Digital Commons Network^™

Who Defines "Healthy"? Ethical Dilemmas Across Competing Interest Groups On Genetic Manipulation And Gene Patents, Haley Guion

DePaul Journal of Health Care Law

No abstract provided.

The International Health Regulations 10 Years On: The Governing Framework For Global Health Security, Lawrence O. Gostin, Mary C. Debartolo, Eric A. Friedman

Georgetown Law Faculty Publications and Other Works

The World Health Organization (WHO) and its global health security treaty, the International Health Regulations (2005) (IHR) have lost the world's confidence after the West African Ebola epidemic. The epidemic led to several high-level reviews of the IHR and global health security more broadly. Here, we propose a series of recommendations for operational and legal reforms to enhance the functioning of the FCGH. It is critical that WHO act on them quickly, before the window of opportunity for fundamental reform closes.

WHO should ensure that all states fulfill their obligations to develop national core surveillance and response capacities, including through …

Inquiry, Experience, And Exploration: Rebooting The Research Project And Making Connections Beyond The English Classroom, Trevor Thomas Stewart, Jeff Goodman

Teaching/Writing: The Journal of Writing Teacher Education

This article describes our efforts to revitalize the research project in the English Language Arts classroom, engage students in the exploration of topics of organic interest, and create opportunities for them to share their findings with authentic audiences.

Virtual Inclusion, Nicole Adams

Inclusion Across the Lifespan Conference

Virtual education offers a continuum of special education services, that includes inclusion. Come to find out how inclusion is delivered in virtual schools and learn about of the techniques and tools they use that can be applied in a brick and mortar inclusion setting!

Signaling Mechanisms That Control Ciliated Cell Differentiation, Benjamin John Gerovac

Open Access Dissertations

An innate front-line defense mechanism termed mucociliary clearance (MCC) occurs in the airway epithelium and is critical for respiratory health. MCC is made possible by the coordinated efforts of goblet and multiciliated cells, two cell types that line the airway epithelium. Maintaining the relative populations of goblet and multiciliated cells is necessary for optimum MCC, however, decreases in the multiciliated cell population and dysfunctional MCC are seen in a variety of respiratory diseases. Despite the clinical relevance, there is still much to understand about the signaling pathways that control multiciliated cell fate. Previous data has shown multiciliated cell differentiation of …

November 21, 2015 (Pages 6661-6788), Pennsylvania Legislative Reference Bureau

Volume 45 (2015)

No abstract provided.

Montana Kaimin, September 30-October 6, 2015, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Curio 2015, James Madison University. College Of Arts And Letters

Curio Magazine

Curio, a magazine highlighting Harrisonburg, Virginia, and its surrounding communities, is published by students in the Media Arts & Design program at James Madison University. Curio is a nonprofit organization supported by the College of Arts and Letters and the School of Media Arts & Design. Subscriptions are not available.

The Triad Of Evil And The Bush Incumbency: Convergence, Competition, And Cooperation, Meryl J. Irwin Carlson

Communication and Theater Association of Minnesota Journal

In this essay, I analyze discourses circulating during the 2004 re-election campaign of George W. Bush and Dick Cheney as a means to explore the interactions of three tropes of “evil” as identified by James P. McDaniel (2003). In the months between September 11, 2001 and November 2, 2004, the tropes of “Evil-in-itself,” “Evil-for-itself,” and “Evil-for-others” converged, combined, and competed in the culmination of criticism leveled at the Bush-Cheney campaign regarding the screening of entrants into events and rallies. Integral to this interaction is the articulation of American democracy with capitalism, as theorized by Kenneth Burke (1969). Ultimately, I argue …

Latin On The Walls, Kent Walker

Theses

A dysfunctional family in rural southeastern Missouri learn to cope with death. During the fortification period after the invasion of Iraq, a soldier plays into the banality of war, pranks, drugs, and inspections create tension in an already tense environment.

A Case Study: The Development Of Safety Tip Sheets For Atv Use In Ranching, Elise Lagerstrom, David P. Gilkey, John Rosecrance, Stacy Hibiske

Safety Health & Industrial Hygiene

Use of all-terrain vehicles (ATVs) has become standard practice on the modern ranch. The unique operating conditions present on a ranch, subject the occupational ATV user to hazards requiring awareness and specialized training. The purpose of this study was to apply social marketing methods to address a specific environmental health and safety issue present in the agricultural industry. A series of four ATV tip sheets were created in topic areas specific to the challenges that ATV operators encounter on a ranch. In order to evaluate the intended audiences’ perception of the tip sheets, a questionnaire was administered to all agriculture …

November 20, 2015, The Dakota Student

The Dakota Student

No abstract provided.

Discovery And Metabolic Engineering Of Steroid Alkaloid Biosynthetic Genes From (Veratrum Californicum), Megan M. Augustin

Theses

The steroid alkaloid cyclopamine has shown much promise as a treatment for cancers in which aberrant hedgehog signaling plays a role. The compound, originally discovered due to its teratogenic effects in sheep, binds to the hedgehog signaling receptor Smoothend and prevents downstream activation. As this pathway is primarily active during embryonic development, overactivation later in life can lead to tumor formation and proliferation. Several studies have shown that cyclopamine can inhibit and even reverse tumor growth, but limited supply will prevent widespread use upon FDA approval of it or any of its semi-synthetic analogs. As high value plant medicinal compounds …

Experimental Evolution And Economics, Terence C. Burnham, Aimee S. Dunlap, David W. Stephens

Educator Preparation & Leadership Faculty Works

This is a theory paper that advocates experimental evolution as a novel approach to study economic preferences. Economics could benefit because preferences are exogenous, axiomatic, and contentious. Experimental evolution allows the empirical study of preferences by placing organisms in designed environments and studying their genotype and phenotype over multiple generations. We describe a number of empirical studies on different aspects of preferences. We argue that experimental evolution has the potential to improve economics.

Investigating The Role Of The Host Multidrug Resistance Associated Protein Transporter Family In Burkholderia Cepacia Complex Pathogenicity Using A Caenorhabditis Elegans Infection Model, Pietro Tedesco, Marco Visone, Ermenegilda Parrilli, Maria Luisa Tutino, Elena Perrin, Isabel Maida, Renato Fani, Francesco Ballestriero, Radleigh Santos, Clemencia Pinilla, Elia Di Schiavi, George Tegos, Donatella De Pascale

Mathematics Faculty Articles

This study investigated the relationship between host efflux system of the non-vertebrate nematode Caenorhabditis elegans and Burkholderia cepacia complex (Bcc) strain virulence. This is the first comprehensive effort to profile host-transporters within the context of Bcc infection. With this aim, two different toxicity tests were performed: a slow killing assay that monitors mortality of the host by intestinal colonization and a fast killing assay that assesses production of toxins. A Virulence Ranking scheme was defined, that expressed the toxicity of the Bcc panel members, based on the percentage of surviving worms. According to this ranking the 18 Bcc strains were …

Quality Of Reporting And Adherence To Arrive Guidelines In Animal Studies For Chagas Disease Preclinical Drug Research: A Systematic Review, Julián Ernesto Nicolás Gulin, Daniela Marisa Rocco, Facundo García-Bournissen

Paediatrics Publications

Publication of accurate and detailed descriptions of methods in research articles involving animals is essential for health scientists to accurately interpret published data, evaluate results and replicate findings. Inadequate reporting of key aspects of experimental design may reduce the impact of studies and could act as a barrier to translation of research findings. Reporting of animal use must be as comprehensive as possible in order to take advantage of every study and every animal used. Animal models are essential to understanding and assessing new chemotherapy candidates for Chagas disease pathology, a widespread parasitic disease with few treatment options currently available. …

The Murray Ledger And Times, November 20, 2015, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

“Carried In The Arms Of Standing Waves:" The Transmotional Aesthetics Of Nora Marks Dauenhauer, Billy J. Stratton

English and Literary Arts: Faculty Scholarship

In recent years, Native, Indigenous, First Nations, and Aboriginal scholars and writers have forged alliances to initiate and support decolonization efforts and the reassertion of native survivance. Native and non-Native scholars have responded to modern challenges by reconceptualizing notions of peoplehood, identity, and nationalism. Following these intellectual contours, rather than conceiving of native culture as totalizing, static, and/or incommensurable—as always already foreign—responsive readings informed by the critical work of Gerald Vizenor can support more sophisticated understandings of native literary production while revealing sites of native transmotion. Through a thusly informed examination of the work of the Tlingit poet, Nora Marks …

13C Tracer Studies Of Metabolism In Mouse Tumor Xenografts, Andrew N. Lane, Jun Yan, Teresa W-M Fan

Toxicology and Cancer Biology Faculty Publications

Mice are widely used for human tumor xenograft studies of cancer development and drug efficacy and toxicity. Stable isotope tracing coupled with metabolomic analysis is an emerging approach for assaying metabolic network activity. In mouse models there are several routes of tracer introduction, which have particular advantages and disadvantages that depend on the model and the questions addressed. This protocol describes the bolus i.v. route via repeated tail vein injections of solutions of stable isotope enriched tracers including ¹³C₆-glucose and ¹³C₅,¹⁵N₂-glutamine. Repeated injections give higher enrichments and over longer labeling …

Researchers Used Cutting-Edge Aerospace Technology To Heal An Elephant's Damaged Tusk, Staff

Browse All News

No abstract provided.

Experiments With Pam And Lisa—A Blogging Exploration Of Mind, Body, And Soul, Lisa Marie Anderson

Theses and Dissertations

The aim of this thesis is to explore expressivist theory of writing. In the 21st century, rhetoricians and writers have taken different stances on the writing process and the pros and cons of free writing, journal writing, and blogging. With these looming theory wars, the author of this thesis wanted to show that there is a benefit to expressivist theory as part of the writing process. This thesis first examines where the author began a personal transformation and over the course of 8 months, she uses the internet to blog about spirituality, gratitude, and enlightenment. The benefit of the World …

Complete Genome Sequence Of Staphylococcus Aureus, Strain Ilri_Eymole1/1, Isolated From A Kenyan Dromedary Camel, Saima Zubair, Anne Fischer, Anne Liljander, Jochen Meens, Jan Hegerman, Hadrien Gourlé, Richard P. Bishop, Ina Roebbelen, Mario Younan, Mudassir Imran Mustafa, Mamoona Mushtaq, Erik Bongcam-Rudloff, Joerg Jores

All Peer-Reviewed Publications

We report the genome of a Staphylococcus aureus strain (ILRI_Eymole1/1) isolated from a nasal swab of a dromedary camel (Camelus dromedarius) in North Kenya. The complete genome sequence of this strain consists of a circular chromosome of 2,874,302 bp with a GC-content of 32.88 %. In silico annotation predicted 2755 protein-encoding genes and 76 non-coding genes. This isolate belongs to MLST sequence type 30 (ST30). Phylogenetic analysis based on a subset of 283 core genes revealed that it falls within the human clonal complex 30 (CC30) S. aureus isolate cluster but is genetically distinct. About 79 % of the protein …

Board Of Trustees Minutes, November 20, 2015, Eastern Washington University

Board of Trustees Minutes

No abstract provided.

Curriculum Minutes 11/20/2015, Curriculum Committee

Curriculum Committee Minutes

In these minutes: Approval of Courses; and EDP Review Committee Recommendation

Burning Resources: Traditional Fuel Uses On The Mongolian Steppe, William T. Linder

Mahurin Honors College Capstone Experience/Thesis Projects

Fuel (wood, bone, dung and coal) and the selection of it has always been an integral part in the lifeways of nomadic pastoralists. Certainly, the gathering of fuel, the storage of it, and its eventual use represents a large part of daily culture. Yet, it remains an understudied aspect of ancient household economies. This is unfortunate since understanding fuel selection and use can also serve to evaluate specific cultural practices and human-­‐environment relationships since there is often a close link between specific types of available fuel and local environmental conditions. Through ethnoarchaeological research in the Altai region of western Mongolia, …

Word-Length Correlations And Memory In Large Texts: A Visibility Network Analysis, Lev Guzmán-Vargas, Bibiana Obregón-Quintana, Daniel Aguilar-Velázquez, Ricardo Hernández-Pérez, Larry S. Liebovitch

Publications and Research

We study the correlation properties of word lengths in large texts from 30 ebooks in the English language from the Gutenberg Project (www.gutenberg.org) using the natural visibility graph method (NVG). NVG converts a time series into a graph and then analyzes its graph properties. First, the original sequence of words is transformed into a sequence of values containing the length of each word, and then, it is integrated. Next, we apply the NVG to the integrated word-length series and construct the network. We show that the degree distribution of that network follows a power law, P(k)∼k−γP(k)∼k-γ, with two regimes, which …

False Universalism Of Global Governance Theories: Global Constitutionalism, Global Administrative Law, International Criminal Institutions And The Global South, Sujith Xavier

PhD Dissertations

Why are theories of global governance unsatisfactory? Why are theories of global governance unable to integrate the lived realities of the people of the global South? International law and its institutions are growing at an unprecedented speed and this expansion has captured the curiosity of international lawyers and international law scholars. As international law and its institutions continue to grow, there are concurrent concerns regarding their democratic foundations. A large body of scholarship encapsulates these anxieties through the prism of global governance. In particular, two specific theories of global governance, global constitutionalism, and global administrative law, seek to introduce ideas …

Essentials Of Herb-Drug Interactions In The Elderly With Cardiovascular Disease, Sulaiman Sultan, Maria Viqar, Rabaiya Ali, A. Jamil Tajik, Arshad Jahangir

Journal of Patient-Centered Research and Reviews

As the number of individuals, particularly the elderly, using herbal products with prescription drugs continues to grow, the risk for adverse interactions increases but remains poorly recognized. The true incidence and nature of adverse herb reactions or herb-drug interactions remains unknown since no postmarketing surveillance mechanism exists. Adverse events are greatly underreported, and information regarding safety mainly comes from case reports and suboptimally conducted studies in a limited number of healthy young volunteers or patients with limited comorbidities. Therefore, convincing evidence for the safety of herbal products in the elderly is lacking, and the true magnitude of problems that herb-drug …

Role Of Micrornas In Alcohol-Induced Multi-Organ Injury., Sathish Kumar Natarajan, Joseph M. Pachunka, Justin L. Mott

Journal Articles: Biochemistry & Molecular Biology

Alcohol consumption and its abuse is a major health problem resulting in significant healthcare cost in the United States. Chronic alcoholism results in damage to most of the vital organs in the human body. Among the alcohol-induced injuries, alcoholic liver disease is one of the most prevalent in the United States. Remarkably, ethanol alters expression of a wide variety of microRNAs that can regulate alcohol-induced complications or dysfunctions. In this review, we will discuss the role of microRNAs in alcoholic pancreatitis, alcohol-induced liver damage, intestinal epithelial barrier dysfunction, and brain damage including altered hippocampus structure and function, and neuronal loss, …

Helminth Infection, Fecundity, And Age Of First Pregnancy In Women, Aaron D. Blackwell, Marilyne D. Tamayo, Bret Beheim, Benjamin C. Trumble, Jonathan Stieglitz, Paul L. Hooper, Melanie Martin, Hillard Kaplan, Michael Gurven

ESI Publications

Infection with intestinal helminths results in immunological changes that influence the odds of comorbid infections, and might also affect fecundity by inducing immunological states supportive of conception and pregnancy. Here we investigate associations between intestinal helminths and fertility in human females, utilizing nine years of longitudinal data from 986 Bolivian forger-horticulturalists, experiencing natural fertility and a 70% helminth prevalence. We find that different species of helminth are associated with opposing effects on fecundity. Infection with roundworm (Ascaris lumbricoides) is associated with earlier first births and shortened interbirth intervals, while infection with hookworm is associated with delayed first pregnancy and extended …