Digital Commons Network^™

Nitroxide Radicals For Low Frequency Electron Paramagnetic Resonance Imaging (Epri), Joshua R. Biller

Electronic Theses and Dissertations

Optimization of nitroxides as probes for EPR imaging requires detailed understanding of spectral properties such as spin lattice relaxation times, spin packet linewidths, and nuclear hyperfine splitting. Initial measurements of relaxation times for six low molecular weight nitroxides at X-band stimulated further measurement at frequencies between 250 MHz and 34 GHz. The impact of tumbling was studied with perdeuterated 2,2,6,6-tetramethyl-4-piperidinyl-1-oxyl (PDT) in five solvents with viscosities resulting in tumbling correlation times, τ_R, between 4 and 50 ps. A set of three ¹⁴N/¹⁵N pairs of nitroxides in water was selected such that τ_R varied between …

Checkup, Lehigh Valley Health Network

Checkup

No abstract provided.

Whole-Lake Experiments Trace Added Terrestrial Particulate Organic Carbon In Benthic Food Webs Of Shallow Lakes, K. Scharnweber, J. Syvaranta, S. Hilt, M. Brauns, M. J. Vanni, Soren Brothers, J. Kohler, J. Knezevic-Jaric, T. Mehner

Watershed Sciences Faculty Publications

Lake ecosystems are strongly linked to their terrestrial surroundings by material and energy fluxes across ecosystem boundaries. However, the contribution of terrestrial particulate organic carbon (tPOC) from annual leaf fall to lake food webs has not yet been adequately traced and quantified. In this study, we conducted whole-lake experiments to trace artificially added tPOC through the food webs of two shallow lakes of similar eutrophic status, but featuring alternative stable regimes (macrophyte rich vs. phytoplankton dominated). Lakes were divided with a curtain, and maize (Zea mays) leaves were added, as an isotopically distinct tPOC source, into one half of each …

Form And Function Remixed: Developmental Physiology In The Evolution Of Vertebrate Body Plans, Stuart A. Newman

NYMC Faculty Publications

The most widely accepted model of evolutionary change, the Modern Evolutionary Synthesis, is based on the gradualism of Darwin and Wallace. They, in turn, developed their ideas in the context of 19th century concepts of how matter, including the tissues of animals and plants, could be reshaped and repatterned. A new physics of condensed, chemically, electrically and mechanically excitable materials formulated in the 20th century was, however, readily taken up by physiologists, who applied it to the understanding of dynamical, external condition-dependent and homeostatic properties of individual organisms. Nerve conduction, vascular and airway dynamics, and propagation of electrical excitations in …

Local Environmental History And The Journey To Ecological Citizenship, Michael B. Smith

Taproot: A Journal of Outdoor Education

This article describes a process of hands-on learning that Professor Michael Smith uses to help college students develop a sense of place and understand the meaning of civic engagement. It also suggests ways of evaluating a teacher’s pedagogical effectiveness. The article first appeared in the book, Citizenship Across the Curriculum, which describes how similar approaches to civic education can also be used in political science, mathematics, the natural sciences, rhetoric and communication studies. Smith’s inclusion of student comments about their course experience is especially insightful for scholars wishing to know more about the learning process.

In The News, Coalition For Education In The Outdoors

Taproot: A Journal of Outdoor Education

This section contains multiple brief news items related to conservation, environment, and outdoor education.

College Of Arts And Sciences E-News Issue 14: June 2014, College Of Arts And Sciences

College of Arts and Sciences news

• CAS News
• STEM instruction reform focus of $1.4 million
• Howard Hughes Medical Institute grant
• WMU wins 2014 Climate Leadership Award from Second Nature
• Faculty Feature
• Dr. Christine Byrd-Jacobs named Graduate College associate dean
• Multiple System Atrophy research by Dr. Charles Ide leads to repeat gift
• Alumni Profiles
• Matt Bahleda '11, political science and philosophy graduate, starts legal career in California
• Jacqui Volkmann '08, organizational communication alumna, talks business and bracelets
• WIDR's first station manager, David Gorski '76, manages multimedia services

A Simulation Protocol For Exercise Physiology In Fontan Patients Using A Closed Loop Lumped-Parameter Model, Ethan Kung, Giancarlo Pennati, Francesco Migliavacca, Tian-Yen Hsia, Richard Figliola, Alison Marsden, Alessandro Giardini

Publications

Background: Reduced exercise capacity is nearly universal among Fontan patients, though its etiology is not yet fully understood. While previous computational studies have attempted to model Fontan exercise, they did not fully account for global physiologic mechanisms nor directly compare results against clinical and physiologic data. Methods: In this study, we developed a protocol to simulate Fontan lower-body exercise using a closed-loop lumped-parameter model describing the entire circulation. We analyzed clinical exercise data from a cohort of Fontan patients, incorporated previous clinical findings from literature, quantified a comprehensive list of physiological changes during exercise, translated them into a computational model …

Characterization Of Pressure Driven And Electro-Kinetically Driven Flow In A Micro-Fluidic Chip Using Particle Imaging Velocimetry, Alexis Paige Weckel

Materials Engineering

The goal of this research is to compare electro-kinetic and pressure driven flow rates and velocity profiles (near wall vs. middle) in a microfluidic chip made of PDMS using particle imaging velocimetry (PIV) of an aqueous solution of fluorescent polystyrene (PS) particles using a laser confocal microscope (LCM). Microfluidic channels were fabricated out of PDMS using a SU-8 mold to be 25mm long and 180um by 1000um. Pressure-driven data did not show the expected parabolic profile because of the large width to depth ratio. In addition, data showed a calculated average significantly higher than the projected particle velocity through the …

The Effect Of Silicon On The Electrochemical Corrosion Resistance Of Carbon Steel, Loan Faget, Michael S. Rouse

Materials Engineering

The purpose of this study was to investigate how the silicon (Si) content of carbon steels affects their electrochemical corrosion resistance. Tests were conducted using concentrated HCl and carbonated water on three carbon steels with different levels of silicon: 0.02, 0,19, and 0.94 weight percent. Like H2S, the prime concern of Chevron, HCl and CO2 are corrosive components in oil refinery. Electrochemical properties were measured using a potentiodynamic test outlined in Standard ASTM G59-97: Test Method for Conducting Potentiodynamic Polarization Resistance Measurements. Previous studies have determined that adding silicon to steel increases the corrosion resistance; however, results show that corrosion …

Development Of Low Temperature, Aqueous Synthesis Method Of Lead Sulfide Quantum Dots, Albert Nakao, Colin Yee

Materials Engineering

Quantum dots have become an active area of research in the past decade due to their unique properties. Quantum confinement effects allow for efficient spectral conversion and size tunable fluorescence and absorption peaks. Near infrared spectral converting lead sulfide quantum dots have potential applications in solar power, biological imaging and communications technology. However at Cal Poly, lead sulfide dots have not been synthesized. The quantum dot synthesis currently adapted at Cal Poly encompasses organometallic precursors at high reaction temperatures, producing cadmium selenium dots. The organometallic approach has been found to produce nanocrystals with high quality photoluminescence, but due to its …

Automating Dicentric Chromosome Detection From Cytogenetic Biodosimetry Data., Peter K Rogan, Yanxin Li, Asanka Wickramasinghe, Akila Subasinghe, Natasha Caminsky, Wahab Khan, Jagath Samarabandu, Ruth Wilkins, Farrah Flegal, Joan H Knoll

Biochemistry Publications

We present a prototype software system with sufficient capacity and speed to estimate radiation exposures in a mass casualty event by counting dicentric chromosomes (DCs) in metaphase cells from many individuals. Top-ranked metaphase cell images are segmented by classifying and defining chromosomes with an active contour gradient vector field (GVF) and by determining centromere locations along the centreline. The centreline is extracted by discrete curve evolution (DCE) skeleton branch pruning and curve interpolation. Centromere detection minimises the global width and DAPI-staining intensity profiles along the centreline. A second centromere is identified by reapplying this procedure after masking the first. Dicentrics …

Long-Term Genomic And Epigenomic Dysregulation As A Consequence Of Prenatal Alcohol Exposure: A Model For Fetal Alcohol Spectrum Disorders, Morgan L Kleiber, Eric J Diehl, Benjamin I Laufer, Katarzyna Mantha, Aniruddho Chokroborty-Hoque, Bonnie Alberry, Shiva M Singh

Biology Publications

There is abundant evidence that prenatal alcohol exposure leads to a range of behavioral and cognitive impairments, categorized under the term fetal alcohol spectrum disorders (FASDs). These disorders are pervasive in Western cultures and represent the most common preventable source of neurodevelopmental disabilities. The genetic and epigenetic etiology of these phenotypes, including those factors that may maintain these phenotypes throughout the lifetime of an affected individual, has become a recent topic of investigation. This review integrates recent data that has progressed our understanding FASD as a continuum of molecular events, beginning with cellular stress response and ending with a long-term …

Divergent Transcriptional Responses To Low Temperature Among Populations Of Alpine And Lowland Species Of New Zealand Stick Insects (Micrarchus)., Luke T Dunning, Alice B Dennis, Brent J Sinclair, Richard D Newcomb, Thomas R Buckley

Biology Publications

In widespread and genetically structured populations, temperature variation may lead to among-population differentiation of thermal biology. The New Zealand stick insect genus Micrarchus contains four species that inhabit different thermal environments, two of which are geographically widespread. RNA-Seq and quantitative PCR were used to investigate the transcriptional responses to cold shock among lowland and alpine species to identify cold-responsive transcripts that differ between the species and to determine whether there is intraspecific geographical variation in gene expression. We also used mitochondrial DNA, nuclear 28S ribosomal DNA and transcriptome-wide SNPs to determine phylogeographic structure and the potential for differences in genetic …

Land Use And Climate Variability Amplify Carbon, Nutrient, And Contaminant Pulses: A Review With Management Implications, Sujay S. Kaushal, Paul M. Mayer, Philippe G. Vidon, Rose M. Smith, Michael J. Pennino, Tamara A. Newcomer, Shuiwang Duan, Claire Welty, Kenneth T. Belt

United States Environmental Protection Agency: Publications

Nonpoint source pollution from agriculture and urbanization is increasing globally at the same time climate extremes have increased in frequency and intensity. We review >200 studies of hydrologic and gaseous fluxes and show how the interaction between land use and climate variability alters magnitude and frequency of carbon, nutrient, and greenhouse gas pulses in watersheds. Agricultural and urban watersheds respond similarly to climate variability due to headwater alteration and loss of ecosystem services to buffer runoff and temperature changes. Organic carbon concentrations/exports increase and organic carbon quality changes with runoff. Nitrogen and phosphorus exports increase during floods (sometimes by an …

Sex-Biased Gene Flow Among Elk In The Greater Yellowstone Ecosystem, Brian K. Hand, Shanyuan Chen, Neil Anderson, Albano Beja-Pereira, Paul C. Cross, Michael Ebinger, Hank Edwards, Robert A. Garrott, Marty D. Kardos, Matt Kauffman, Erin L. Landguth, Arthur Middleton, Brandon Scurlock, P.J. White, Pete Zager, Michael K. Schwartz, Gordon Luikart

United States Geological Survey: Staff Publications

We quantified patterns of population genetic structure to help understand gene flow among elk populations across the Greater Yellowstone Ecosystem. We sequenced 596 base pairs of the mitochondrial control region of 380 elk from eight populations. Analysis revealed high mitochondrial DNA variation within populations, averaging 13.0 haplotypes with high mean gene diversity (0.85). The genetic differentiation among populations for mitochondrial DNA was relatively high (FST = 0.161; P = 0.001) compared to genetic differentiation for nuclear microsatellite data (FST = 0.002; P = 0.332), which suggested relatively low female gene flow among populations. The estimated ratio of male to female …

Digitalcommons Report: 2014, Jean Bigger

DigitalCommons Documents

DigitalCommons has been fully operational for two and a half years:

• 464 works to date | 43,278 full-text downloads to date | 27,613 downloads in the past years

Spatial Transmission Of 2009 Pandemic Influenza In The Us, Julia R. Gog, Sebastien Ballesteros, Cecile G. Viboud, Lone Simonsen, Ottar N. Bjornstad, Jeffrey Shaman, Dennis L. Chao, Farid Khan, Bryan T. Grenfell

Global Health Faculty Publications

The 2009 H1N1 influenza pandemic provides a unique opportunity for detailed examination of the spatial dynamics of an emerging pathogen. In the US, the pandemic was characterized by substantial geographical heterogeneity: the 2009 spring wave was limited mainly to northeastern cities while the larger fall wave affected the whole country. Here we use finely resolved spatial and temporal influenza disease data based on electronic medical claims to explore the spread of the fall pandemic wave across 271 US cities and associated suburban areas. We document a clear spatial pattern in the timing of onset of the fall wave, starting in …

Much Ado About Something: The First Amendment And Mandatory Labeling Of Genetically Engineered Foods, Stephen Tan, Brian Epley

Washington Law Review

This Article evaluates the free speech implications of laws requiring that GE foods be labeled and concludes that such regulations would meet all First Amendment requirements for compelled commercial speech. Part I traces the history of food labeling in the United States, the advent of genetic engineering, and the application of that technology in agriculture and the food industry. Part II evaluates the scope of commercial free speech and the appropriate test to be applied in determining whether a GE food labeling law would violate the First Amendment. Part III examines the impacts of an agricultural and food system increasingly …

Much Ado About Something: The First Amendment And Mandatory Labeling Of Genetically Engineered Foods, Stephen Tan, Brian Epley

Washington Law Review

This Article evaluates the free speech implications of laws requiring that GE foods be labeled and concludes that such regulations would meet all First Amendment requirements for compelled commercial speech. Part I traces the history of food labeling in the United States, the advent of genetic engineering, and the application of that technology in agriculture and the food industry. Part II evaluates the scope of commercial free speech and the appropriate test to be applied in determining whether a GE food labeling law would violate the First Amendment. Part III examines the impacts of an agricultural and food system increasingly …

Gwas Identifies An Nat2 Acetylator Status Tag Single Nucleotide Polymorphism To Be A Major Locus For Skin Fluorescence, Karen M. Eny, Helen L. Lutgers, John Maynard, Barbara E.K. Klein, Kristine E. Lee, Patricia A. Cleary, +20 Additional Authors

Epidemiology Faculty Publications

Aims/hypothesis

Skin fluorescence (SF) is a non-invasive marker of AGEs and is associated with the long-term complications of diabetes. SF increases with age and is also greater among individuals with diabetes. A familial correlation of SF suggests that genetics may play a role. We therefore performed parallel genome-wide association studies of SF in two cohorts.

Methods

Cohort 1 included 1,082 participants, 35–67 years of age with type 1 diabetes. Cohort 2 included 8,721 participants without diabetes, aged 18–90 years.

Results

rs1495741 was significantly associated with SF in Cohort 1 (p < 6 × 10−10), which is known to tag theNAT2 acetylator phenotype. The fast acetylator genotype was associated …

News From Hope College, Volume 45.5: June, 2014, Hope College

News from Hope College

No abstract provided.

Legal Protections For The 'Personal Best' Of Each Employee: Title Vii's Prohibition On Sex Discrimination, The Legacy Of Price Waterhouse V. Hopkins, And The Prospect Of Enda, Mary Anne Case

Articles

No abstract provided.

Gota A Gota, No. 5, 2014, Toni Pérez Fernández

KIP Articles

Portada de GOTA A GOTA nº 5 (2014) -- Editorial y datos de la publicación -- Presencia de Dolichorhabditis tipulae (Lam et Webster, 1971) Andrássy, 2005 (Nematoda, Rhabditida) en el Sistema de la Murcielaguina (Provincia de Jaén, España) / Joaquín Abolafia Cobaleda y Jaime Lechuga Puñal -- El cristal de Hispania (lapis specularis) / Roberto F. García -- Inventario de gasterópodos de la Cueva "Los Márquez"/ Félix Ríos Jiménez y Juan Sebastián Torres Alba -- Complejo kárstico Las Motillas (Términos Municipales Jerez-Cortes, Cádiz-Málaga)

Draft Environmental Impact Report: City Of Clearlake General Plan Update, Hannah Cha

Master's Theses

The City of Clearlake in northern California initiated its first general plan update in 2012.The City decided to do an Environmental Impact Report (EIR) for the general plan update in order to fulfill the California Environmental Quality Act’s (CEQA) requirements.The author wrote the Agriculture and Biological Resources sections of the EIR.She explains the CEQA process for a programmatic-level EIR, and summarizes the lessons learned and recommendations for CEQA.

General CEQA issues include fear of litigation and vague requirements for thresholds of significance.Additional CEQA issues include difficulty applying the same level of analysis to programmatic projects when the Environmental Checklist is …

The Effect Of Temperature And Extraction Technique On The Binding Interactions And Hydrolysis Of Β-Lactoglobulin With Milk Fat Globule Membrane (Mfgm), Corbin R. Kembel

Master's Theses

Whey protein, containing predominately b-Lactoglobulin (b-LG), is a popular choice among consumers looking for an excellent protein source. Likewise, fat is a natural component in milk and dairy products. Lipids are packaged within a membrane called the Milk Fat Globule Membrane (MFGM). The MGFM contains a variety of lipids and proteins. Although b-LG has been extensively characterized, the function of the protein is largely unknown. The objectives of this study were to assess the enzymatics of b-LG in an isolated system, evaluate the propensity of b-LG to bind to MFGM, determine the effects of temperature and fat extraction method on …

Beef Export Price Response To Sanitary Status And Traceability Systems: Implications For Paraguay, Silvana Careaga

Master's Theses

Global beef markets are highly influenced by sanitary issues, mainly related to animal health and food safety, which have been determining levels and trends in global beef trade. Food safety issues affecting human health such as bovine spongiform encephalopathy (BSE) associated with Creutzfeldt-Jacob Disease (vCJD) in humans, and other diseases affecting production such as foot and mouth disease (FMD) has encouraged putting these issues to beef trade attention. A way to address these concerns and comply with international standards is the use of traceability systems in order to quickly identify hazard sources and assure beef quality and safety. The goal …

Repeating The Failures Of Carbon Trading, Brittany A. Harris

Washington International Law Journal

Carbon emissions trading, or cap-and-trade, is increasingly in vogue among Pacific Rim countries as a means of combating climate change. In theory, cap-and-trade promises to solve climate change by capping and gradually reducing the amount of carbon dioxide and greenhouse gas emissions, and to do so with maximum economic efficiency. In reality, environmentally effective and economically efficient carbon emission trading systems have eluded both the international community and the European Union, and in practice have arguably increased emissions by artificially prolonging and legitimizing reliance on fossil fuels. In spite of this poor track record, five countries on the Pacific Rim …

Toward A Co-Vivial Community: Hopes Found In The Friendship Among People With Intellectual Disability Labels, Maho Suzuki

Dissertations - ALL

This is a qualitative study of friendships among people with intellectual disability labels in two countries - the United States and Japan. As a field to study friendships among adults with intellectual disability label, I gained access to two sheltered workshops ("The Farm" in the U.S. and "The Kapu Kapu" in Japan) and conducted participant observation, through which I wished to identify broader, multiple, and more humane ways to define competence and human value that could validate people labeled intellectually disabled whose humanity and citizenship are often doubted by dominant standards in industrialized societies. In addition to resisting social standards …

Book Review - Abominable Science!: Origins Of The Yeti, Nessie, And Other Famous Cryptids, J. Matthew Hoch

Marine & Environmental Sciences Faculty Articles

No abstract provided.