Digital Commons Network^™

Characterization Of The Discriminative Stimulus Properties Of The Atypical Antipsychotic Amisulpride In C57bl/6 Mice, Timothy J. Donahue

Theses and Dissertations

Amisulpride, a benzamide derivative, is an atypical antipsychotic drug used to treat both schizophrenia and depression. Amisulpride is a selective antagonist at dopamine D₂ and D₃ receptors and at serotonin 5-HT_2B and 5-HT₇ receptors and displays an atypical clinical profile with reduced extrapyramidal motor effects. The drug has a chiral center and is a mixture of two optical isomers: (S)-amisulpride and (R)-amisulpride. The present study used a two-lever drug discrimination assay to allow a direct comparison between amisulpride and its two isomers. Additionally, substitution testing was conducted with the typical antipsychotics, atypical antipsychotics, antidepressants, …

A Pollination Network Of Cornus Florida, James H. Lee

Theses and Dissertations

From the agent-based, correlated random walk model presented, we observe the effects of varying the parameter values of maximum insect turning area, ��_max, density of trees, ω, maximum pollen carryover, ��_max, and probability of fertilization, P_��, on the distribution of pollen within a population of Cornus florida (flowering dogwood). We see that varying ��_max and ��_max changes the dispersal distance of pollen, which greatly affects many measures of connectivity. The clustering coefficient of fathers is maximized when ��_max is between 60° and 90°. Varying ω does not have a major …

Enhancing Critical Thinking In Clinical Laboratory Students: A Multimodal Model, Denise Marie Juroske Short

Theses and Dissertations

The purpose of this study was to improve critical thinking skills in clinical laboratory technologists through the development, implementation, and assessment of a multimodal model targeting critical thinking skills. Clinical laboratory technologists influence patient care through the testing of laboratory samples. Employers of these entry level professionals identified a need for improved critical thinking skills. This quasi-experimental study aimed to design a multimodal critical thinking model, implement the model into the clinical laboratory educational curriculum, and assesses this skill set for students in a pre-test / post-test format. The model was delivered and assessed for 47 clinical laboratory students at …

Perceptions Of And Implicit Attitudes Toward Women: The Influence Of Parental Status, Race, And Label Choice, Annalucia Bays

Theses and Dissertations

Previous research suggests that childfree and childless women are perceived more negatively than mothers. This study investigated attitudes based on parental status, race, and descriptive label. Undergraduate students (N = 386) were randomized to consider targets described as childless, childfree, or mothers/parents. Participants completed a personality characteristic rating scale, the competence and warmth scales of the Stereotype Content Model, an evaluation thermometer, a measure of pronatalism, and a Single Category Implicit Association Test. Childless and childfree women of all races were perceived more negatively than mothers, and women in all parental status groups were ambivalently stereotyped. Implicit attitudes favored …

Second Skin, Britta Bielak

Theses and Dissertations

Reason for writing. The space of confusion and possibility where the practices of art and design collide seems to be in a constant amoebic state. This place of shared influence and growth seems to pervade not only the intersection of these two disciplines, but within interior design, the intersection of people and space. How can the boundaries between an interior space and it’s inhabitants be as richly embedded with tension and opportunity as the edges where art and design meet? Like art and design, how can a space and it’s visitors interact to affect one another?

Problem + Methodology: This …

Light Mediated Drug Delivery Using Photocaged Molecules And Photoswitchable Peptides, Deboleena Mitra

Theses and Dissertations

There are many different types of targeted therapy for cancer treatment. The method of light mediated targeted therapy that we have developed uses photocaged molecules and photoswitchable peptides.

In photocaging, a biologically active molecule is made inactive by the attachment of a photocleavable blocking group. On exposure to UV radiation the photocleavable entity is removed and the biologically active molecule is released. Using this concept we have designed a prodrug that consists of a cell impermeable hydrophilic molecule attached to a photocaged doxorubicin. Upon irradiation with UV light the photosensitive group is removed and cytotoxic doxorubicin is released at the …

Repetition, Betsy J. Yost

Theses and Dissertations

Artist Statement

My work is about memory, and my awareness of the repetition of large and small events in my life. In my paintings, drawings, and mixed media I create rhythmic patterns with images and colors to imply a sense of recurrence. I often repeat imagery such as paper dolls or geometric and organic shapes in my work. I choose and repeat shapes and colors that remind me of events in my childhood and in my life as an adult. I see these multiple images as symbolic self-portraits which prompt memories of recurring events, such as waking up each morning …

Sildenafil And Celecoxib Interact To Kill Breast Cancer Cells, Brittany Binion

Theses and Dissertations

Breast cancer is the second most commonly diagnosed cancer among American women and is responsible for the second highest number of cancer-related deaths. Targeted therapeutic agents sildenafil, a phosphodiesterase type 5 inhibitor, and celecoxib, a cyclooxygenase-2 inhibitor, have been used individually in conjunction with other chemotherapeutic agents to enhance cell killing in a variety of cancers. Sildenafil when combined with traditional chemotherapeutic drugs, such as the taxanes and anthracyclines, or celecoxib combined with traditional hormone therapies have been used to increase cytotoxicity and cell killing. The data presented here demonstrates that the novel combination of sildenafil and celecoxib work together …

Video Games: Their Effect On Society And How We Must Modernize Our Pedagogy For Students Of The Digital Age, Christopher J. Baker

Theses and Dissertations

This thesis aims to explore how video games have become an extremely beneficial tool in regards to education, art, medicine, psychology, economics, and beyond. Chapter 1 focuses on how ubiquitous video games have become in America, and what makes video games such a uniquely enjoyable experience to warrant such popularity. Chapter 2 explores how video games have become instrumental in various fields. Chapter 3 discusses the role that video games now play in the world of education; specifically how we, as educators, must adapt a modern pedagogy best suited to students who have grown up with video games, which have …

"Mining" For A Reference Condition In Southern West Virginia Streams, Matthew Rouch

Theses and Dissertations

Quarterly samples were used to estimate assemblage-level (all species combined) fish production within three minimally-impacted, southern West Virginia streams. The total annual fish production estimate was highest in Slaunch Fork (37.52 kg∙ha^-1∙y^-1), a tributary of the Tug Fork River, and lowest in Cabin Creek (10.59 kg∙ha^-1∙y^-1), a Guyandotte River tributary. Creek Chub Semotilus atromaculatus, Mottled Sculpin Cottus bairdii and Blacknose Dace Rhinicthys atratulus were the most abundant species among sites, accounting for >90% of all sampled individuals. Reference condition criteria were also selected and metrics calculated for each of the three …

Implementing Social Equity In The Public Sector: How Community Colleges Achieve The Dream, Kasey J. Martin

Theses and Dissertations

Equity is an American ideal, one that is considered the cornerstone to good governance (Gooden, 2011). Achieving equity requires the eradication of racial disparities in opportunities and outcomes, particularly in education. Creating equitable educational experiences at community colleges is the focus of this research.

The purpose of study is to examine the issue of social equity within community colleges in an effort to understand: (1) their efforts to promote student success through equity; (2) their commitment to social equity; and (3) the institutional change that is necessary to create an institutional culture that values social equity and is accountable for …

Factors That Predict Incident Reporting Behavior In Certified Registered Nurse Anesthetists, Nicole K. Damico

Theses and Dissertations

Improving patient safety through reduction of medical errors is a national priority. One of the strategies widely utilized to address this issue is the use of incident reporting systems. The purpose of this study was to describe factors that predict the likelihood that Certified Registered Nurse Anesthetists (CRNAs) will use incident reporting systems, guided by the theory of planned behavior (Ajzen, 1991). A non-experimental, correlational research design was utilized to achieve the study aims. Following IRB approval, a cross-sectional survey was administered electronically to a random sample of practicing CRNAs. Correlational analyses and a standard logistic regression were utilized to …

The Effect Of Sleep Medication Use And Poor Sleep Quality On Risk Of Falls In Community-Dwelling Older Adults, Yaena Min

Theses and Dissertations

The work presented in this dissertation focuses on the association between sleep medication use, poor sleep, and falls in community-dwelling adults 65 years or older. Sleep complaints and the consumption of medications to aid sleep are common in older adults. Psychotropic medications, such as sedative hypnotics, are associated with risk of falls in older adults. However, very few studies have assessed the impact of poor sleep and sleep medication use on the risk of falls in community-dwelling older adults. In the first project, a cross-sectional analysis of the Health and Retirement Study (HRS) 2010 data was conducted to determine the …

New Artifacts For The Knowledge Discovery Via Data Analytics (Kdda) Process, Yan Li

Theses and Dissertations

Recently, the interest in the business application of analytics and data science has increased significantly. The popularity of data analytics and data science comes from the clear articulation of business problem solving as an end goal. To address limitations in existing literature, this dissertation provides four novel design artifacts for Knowledge Discovery via Data Analytics (KDDA). The first artifact is a Snail Shell KDDA process model that extends existing knowledge discovery process models, but addresses many existing limitations. At the top level, the KDDA Process model highlights the iterative nature of KDDA projects and adds two new phases, namely Problem …

Barriers And Facilitators To Infant Feeding Among Low-Income African American Women, Cecilia E. Barbosa

Theses and Dissertations

Objective The purpose of the mixed methods study was to compare barriers and facilitators encountered by low-income African American women who engaged in different infant feeding practices. Methods Using the positive deviance approach and modified Integrated Model as theoretical frameworks, the research began with a qualitative study that informed a survey examining intention, skills, and environmental factors differentiating women’s infant feeding practices. Results Twenty-eight and 190 low-income African American adult women participated in focus groups or interviews and a survey, respectively. In the qualitative study, positive deviants, who breastfed for at least four months, seemed to have stronger breastfeeding intentions, …

Novel Compounds As Potential Alzheimer's Disease Therapeutics And Inhibitors Of The Nlrp3 Inflammasome, Jeremy E. Chojnacki

Theses and Dissertations

Alzheimer’s disease is a devastating neurodegenerative disorder and the leading cause of dementia. The disease manifests via several pathologies including neuroinflammation, oxidative stress, metal ion dyshomeostasis, and cell death. To address the multifaceted nature of this disorder, the design of several diverse compounds, targeting many pathological effects, was generated. First, a series of compounds based on curcumin and diosgenin were synthesized following the bivalent design strategy. Two compounds were discovered to have neuroprotective ability, anti-oxidative function, and anti-Aß oligomerization (AßO) properties. A second set of molecules was also designed, wherein a hybrid compound strategy was utilized. Three hybrids were to …

Methods For Integrative Analysis Of Genomic Data, Paul Manser

Theses and Dissertations

In recent years, the development of new genomic technologies has allowed for the investigation of many regulatory epigenetic marks besides expression levels, on a genome-wide scale. As the price for these technologies continues to decrease, study sizes will not only increase, but several different assays are beginning to be used for the same samples. It is therefore desirable to develop statistical methods to integrate multiple data types that can handle the increased computational burden of incorporating large data sets. Furthermore, it is important to develop sound quality control and normalization methods as technical errors can compound when integrating multiple genomic …

Why Female Suicide Bombers? A Closer Look At The Liberation Tigers Of Tamil Eelam And Chechen Separatists, Latisha T. Campbell

Theses and Dissertations

The central hypothesis of this study is that terrorist organizations choose to use females as suicide bombers not only as tactical innovation but also to “signal” or send a message to various audiences. In order to meet the research objectives of this study, two terrorist organizations—the Liberation Tigers of Tamil Eelam and the Chechen Separatists or those individuals associated with the Chechen Resistance—are examined in detail from their inception through 2013 using a structured focused comparison methodology.

Evidence is found to support both of the studies’ main hypotheses. First, female suicide bombers are used by terrorist organizations because they are …

Dīpaṅkara Buddha And The Patan Samyak Mahādāna In Nepal: Performing The Sacred In Newar Buddhist Art, Kerry Lucinda Brown

Theses and Dissertations

Every four years, in the middle of a cold winter night, devotees bearing images of 126 Buddhas, Bodhisattvas, and other important deities assemble in the Nepalese city of Patan for an elaborate gift giving festival known as Samyak Mahādāna (“The Perfect Great Gift”). Celebrated by Nepal’s Newar Buddhist community, Samyak honors one of the Buddhas of the historical past called Dīpaṅkara. Dīpaṅkara’s importance in Buddhism is rooted in ancient textual and visual narratives that promote the cultivation of generosity through religious acts of giving (Skt. dāna). During Samyak, large images of Dīpaṅkara Buddha ceremoniously walk in procession to the …

Anaplasma Phagocytophilum Nutritional Virulence Mechanisms Target The Host Cell Secretory Pathway, Hilary Kay Truchan

Theses and Dissertations

Obligate intracellular pathogens must acquire host cell-derived nutrients to facilitate their survival. One such bacterial pathogen, Anaplasma phagocytophilum, replicates within neutrophils and non-phagocytic cells in a bacterial-modified, host cell-derived vacuole. The bacterium exploits host cell vesicular trafficking pathways to route nutrients to its vacuole and utilizes Rab GTPases, guanine nucleotide-dependent, vesicular trafficking regulators, to do so. We previously discovered that the A. phagocytophilum vacuolar membrane is decorated with a specific subset of Rab GTPases - Rab1, Rab4A, Rab10, Rab11, Rab14, Rab22A and Rab35. Rab1 is exclusively found on the endoplasmic reticulum (ER) and thus its localization suggests that the …

An Investigation Of The Differences Between Continuing And Non-Continuing Undergraduate Special Admission Students Related To Academic Advising Factors, Kevin P. Reeves

Theses and Dissertations

This study examined some differences between continuing and non-continuing special admission students in areas of academic advising in ways that are more systematic and thorough than past research. The premise of the study is that having a clearer understanding of how academic advising affects retention might provide colleges and universities with information to optimize the collegiate experience for special admission students. Therefore, research on the effect academic advising has on special admission student retention might offer insight into how the interactions between student and advisor affect retention issues.

A non-experimental descriptive research design was employed to investigate the differences between …

Isolation And Characterization Of Multipotent Lung Stem Cells From P53 Mutant Mice Models, Venkat Sundar Gadepalli

Theses and Dissertations

Recent advances in understanding lung biology have shown evidence for the existence of resident lung stem cells. Independent studies in identifying and characterizing these somatic lung stem cells have shown the potential role of these cells in lung repair and regeneration. Understanding the functional characteristics of these tissue resident stem/progenitor cells has gained much importance with increasing evidence of cancer stem cells, cells in a tumor tissue with stem cell characteristics. Lung cancer is most commonly characterized by loss of p53 function which results in uncontrolled cell divisions. Incidence of p53 point mutations is highest in lung cancer, with a …

Nf-Κb P50: The Role Of Redox Signaling And Loss Of Function In Dysregulated Microglial Activation, Thomas Taetzsch

Theses and Dissertations

Abstract

NF-κB p50: THE ROLE OF REDOX SIGNALING AND LOSS OF FUNCTION IN DYSREGULATED MICROGLIAL ACTIVATION

By Thomas J Taetzsch B.S.

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University.

Virginia Commonwealth University, 2014

Major Director: Michelle L Block PhD,

IUPUI Associate Professor

Department of Anatomy and Neurobiology

Oxidative stress and chronic microglia-mediated inflammation are well characterized underlying factors in neurodegenerative disease. While it is clear that increased levels of inflammation and augmented oxidative stress in the aged brain create an environment that is particularly harmful to neurons, little …

Hang-Yong High-Speed Railway And Ningbo’S Industrial Structure: A Conceptual Analysis, Dongxuan Ying

Theses and Dissertations

High speed railway and promote the economic development of the city. So the operation of high-speed railway in Ningbo to Hangzhou, Ningbo’s opportunity and challenge, tourism, transportation, business, industry, real estate industry, headquarters economy, financial, cultural and creative industries, attract talent. Although short-term high iron research is very difficult to see effect, but through some research can guess and judge the impact of high-speed rail industry of Ningbo city and some Suggestions put forward the Ningbo, Hang-Yong high-speed railway.

Preparing Teachers Of Students With Autism Spectrum Disorders: Evidence-Based Practices And Teacher Self-Efficacy, Jane E. Strong

Theses and Dissertations

ABSTRACT

PREPARING TEACHERS OF STUDENTS WITH AUTISM SPECTRUM DISORDER: EVIDENCE-BASED PRACTICES AND TEACHER SELF-EFFICACY

By Jane E. Strong

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University.

Virginia Commonwealth University, 2014

Major Director: Evelyn Reed, Ph.D., Associate Professor

Department of Special Education and Disability Policy

School of Education

There is a need for intensified, rapid, and special emphasis on training of teachers for students on the autism spectrum (NRC, 2001). The current movement in the field emphasizing the use of evidence-based practices in designing instructional methods should be emphasized …

Quantum Efficiency Enhancement For Gan Based Light-Emitting Diodes And Vertical Cavity Surface-Emitting Lasers, Fan Zhang

Theses and Dissertations

This thesis explores the improvement of quantum efficiencies for InGaN/GaN heterostructures and their applications in light-emitting diodes (LEDs) and vertical cavity surface-emitting lasers (VCSELs). Different growth approaches and structural designs were investigated to identify and address the major factors limiting the efficiency. (1) Hot electron overflow and asymmetrical electron/hole injection were found to be the dominant reasons for efficiency degradation in nitride LEDs at high injection; (2) delta p-doped InGaN quantum barriers were employed to improve hole concentration inside the active region and therefore improve hole injection without sacrificing the layer quality; (3) InGaN active regions based on InGaN multiple …

A Diamond In The Rough: Trans-Substantivity Of The Federal Rules Of Civil Procedure And Its Detrimental Impact On Civil Rights, Suzette Malveaux

Publications

No abstract provided.

Inmates For Rent, Sovereignty For Sale: The Global Prison Market, Benjamin Levin

Publications

In 2009, Belgium and the Netherlands announced a deal to send approximately 500 Belgian inmates to Dutch prisons, in exchange for an annual payment of £26 million. The arrangement was unprecedented, but justified as beneficial to both nations: Belgium had too many prisoners and not enough prisons, whereas the Netherlands had too many prisons and not enough prisoners. The deal has yet to be replicated, nor has it triggered sustained criticism or received significant scholarly treatment. This Article aims to fill this void by examining the exchange and its possible implications for a global market in prisoners and prison space. …

The Capture Of International Intellectual Property Law Through The U.S. Trade Regime, Margot E. Kaminski

Publications

For years, the United States has included intellectual property ("IP") law in its free trade agreements. This Article finds that the IP law in recent U.S. free trade agreements differs subtly but significantly from U.S. IP law. These differences are not the result of deliberate government choices, but of the capture of the U.S. trade regime.

A growing number of voices has publicly criticized the lack of transparency and democratic accountability in the trade agreement negotiating process. But legal scholarship largely praises the 'fast track" trade negotiating system. This Article reorients the debate over the trade negotiating process away from …

The Story Behind A Letter In Support Of Professor Derrick Bell, Cheryl Nelson Butler, Sherrilyn Ifill, Suzette Malveaux, Margaret E. Montoya, Natsu Taylor Saito, Nareissa L. Smith, Tanya Washington

Publications

Professor Derrick A. Bell, Jr. had a long and proud history of disturbing authority. He is widely noted as one of the founders of Critical Race Theory. His scholarship on race was not only a direct challenge to the traditionally conservative legal academy, but also to the more liberal bastions within the academy, such as the Critical Legal Studies movement. His writings about the role of race in American law have made him one of the most prominent legal scholars of a generation.

However, Professor Bell did not merely write about racial injustices. He was willing to take risks to …