of satellite cell activity is also a cause of sarcopenia. We tested this hypothesis in male sedentary mice by experimentally depleting satellite cells in young adult animals to a degree sufficient to impair regeneration throughout the rest of their lives. A detailed analysis of multiple …

Frank Miller’S Sin City College Football: A Game To Die For And Other Lessons About The Right Of Publicity And Video Games, Jordan M. Blanke

Washington and Lee Law Review

The challenge of finding a workable solution for applying the right of publicity is a formidable one because it implicates not only a delicate balance between First Amendment rights and the rights of publicity, but also the complications of varying state laws. The best of the tests developed by the courts so far—the transformative use test—was borrowed from copyright law and itself reflects a careful balance between First Amendment and copyright interests. Additionally, because of dramatic progress in technology, it is likely that in the near future this balancing will often involve not only the rights of publicity and the …

Yale School Of Medicine Facts & Figures 2015-2016, Yale School Of Medicine Office Of Communications

Facts & Figures – annual Yale School of Medicine numbers

Provided by the Office of Communications, the Facts and Figures brochure is produced annually as a way to provide a snapshot of key facts and data related to the School of Medicine as well as the Medical Campus. This includes enrollment data, research activity, financial summaries, and more.

Bioturbating Animals Control The Mobility Of Redox-Sensitive Trace Elements In Organic-Rich Mudstone, Dario Harazim, Duncan Mcilroy, Nicholas P. Edwards, Roy A. Wogelius, Phillip L. Manning, Kristin M. Poduska, Graham D. Layne, Dimosthenis Sokaras, Roberto Alonso-Mori, Uwe Bergmann

Faculty Publications

© 2015 Geological Society of America. Bioturbating animals modify the original mineralogy, porosity, organic content, and fabric of mud, thus affecting the burial diagenetic pathways of potential hydrocarbon source, seal, and reservoir rocks. High-sensitivity, synchrotron rapid scanning X-ray fluorescence elemental mapping reveals that producers of phycosiphoniform burrows systematically partition redox-sensitive trace elements (i.e., Fe, V, Cr, Mn, Co, Ni, Cu, and As) in fine-grained siliciclastic rocks. Systematic differences in organic carbon content (total organic carbon >1.5 wt%) and quality (Δ13Corg~0.6%) are measured between the burrow core and host sediment. The relative enrichment of redox-sensitive elements in the burrow core does …

Challenges And Opportunities For Implementing Evidence-Based Antenatal Care In Mozambique: A Qualitative Study, Adriano Biza, Ingeborg Jille-Traas, Mercedes Colomar, Maria Belizan, Jennifer Requejo Harris, Beatrice Crahay, Mario Merialdi, My Huong Nguyen, Fernando Althabe, Alicia Aleman, Eduardo Berge, Alicia Carbonell, Leonardo Chavane, Therese Delvaux, Diederike Geelhoed, Metin Gülmezoglu, Celsa Regina Malapende, Armando Melo, Nafissa Bique Osman, Mariana Widmer, Marleen Temmerman, Ana Pilar Betrán

Obstetrics and Gynaecology, East Africa

Background: Maternal mortality remains a daunting problem in Mozambique and many other low-resource countries. High quality antenatal care (ANC) services can improve maternal and newborn health outcomes and increase the likelihood that women will seek skilled delivery care. This study explores the factors influencing provider uptake of the recommended package of ANC interventions in Mozambique.

Methods: This study used qualitative research methods including key informant interviews with stakeholders from the health sector and a total of five focus group discussions with women with experience with ANC or women from the community. Study participants were selected from three health centers located …