Digital Commons Network^™

Multisite Phosphorylation Of The Sum1 Transcriptional Repressor By S-Phase Kinases Controls Exit From Meiotic Prophase In Yeast., Daniel Corbi, Sham Sunder, Michael Weinreich, Aikaterini Skokotas, Erica S Johnson, Edward Winter

Department of Biochemistry and Molecular Biology Faculty Papers

Activation of the meiotic transcription factor Ndt80 is a key regulatory transition in the life cycle of Saccharomyces cerevisiae because it triggers exit from pachytene and entry into meiosis. The NDT80 promoter is held inactive by a complex containing the DNA-binding protein Sum1 and the histone deacetylase Hst1. Meiosis-specific phosphorylation of Sum1 by the protein kinases Cdk1, Ime2, and Cdc7 is required for NDT80 expression. Here, we show that the S-phase-promoting cyclin Clb5 activates Cdk1 to phosphorylate most, and perhaps all, of the 11 minimal cyclin-dependent kinase (CDK) phospho-consensus sites (S/T-P) in Sum1. Nine of these sites can individually promote …

2014 Central Washington University Commencement, Central Washington University

Commencement Programs

A commencement program from graduation ceremonies at Central Washington University.

Dominican Hosts International Big History Conference, Sarah Gardner, Dave Albee

Press Releases

The conference was hosted by Dominican's First Year Big History program which, in the last two years, hosted educators from the United States, South Korea, Brazil and Australia on campus for its annual Big History Summer Institute.

Effects Of The Interception Of Litterfall By The Understory On Carbon Cycling In Eucalyptus Plantations Of South China, Long Yang, Jun Wang, Yuhui Huang, Dafeng Hui, Meili Wen

Biology Faculty Research

For the purposes of forest restoration, carbon (C) fixation, and economic improvement, eucalyptus (Eucalyptus urophylla) has been widely planted in South China. The understory of eucalyptus plantations is often occupied by a dense community of the fern Dicranopteris dichotoma, which intercepts tree canopy leaf litter before it reaches the ground. To understand the effects of this interception of litterfall on C cycling in eucalyptus plantations, we quantified the mass of intercepted litter and the influences of litterfall interception on litter decomposition and soil respiration. The total mass of E. urophylla litterfall collected on the understory was similar to that collected …

Uncertainty Quantification Driven Predictive Multi-Scale Model For Synthesis Of Mycotoxins, Sourav Banerjee, Gabriel A. Terejanu, Anindya Chanda

Faculty Publications

Many toxic molds synthesize and release an array of poisons, termed mycotoxins that have an enormous impact on human health, agriculture and economy [1]. These molds contaminate our buildings, indoor air and crops, cause life threatening human and animal diseases and reduce agricultural output [2]. In order to design appropriate approaches to minimize the detrimental effects of these fungi, it is essential to develop diagnostic methodologies that can rapidly and accurately determine based on fungal strains and their growth patterns, the extent of mycotoxin mediated damage caused to the environment.Here we developed a novel multi-scale predictive mathematical model that could …

Eastern Washington University Commencement Program, 2014, Eastern Washington University

Commencement Programs

Program for Eastern Washington University's spring commencement in 2014

Traceability Implementation In Organic Farming: Case Study, Chamomile Tea Production, Shaima Abdelfattah Ibrahim

Theses and Dissertations

Implementing a traceability plan in an herbal production plant is a complex task. In this study an attempt to integrate food safety, quality and traceability through the different stages of the organic German Chamomile (Matricaria recutita) production chain was made. First, all the current relevant international laws, regulations and standards regarding traceability, safety and quality, with emphasis on how and why they are necessary for any food production chain, were set forward. Second, physico-chemical and microbiological analyses were run throughout the different processing stages of production, for four different Chamomile batches produced over the same season using the same farming …

Teaching To The Test: A Pragmatic Approach To Teaching Logic, Seth C. Vannatta

Education and Culture

The proper goal of an introductory logic course, teaching critical thinking, is best achieved by maintaining the principle of continuity between student experiences and the curriculum. To demonstrate this I explain Dewey’s naturalistic approach to logic and the process of inquiry, one which presents the elements of traditional logic in the context of student experiences. I offer an example of a logic textbook which models the maintenance of the principle of continuity I advocate. Last, I advocate a pluralistic and experimental approach to accomplish this, including methods that rely on the role of the body in learning and reasoning.

Unity Vs. Uniformity: The Influence Of Ziya Gökalp And John Dewey On The Education System Of The Republic Of Turkey, Rasit Celik

Education and Culture

Creating a democratic nation-state and sustaining its progress was seen by the founders of the Republic of Turkey as necessary to achieving the goal of becoming a distinguished member among developed civilizations. The founders conceived of education as a main instrument in disseminating this new ideology and ensuring the emergence of a culture of democracy in Turkish society. Accordingly, establishing a new education system was a primary consideration during the early years of the Republic. Scholars, looking at the issue from diverse perspectives, have routinely revealed the influence of John Dewey’s report on Turkish education and discussed how his recommendations …

On The Sustainable Management Of Sewage Sludge Disposal In Apulia, A.M. Lotito, U. Fratino, M. Blonda

Wastewater and Biosolids Treatment and Reuse: Bridging Modeling and Experimental Studies

No abstract provided.

06-13-2014 Summer Science & Math Academy Starts Sunday At Swosu, Southwestern Oklahoma State University

THE BARK ARCHIVE 2014

Southwestern Oklahoma State University will host its annual Summer Science & Mathematics Academy (SSMA) on the Weatherford campus starting June 15 and continuing through June 27.

Wastewater Treatment And Reuse In The Oil & Petrochem Industry – A Case Study, Alberto Girardi

Wastewater and Biosolids Treatment and Reuse: Bridging Modeling and Experimental Studies

No abstract provided.

Design Of Semiconductors-Based Composites For The Efficient Photodegradation Of Organic Micropollutants In Water, Giuseppe Mele

Wastewater and Biosolids Treatment and Reuse: Bridging Modeling and Experimental Studies

No abstract provided.

Wastewater Reuse In Apulia: Between Dream And Reality, Antonio Lopez

Wastewater and Biosolids Treatment and Reuse: Bridging Modeling and Experimental Studies

No abstract provided.

The Setonian, June 13, 2014, Seton Hall University

2014

No abstract provided.

Kasich Announces Reappointment Of A&S Biology Alum To Ohio University Board, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Class Of 2018: North Baltimore Senior To Study Biology Premed, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Forensic Chemistry, Carrie Duesing, Bonnie Brawner

Understanding by Design: Complete Collection

Students will independently use their learning to… --apply chemistry knowledge in a real-world situation. --use problem-solving skills to investigate a mock crime --integrate multiple skills, techniques, chemistry tools, chemistry (or physics or biology) concepts to solve a real-world problem.

Class Of 2018: Ohio University Credit Union Scholarship Recipient To Study Biology, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Integrating Sequence And Array Data To Create An Improved 1000 Genomes Project Haplotype Reference Panel, Olivier Delaneau, Jonathan Marchini, Gil A. Mcveanh, Peter Donnelly, Gerton Lunter, Jonathan L. Marchini, Simon Myers, Anjali Gupta-Hinch, Zamin Iqbal, Iain Mathieson, Andy Rimmer, Dionysia K. Xifara, Angeliki Kerasidou, Claire Churchhouse, David M. Altshuler, Stacey B. Gabriel, Eric S. Lander, Namrata Gupta, Mark J. Daly, Mark A. Depristo, Eric Banks, Gaurav Bhatia, Mauricio O. Carneiro, Guillermo Del Angel, Giulio Genovese, Robert E. Handsaker, Chris Hartl, Steven A. Mccarroll, James C. Nemesh, Ryan E. Poplin, Stephen F. Schaffner, Khalid Shakir, Pardis C. Sabeti, Sharon R. Grossman

Faculty Publications

A major use of the 1000 Genomes Project (1000GP) data is genotype imputation in genome-wide association studies (GWAS). Here we develop a method to estimate haplotypes from low-coverage sequencing data that can take advantage of single-nucleotide polymorphism (SNP) microarray genotypes on the same samples. First the SNP array data are phased to build a backbone (or 'scaffold') of haplotypes across each chromosome. We then phase the sequence data 'onto' this haplotype scaffold. This approach can take advantage of relatedness between sequenced and non-sequenced samples to improve accuracy. We use this method to create a new 1000GP haplotype reference set for …

A Rule-Based Prognostic Model For Type 1 Diabetes By Identifying And Synthesizing Baseline Profile Patterns, Ying Lin, Xiaoning Qian, Jeffrey Krischer, Kendra Vehik, Hye-Seung Lee, Shuai Huang

Industrial and Management Systems Engineering Faculty Publications

Objective: To identify the risk-predictive baseline profile patterns of demographic, genetic, immunologic, and metabolic markers and synthesize these patterns for risk prediction.

Research Design and Methods: RuleFit is used to identify the risk-predictive baseline profile patterns of demographic, immunologic, and metabolic markers, using 356 subjects who were randomized into the control arm of the prospective Diabetes Prevention Trial-Type 1 (DPT-1) study. A novel latent trait model is developed to synthesize these baseline profile patterns for disease risk prediction. The primary outcome was Type 1 Diabetes (T1D) onset.

Results: We identified ten baseline profile patterns that were significantly predictive to the …

Developing Crosslinking Constructs Of Protein Kinase R, Prisma E. Lopez

Honors Scholar Theses

Protein Kinase R (PKR) is a key component of the innate immune antiviral response. PKR is activated upon binding to dsRNA. However, recent studies have shown that PKR can also bind to and become activated by duplex RNAs containing complex secondary structure. The mechanism of PKR binding and activation by these RNAs is currently not known. The approach taken here to determine the mechanism of PKR binding by these RNAs is through the development of PKR constructs that are capable of covalently binding to RNAs. Constructs were created by site-specific incorporation of an unnatural, photoactivatable amino acid within PKR. These …

Nutrient Additions To Mitigate For Loss Of Pacific Salmon: Consequences For Stream Biofilm And Nutrient Dynamics, Amy Marcarelli, Colden V. Baxter, Mark S. Wipfli

Department of Biological Sciences Publications

Mitigation activities designed to supplement nutrient and organic matter inputs to streams experiencing decline or loss of Pacific salmon typically presuppose that an important pathway by which salmon nutrients are moved to fish (anadromous and/or resident) is via nutrient incorporation by biofilms and subsequent bottom-up stimulation of biofilm production, which is nutrient-limited in many ecosystems where salmon returns have declined. Our objective was to quantify the magnitude of nutrient incorporation and biofilm dynamics that underpin this indirect pathway in response to experimental additions of salmon carcasses and pelletized fish meal (a.k.a., salmon carcass analogs) to 500-m reaches of central Idaho …

In Vivo Effects Of A Ramba And Vitamin A Deficiency On Ovary Development, Michael H. Akroush

College of Science and Health Theses and Dissertations

The active metabolite of vitamin A, retinoic acid, is vital to several physiological functions, and is most notably associated with vision and organ development Its role in the male reproductive system is well understood, but studies in female reproduction are lacking. Recent studies show that Cyp26b1, a retinoic acid degrading enzyme, is expressed highly in the Day1-10 mouse ovary. This time point correlates with establishment of the primordial follicle pool. In vitro studies show that both retinoic acid and R115866, an agent that blocks retinoic acid metabolism, increase cell proliferation. Because of this, we hypothesized that retinoic acid plays a …

A Scale Of Heroic Cognition For Workplace Contexts, Patrick Joseph Furey

College of Science and Health Theses and Dissertations

Interest in research on heroism has begun to increase during the past decade, but, despite the ancient roots of heroism embedded deeply in cultures around the world, empirical work on the subject is relatively sparse. Direct and explicit empirical study of heroism in organizational contexts, specifically, is especially rare. The lack of organizational heroism research is surprising. There is a preponderance of evidence that organizational wrongdoing is observed across many organizations, sometimes to great extremes that are in violation of federal law, and it can have profound social impact. Organizational members who become aware of extreme wrongdoing committed by others …

Redox-Neutral Catalytic Spirocyclization Of Para-Methoxy Aryl Alkynoate Esters, Mark Docto Aparece

College of Science and Health Theses and Dissertations

Spirocycles are a class of molecules consisting of a quaternary atom al the junction of two fused rings. This structural motif is found in a number of biologically active natural products and pharmaceuticals. Current strategies to synthesize these structures include classical methods such as alkylation and rearrangement, as well as more modern methods reported in the past decade which utilize electrophilic halogen reagents. As part of our research interests in clectrophilic transition metal catalysts to effect powerful transformations, we developed the first redox-neutral spirocyclization of para-methoxy aryl alkynoate esters using homogeneous gold catalysis. The reaction proceeds at ambient temperature in …

Empowerment Of Underrepresented Racial/Ethnic Minority College Students In The United States: Developing And Testing The College Student Empowerment Scales For Racial/Ethnic Minorities, Lindsey Therese Back

College of Science and Health Theses and Dissertations

Empowerment, a core value of community psychology, is defined as a process by which people, organizations, and communities gain mastery over issues of concern to them in their lives (Rappaport, 1987). In community psychology, empowerment is understood as a construct particularly and primarily salient for minority t,>roups who hold a marginalized position in society, as psychological empowerment is a product of an individual's interaction with his or her context. Consistent with a social justice framework, community psychology attempts to empower those who have traditionally been disenfranchised in particular contexts. One such population is underrepresented racial/ethnic minority students in higher …

"Is That What You Dream About? Being A Monster?": Bella Swan And The Construction Of The Monstrous-Feminine In The Twilight Saga, Amanda Jayne Firestone

USF Tampa Graduate Theses and Dissertations

ABSTRACT

This dissertation argues that Bella Swan is a representation of Barbara Creed's monstrous-feminine which serves to reinforce ideologies that insist women are abject, inherently dangerous to men, and threatening to a patriarchal status quo. Through close-textual analysis of The Twilight Saga, I demonstrate how the monstrous-feminine frames the hysterical teenage body, hypersexuality, and eternal motherhood as simultaneously unacceptable and unavoidable. These negative women's stereotypes continue to persist in dominant popular culture, and this doublebind is overcome only by the impossible perfection of vampirism. The monstrous-feminine invites constructions of teenage bodies as unstable and unreliable, women's sexuality as dangerous and …

Practicing Patienthood Online: Social Media, Chronic Illness, And Lay Expertise, Collette Sosnowy

Publications and Research

The use of digital technologies and social media by people with serious illness to find, share, and create health information is much celebrated but rarely critiqued. Proponents laud “Health 2.0” as transforming health care practice and empowering patients. Critics, however, argue that a discourse of developing lay expertise online masks the disciplinary practices of the neoliberal state’s emphasis on individual responsibility. Notably, the perspectives of people who are engaging with social media related to their health and illness are under-represented in this debate. This research examines the experiences and perspectives of women who blog about their lives with Multiple Sclerosis …

Water And Health In The Nandamojo Watershed Of Costa Rica: Community Perceptions Towards Water, Sanitation, And The Environment, James Mcknight

USF Tampa Graduate Theses and Dissertations

Understanding the relationships between human health, water, sanitation, and environmental health is a requirement to understanding the challenges that face researchers when it comes to addressing global health relating to water and sanitation. Access to improved water and sanitation is not only a precondition to health, but to all aspects of daily living. Target 7.C of the Millennium Development Goals (MDGs) addresses worldwide disparities in access to improved water and sanitation by calling for the reduction in "half of the proportion of people without sustainable access to safe drinking water and sanitation by 2015". Over 90% of the population of …