Digital Commons Network^™

The Global Cancer Genomics Consortium's Third Annual Symposium: From Oncogenomics To Cancer Care, Luis Costa, Sandra Casimiro, Sudeep Gupta, Stefan Knapp, M. Radhakrishna Pillai, Mazakazu Toi, Rajendra Badwe, Maria Carmo-Fonesca, Rakesh Kumar

Biochemistry and Molecular Medicine Faculty Publications

The Global Cancer Genomics Consortium (GCGC) is a cohesive network of oncologists, cancer biologists and structural and genomics experts residing in six institutions from Lisbon, United Kingdom, Japan, India, and United States. The team is using its combined resources and infrastructures to address carefully selected, shared, burning questions in cancer medicine. The Third Annual Symposium was organized by the Institute of Molecular Medicine, Lisbon Medical School, Lisbon, Portugal, from September 18 to 20, 2013. To highlight the benefits and limitations of recent advances in cancer genomics, the meeting focused on how to better translate our gains in oncogenomics to cancer …

College Senate Minutes May 15, 2014, Bronx Community College Senate

BCC Governance Archives

Minutes for the meeting of the College Senate on May 15, 2014.

Neural Circuitry Underlying The Central Hypertensive Action Of Nesfatin-1: Melanocortins, Corticotropin-Releasing Hormone, And Oxytocin, Gina L.C. Yosten, Willis K. Samson

Biological Sciences Faculty Research & Creative Works

Nesfatin-1 is produced in the periphery and in the brain where it has been demonstrated to regulate appetite, stress hormone secretion, and cardiovascular function. The anorexigenic action of central nesfatin-1 requires recruitment of neurons producing the melanocortins and centrally projecting oxytocin (OT) and corticotropin-releasing hormone (CRH) neurons. We previously have shown that two components of this pathway, the central melanocortin and oxytocin systems, contribute to the hypertensive action of nesfatin-1 as well. We hypothesized that the cardiovascular effect of nesfatin-1 also was dependent on activation of neurons expressing CRH receptors, and that the order of activation of the melanocortin-CRH-oxytocin circuit …

Harvest Incentives: A Tool For Managing Aquatic Invasive Species, Bob Wiltshire, Nathan Stone, Marshall Meyers, Bill Hyatt, Lori Williams, Jason Goldberg, Susan Pasko, Leah Elwell

National Invasive Species Council

Conclusion

The success of any harvest incentive program to address aquatic invasive species will depend upon numerous biological, socioeconomic, and legal considerations. Programs that encourage harvest may be a successful management tool in targeting small, distinct populations; in high priority areas within a larger invasion; or they may play a supplementary role within larger control programs. Their use, however, will require careful review, planning, and monitoring to ensure success and that they do not unintentionally lead to further spread of invasive species, cause additional harm to native species, or waste valuable resources.

Google Glass Inspires University Projects, Danielle Kamp

News and Events (Discontinued Series)

No abstract provided.

Principles Of Structure-Function Relationships Applicable To Sensing Materials ─ Explosives And Bio-Diagnosis, Hyun-Sook Jang

Doctoral Dissertations

Functions of nanomaterials can be strongly dependent on their structures. Therefore, the knowledge of structure-function relationship can provide important information for designing functional materials. This dissertation aims to gain fundamental knowledge through structural analysis of nano-sensing materials for explosives and bio-diagnosis in order to enhance the sensitivity.

The main project of my research involved the investigation into the fluorescence and quenching mechanisms of pyrene with a series of organic salts and/or polystyrene of a variety of architectures as well as the function of explosive detection. The major findings of this dissertation includes: (1) the formation of pyrene excimers can be …

Nelson V. State Appellant's Reply Brief Dckt. 40661

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Roundworms Unlock New Information On Fertility, Alicia Rohan

Browse All News

No abstract provided.

Volunteers Needed For Uab's Prison Lecture Series, Linda Gunter

Browse All News

No abstract provided.

Do The Beaf Insulator Proteins Regulate Genes Involved In Cell Polarity And Neoplastic Growth?, Craig M. Hart

Faculty Publications

It was reported that a chromosome with the BEAFNP6377 (NP6377) allele leads to a loss of cell polarity and neoplastic growth in Drosophila melanogaster when homozygous (Gurudatta et al., 2012). We had previously generated the BEAFAB-KO (AB-KO) allele by homologous recombination and did not note these phenotypes (Roy et al., 2007). Both alleles are null mutations. It was unclear why two null alleles of the same gene would give different phenotypes. To resolve this, we performed genetic tests to explore the possibility that the chromosome with the NP6377 allele contained other, second site mutations that might account for the different …

Turtle Town: Creating A Self-Sustainable Ecosystem Using An Ecological Approach To Turtle Aquarium Design, Sheena K. O'Donnell

Undergraduate University Honors Capstones

Typical pet turtle tank setups do not utilize the complete nutrient cycle seen in a functional natural ecosystem. This dysfunction results in waste and nutrient buildup, which is currently managed by water changes and regular tank cleaning. This type of maintenance can be costly and time-consuming -- not to mention unpleasant and hazardous to the aquarium owner's health. This study tested the effectiveness of using plants as part of a proposed ecological tank design to minimize waste buildup by utilizing nutrients. Wastewater from a dirty turtle tank was transferred to a tank setup containing three plants (Experimental Batch 1), while …

Ultraviolet Radiation, Aging And The Skin: Prevention Of Damage By Topical Camp Manipulation, Alexandra Amaro-Ortiz, Betty Yan, John A. D’Orazio

Markey Cancer Center Faculty Publications

Being the largest and most visible organ of the body and heavily influenced by environmental factors, skin is ideal to study the long-term effects of aging. Throughout our lifetime, we accumulate damage generated by UV radiation. UV causes inflammation, immune changes, physical changes, impaired wound healing and DNA damage that promotes cellular senescence and carcinogenesis. Melanoma is the deadliest form of skin cancer and among the malignancies of highest increasing incidence over the last several decades. Melanoma incidence is directly related to age, with highest rates in individuals over the age of 55 years, making it a clear age-related disease. …

The Observer, Central Washington University

Student Newspaper

Student newspaper for Central Washington University for May 15-21, 2014. Vol. 97, No. 6.

Burkitt Lymphoma In A Pediatric Patient With Hereditary Multiple Exostose, Sara D. Prince, Portia A. Krieger, Md, Andrew W. Walter, Ms, Md

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Introduction

Hereditary multiple exostoses (HME) is an autosomal dominant disorder characterized by the growth of multiple bony tumors. These tumors include benign osteochondromas and less commonly, malignant tumors that arise from transformation of exostoses into secondary osteosarcomas and chondrosarcomas [1,3]. There have been no reported cases of lymphoma in the pediatric HME population. We report a case of a 10 year old boy with HME who developed Burkitt lymphoma of the abdomen.

Engineered Plasmonic Nanostructures For Nanomedicine, Christopher Matthew Portz

McKelvey School of Engineering Graduate Student Theses & Dissertations

No abstract provided.

The Pseudomonas Aeruginosa Exoenzyme Y Impairs Endothelial Cell Proliferation And Vascular Repair Following Lung Injury, Trevor C. Stevens, Cristhiaan D. Ochoa, K. Adam Morrow, Matthew J. Robson, Nutan Prasain, Chun Zhou, Diego F. Alvarez, Dara W. Frank, Ron Balczon, Troy Stevens

University Faculty and Staff Publications

Exoenzyme Y (ExoY) is a Pseudomonas aeruginosa toxin that is introduced into host cells through the type 3 secretion system (T3SS). Once inside the host cell cytoplasm, ExoY generates cyclic nucleotides that cause tau phosphorylation and microtubule breakdown. Microtubule breakdown causes interendothelial cell gap formation and tissue edema. Although ExoY transiently induces interendothelial cell gap formation, it remains unclear whether ExoY prevents repair of the endothelial cell barrier. Here, we test the hypothesis that ExoY intoxication impairs recovery of the endothelial cell barrier following gap formation, decreasing migration, proliferation, and lung repair. Pulmonary microvascular endothelial cells (PMVECs) were infected with …

Towards Structural Systems Pharmacology To Study Complex Diseases And Personalized Medicine, Lei Xie, Xiaoxia Ge, Hepan Tan, Li Xie, Yinliang Zhang, Thomas Hart, Xiaowei Yang, Philip E. Bourne

Publications and Research

Genome-Wide Association Studies (GWAS), whole genome sequencing, and high-throughput omics techniques have generated vast amounts of genotypic and molecular phenotypic data. However, these data have not yet been fully explored to improve the effectiveness and efficiency of drug discovery, which continues along a one-drug-one-target-one-disease paradigm. As a partial consequence, both the cost to launch a new drug and the attrition rate are increasing. Systems pharmacology and pharmacogenomics are emerging to exploit the available data and potentially reverse this trend, but, as we argue here, more is needed. To understand the impact of genetic, epigenetic, and environmental factors on drug action, …

Louisiana State University Health Sciences Center - 2014 - 140th Commencement, Office Of The Registrar, Lsu Health Sciences Center-No

Graduation & Commencement Programs

The program for the 140th Commencement of LSU Health Sciences Center - New Orleans held May 15, 2014.

Dissolved Nutrient Ratios And Concentrations Affect Fungal Reproduction And Community Structure Associated With Submerged Leaf Litter And Wood, Jennifer Fitzgerald

Electronic Theses and Dissertations

Litter-associated fungi are important intermediaries in carbon and energy flow in streams. They can obtain nitrogen (N) and phosphorus (P) from both the substrate and the water column. I tested the effects of dissolved nutrients (dissolved inorganic nitrogen (DIN) 40-975 µg/L, soluble reactive phosphorus (SRP) 2-135 µg/L, N:P ratios 2:1, 16:1, 128:1) on fungi associated with leaf litter (maple and rhododendron) and wood in streamside channels at Coweeta Long Term Ecological Research site, North Carolina. This study addressed two main questions: (1) will fungal reproduction (sporulation rate of aquatic hyphomycetes) peak at a dissolved N:P ratio similar to nutrient stoichiometry …

The Bactericidal Effect Of Dendritic Copper Microparticles, Contained In An Alginate Matrix, On Escherichia Coli, Sf Thomas, P Rooks, F Rudin, S Atkinson, Et Al

School of Biological and Marine Sciences

Although the bactericidal effect of copper has been known for centuries, there is a current resurgence of interest in the use of this element as an antimicrobial agent. During this study the use of dendritic copper microparticles embedded in an alginate matrix as a rapid method for the deactivation of Escherichia coli ATCC 11775 was investigated. The copper/alginate produced a decrease in the minimum inhibitory concentration from free copper powder dispersed in the media from 0.25 to 0.065 mg/ml. Beads loaded with 4% Cu deactivated 99.97% of bacteria after 90 minutes, compared to a 44.2% reduction in viability in the …

Real Stem: Scientific Research For Rural Georgia High School Students, Deborah Walker, Robert L. Mayes, Raushanah Oglesby

Teaching & Learning: Faculty Presentations (2012-2017)

This is the story of creating a STEM research experience for students through a partnership between research institutes, university faculty, and high school teachers.

Projected Future Distributions Of Vectors Of Trypanosoma Cruzi In North America Under Climate Change Scenarios, Miroslava Garza, Teresa Patricia Feria-Arroyo, Edgar A. Casillas, Victor Sanchez-Cordero, Chissa-Louise Rivaldi, Sahotra Sarkar

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Background

Chagas disease kills approximately 45 thousand people annually and affects 10 million people in Latin America and the southern United States. The parasite that causes the disease, Trypanosoma cruzi, can be transmitted by insects of the family Reduviidae, subfamily Triatominae. Any study that attempts to evaluate risk for Chagas disease must focus on the ecology and biogeography of these vectors. Expected distributional shifts of vector species due to climate change are likely to alter spatial patterns of risk of Chagas disease, presumably through northward expansion of high risk areas in North America.

Methodology/Principal Findings

We forecast the future …

Numerical Simulation And Optimization Of Carbon Dioxide Utilization And Storage In Enhanced Gas Recovery And Enhanced Geothermal Systems, James H. Biagi

McKelvey School of Engineering Graduate Student Theses & Dissertations

With rising concerns surrounding CO₂ emissions from fossil fuel power plants, there has been a strong emphasis on the development of safe and economical Carbon Capture Utilization and Storage (CCUS) technology. Two methods that show the most promise are Enhanced Gas Recovery (EGR) and Enhanced Geothermal Systems (EGS). In Enhanced Gas Recovery a depleted or depleting natural gas reservoir is re-energized with high pressure CO₂ to increase the recovery factor of the gas. As an additional benefit following the extraction of natural gas, the reservoir would serve as a long-term storage vessel for the captured carbon. CO_{2 …}

An Ecological Framework To Assess Sustainability Impacts For An Evolving Consumer Electronic Product System, Erinn G. Ryen

Theses

Consumer electronics have revolutionized the manner in which we work, read, and entertain ourselves. However, this transformation comes at a high cost, with significant energy input and emissions releases across all stages of the electronic product life cycle. The limited success of per product efficiency improvements, often formulated in the field of industrial ecology, does not address the electronic product system as a whole because escalating consumption may actually offset any individual impact reductions. Additionally, existing industrial ecology models fail to effectively capture energy, material, and waste flows associated with real consumption patterns, as consumers purchase, use, and discard a …

Use Of Cholera Toxin B As A Vaccine Adjuvant Activates Antigen Presenting Cells And Stimulates Production Of Pro-Inflammatory Cytokines, Heather C. Romlein

Seton Hall University Dissertations and Theses (ETDs)

Francisella tularensis is an intracellular pathogen that has been classified as a category “A” bioterrorism agent by the Centers For Disease Control. To date, there is no approved vaccine to provide protection against this pathogen. Previous in vivo studies with mice have shown that a mucosally targeted vaccine preparation of inactivated F. tularensis (iFt) adjuvanted with Cholera toxin “B” (CTB), successfully granted full protection against a less virulent strain (FT LVS) of the bacterium and provided partial protection against a more virulent strain (SchuS4). However, the mechanisms of this protection are not fully understood. In this …

Primary Structure And Solution Conditions Determine Conformational Ensemble Properties Of Intrinsically Disordered Proteins, Albert Hsuan-Han Mao

All Theses and Dissertations (ETDs)

Intrinsically disordered proteins (IDPs) are a class of proteins that do not exhibit well-defined three-dimensional structures. The absence of structure is intrinsic to their amino acid sequences, which are characterized by low hydrophobicity and high net charge per residue compared to folded proteins. Contradicting the classic structure-function paradigm, IDPs are capable of interacting with high specificity and affinity, often acquiring order in complex with protein and nucleic acid binding partners. This phenomenon is evident during cellular activities involving IDPs, which include transcriptional and translational regulation, cell cycle control, signal transduction, molecular assembly, and molecular recognition. Although approximately 30% of eukaryotic …

Miniaturization Of Electrical Ultrafine Particle Sizers, Siqin He

McKelvey School of Engineering Graduate Student Theses & Dissertations

Nanoparticles, or ultrafine particles, have potential risks for human health, and the adverse health effects caused by ultrafine particles have been proven to be size related. To meet the increasing demanding for personal exposure monitoring and spatial distribution measurements of ultrafine particles, this dissertation studied the development and miniaturization of electrical ultrafine particle sizers (EUPS). There are three essential components for developing a EUPS unit: a charger to electrically charge the sample particles, an electrical mobility classifier to classify the charged particles, and a downstream particle count detector to measure the number concentrations. Two generations of EUPS were developed in …

Modeling And Development Of Iterative Reconstruction Algorithms In Emerging X-Ray Imaging Technologies, Jiaofeng Xu

All Theses and Dissertations (ETDs)

Many new promising X-ray-based biomedical imaging technologies have emerged over the last two decades. Five different novel X-ray based imaging technologies are discussed in this dissertation: differential phase-contrast tomography (DPCT), grating-based phase-contrast tomography (GB-PCT), spectral-CT (K-edge imaging), cone-beam computed tomography (CBCT), and in-line X-ray phase contrast (XPC) tomosynthesis. For each imaging modality, one or more specific problems prevent them being effectively or efficiently employed in clinical applications have been discussed. Firstly, to mitigate the long data-acquisition times and large radiation doses associated with use of analytic reconstruction methods in DPCT, we analyze the numerical and statistical properties of two classes …

Estimating The Prevalence And Correlates Of Psychiatric Disorders And Mental Health Problems Among Undocumented Mexican Immigrants Using The National Latino And Asian American Study, Elián P. Cabrera-Nguyen

Arts & Sciences Graduate Student Theses and Dissertations

This study examines the prevalence and correlates of psychiatric disorders and mental health problems among undocumented Mexican immigrants using the National Latino and Asian American Study (NLAAS). Two approaches were used to obtain estimates for likely undocumented Mexican immigrants (LUMIs): (1) creation of a proxy variable, and (2) multiple imputation using chained equations. Results indicated that LUMIs had greater prevalence rates for specific anxiety disorders, depressive disorders and poor self-rated mental health compared to documented Mexican immigrants. Next, potential mediators of poor mental health were identified. Finally, LUMIs were compared with other Latino groups by nativity status. This study concludes …

Effect Of Retrieval Practice On Applied Knowledge: Evidence From A Professional Training Program, Jenna Voss

Arts & Sciences Graduate Student Theses and Dissertations

A primary goal of deaf education teacher preparation programs is to help students acquire a sufficient body of factual and pedagogical knowledge and retain it for future application while serving children with hearing loss and their families. One potential way to improve teacher preparation is through the implementation of retrieval practice, a strategy to promote learning and retention of material over time. This study examined whether retrieval practice could be used to improve learning in an authentic educational environment, using real content, and real materials. While this study provided important information regarding the implementation of retrieval practice authentic classrooms, it …