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2014

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Detection And Cellular Imaging Of Human Cancer Enzyme Using A Turn-On, Wavelength-Shiftable, Self-Immolative Profluorophore, Suraj U. Hettiarachchi, Bijeta Prasai, Robin L. Mccarley May 2014

Detection And Cellular Imaging Of Human Cancer Enzyme Using A Turn-On, Wavelength-Shiftable, Self-Immolative Profluorophore, Suraj U. Hettiarachchi, Bijeta Prasai, Robin L. Mccarley

Faculty Publications

A frontier area in the development of activatable (turn-on) fluorescence-based probes is that concerned with rapid and selective stimulus triggering of probe activation so as to allow for biomarker identification and cellular imaging. The work here is concerned with a cloaked fluorophore composed of a reporter whose fluorescence is efficiently quenched by it being bound to an activatable trigger group through a novel self-immolative linker. Highly selective and rapid activation of the trigger group is achieved by chemical and enzymatic means that result in activated trigger group detachment from the self-immolative linker, with the latter subsequently cleaved from the reporter …

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Exploring Different Operationalizations Of Employee Engagement And Their Relationships With Workplace Stress And Burnout Among It Professionals In Community Hospitals, Paula E. Anthony-Mcmann May 2014

Exploring Different Operationalizations Of Employee Engagement And Their Relationships With Workplace Stress And Burnout Among It Professionals In Community Hospitals, Paula E. Anthony-Mcmann

Human Resource Development Theses and Dissertations

This study suggested that the relationships between workplace stress, burnout and employee engagement depend on how the construct of employee engagement is actually measured. The study's hypotheses predicted negative relationships between employee engagement and workplace stress and further predicted that burnout would play a mediating role in those negative relationships. However, it was predicted that even similarly conceptualized measures of employee engagement would expose different relationships with these variables suggesting that the selection of employee engagement measurement instruments is vital both to understanding different aspects of the construct and to its operationalization in practice. Responding to a resurgence in scholarly …

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Femininity, Masculinity, Gender, And The Role Of Shame On Christian Men And Women In The Evangelical Church Culture, Joy L. Hottenstein May 2014

Femininity, Masculinity, Gender, And The Role Of Shame On Christian Men And Women In The Evangelical Church Culture, Joy L. Hottenstein

Doctor of Psychology (PsyD)

Previous research has suggested that individuals (men and women) who endorse more feminine characteristics according to Bem’s Sex Role Inventory (BSRI) are more prone to shame. There have been no known studies conducted to determine if this link also exists within the Evangelical Christian church. Shame, across the research literature, is linked to psychological maladjustment and is defined as a sense that one’s core self is defective and comes up short on expectations. The purpose of this study is to test the relationship between gender, gender role, and shame for men and women who are active in the Evangelical church …

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Environmental Stimulation Chamber For Nanosatellite Functional Testing, Taylor Donato, Nicholas Page, Joshua Summers, Brandon Wood May 2014

Environmental Stimulation Chamber For Nanosatellite Functional Testing, Taylor Donato, Nicholas Page, Joshua Summers, Brandon Wood

Mechanical Engineering Senior Theses

The goal of this project is to develop a nanosatellite thermal testing chamber for the Robotic Systems Laboratory at Santa Clara University. The nanosatellite industry has thrived in recent years and continues to grow at the level of universities and small businesses. To meet this demand, the team designed and built a testing bed capable of achieving environmental conditions adequate for testing nanosatellite hardware as a low-cost and low-maintenance alternative to more expensive and robust systems. Furthermore, the design can be fully manufactured and assembled at the university or small business level with inexpensive, sustainable, and commercially available components. The …

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Binding Of Solvated Peptide (Eplqlkm) With A Graphene Sheet Via Simulated Coarse-Grained Approach, Somayyeh Sheikholeslami, R. B. Pandey, Nadiya Dragneva, Wely Floriano, Oleg Rubel, Stephen A. Barr, Zhifeng Kuang, Rajiv Berry, Rajesh Naik, Barry Farmer May 2014

Binding Of Solvated Peptide (Eplqlkm) With A Graphene Sheet Via Simulated Coarse-Grained Approach, Somayyeh Sheikholeslami, R. B. Pandey, Nadiya Dragneva, Wely Floriano, Oleg Rubel, Stephen A. Barr, Zhifeng Kuang, Rajiv Berry, Rajesh Naik, Barry Farmer

Faculty Publications

Binding of a solvated peptide A1 (1E 2P 3L 4Q 5L 6K 7M) with a graphene sheet is studied by a coarse-grained computer simulation involving input from three independent simulated interaction potentials in hierarchy. A number of local and global physical quantities such as energy, mobility, and binding profiles and radius of gyration of peptides are examined as a function of temperature (T). Quantitative differences (e.g., the extent of binding within a temperature range) and qualitative similarities are observed in results from three simulated potentials. Differences in variations of both local and …

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Overexpression Of The Astrocyte Glutamate Transporter Glt1 Exacerbates Phrenic Motor Neuron Degeneration, Diaphragm Compromise, And Forelimb Motor Dysfunction Following Cervical Contusion Spinal Cord Injury., Ke Li, Charles Nicaise, Daniel Sannie, Tamara J Hala, Elham Javed, Jessica L Parker, Rajarshi Putatunda, Kathleen A Regan, Valérie Suain, Jean-Pierre Brion, Fred Rhoderick, Megan C Wright, David J Poulsen, Angelo C Lepore May 2014

Overexpression Of The Astrocyte Glutamate Transporter Glt1 Exacerbates Phrenic Motor Neuron Degeneration, Diaphragm Compromise, And Forelimb Motor Dysfunction Following Cervical Contusion Spinal Cord Injury., Ke Li, Charles Nicaise, Daniel Sannie, Tamara J Hala, Elham Javed, Jessica L Parker, Rajarshi Putatunda, Kathleen A Regan, Valérie Suain, Jean-Pierre Brion, Fred Rhoderick, Megan C Wright, David J Poulsen, Angelo C Lepore

Farber Institute for Neuroscience Faculty Papers

A major portion of spinal cord injury (SCI) cases affect midcervical levels, the location of the phrenic motor neuron (PhMN) pool that innervates the diaphragm. While initial trauma is uncontrollable, a valuable opportunity exists in the hours to days following SCI for preventing PhMN loss and consequent respiratory dysfunction that occurs during secondary degeneration. One of the primary causes of secondary injury is excitotoxic cell death due to dysregulation of extracellular glutamate homeostasis. GLT1, mainly expressed by astrocytes, is responsible for the vast majority of functional uptake of extracellular glutamate in the CNS, particularly in spinal cord. We found that, …

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State V. Stone-Jones Appellant's Brief Dckt. 41513 May 2014

State V. Stone-Jones Appellant's Brief Dckt. 41513

Not Reported

No abstract provided.

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Digital Baboon: Curating 30 Years Of Primatology Research Data, Cynthia Hudson-Vitale, Jennifer Moore May 2014

Digital Baboon: Curating 30 Years Of Primatology Research Data, Cynthia Hudson-Vitale, Jennifer Moore

WashU Libraries Presentations

Many digital data curators will agree that making digital storage, online platform, digitization best practices, and metadata schema choices is a complicated process, even for a simple database. Curating a project that encompasses tooth casts, palm prints, field sheets, videos, images, and a database assembled over a thirty-year period extends those challenges, but also creates an opportunity to preserve and share an irreplaceable contribution to research. Librarians at Washington University in St. Louis are currently working with Dr. Jane Phillips-Conroy, Professor of Physical Anthropology; Anatomy and Neurobiology, to digitally curate this heterogeneous mix of physical and digital data. Dr. Phillips-Conroy’s …

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The Alestle - Vol. 66 No. 33 - 05/28/2014, Southern Illinois University Edwardsville May 2014

The Alestle - Vol. 66 No. 33 - 05/28/2014, Southern Illinois University Edwardsville

The Alestle

Vol. 66 No. 33

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Roles Of Seed Dispersal And Environmental Filters In Establishment Of The Dominant Shrubs: Morella Cerifera And M. Pensylvanica, On An Atlantic Barrier Island, Benjamin Dows May 2014

Roles Of Seed Dispersal And Environmental Filters In Establishment Of The Dominant Shrubs: Morella Cerifera And M. Pensylvanica, On An Atlantic Barrier Island, Benjamin Dows

Theses and Dissertations

Patterns of the expansion of woody cover into grasslands on barrier islands of the Virginia coast were investigated. Seed dispersal of the dominant shrub Morella spp., was sampled deploying seed traps (n = 82) throughout a landscape under shrub encroachment pressure on Hog Island, VA. Traps were placed underneath: fruiting Morella, non-fruiting Morella, co-occurring species (Iva frutescens and Baccharis halimifolia) and in grass land, (no shrub cover). Environmental filters that act upon dispersed seeds and subsequently determine establishment patterns were also investigated. Dispersal distribution throughout the encroachment zone was leptokurtic and dispersal among cover types suggest co-occurring shrub species facilitate …

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Perceived Discrepancies In Men's Motivations For Gender-Conforming Behaviors And Romantic Relationship Outcomes, Jonathan Robert Weaver May 2014

Perceived Discrepancies In Men's Motivations For Gender-Conforming Behaviors And Romantic Relationship Outcomes, Jonathan Robert Weaver

USF Tampa Graduate Theses and Dissertations

Healthy romantic relationships are positively associated with physical and mental health outcomes, and past research has shown that traditional masculinity negatively impacts relationship satisfaction. The current study examined the effects of men's discrepancies between their self-ratings and perceptions of their peers' on autonomous and pressured motivations to act agentically on relationship outcomes for both partners in a heterosexual relationship. In addition, men's investment in gender ideals was measured as a potential moderator and men's self-esteem as a potential mediator. Specifically, it was predicted that men's self-esteem would mediate the association between the investment-by-discrepancies (autonomous and pressured) interactions and relationship satisfaction …

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A Journey Into The Brain: From Molecules To Behavior, Johnathan King May 2014

A Journey Into The Brain: From Molecules To Behavior, Johnathan King

Meeting of the Minds

No abstract provided.

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Key Performance Indicators 2007-2012, Planning And Institutional Research May 2014

Key Performance Indicators 2007-2012, Planning And Institutional Research

Criterion 4 Documents

No abstract provided.

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Noel-Levitz Retention Report 2012, David Trites May 2014

Noel-Levitz Retention Report 2012, David Trites

Criterion 4 Documents

No abstract provided.

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Tolstoy’S Jesus Versus Dostoevsky’S Christ: A Tale Of Two Christologies, John Givens May 2014

Tolstoy’S Jesus Versus Dostoevsky’S Christ: A Tale Of Two Christologies, John Givens

From Russia with Love Symposium

No abstract provided.

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Withanolides, Probes And Binding Targets And Methods Of Use Thereof, Royce Mohan, Paola Bargagna-Mohan, Kyung Bo Kim May 2014

Withanolides, Probes And Binding Targets And Methods Of Use Thereof, Royce Mohan, Paola Bargagna-Mohan, Kyung Bo Kim

Ophthalmology and Visual Science Faculty Patents

Novel withanolide chemical genetic probes identify the in vivo binding target of withaferin A, which is the intermediate filament type III protein vimentin. In addition, a withanolide-based small molecule screening method screens drug candidates that target intermediate filament type III proteins. The method includes introducing a tagged linker covalently bonded to the withanolide molecule to form a withanolide probe. Better or alternative small molecule compounds as potential drug candidates can be generated based on their likely affinity for the determined binding site in vimentin. The affinity labeled withanolide can also be used to find intermediate filament-associated proteins using chemical proteomics …

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Controlling Cytomegalovirus: Helping The Immune System Take The Lead, Patrick J. Hanley, Catherine M. Bollard May 2014

Controlling Cytomegalovirus: Helping The Immune System Take The Lead, Patrick J. Hanley, Catherine M. Bollard

Pediatrics Faculty Publications

Cytomegalovirus, of the Herpesviridae family, has evolved alongside humans for thousands of years with an intricate balance of latency, immune evasion, and transmission. While upwards of 70% of humans have evidence of CMV infection, the majority of healthy people show little to no clinical symptoms of primary infection and CMV disease is rarely observed during persistent infection in immunocompetent hosts. Despite the fact that the majority of infected individuals are asymptomatic, immunologically, CMV hijacks the immune system by infecting and remaining latent in antigen-presenting cells that occasionally reactivate subclinically and present antigen to T cells, eventually causing the inflation of …

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Islamic Feminism: A Discourse Of Gender Justice And Equality, Breanna Ribeiro May 2014

Islamic Feminism: A Discourse Of Gender Justice And Equality, Breanna Ribeiro

Senior Theses

This paper examines Islamic feminism using structural methodology and the phenomenological approach to examine the component of Muslim feminists' activism that utilizes ijtihad and tafsir to reinterpret patriarchal rhetoric and highlight Islamic discourses that validate gender equality. These scholars and activists critically analyze Islamic theology by employing hermeneutics in order to produce Islamic exegeses that affirm social justice, gender equality, and liberation. Religion plays a critical role in building collective cultural identities; therefore, examining sacred texts' representation and prescription of gender roles and mores generates an understanding of the gender order in the community of believers, while simultaneously exposing contextual …

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Memorandum: Quality Assurance Of 2013 Great Bay Estuary Eelgrass Monitoring Program Conducted By Kappa Mapping, Inc., Matthew A. Wood May 2014

Memorandum: Quality Assurance Of 2013 Great Bay Estuary Eelgrass Monitoring Program Conducted By Kappa Mapping, Inc., Matthew A. Wood

Quality Assurance Project Plans

The purpose of this memorandum is to document the results of quality assurance checks on the 2013 Great Bay Estuary Eelgrass Monitoring Program.

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2014-May-27-Etsu Hosting Two Tennessee Governor’S Schools, University Marketing And Communications, East Tennessee State University May 2014

2014-May-27-Etsu Hosting Two Tennessee Governor’S Schools, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

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Oparil, Uab Earn High Marks For Treatment Of Hypertension, Reporter Staff May 2014

Oparil, Uab Earn High Marks For Treatment Of Hypertension, Reporter Staff

Browse All News

No abstract provided.

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Structural Approaches For Targeted Therapy, Somdutta Saha May 2014

Structural Approaches For Targeted Therapy, Somdutta Saha

Theses and Dissertations

Tumor associated carbohydrate antigens (TACAs) are a class of glycans with important structural and signaling functions playing a major role in cell proliferation, differentiation, and apoptosis relevant to oncology. Tumor cells expressing TACAs influence prognosis and survival of cancer patients. We have used structure-based approaches to study antigen-antibody interactions in the tumor micro-environment and designed a peptidyl ligand that mimics the molecular topology of TACAs even though they are chemically dissimilar but functionally equivalent molecular structures. The work on antibody-TACA interactions suggests that in designing antibodies, careful consideration should be made in using mutations that enhance the rigidity of an …

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Development Of The Tocoflexols: A New Kind Of Tocotrienol Analogues With Enhanced Bioavailability, Awantika Singh May 2014

Development Of The Tocoflexols: A New Kind Of Tocotrienol Analogues With Enhanced Bioavailability, Awantika Singh

Theses and Dissertations

Vitamin E is composed of two series of closely related compounds, tocopherols and tocotrienols, which show a widely varying degree of biological effectiveness. In recent years, the tocotrienols have gained considerable attention because of their beneficial effects in areas such as cholesterol reduction, neuroprotection, radiation protection and cancer treatment and prevention. Unfortunately, the potential of the tocotrienols has been hampered because their short circulation half-life that limits their bioavailability. The short circulation half-life of the tocotrienols is related to their low affinity for the &alpha,-tocopherol transfer protein, the protein responsible for maintaining the plasma level of the vitamin E. Tocotrienols …

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May 27, 2014 Ereporter, University Of Alabama At Birmingham May 2014

May 27, 2014 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

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Cannabinoid 2 (Cb2) Receptor Gene Promoter And Unique Rna Transcripts In B Cells And Methods Of Use, Thomas W. Klein, Tracy Sherwood, Liang Nong, Cathy Newton May 2014

Cannabinoid 2 (Cb2) Receptor Gene Promoter And Unique Rna Transcripts In B Cells And Methods Of Use, Thomas W. Klein, Tracy Sherwood, Liang Nong, Cathy Newton

USF Patents

Cannabinoid receptor 2 (CB2) is expressed in B lymphocytes and is involved in immune regulation. Mouse splenic B cells express three CB2 transcripts utilizing two different first exons. Human peripheral blood B cells express one CB2 transcript utilizing one first exon. Alignment of sequenced RACE products to either the mouse or human genome reveals that isolated transcripts contain previously unidentified transcriptional start sites (TSS). B cells from mouse and human preferentially express one transcript, exon 1a in mouse and exon 1 in human. Multiple CB2 TSSs are utilized in mouse splenic B cells and one TSS in human peripheral blood …

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Post Protein Hydrolysis Removal Of A Potent Ribonuclease Inhibitor And The Enzymatic Capture Of Dna, Matt Ewert May 2014

Post Protein Hydrolysis Removal Of A Potent Ribonuclease Inhibitor And The Enzymatic Capture Of Dna, Matt Ewert

USF Patents

The present invention concerns compositions and methods of extracting infectious pathogens from a volume of blood. In one embodiment, the method includes the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The present invention also concerns materials and methods for removing aurintricarboxylic acid (ATA) from a sample.

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Devices And Methods For Delivering Molecules To The Heart With Electric Fields, Richard Heller, William Marshall, Mark J. Jaroszeski May 2014

Devices And Methods For Delivering Molecules To The Heart With Electric Fields, Richard Heller, William Marshall, Mark J. Jaroszeski

USF Patents

A device and related methodologies to deliver molecules to the cells that comprise any tissues. The invention includes a catheter-based electrode and methods for its use for the delivery of molecules to cardiac tissue, blood vessels, other tissues/organs that can be accessed through a luminal tissue, and luminal tissues. The invention is also a non-catheter based electrode for performing the same functions. In certain embodiments the electrode utilizes a segmented electrode array wherein each electrode is separately addressable by a source of electricity.

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The Abstraction Of Toys, Dan Ruben Thornhill May 2014

The Abstraction Of Toys, Dan Ruben Thornhill

Theses and Dissertations

painting style. The toys depicted in the paintings were used at on time by my two grandchildren, Kaylee Smith and Brennan Thornhill, and serve as inspiration for this body of work. These compositions are based on direct observations of the toys used in this series, and relate to abstraction as defined in this thesis as simplification, distortion, exaggeration, invention, and erasure. The works that date later in the series fall under this definition. My work draws heavily upon Pablo Picasso and is influenced by his use of abstraction. The series tries to capture the essence of the toys and evoke …

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Change Blindness And The Relationship Of College Students With Different Majors, Samuel Friedman May 2014

Change Blindness And The Relationship Of College Students With Different Majors, Samuel Friedman

Theses and Dissertations

Change blindness is defined as a psychological phenomenon that occurs when a change in a visual stimulus goes unnoticed by the observer (Boundless, 2013). Change blindness can be any change in one's visual field and occurs due to the lack of attention or obstruction in one's visual field. A variety of factors influence change blindness, and gender became a major part to research. The purpose of this study was to study the influence of gender on change blindness and the relationship to college students' majors. Past research has shown us that females tend to be more visually detailed than males. …

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Briggs Library Takes Part In Assessment In Action, University Relations May 2014

Briggs Library Takes Part In Assessment In Action, University Relations

Campus News Archive

Briggs Library is one of 73 institutions selected to take part in the program.

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