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2014

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Origin Of Maternal Age Effect In Congenital Heart Disease Risk For Offspring, Claire Elaine Schulkey Dec 2014

Origin Of Maternal Age Effect In Congenital Heart Disease Risk For Offspring, Claire Elaine Schulkey

Arts & Sciences Graduate Student Theses and Dissertations

Increasing maternal age is widely acknowledged to lead to greater likelihood of pregnancy complications and congenital abnormalities, but the basis of this effect has not been well studied. Often dismissed as the product of oocyte ageing, the mechanistic basis of this maternal age effect is likely more complex.Congenital heart disease is a classic complex disease with multiple genetic and environmental modifiers, including maternal age. Maternal ageing is a known risk-factor in humans, and has been shown to exist in an Nkx2-5 haploinsufficient mouse model for the disease. This mouse model's maternal age risk is dependent upon strain background, with C57BL/6N …


Kinetic Analysis And Inhibition Studies Of Iron-Dependent Histone Demethylases, Barbara Gordon Cascella Dec 2014

Kinetic Analysis And Inhibition Studies Of Iron-Dependent Histone Demethylases, Barbara Gordon Cascella

Arts & Sciences Graduate Student Theses and Dissertations

The research presented herein focuses on the kinetics and inhibition of the KDM4 subfamily of Jumonji C (JmjC) domain-containing histone demethylases (HDMs). Belonging to the larger class of alpha-ketoglutarate (alpha-KG)-dependent, non-heme iron monooxygenases, the JmjC-HDMs remove methyl groups from mono-, di-, and tri-methylated histone lysine residues through an Fe(IV)-oxo-catalyzed hydroxylation reaction. JmjC-HDMs have been found to play integral roles in the maintenance of genomic integrity as well as in the regulation of transcription. Three KDM4 members were studied: the mixed H3K9/H3K36 demethylases KDM4A and KDM4C, and the pure H3K9 demethylase KDM4E. KDM4C is a hypoxia-inducible factor 1 (HIF-1) target gene …


Synthesis And Characterization Of Pbs Quantum Sheets Through Lamellar Assembly, And Updates To The Cdse Quantum Wire Synthesis, Paul James Morrison Dec 2014

Synthesis And Characterization Of Pbs Quantum Sheets Through Lamellar Assembly, And Updates To The Cdse Quantum Wire Synthesis, Paul James Morrison

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation reports the novel synthesis of PbS quantum plates (QPs) via a reaction executed at low temperatures. The PbS QPs are grown in a template-assisted mechanism, with the first excitonic peak observed in the visible region of light at ~620 nm (2.0 eV), at an energy radically different than the band gap of bulk PbS (~3000 nm, 0.42eV). The large energy shift is due to the extremely thin dimension of these nanoplates, which is determined to be ~1 nm in thickness. Thickness measurements are made in a powder X-ray diffractometer (XRD) at low angles (between 2-15º 2θ). These measurements …


Gothic Literature And The Politics Of Indistinction, Nicholas Everett Miller Dec 2014

Gothic Literature And The Politics Of Indistinction, Nicholas Everett Miller

Arts & Sciences Graduate Student Theses and Dissertations

I recover the Gothic as a literature of political possibility. While scholars have long associated the Gothic tradition with political fear, I argue that Gothic novels challenge liberal ideas of the self to produce a sometimes radically egalitarian politics of freedom in the late-eighteenth and early-nineteenth centuries. Edmund Burke made much of the fearfulness of an egalitarian politics in the 1790s, and literary historians have relied on his influence to argue that Gothic fiction is primarily an expression of the fear that comes with the collapse of familial, social, and political distinctions. But fear is not all that accompanies such …


Polyol Synthesis Of Silver Nanowires By Heterogeneous Nucleation And Mechanistic Aspects Influencing Its Length And Diameter, Waynie M. Schuette Dec 2014

Polyol Synthesis Of Silver Nanowires By Heterogeneous Nucleation And Mechanistic Aspects Influencing Its Length And Diameter, Waynie M. Schuette

Arts & Sciences Graduate Student Theses and Dissertations

Various additives are employed in the polyol synthesis of silver nanowires (Ag NWs), which are typically halide salts such as NaCl. A variety of mechanistic roles have been suggested for these additives. My research showed that the early addition of NaCl in the polyol synthesis of Ag NWs from AgNO3 in ethylene glycol results in the rapid formation of AgCl nanocubes, which induce the heterogeneous nucleation of metallic Ag upon their surfaces. Ag NWs subsequently grow from these nucleation sites. The conclusions are supported by studies using ex-situ generated AgCl nanocubes.Additionally, the final mean silver nanowire diameter is found to …


Uncertainty Relation For Mutual Information, James Schneeloch, Curtis J. Broadbent, John C. Howell Dec 2014

Uncertainty Relation For Mutual Information, James Schneeloch, Curtis J. Broadbent, John C. Howell

Mathematics, Physics, and Computer Science Faculty Articles and Research

We postulate the existence of a universal uncertainty relation between the quantum and classical mutual informations between pairs of quantum systems. Specifically, we propose that the sum of the classical mutual information, determined by two mutually unbiased pairs of observables, never exceeds the quantum mutual information. We call this the complementary-quantum correlation (CQC) relation and prove its validity for pure states, for states with one maximally mixed subsystem, and for all states when one measurement is minimally disturbing. We provide results of a Monte Carlo simulation suggesting that the CQC relation is generally valid. Importantly, we also show that the …


Human Trafficking & Native Peoples In Oregon: A Human Rights Report, Haley Weedn, Joseph Scovel, Jason Juran Dec 2014

Human Trafficking & Native Peoples In Oregon: A Human Rights Report, Haley Weedn, Joseph Scovel, Jason Juran

American Indian Law Journal

No abstract provided.


Sovereignty, Economic Development, And Human Security In Native American Nations, W. Gregory Guedel Dec 2014

Sovereignty, Economic Development, And Human Security In Native American Nations, W. Gregory Guedel

American Indian Law Journal

No abstract provided.


No Tribal Court Is An Island? Citation Practices Of The Tribal Judiciary, Rose Carmen Goldberg Dec 2014

No Tribal Court Is An Island? Citation Practices Of The Tribal Judiciary, Rose Carmen Goldberg

American Indian Law Journal

No abstract provided.


Fresh Pursuit: A Survey Of Law Among States With Large Land Based Tribes, Erin E. White Dec 2014

Fresh Pursuit: A Survey Of Law Among States With Large Land Based Tribes, Erin E. White

American Indian Law Journal

No abstract provided.


Beyond Blood Quantum: The Legal And Political Implications Of Expanding Tribal Enrollment, Tommy Miller Dec 2014

Beyond Blood Quantum: The Legal And Political Implications Of Expanding Tribal Enrollment, Tommy Miller

American Indian Law Journal

No abstract provided.


Aicpa Code Of Professional Conduct Effective December 15, 2014, Unless Early Implemented. Updated For All Official Releases Through December 15, 2014, American Institute Of Certified Public Accountants (Aicpa) Dec 2014

Aicpa Code Of Professional Conduct Effective December 15, 2014, Unless Early Implemented. Updated For All Official Releases Through December 15, 2014, American Institute Of Certified Public Accountants (Aicpa)

AICPA Professional Standards

No abstract provided.


Climate-Induced Changes In The Germination Phenology Of Boechera Stricta, Samuel Johnson Dec 2014

Climate-Induced Changes In The Germination Phenology Of Boechera Stricta, Samuel Johnson

Theses and Dissertations

Climate change is having demonstrable, worldwide impacts on ecological systems in ways that have modified aspects of organism behavior. Plant phenologies have responded to warmer temperatures in a variety of ways that may have implications for long-term species survival. How germination phenology changes in response to warmer climate is a largely unexplored question yet the ability of a plant to advance or delay germination in unfavorable conditions is critical for survival. Knowing the relative success and timing of germination under different climate regimes is important in understanding whether species can keep pace with the rate of climate change via migration …


Automated Scratchpad Mapping And Allocation For Embedded Processors, Yang Gao Dec 2014

Automated Scratchpad Mapping And Allocation For Embedded Processors, Yang Gao

Theses and Dissertations

Embedded system-on-chip processors such as the Texas Instruments C66 DSP and the IBM Cell provide the programmer with a software controlled on-chip memory to supplement a traditional but simple two-level cache. By decomposing data sets and their corresponding workload into small subsets that fit within this on-chip memory, the processor can potentially achieve equivalent or better performance, power efficiency, and area efficiency than with its sophisticated cache. However, program controlled on chip memory requires a shift in the responsibility for management and allocation from the hardware to the programmer. Specifically, this requires the explicit mapping of program arrays to specific …


Neodymium Isotopic Signature Of The Deep Western Boundary Current And The Distribution Of Neodymium Isotopes And Concentrations Across Line W, Brian Daniel Duggan Dec 2014

Neodymium Isotopic Signature Of The Deep Western Boundary Current And The Distribution Of Neodymium Isotopes And Concentrations Across Line W, Brian Daniel Duggan

Theses and Dissertations

The capacity of the neodymium (Nd) 143Nd/144Nd ratio to trace modern ocean circulation accurately allows for the assumption that the ratio can also accurately trace paleo ocean circulation. Therefore, a complete understanding of Nd cycling and its effect on the isotopic composition in the oceans is vital. Traditionally, Nd isotopic composition (Nd IC) is considered a conservative property in the open ocean, while coastal and margin environments tend to be dictated by nonconservative exchange processes. However, Nd concentrations ([Nd]) in the open ocean typically display a nutrient like profile, increasing with depth. Such a discrepancy between Nd IC and [Nd] …


Gender Influenced Social Welfare Reforms At The South Carolina Confederate Soldiers’ Home And Infirmary: An Institutional History (1908 - 1957), Brian Dolphin Dec 2014

Gender Influenced Social Welfare Reforms At The South Carolina Confederate Soldiers’ Home And Infirmary: An Institutional History (1908 - 1957), Brian Dolphin

Theses and Dissertations

The South Carolina Confederate Soldiers’ Home and Infirmary in Columbia opened in 1909, serving two aged and infirm veterans per county. The last former Confederate state to establish a residential facility for veterans, South Carolina became the first state to reserve positions for women on the managing board. Women on the Board exercised more power there than at any comparable institution in the South, with policy implications that featured an increasingly inclusive policy for accommodation of women as both Confederate Soldiers’ Home and Infirmary administrators and occupants. When the institution closed in 1957, it had cared for women for a …


Which Student Characteristics Correlate With Discipline Referrals? A Case Study Of A Diverse, High-Poverty Rural School District In The South, Jeannie Baltimore Monson Dec 2014

Which Student Characteristics Correlate With Discipline Referrals? A Case Study Of A Diverse, High-Poverty Rural School District In The South, Jeannie Baltimore Monson

Theses and Dissertations

The purpose of this study was to examine the correlates of discipline referrals in a diverse, high-poverty rural school district. The framework is based upon the Diamond (2004) study which, like this research, was built on the notion that socioeconomic inequality is a major factor for disproportionality in student discipline. This study identified the assets and deficits of the sample population and analyzed them in relationship to the referrals accrued. This study was conducted in a small, rural, southern school district. Of the population, approximately 78% are on free and reduced lunch and is made up of Caucasian students, 53%, …


Slow Wave Structures Integrated With Ferro-Magnetic And Ferro-Electric Thin Films For Smart Rf Applications, B M Farid Rahman Dec 2014

Slow Wave Structures Integrated With Ferro-Magnetic And Ferro-Electric Thin Films For Smart Rf Applications, B M Farid Rahman

Theses and Dissertations

Modern communications systems are following a common trend to increase the operational frequency, level of integration and number of frequency bands. Although 90-95% components in a cell phone are passives which take 80% of the total board area. High performance RF passive components play limited role and are desired towards this technological advancement. Slow wave structure is one of the most promising candidates to design compact RF and mm-Wave passive components. Slow wave structures are the specially designed transmission line realized by placing the alternate narrow and wide signal conductors in order to reduce the physical size of the components. …


Finite Element Analysis Simulations Of Micro And Nano-Electromechanical Sensors For Design Optimization, Nicholas Frank Deroller Dec 2014

Finite Element Analysis Simulations Of Micro And Nano-Electromechanical Sensors For Design Optimization, Nicholas Frank Deroller

Theses and Dissertations

Micro and Nano-electromechanical sensors (MEMS and NEMS) provide a means of actively sensing minute changes in the surrounding environment. Small changes in temperature, momentum, and strain may be sensed in passive modes while greater sensing possibilities exist in active modes. Theoretical femto-gram resolution mass detection and heated element sensing methods may be used while volatile organic compound (VOC) sensing may be achieved when combined with a functionalization layer or device heating. These devices offer a great reduction in cost and offer increased mobility by allowing a "lab-on-chip" solution for the prospective user while also greatly reducing the amount of energy …


An Analysis Of The Cultural Invariance Of A Visual-Motor Integration Measure, Emma Kate C. Wright Dec 2014

An Analysis Of The Cultural Invariance Of A Visual-Motor Integration Measure, Emma Kate C. Wright

Theses and Dissertations

As diverse populations within schools increase, the need for culturally-sensitive assessment is essential; however, test of ability vary in their degree of influence from culture. No test is “culture free,” but the low-linguistic demands on test of visual-motor integration (VMI) make them appropriate for use with diverse populations. Variation in VMI test performance due to cultural factors has negative implications for test interpretation and use with diverse populations because of VMI’s significant association with school readiness, academic achievement, social-emotional functioning, and neuropsychological assessment. The current study explored the cultural invariance of the Bender Motor Gestalt Test, Second Edition (BG-II), a …


Design And Development Of A Novel Class Of Cell Cycle Cdk Inhibitors Targeting The Cyclin Binding Groove Utilizing The Replace Strategy, Padmavathy Nandha Premnath Dec 2014

Design And Development Of A Novel Class Of Cell Cycle Cdk Inhibitors Targeting The Cyclin Binding Groove Utilizing The Replace Strategy, Padmavathy Nandha Premnath

Theses and Dissertations

Inhibition of CDK2 activity in G1 and S phases of the cell cycle can promote selective apoptosis of cancer cells through the E2F1 pathway. Currently available CDK inhibitors target the ATP binding pocket and result in lack of specificity for the cell cycle vs. the transcriptional CDKs. It has been shown that a peptide HAKRRLIF derived from the tumor suppressor p21 binds to the cyclin binding groove (CBG) and selectively inhibits cell cycle CDKs (CDK2/Cyclin A, CDK2/Cyclin E and CDK4/Cyclin D). The CBG is unique to cell cycle CDKs hence targeting this site avoids the inhibition of transcriptional CDKs can …


Semiparametric Regression Analysis Of Bivariate Interval-Censored Data, Naichen Wang Dec 2014

Semiparametric Regression Analysis Of Bivariate Interval-Censored Data, Naichen Wang

Theses and Dissertations

Survival analysis is a long-lasting and popular research area and has numerous applications in all fields such as social science, engineering, economics, industry, and public health. Interval-censored data are a special type of survival data, in which the survival time of interest is never exactly observed but is known to fall within some observed interval. Interval-censored data arise commonly in real-life studies, in which subjects are examined at periodical or irregular follow-up visits. In this dissertation, we develop efficient statistical approaches for regression analysis of bivariate intervalcensored data, in which the two survival times of interest are correlated and both …


Telescopes And Spyglasses: Using Literary Theories In High School Classrooms, Danielle M. Rains Dec 2014

Telescopes And Spyglasses: Using Literary Theories In High School Classrooms, Danielle M. Rains

Honors Projects

This handbook is structured in a way that can be directly applied to the classroom. The theories are organized and ordered to build on one another; the skills that your students learn from one will help them complete the tasks of the next. Each chapter provides information about the theory, how to conduct a reading following the theory’s guidelines, and how to introduce the theory to your students.


Learning To Swim: The Act Approach To Living With Depression, Ashley Martinez Dec 2014

Learning To Swim: The Act Approach To Living With Depression, Ashley Martinez

Honors Projects

This illustrated self-help manual was designed as a basis for treatment for individuals of a wide range of ages experiencing depression. The therapeutic base of the manual is Acceptance and Commitment Therapy (ACT), which outlines the pathology of depression as problems in functioning rather than problems in the individual. The ACT theory of depression views problems in functioning as centered around the way negative emotions are perceived and processed through language and problematic actions or inaction as a result of cognitive distortions. Because of problems with language, the manual is illustrated to help the reader understand the foundations of ACT …


A Liberal State Of Mind: Formal Reconstructions Of Statehood In The Anglophone African Novel, Maya Ganapathy Dec 2014

A Liberal State Of Mind: Formal Reconstructions Of Statehood In The Anglophone African Novel, Maya Ganapathy

Arts & Sciences Graduate Student Theses and Dissertations

While the idea of the nation and national identity is often taken as the starting point for examinations of the African state, this dissertation explores the transnational dimensions of the African novel and the way in which English-language writers from Africa imagine a state that more adequately captures their desire to freely inhabit a global literary marketplace. Although critics of the Anglophone African novel tend to understand the fictional state as an object of unremitting political critique (often simply as a reflection of its real-world counterpart), the African state, when viewed through the methodological lens of narrative form, becomes the …


Not Too Sharp To Make Network Television Debut, Tracey Bentley Dec 2014

Not Too Sharp To Make Network Television Debut, Tracey Bentley

UNH Today Archive

No abstract provided.


State V. Gonzales Respondent's Brief Dckt. 42010 Dec 2014

State V. Gonzales Respondent's Brief Dckt. 42010

Not Reported

No abstract provided.


December 15, 2014: President's Christmas Party, Visionary Of The Year, Christmas Songs, Saint Mary's College Of California Dec 2014

December 15, 2014: President's Christmas Party, Visionary Of The Year, Christmas Songs, Saint Mary's College Of California

SMC Bulletin 2013-2020

No abstract provided.


Research On Sealing Performance Of Hydrostatic Pressure Mechanical Seal, Wei-Bing Zhu, He-Shun Wang, Sheng-Ren Zhou Dec 2014

Research On Sealing Performance Of Hydrostatic Pressure Mechanical Seal, Wei-Bing Zhu, He-Shun Wang, Sheng-Ren Zhou

Journal of Marine Science and Technology–Taiwan

The hydrostatic pressure mechanical seal has many advantages, and it can be used in rotating machines with lower speed. Based on the externally pressurized stable gas lubrication theory, the control equation of end face flow field for hydrostatic pressure mechanical seal with orifice compensation was established. The functional extremum algorithm and the finite element method were used to solve this equation. The effects of gas film thickness, air supply pressure, throttle orifice number and diameter, on face opening force and gas film stiffness were discussed in detail. The results show that the opening force decreases with the widening of face …


Performance Evaluation Of Three Types Of Passive Micromixer With Convergent-Divergent Sinusoidal Walls, Arshad Afzal, Kwang-Yong Kim Dec 2014

Performance Evaluation Of Three Types Of Passive Micromixer With Convergent-Divergent Sinusoidal Walls, Arshad Afzal, Kwang-Yong Kim

Journal of Marine Science and Technology–Taiwan

A passive split-and-recombination micromixer with convergent-divergent channel walls of sinusoidal variation has been investigated using numerical simulations. With water and ethanol as working fluids, the analysis was performed using Navier-Stokes equations with convection-diffusion model in a Reynolds number range, 10  Re  70. Performances of three configurations with different split-and-recombination arrangements were evaluated in terms of mixing index and pressure drop. A parametric study was also conducted with two geometrical parameters, i.e., the ratios of throat-width to diameter of circular wall and diameter of circular wall to amplitude. The results showed a significant dependence of the mixing performance on …