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2015

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Creation Of A 3d Construct To Aid Cell Migration And Promote Cell Capture, Joseph Michael Sanders Jan 2015

Creation Of A 3d Construct To Aid Cell Migration And Promote Cell Capture, Joseph Michael Sanders

Legacy Theses & Dissertations (2009 - 2024)

Most cancer-related deaths are attributed to metastasis. The tumor microenvironment is a complex environment which is not fully understood. The Nano Intravital Device (NANIVID) is a versatile, biocompatible device that allows for the manipulation of the tumor microenvironment in vitro and in vivo, providing a platform to study various aspects of tumor progression. The purpose of this study is to modify the NANIVID to resemble the tumor microenvironment in order to allow for a seamless transition from the in vivo environment into the engineered environment within the NANIVID. This engineered microenvironment will promote cell migration and cell capture. It has …

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Examining The Craniofacial Biomechanics Of Paranthropus Boisei, Amanda L. Smith Jan 2015

Examining The Craniofacial Biomechanics Of Paranthropus Boisei, Amanda L. Smith

Legacy Theses & Dissertations (2009 - 2024)

An engineering method, finite element analysis (FEA), was used to examine the craniofacial biomechanics of Paranthropus boisei. The craniofacial morphology of Paranthropus boisei exhibits a number of highly derived characteristics that have commonly been thought to be related to feeding. This series of studies includes an ex vivo strain gage study (validation of techniques), an assessment of the effects of intraspecific craniofacial shape variation in chimpanzees (Pan troglodytes), and an examination of the feeding biomechanics of Paranthropus boisei. Modeling experiments were also conducted to test mechanical hypotheses regarding the effects of specific derived craniofacial features on Paranthropus feeding function.

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The Biomechanical And Behavioral Significance Of The Neanderthal Femur, Kelli Hamm Tamvada Jan 2015

The Biomechanical And Behavioral Significance Of The Neanderthal Femur, Kelli Hamm Tamvada

Legacy Theses & Dissertations (2009 - 2024)

The Neanderthal (Homo neanderthalensis) femur is distinct from that of recent modern humans (Homo sapiens). Broadly speaking, the Neanderthal femur is more "robust", meaning that it appears to be biomechanically stronger, and it is more curved, which may enhance the predictability of the stresses and strains experienced by the bone. It has been hypothesized that the Neanderthal morphology is an adaptation to withstand elevated and repetitive loads associated with increased mobility. This study tests the mobility hypothesis using comparative and biomechanical methods. Specifically, this study sought to test the mobility hypothesis by a) determining whether or not a relationship exists …

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Ill Living : Hemingway's Writing And My Father's Death, Jennifer R. Morrill Jan 2015

Ill Living : Hemingway's Writing And My Father's Death, Jennifer R. Morrill

Legacy Theses & Dissertations (2009 - 2024)

Abstract

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Brown Adipogenesis Of Mouse Embryonic Stem Cells In Alginate Microstrands, Andrea Mannarino Unser Jan 2015

Brown Adipogenesis Of Mouse Embryonic Stem Cells In Alginate Microstrands, Andrea Mannarino Unser

Legacy Theses & Dissertations (2009 - 2024)

The ability of brown adipocytes (fat cells) to dissipate energy as heat shows great promise for the treatment of obesity and other metabolic disorders. Employing pluripotent stem cells, with an emphasis on directed differentiation, may overcome many issues currently associated with primary fat cell cultures. However, brown adipocytes are difficult to transplant in vivo due to the instability of fat, in terms of necrosis and neovascularization, once injected. Thus, 3D cell culture systems that have the potential to mimic adipogenic microenvironments are needed, not only to advance brown fat implantation, but also to better understand the role of brown adipocytes …

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An Investigation Of Alkaline Earth And Rare Earth Elements In Human Bone Following Long-Term Parenteral Nutrition, Aubrey L. Galusha Jan 2015

An Investigation Of Alkaline Earth And Rare Earth Elements In Human Bone Following Long-Term Parenteral Nutrition, Aubrey L. Galusha

Legacy Theses & Dissertations (2009 - 2024)

This investigation focused on a unique collection of archived human bones obtained post-mortem from 7 patients, who had received long-term parenteral nutrition (PN) for up to 21 years. Parenterals are administered intravenously as a nutritional supplement, and may be contaminated with metals, which are completely absorbed into the blood compartment. Some metal contaminants may be deposited in the body’s reservoir for inorganic elements – bone.

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Characterization Of Metallic And Semimetallic Oxide Nanoparticles In Industrial Wastewater And Associated Toxicity, Gary Roth Jan 2015

Characterization Of Metallic And Semimetallic Oxide Nanoparticles In Industrial Wastewater And Associated Toxicity, Gary Roth

Legacy Theses & Dissertations (2009 - 2024)

Engineered nanomaterials (ENMs) play an increasing role in manufacturing and consumer products. Currently, there is no standard approach to studying ENM toxicity, and a growing body of literature suggests that ENMs may have toxicity differing from similar compounds in bulk or dissolved form. I examined ENMs used in the semiconductor manufacturing process called chemical-mechanical planarization (CMP) for their properties, removal in the wastewater treatment system (WWT), in-vitro toxicity, and location post-inhalation in-vivo. It was found that ENMs in CMP slurries have morphology determined by their elemental composition, but assessment of size and concentration can differ substantially between accepted techniques. Particles …

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The Implementation Of Judicial Policy In Crime Laboratories : An Examination Of The Impact Of Melendez-Diaz V. Massachusetts, Catherine L. Bonventre Jan 2015

The Implementation Of Judicial Policy In Crime Laboratories : An Examination Of The Impact Of Melendez-Diaz V. Massachusetts, Catherine L. Bonventre

Legacy Theses & Dissertations (2009 - 2024)

In Melendez-Diaz v. Massachusetts (2009), the United States Supreme Court held that the Sixth Amendment right to confront adverse witnesses includes the right to confront forensic analysts who produce affidavits certifying the results of forensic examinations used against defendants at trial. The decision thus invalidated the practice of substituting forensic laboratory reports for live testimony in criminal trials. Melendez-Diaz was a divided decision in which four dissenting Justices predicted onerous practical consequences for the practice of forensic science in the United States. Through a web-based survey and semi-structured interviews, this dissertation explored the practical impact of the decision on crime …

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Factors Associated With Solving Pulsed-Field Gel Electrophoresis Clusters In New York State Outside Of New York City, 2008-2012, Madhu Anand Jan 2015

Factors Associated With Solving Pulsed-Field Gel Electrophoresis Clusters In New York State Outside Of New York City, 2008-2012, Madhu Anand

Legacy Theses & Dissertations (2009 - 2024)

Motivation and Rationale

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The Effect Of A Dual Coding Elucidation Technique On Idiom Comprehension In Esl And Efl Learners, Denis Samburskiy Jan 2015

The Effect Of A Dual Coding Elucidation Technique On Idiom Comprehension In Esl And Efl Learners, Denis Samburskiy

Legacy Theses & Dissertations (2009 - 2024)

This study relied on the assumption that literal meaning of some idiomatic expressions (i.e., their conceptual motivation) could have a positive effect on the comprehension of their correct figurative sense. To test this hypothesis, a Dual Coding elucidation technique, in which important elements of correct figurative meaning were mapped onto literal ones, was designed to facilitate the comprehension of 15 highly imageable idioms. This technique was administered in the form of an online questionnaire to Russian- and Korean-speaking EFL and ESL learners. The facilitative effect of this technique was assessed taking into account several relevant variables: the learners’ levels of …

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A Novel Method For Studying Gene Regulatory Elements In Vivo Reveals Essential Roles For Intron Splicing In Neurofilament Gene Expression, Chen Wang Jan 2015

A Novel Method For Studying Gene Regulatory Elements In Vivo Reveals Essential Roles For Intron Splicing In Neurofilament Gene Expression, Chen Wang

Legacy Theses & Dissertations (2009 - 2024)

Axon outgrowth requires coordinated expression of critical cytoskeletal genes in response to extracellular cues. The spatial and temporal expression of these genes is regulated transcriptionally and posttranscriptionally. Such regulation is largely mediated through the activity of cis-regulatory elements within the cytoskeletal DNAs and RNAs, which recruit specific sets of trans-factors such as DNA- and RNA-binding proteins, as well as microRNAs. To identify the functionally active cis-elements, characterize their dynamically changing sets of trans-factors, and investigate the association between the two sets of regulators in the context of an intact developing nervous system, one needs to combine appropriate in vivo strategies …

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Ten Klicks South Of Whiskey : A Play In Three Acts, Ryan Jeffrey Smithson Jan 2015

Ten Klicks South Of Whiskey : A Play In Three Acts, Ryan Jeffrey Smithson

Legacy Theses & Dissertations (2009 - 2024)

Ten Klicks South of Whiskey is a stage performance in three acts, consisting mostly of monologues from soldiers of various backgrounds. It follows the trials of 4th platoon, Delta Troop, 463rd Cavalry Squadron, a fictional unit that achieves a near-mythic reputation of heroism and invulnerability in Iraq. As the monologues begin to reveal, however, not every tale about the 463rd can be substantiated. The audience is first challenged to search for truth and then to understand that truth is not the ultimate--or even the desired--goal of war stories.

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Vitamin D Signaling And The Impact On Mouse Mammary Gland Epithelium, Donald Grant Matthews Jan 2015

Vitamin D Signaling And The Impact On Mouse Mammary Gland Epithelium, Donald Grant Matthews

Legacy Theses & Dissertations (2009 - 2024)

A strong correlation between vitamin D deficiency and increased breast cancer incidence and mortality has been well established, leading researchers to further examine the possibility of using vitamin D in treatment and prevention strategies. Our long term goal is to elucidate the mechanisms by which vitamin D pathway signaling impacts on breast cancer. Generation of the high-affinity vitamin D receptor (VDR) ligand 1,25-dihydroxyvitamin D (1,25-D) from 25-hydroxyvitamin D (25-D) is mediated by CYP27B1 which is present and developmentally regulated in multiple tissues including the mammary gland. We utilized transgenic mouse models combined with diet-induced vitamin D deficiency to determine whether …

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3d-Bioengineering Of The Conventional Outflow Tract For High Throughput Drug Or Gene Transfer Screening For Glaucoma Treatment, Cula Nolise Dautriche Jan 2015

3d-Bioengineering Of The Conventional Outflow Tract For High Throughput Drug Or Gene Transfer Screening For Glaucoma Treatment, Cula Nolise Dautriche

Legacy Theses & Dissertations (2009 - 2024)

Among ocular pathologies, glaucoma remains the second leading cause of blindness. The molecular mechanisms that lead to glaucoma have been attributed to damage of the conventional outflow tract. Conventional outflow tissues, a composite of the trabecular meshwork and the Schlemm's canal, regulate and maintain homeostatic responses of aqueous humor outflow. In glaucoma, drainage of aqueous humor into the Schlemm's canal is hindered, leading to an increase in intraocular pressure (IOP). That increase in IOP is directly correlated with retinal ganglion cell death, eliminating the relay of visual information to the thalamus and visual cortex, leading to blindness. Although disturbance in …

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Using Storm-Watersheds And A Multi-Criteria Decision Model For Biodiversity Conservation In An Urban Environment, Christina M. Chiappetta Jan 2015

Using Storm-Watersheds And A Multi-Criteria Decision Model For Biodiversity Conservation In An Urban Environment, Christina M. Chiappetta

Legacy Theses & Dissertations (2009 - 2024)

Many planning and land use decisions in New York State are controlled at the local (town or municipal) level, not an optimal scale for planning and implementing resource conservation management. Watershed boundaries provide a more ecologically meaningful scale for conservation, because they capture a full range of natural ecosystem processes that span political boundaries. However, defining an urban watershed is complicated by stormwater infrastructure, so standard topographic watershed boundaries may be inadequate for urban resource conservation even when applied at the watershed scale. Storm-watersheds distort both municipal and watershed boundaries, because the flows are redirected in ways that are often …

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Shakespearean Avatars : Modern African And South-East Asian Adaptations, Rebekah Bale Jan 2015

Shakespearean Avatars : Modern African And South-East Asian Adaptations, Rebekah Bale

Legacy Theses & Dissertations (2009 - 2024)

My dissertation looks at adaptation of plays by Shakespeare in African and Asian contexts. It focuses on how and why certain writers from a post-colonial background use Shakespeare as a basis for their adaptation. I consider contemporary adaptations from the 1960s to the 1990s. My aim is to focus on adaptations that are distinctly indigenous in terms of place and time, but remain connected to an influential Shakespearean play. I focus on adaptations that were written during the post-colonial period in order to investigate how literary adaptations are mediated through politically diverse landscapes both in Africa and Asia.

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Expecting The Unexpected : A Precautionary Principle Addressing Unconsidered Dangers, John Raymond Milanese Jan 2015

Expecting The Unexpected : A Precautionary Principle Addressing Unconsidered Dangers, John Raymond Milanese

Legacy Theses & Dissertations (2009 - 2024)

Most precautionary principles discussed in the regulatory literature argue that one ought to be more risk averse when one is uncertain about the probability of some sig- nificant danger. I explore a new kind of precautionary principle, one that addresses avoiding dangers we did not explicitly consider at all. Since it is unclear how uncon- sidered dangers could be avoided, I sketch a methodology for identifying situations where unconsidered dangers seem especially likely, by drawing from the literature in psychology on heuristics and biases and evaluating our cognitive “blind spots.”

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Landowner Knowledge And Opinions Of Invasive Species And Their Management Surrounding A Suburban Nature Preserve, Christina Mclaughlin Jan 2015

Landowner Knowledge And Opinions Of Invasive Species And Their Management Surrounding A Suburban Nature Preserve, Christina Mclaughlin

Legacy Theses & Dissertations (2009 - 2024)

Invasive species are a growing human-caused threat to biodiversity around the globe as they are moved both accidentally and intentionally through trade routes. The human component of conservation management is especially critical in invasive species, as human awareness is key to preventing and rapidly responding to new introductions. Yet the social component of management is poorly studied, even as outreach efforts continue to grow in an effort to gain public support. This study attempts to understand public knowledge and opinions toward invasive species and their management through an online survey of neighboring landowners to a suburban nature preserve, the Albany …

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Bioengineering In Vitro Human Trabecular Meshwork Models For Glaucoma Therapeutic Screening, Karen Yud Torrejon Jan 2015

Bioengineering In Vitro Human Trabecular Meshwork Models For Glaucoma Therapeutic Screening, Karen Yud Torrejon

Legacy Theses & Dissertations (2009 - 2024)

Glaucoma refers to a group of slowly progressing eye disorders that lead to damage to the optic nerve, resulting in irreversible vision loss. Recent statistics by the World Health Organization places glaucoma as a leading cause of blindness worldwide, affecting nearly 80 million people. Lowering intraocular pressure (IOP) is currently the only effective target for therapeutic intervention in glaucoma. IOP is mostly controlled by the outflow of the aqueous humor (AH) through the trabecular meshwork (TM). The TM and adjacent endothelium of Schlemm’s canal, known as the conventional outflow-tract, control AH outflow and thus determine IOP.

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Vitamin D Regulates Metabolic Gene Expression, Glutamate And Glutamine Utilization, And Mitochondrial Function In Human Mammary Epithelial Cells, Sarah Beaudin Jan 2015

Vitamin D Regulates Metabolic Gene Expression, Glutamate And Glutamine Utilization, And Mitochondrial Function In Human Mammary Epithelial Cells, Sarah Beaudin

Legacy Theses & Dissertations (2009 - 2024)

Exposure to 1,25-Dihydroxyvitamin D (1,25D) decreases proliferation and induces differentiation in telomerase-immortalized human mammary epithelial (hTERT-HME1) cells. The studies described here addressed the mechanisms by which these effects are exerted. Microarray experiments were used to identify a subset of metabolic genes and pathways that are altered by 1,25D. In particular, genes involved in glutamate and glutamine utilization, including SLC1A1 and GLUL, were studied. Interestingly, qPCR analysis in a panel of six cell lines, representing either normal epithelial tissue or breast cancer, demonstrated diverse gene expression responses to 1,25D. In an isogenic model of mammary cell transformation, 1,25D altered gene expression …

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Using A Novel Multiplexing Method To Track Cell Populations And Cytodifferentiation During Development Of The Submandibular Salivary Gland, Charles Thomas Manhardt Jan 2015

Using A Novel Multiplexing Method To Track Cell Populations And Cytodifferentiation During Development Of The Submandibular Salivary Gland, Charles Thomas Manhardt

Legacy Theses & Dissertations (2009 - 2024)

The development of submandibular salivary glands is complex and requires coordination of specific signaling events. Submandibular salivary glands originate as an epithelial invagination into the adjacent mesenchyme that leads to a single stalk and end bud; this end bud will go through a clefting process. Numerous rounds of clefting will lead to a fully developed salivary gland by this process, which is known as branching morphogenesis. As the gland undergoes morphogenesis, specific cues leading to differentiation of multiple cell types and even epithelial sub classes are required. By the later stages of development the glands are fully innervated, have an …

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Nosh-Aspirin (Nbs-1120), A Dual Nitric Oxide And Hydrogen Sulfide-Releasing Hybrid, Reduces Inflammatory Pain, Miriam D. Fonseca, Fernando Q. Cunha, Khosrow Kashfi, Thiago M. Cunha Jan 2015

Nosh-Aspirin (Nbs-1120), A Dual Nitric Oxide And Hydrogen Sulfide-Releasing Hybrid, Reduces Inflammatory Pain, Miriam D. Fonseca, Fernando Q. Cunha, Khosrow Kashfi, Thiago M. Cunha

Publications and Research

The development of nitric oxide (NO)- and hydrogen sulfide (H2S)-releasing nonsteroidal anti-inflammatory drugs (NSAIDs) has generated more potent anti-inflammatory drugs with increased safety profiles. A new hybrid molecule incorporating both NO and H2S donors into aspirin (NOSH-aspirin) was recently developed. In the present study, the antinociceptive activity of this novel molecule was compared with aspirin in different models of inflammatory pain. It was found that NOSH-aspirin inhibits acetic acid-induced writhing response and carrageenan (Cg)-induced inflammatory hyperalgesia in a dosedependent (5–150 lmol/kg, v.o.) manner, which was superior to the effect of the same doses of aspirin. NOSH-aspirin’s antinociceptive effect was also …

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Role Of Sigma-1 Receptors In Neurodegenerative Diseases, Linda Nguyen, Brandon P. Lucke-Wold, Shona A. Mookerjee, John Z. Cavendish, Matthew J. Robson, Anna L. Scandinaro, Rae Reiko Matsumoto Jan 2015

Role Of Sigma-1 Receptors In Neurodegenerative Diseases, Linda Nguyen, Brandon P. Lucke-Wold, Shona A. Mookerjee, John Z. Cavendish, Matthew J. Robson, Anna L. Scandinaro, Rae Reiko Matsumoto

Faculty Publications & Research of the TUC College of Pharmacy

Neurodegenerative diseases with distinct genetic etiologies and pathological phenotypes appear to share common mechanisms of neuronal cellular dysfunction, including excitotoxicity, calcium dysregulation, oxidative damage, ER stress and mitochondrial dysfunction. Glial cells, including microglia and astrocytes, play an increasingly recognized role in both the promotion and prevention of neurodegeneration. Sigma receptors, particularly the sigma-1 receptor subtype, which are expressed in both neurons and glia of multiple regions within the central nervous system, are a unique class of intracellular proteins that can modulate many biological mechanisms associated with neurodegeneration. These receptors therefore represent compelling putative targets for pharmacologically treating neurodegenerative disorders. In …

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Joint Attention Intervention With Assisting Parent­ Mediated Techniques To Increase A Toddler With Autism Spectrum Disorders' Use Of Joint Attention: A Single Case Study, Rebecca Schulz Jan 2015

Joint Attention Intervention With Assisting Parent­ Mediated Techniques To Increase A Toddler With Autism Spectrum Disorders' Use Of Joint Attention: A Single Case Study, Rebecca Schulz

All Graduate Theses, Dissertations, and Other Capstone Projects

Attention Intervention (JAI) conducted by graduate researcher, parent, and caregiver, would change the use of joint attention (JA) by a three-year-old suspected of having Autism Spectrum Disorder (ASD). The participant was a three-­year-­old child suspected of having ASD. Intervention was conducted twice per week for 30-45 minute duration by the student graduate researcher at a university clinic under the supervisor of Dr. Bonnie Berg, CCC­SLP. The parent and child's caregiver were trained in JAI and implemented the intervention daily in the home environment. The author's research question was, "Will the use of a JAI parent­mediated intervention model increase the JA …

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Capp 120.10: Introduction To Computers, Anthony W. Becker Jan 2015

Capp 120.10: Introduction To Computers, Anthony W. Becker

University of Montana Course Syllabi

No abstract provided.

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Capp 120.07: Introduction To Computers, Anthony W. Becker Jan 2015

Capp 120.07: Introduction To Computers, Anthony W. Becker

University of Montana Course Syllabi

No abstract provided.

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Capp 120.05: Introduction To Computers, Anthony W. Becker Jan 2015

Capp 120.05: Introduction To Computers, Anthony W. Becker

University of Montana Course Syllabi

No abstract provided.

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Mart 232.02: Interactive Web Ii, Cheryl M. Galipeau Jan 2015

Mart 232.02: Interactive Web Ii, Cheryl M. Galipeau

University of Montana Course Syllabi

No abstract provided.

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Biob 101n.11c: Discover Biology Laboratory, Gregory Peters Jan 2015

Biob 101n.11c: Discover Biology Laboratory, Gregory Peters

University of Montana Course Syllabi

No abstract provided.

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Mart 232.01: Interactive Web Ii, Cheryl M. Galipeau Jan 2015

Mart 232.01: Interactive Web Ii, Cheryl M. Galipeau

University of Montana Course Syllabi

No abstract provided.

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