Digital Commons Network^™

Governing A Global Commons: Sharks In The High Seas, Jared R. Wigginton

Villanova Environmental Law Journal (1991 - )

No abstract provided.

Alternative Lithographic Methods For Variable Aspect Ratio Vias, Anthony R. Schepis

Theses

The foundation of semiconductor industry has historically been driven by scaling. Device size reduction is enabled by increased pattern density, enhancing functionality and effectively reducing cost per chip. Aggressive reductions in memory cell size have resulted in systems with diminishing area between parallel bit/word lines. This affords an even greater challenge in the patterning of contact level features that are inherently difficult to resolve because of their relatively small area, a product of their two domain critical dimension image. To accommodate these trends there has been a shift toward the implementation of elliptical contact features. This empowers designers to maximize …

Controlling Pseudomonas Aeruginosa Biofilms And Persister Cells By Manipulating Cell-Cell Signaling, Shuyuan Ma

Theses - ALL

Bacterial cells often form sessile biofilms that are up to 1,000 times more resistant to antimicrobial agents than free-living cells. Meanwhile, bacteria produce a small subpopulation of slow-growing or non-growing persister cells that exhibit high tolerance to antibiotics. Both biofilms and persister cells play important roles in the recalcitrance of chronic infections. Recent studies have shown that bacterial cell-to-cell communication, named quorum sensing (QS), is involved in the biofilm and persister formation.

In this study, we investigated the effects of quorum sensing signals N-(3-oxododecanoyl)-homoserine lactone (3-oxo-C12-HSL) and N-butyryl homoserine lactone (C4-HSL) on isolated Pseudomonas aeruginosa PAO1 and PDO300 persister cells. …

Neurotrophic Factor Gdnf Promotes Survival Of Salivary Stem Cells, Nan (Tori) Xiao, Yuan Lin, Hongbin Cao, Davud Sirjani, Amato J. Giaccia, Albert C. Koong, Christina S. Kong, Maximilian Diehn, Quynh-Thu Le

All Dugoni School of Dentistry Faculty Articles

Stem cell-based regenerative therapy is a promising treatment for head and neck cancer patients that suffer from chronic dry mouth (xerostomia) due to salivary gland injury from radiation therapy. Current xerostomia therapies only provide temporary symptom relief, while permanent restoration of salivary function is not currently feasible. Here, we identified and characterized a stem cell population from adult murine submandibular glands. Of the different cells isolated from the submandibular gland, this specific population, Lin-CD24+c-Kit+Sca1+, possessed the highest capacity for proliferation, self renewal, and differentiation during serial passage in vitro. Serial transplantations of this stem cell population into the submandibular gland …

Probiotic Potential Of Bacterial Isolates From ‘Amabere Amaruranu’ Cultured Milk, Blaise B. Boyiri

Electronic Theses and Dissertations

Probiotics are viable nonpathogenic microbes that positively affect host health. Probiotics inhibit infection, activate immunity, and promote mucosal-barrier development. Many microbes have probiotic activity. Nonetheless, the selection of stable strains and their specific mechanism(s) of action are not fully elucidated. Bacteria from ‘Amabere amaruranu’ cultured milk from Kenya were isolated and identified by PCR sequence analysis of the 16S rRNA gene. Isolates were examined for stability to acid and bile, antimicrobial activity, mucin production, and degradation and sensitivity to antibiotics, hence their potential for probiotics. Lactobacillus isolates were acid unstable, bile-stable, nonmucinolytic, and presented antibacterial activity. L. rhamnosus cell fractions …

Coach And Athlete Perceptions Of An Athlete Monitoring And Strength And Conditioning Program, Jacob P. Reed

Electronic Theses and Dissertations

Purpose: The purpose of this investigation was to assess athlete perceptions of an athlete monitoring program throughout an academic year and coach perceptions throughout a competitive season. The secondary purpose was to develop a questionnaire designed to assess coach and athlete perceptions of the monitoring program. Methods: Athletes and coaches participating in the athlete monitoring program at East Tennessee State University’s (ETSU) Sport Performance Enhancement Consortium (SPEC) were invited to participate. Reliability for the coach and athlete questionnaires and principle components analysis (PCA) of the athlete questionnaire was completed after initial development of the questionnaire (11 questions for athletes and …

An Empirical Analysis Of The Role Of Geography In Sustainability Education, Makayla Jane Bonney

Theses

Many within and outside of the discipline of geography see it as a highly appropriate home for sustainability studies. Despite a history of human-environment education within geography and support from professional research or education organizations, some studies show that geography has not developed a lead role in sustainability education. This study examines the role of geography in offering "Sustainability Focused" courses as reported by AASHE STARS institutions with geography programs. The results show that although geography departments are highly utilized when available at an institution -offering the highest proportion of sustainability courses, averaging 14% of "Sustainability Focused" curriculum- there is …

A Scale To Measure The Complexity And Perceptual-Cognitive Skills In Soccer, Maurici Abraham Lopez Felip

Theses

The complexity of dynamical systems (spanning brain, body and environment) can yield complex adaptive behaviors from non-linear interactions of individuals in space and time. A lack of reliable instruments to assess these varying behaviors results in inferences of how changes in behavior occurred over an extended period of time rather than being based on direct scientific measures. The aim of this study was to develop a scale of complexity and perceptual-cognitive skills' assessment in the sport soccer and to evaluate structural and criterion reliability. Based on the embodied cognition literature, the construct of this scale was identified with three dimensions …

Putting Men Back In The Menstrual Cycle: A Qualitative Analysis Of Men's Perceptions Of Menstruation, Katherine Fishman

Theses

Although menstruation is typically regarded as an indication of health (Kissling, 1996), strong cultural messages about menstruation perpetuate the belief that it is dirty, disgusting and a state that must be managed (Ussher, 2006). Many women internalize this belief and go to great lengths to hide their menstrual status (Chrisler, 2007). Negative attitudes toward menstruation have been linked to decreased body satisfaction (Schooler, Ward, Meriwether, & Caruthers, 2005), perceptions of decreased competence and likability (Roberts, Goldenberg, Power, & Pyszynski, 2002), and the belief that menstruating women are more emotional, less attractive, and more irritable than non-menstruating women (Forbes, Adams-Curtis, White, …

Foreword, Katharine T. Bartlett, Elizabeth S. Scott

Law and Contemporary Problems

No abstract provided.

An Off-Label Use Of Parental Rights? The Unanticipated Doctrinal Antidote For Professor Mnookin’S Diagnosis , Emily Buss

Law and Contemporary Problems

No abstract provided.

From Third Parties To Parents: The Case Of Lesbian Couples And Their Children , Nancy D. Polikoff

Law and Contemporary Problems

No abstract provided.

The Child-Welfare System And The Limits Of Determinacy , Clare Huntington

Law and Contemporary Problems

No abstract provided.

Child Custody Revisited , Robert Mnookin

Law and Contemporary Problems

No abstract provided.

Estimating The Number Of Cases Of Occupational Cancer In Quebec, France Labrèche, Patrice Duguay, Alexandre Boucher, Robert Arcand

Portraits statistiques

Comme dans la majorité des pays industrialisés, le cancer constitue la première cause de décès au Québec : en 2013, on estime à 20 200 le nombre de décès par cancer et à 48 700 le nombre de nouveaux diagnostics de cancer.

La cancérogénèse est un processus multifactoriel et complexe, qui débute plusieurs années avant que le cancer n’apparaisse cliniquement. Un cancer est considéré d’origine professionnelle lorsqu’il résulte de l’exposition, en milieu de travail, à un agent chimique, physique ou biologique, ou encore de conditions inhérentes à une activité de travail. Il s’agit d’un cancer qui ne se serait probablement …

Genetic Variations In Two Seahorse Species (Hippocampus Mohnikei And Hippocampus Trimaculatus): Evidence For Middle Pleistocene Population Expansion, Yanhong Zhang, Nancy Kim Pham, Huixian Zhang, Junda Lin, Qiang Lin

Ocean Engineering and Marine Sciences Faculty Publications

Population genetic of seahorses is confidently influenced by their species-specific ecological requirements and life-history traits. In the present study, partial sequences of mitochondrial cytochrome b (cytb) and control region (CR) were obtained from 50 Hippocampus mohnikei and 92 H. trimaculatus from four zoogeographical zones. A total of 780 base pairs of cytb gene were sequenced to characterize mitochondrial DNA (mtDNA) diversity. The mtDNA marker revealed high haplotype diversity, low nucleotide diversity, and a lack of population structure across both populations of H. mohnikei and H. trimaculatus. A neighbour-joining (NJ) tree of cytb gene sequences showed that H. mohnikei haplotypes formed …

The Non-Erythroid Membrane Skeleton And Its Role In Mechanotransduction, Eleni Kinfe Degaga

Dissertations - ALL

The thesis is concerned with questions regarding cellular bio-mechanics and cell surface interactions. A particular focus is thereby on the role of the spectrin membrane skeleton in transducing forces to and from non-erythroid mammalian cells. This spectrin based membrane skeleton has been the focus of much study in the context of red blood cells, as it determines their mechanical properties due to the lack of an extended actin based cytoskeleton. In stark contrast, the corresponding structure in non-erythroids is much less studied and understood, although it seems to play important roles in organization of membrane associated proteins, cellular mechanics, adhesion, …

Rorα Binds To E2f1 To Inhibit Cell Proliferation And Regulate Mammary Gland Branching Morphogenesis, Gaofeng Xiong, Ren Xu

Markey Cancer Center Faculty Publications

Retinoic acid receptor-related orphan nuclear receptor alpha (RORα) is a potent tumor suppressor that reduces cell proliferation and inhibits tumor growth. However, the molecular mechanism by which it inhibits cell proliferation remains unknown. We demonstrate a noncanonical nuclear receptor pathway in which RORα binds to E2F1 to inhibit cell cycle progression. We showed that RORα bound to the heptad repeat and marked box region of E2F1 and suppressed E2F1-regulated transcription in epithelial cells. Binding of RORα inhibited E2F1 acetylation and its DNA-binding activity by recruiting histone deacetylase 1 (HDAC1) to the protein complexes. Knockdown of HDAC1 or inhibition of HDAC …

The Apical Polarity Complex Protein, Pals1, Regulates Cell Fate In The Development Of Cerebellum And Neocortex, Jun Young Park

Dissertations and Theses (Open Access)

Through their biased localization and function within the cell, polarity complex proteins are necessary to establish the cellular asymmetry required for tissue organization. Well-characterized germinal zones, mitogenic signals, and cell types make the cerebellum and neocortex excellent models to address the critical function of polarity complex proteins in the generation and organization of neural tissues. Here we report a focal distribution of Pals1, a central component of the apical complex, in progenitors. Our genetic analyses revealed that Pals1 deletion in the brain developed a remarkably undersized and disrupted layer structure of cerebral cortex and cerebellum. Furthermore we demonstrated that Pals1 …

Development Of Poly(Lactic Acid)-Poly(Ethylene Glycol) Nanoparticles For The Delivery Of Non- Toxic Drug In Combination Therapy For The Treatment Of Glioblastoma And Neuroblastoma, Olivia Grace Decroes

All Theses

Glioblastoma and neuroblastoma are both solid-form tumors. Glioblastomas primarily reside in the brain, while neuroblastomas are found in the sympathetic nervous system. Both glioblastoma and neuroblastoma re classified as orphan diseases, which affect less than 200,000 individuals a year. Over the course of 5 years, 40% of patients diagnosed with neuroblastomas and only 6% of patients diagnosed will glioblastomas will be living.^73,74. Glioblastoma and neuroblastoma tumors possess a gene known as MGMT. MGMT is used by tumors as a DNA repair mechanism, which increases the likelihood these tumors will become resistant to traditional drug therapies.^28,37 Other pathways, …

The Effect Of Romantic Jealousy On Self-Control: An Examination Of Trait Constructs And Sex Differences Based On Survey And Experimental Data, Lyndsay A. Nelson

Electronic Theses and Dissertations

A large body of research has demonstrated that the experience of romantic jealousy is often associated with a variety of negative outcomes. However, evolutionary psychologists have provided evidence that jealousy is an adaptive emotion that can aid with mate retention. Together these lines of research suggest that jealousy may at times work to protect and enhance one’s relationship, whereas in other cases it could lead to harmful consequences. Considering the varying outcomes of jealousy, it is critical that research explore more specifically how this complex state operates and how it affects individuals’ functioning. In the present research I conducted 2 …

Examining The Influence Of Farmers' Market Motivations On Access To Healthful Foods And Business Opportunities For Farms, Rachel K. Ward

Electronic Theses and Dissertations

Farmers’ markets are increasingly promoted as mechanisms for improving access to healthful foods for low-income households, as they are relatively inexpensive to establish and they can provide affordable food for low-income households by offering Supplemental Nutrition Assistance Program Electronic Benefit Transfer (SNAP/EBT). SNAP/EBT at markets also expands revenue opportunities for participating farmers. Market mangers provide a critical role in overseeing SNAP/EBT at markets and influencing business opportunities for farmers. Using a mixed-method approach, this study aimed to evaluate how managers’ motivations influence SNAP/EBT availability and participation at markets and business opportunities for small- and moderate- sized farms.

To develop a …

Use Of Unmanned Aerial Vehicles (Uav) For Urban Tree Inventories, Brian Ritter

All Theses

In contrast to standard aerial imagery, unmanned aerial systems (UAS) utilize recent technological advances to provide an affordable alternative for imagery acquisition. Increased value can be realized through clarity and detail providing higher resolution (2-5 cm) over traditional products. Many natural resource disciplines such as urban forestry will benefit from UAS. Tree inventories for risk assessment, biodiversity, planning, and design can be efficiently achieved with the UAS. Recent advances in photogrammetric processing have proved automated methods for three dimensional rendering of aerial imagery. Point clouds can be generated from images providing additional benefits. Association of spatial locational information within the …

Foxes Propose New Guidelines For Henhouse Design: Comments On Niso’S Proposed Open Access Metadata Standards, Paul Royster

University of Nebraska-Lincoln Libraries: Faculty Publications

This commentary is in response to: NISO RP-22-201x, Open Access Metadata and Indicators (draft for comment), which is available at: http://www.niso.org/apps/group_public/document.php?document_id=12047

NISO is the National Information Standards Organization, a non-profit industry organization whose mission statement reads: “NISO fosters the development and maintenance of standards that facilitate the creation, persistent management, and effective interchange of information so that it can be trusted for use in research and learning.” Their recently-issued proposed guidelines for new metadata fields to be attached to scholarly works purport to address and clarify issues of access and re-licensing surrounding the electronic distribution of journal articles. Briefly, they …

Characterization Of Greenbug Feeding Behavior And Aphid (Hemiptera: Aphididae) Host Preference In Relation To Resistant And Susceptible Tetraploid Switchgrass Populations, Kyle G. Koch, Nathan Palmer, Mitch Stamm, Jeff D. Bradshaw, Erin Blankenship, Lisa M. Baird, Gautam Sarath, Tiffany M. Heng-Moss

Department of Entomology: Faculty Publications

Two choice studies were performed to evaluate greenbug, Schizaphis graminum (Rondani), and yellow sugarcane aphid, Sipha flava (Forbes), preference for two tetraploid switchgrass populations, Summer and Kanlow, and one experimental hybrid, K×S, derived by crossing Kanlow (male)×Summer (female) plants. Additionally, an assessment of S. graminum feeding behavior was performed on the same switchgrass populations, by using the electrical penetration graph (EPG) technique. Choice studies for S. flava indicated a lack of antixenosis, with no preference by aphids among any of the switchgrass populations at any time point. However, choice studies with S. graminum indicated a preference for the K×S plants …

Temperature Alters Food Web Body-Size Structure, Jean P. Gibert, John P. Delong

School of Biological Sciences: Faculty Publications

The increased temperature associated with climate change may have important effects on body size and predator– prey interactions. The consequences of these effects for food web structure are unclear because the relationships between temperature and aspects of food web structure such as predator–prey body-size relationships are unknown. Here, we use the largest reported dataset for marine predator–prey interactions to assess how temperature affects predator–prey body-size relationships among different habitats ranging from the tropics to the poles. We found that prey size selection depends on predator body size, temperature and the interaction between the two. Our results indicate that (i) predator–prey …

The Mucosal Expression Pattern Of Interferon-Ε In Rhesus Macaques, Andrew Demers, Guobin Kang, Fangrui Ma, Wuxun Lu, Zhe Yuan, Yue Li, Mark Lewis, Edmundo N. Kraiselburd, Luis Montaner, Qingsheng Li

Qingsheng Li Publications

Type I IFNs play an important role in innate and adaptive immunity against viral infections. A novel type I IFN, namely IFN-ε, which can protect against vaginal transmission of HSV2 and Chlamydia muridarum bacterial infection, has been described in mice and humans. Nevertheless, the principle cell type and the expression pattern of IFN-ε in tissues remain uncertain. In addition, the expression of IFN-ε in Indian rhesus macaques (Macaca mulatta) has not been reported. Here, we analyzed IFN-ε expression in multiple mucosal sites of uninfected or SIV-infected Indian rhesus macaques using IHCS. We report for the first time the …

Microribonucleic Acids And Vascular Restenosis, Zhi-Xing Fan, Jian Yang

Saudi Medical Journal

Microribonucleic acids (miRNAs) are small non-coding RNAs, which control diverse cellular functions by either promoting degradation or inhibiting target messenger RNA translation. An aberrant expression profile of miRNAs has been linked to human diseases, including cardiovascular dysfunction. This review summarizes the latest insights in the identification of vascular-specific miRNAs and the underlying mechanisms for their roles in vascular restenosis mainly by influencing the proliferation and migration of vascular smooth muscle cell. Here, we discuss miRNA-based drug and gene therapy in vascular restenosis.

Cytotoxic Effect Of Salvadora Persica Extracts On Human Gingival Fibroblast Cells, Hanan A. Balto, Khaled K. Al-Manei, Talal M. Bin-Mohareb, Zahid A. Shakoor, Solaiman M. Al-Hadlaq

Saudi Medical Journal

OBJECTIVES: To assess the cytotoxic potential of Salvadora persica (S. persica) extracts on human gingival fibroblast (HGF) cells. METHODS: This study was conducted between January and May 2012 in collaboration with Dental Caries Research Chair, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. Extracts of S. persica using hexane, ethylacetate, and ethanol as solvents at concentrations of 0.5 mg/ml and 1 mg/ml were evaluated for their cytotoxic activity against HGFs using the 3 cytotoxic assays: (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a tetrazole) (MTS), lactic dehydrogenase (LDH), and crystal violet (CV). International standards for the evaluation of medical materials recommended cut-off value of …

Ten-Year Review Of Invasive Candida Infections In A Tertiary Care Center In Saudi Arabia, Ali S. Omrani, Eyad A. Makkawy, Kamran Baig, Abdullah A. Baredhwan, Souad A. Almuthree, Noura A. Elkhizzi, Ali M. Albarrak

Saudi Medical Journal

OBJECTIVES: To review the epidemiology of invasive Candida infections in a single center in Saudi Arabia over a subsequent 10-year period. METHODS: This retrospective study was carried out in a single center in Saudi Arabia over a 10-year period. Records of all patients with invasive Candida infections (ICI) over the period from January 2003 to December 2012 were reviewed. Mann-Whitney U test was used for comparison of Candida albicans (C. albicans) versus non-albicans Candida species, and fluconazole resistance versus fluconazole susceptible in relation to crude mortality at 30 days and 90 days. RESULTS: Eight hundred positive sterile site cultures, associated …