Digital Commons Network^™

2014-2015 Faculty Senate Roster, Faculty Senate, East Tennessee State University

Faculty Senate Agendas and Minutes

No abstract provided.

2014 Utah State University Student Orientation Guide, Utah State University

The Utah Statesman

A special supplemental magazine provided by The Utah Statesman to take a closer look at some of the services and departments available at Utah State University.

Vol. 37 No. 2 (2014): Pacific Studies Full Issue, The Jonathan Nāpela Center For Hawaiian And Pacific Islands Studies

Pacific Studies

Pacific Studies is published two times a year by The Jonathan Nāpela Center for Hawaiian and Pacific Studies, Brigham Young University Hawai‘i #1979, 55–220 Kulanui Street, Lāʻie, Hawai‘i 96762, but responsibility for opinions expressed in the articles rests with the authors alone. Subscription rate is US $26.00 yearly, payable to The Jonathan Nāpela Center for Hawaiian and Pacific Studies. The Jonathan Nāpela Center for Hawaiian and Pacific Studies (formerly The Pacific Institute) is an organization funded by Brigham Young University Hawai‘i. The Center assists the University in meeting its cultural and educational goals by undertaking a program of teaching, research, …

Book Review Forum: Glenn Petersen, Traditional Micronesian Societies: Adaptation, Integration, And Political Organization, Nancy J. Pollock

Pacific Studies

Glenn Petersen. Traditional Micronesian Societies: Adaptation, Integration, and Political Organization. Honolulu: University of Hawai'i Press, 2009. Pp. 288. ISBN: 978-0-8248-3248-3. US$42.00 cloth.

Review: NANCY J . POLLOCK

RESEARCHER, VICTORIA UNIVERSITY (RETIRED )

The Battle May Be Over, But What About The War? Examining The Esa In The Crusade Against Global Warming After In Re Polar Bear Endangered Species Act Listing And Section 4(D) Rule Litigation, Alanna Kearney

Villanova Environmental Law Journal (1991 - )

No abstract provided.

Microbial Community Assembly Found With Sponge Orange Band Disease In Xestospongia Muta (Giant Barrel Sponge), Rebecca Mulheron

HCNSO Student Theses and Dissertations

The giant barrel sponge, Xestospongia muta is an iconic and essential species of the coral reefs in South Florida. The sponge has primary roles providing ecosystem services and creating unique habitats for diverse microbial communities. On April 27, 2012 an outbreak of Sponge Orange Band Disease (SOB) was detected off the coast of South Florida. The disease begins with sponge bleaching, followed by mesohyl or “mesohyl” necrosis and often total mesohyl disintegration. Sampling from two diseased populations at Boynton Beach and Fort Lauderdale, FL took place on May 11th and May 29th, 2012. Each of the nine diseased sponges from …

Faculty Handbook Section Iii - Arts And Sciences And College Of Professional Studies Policies And Procedures - Updated 8/1/2014, All Faculty

Faculty Handbooks

No abstract provided.

Benchmarks 2014, August 8, The Rockefeller University

BenchMarks 2014

BenchMarks. Friday, August 8, 2014

The community newsletter of The Rockefeller University

BenchMarks is published monthly and is distributed on the campus of The Rockefeller University. It produced by the Office of Communications and Public Affairs

The Investigation Of Self-Determination In Students Participating In Higher Education With An Invisible Disability, Joseph Daniel Bryant Ii

Dissertations

The enrollment of students with invisible disabilities has continued to increase unabated in postsecondary environments. As a result of the applicable laws governing the provision of accommodations and/or modifications in higher education, the impetus and responsibility to succeed rests almost entirely with the individual student. Research showed for many students with invisible disabilities, the transition from a more passive role in the acquisition of education at the primary and secondary levels to a more active role in the acquisition of higher education at the post-secondary level was difficult, as evidenced by a large percentage of such students failing to complete …

Functional Analysis Of Ear Plugging And Treatment Analysis Of Noise Dampening Headphones, Erin M. Beardsley Psyd

All Student Scholarship

This current study presents a single case comprehensive functional behavioral assessment of ear plugging behavior that began with the application of traditional functional analysis technology and followed the function based treatment recommendations through a systematic treatment analysis. Results of the functional analysis indicated that the behavior was maintained by automatic positive reinforcement (i.e. ear plugging behaviors produced a reinforcing sensory consequence). These data were in contrast to prior clinical impressions that the individual’s ear plugging behaviors were maintained by automatic negative reinforcement (i.e. ear plugging served to block aversive auditory stimuli). To test hypothesis that headphones were functionally equivalent with …

Multiplex Ssr-Pcr Analysis Of Genetic Diversity And Redundancy In The Philippine Rice (Oryza Sativa L.) Germplasm Collection, Jamaica L. Delos Reyes, Vivian A. Panes, Dindo A. Tabanao, Gabriel O. Romero

Biology Faculty Publications

Rice germplasm conservation is vital to ensuring the availability of a rich gene pool for future varietal improvement programs. However, with limited resources for gene banking, there is a need to identify and prioritize unique accessions in the PhilRice gene bank for maximum resource utilization. A robust and unequivocal way to identify duplicates is through multiplex SSR-PCR DNA fingerprinting. The present study established the optimal concentrations and reaction conditions for the successful amplification of PCR products using a multiplex panel composed of rice simple sequence repeat (SSR) markers, namely RM312, RM316, RM514 and RM171. The panel was then used to …

Putting The Person First : An Examination Of Thought Disorder And Personality Heterogeneity In Schizophrenia., Catherine Rose Robertson

Electronic Theses and Dissertations

The Recovery Model of mental illness, emerging as the new zeitgeist in regards to treatment, emphasizes the optimization of functioning for each individual, using personal strengths and preferences to drive the recovery process. Thought disorder has long been considered a core symptom of schizophrenia and has been implicated in multiple domains of functional outcome. In spite of its relationship to functioning and substantial heterogeneity of the phenomenon, little to no research has examined potential factors which may be related to these differences in thought disorder and its related domains of functioning. The current study proposes that “normal” personality traits, such …

The Problem Of The Twenty-First Century In The Cherokee Nation Is The Problem Of The Color-Line : How The Cherokee Freedmen Have Articulated A Sense Of Cultural Identity And Citizenship Claims Over Time., Shannon Spears

Electronic Theses and Dissertations

This research investigates the Cherokee Freedmen, who are people of African-American descent and peoples of mixed African-American and Native American descent, who were once enslaved by Cherokees in the Cherokee Nation, and who have articulated their identity and tribal citizenship status as Cherokee Natives in the Cherokee Nation. Upon emancipation, the Cherokee Nation adopted the Cherokee Freedmen as equal citizens in the Cherokee Nation under article nine from the Treaty of 1866, but this changed after citizens were recorded on the Dawes Rolls based upon blood quantum. The theoretical framework of this research is Antonio Gramsci’s theoretical perspective of cultural …

Building A Metabolic Bridge Between Glycolysis And Sphingolipid Biosynthesis : Implications In Cancer., Morgan L. Stathem

Electronic Theses and Dissertations

Cancer therapeutics has seen an emergence and re-emergence of two metabolic fields in recent years, namely bioactive sphingolipids and glycolytic metabolism. Anaerobic glycolysis and its role in cancer has been recognized in cancer biology over 90 years. In recent decades, the role of sphingolipids in cancer cell metabolism has gained recognition, notably ceramide’s essential role in programmed cell death and the role of the glucosylceramide synthase (GCS) in chemotherapeutic resistance. Despite this knowledge, a direct link between these two fields has yet to be concretely drawn. Herein, we show that in a model of highly glycolytic cells, generation of the …

Inducible Tumor Difference Between Rapid And Slow Rat Nat2 Congenic Fischer 344 Rats Administered Methyl-Nitrosourea., Marcus W. Stepp

Electronic Theses and Dissertations

Human arylamine N-acetyltransferase 1 (NAT1) is a well-known phase II metabolic enzyme that has been associated with carcinogenesis. Its role in the biotransformation of aromatic and heterocyclic amine carcinogens has been investigated for many years, but more recent investigations focus on a possible endogenous role of human NAT1 in cancer initiation and progression. We conducted in vivo studies using homozygous Fischer 344 rats, congenic at the rat Nat2 locus for high (rapid) and low (slow) activity. Wistar Kyoto inbred rats were used to breed in the slow activity rat Nat2 locus into the Fischer 344 inbred rat, which contains the …

Dispositional Mindfulness And Working Memory In The Context Of Acute Stress., Lauren M. Vines

Electronic Theses and Dissertations

The neuropsychological domain of working memory and the nearly 3000 year-old Buddhist construct of mindfulness appear to be disparate concepts. However, the measurable decline of working memory capacity (WMC) under stress, in combination with the stress-reducing and attention-focusing effects of mindfulness suggest potential augmentation of working memory through the engagement of mindful practice. A theoretical process through which dispositional mindfulness exerts a moderating effect on WMC reduction following an acute stressor is proposed. To investigate processes within this theoretical framework, a sample of undergraduate college students (N = 67) were assessed across various measures, including level of dispositional mindfulness, affective …

Penalized Regressions For Variable Selection Model, Single Index Model And An Analysis Of Mass Spectrometry Data., Yubing Wan

Electronic Theses and Dissertations

The focus of this dissertation is to develop statistical methods, under the framework of penalized regressions, to handle three different problems. The first research topic is to address missing data problem for variable selection models including elastic net (ENet) method and sparse partial least squares (SPLS). I proposed a multiple imputation (MI) based weighted ENet (MI-WENet) method based on the stacked MI data and a weighting scheme for each observation. Numerical simulations were implemented to examine the performance of the MIWENet method, and compare it with competing alternatives. I then applied the MI-WENet method to examine the predictors for the …

Numerical Investigation Of Hydrodynamic Focusing And Coulter Principle In A Microfluidic Device, Muheng Zhang

Electronic Theses and Dissertations

Particle information such as particle size and amount is significant to many fields such as chemical engineering, biological research, medical analysis, and environment detection. Microfluidic Coulter counter is suitable for this task because it can get fast and accurate analysis. However, the fundamental principle and several design strategies details are still needed to be analyzed and modeled in order to improve its performance. This dissertation focused on several challenges from the numerical simulation aspects. First one is the analysis for the hydrodynamic focusing in microfluidic Coulter Counter. In recent years, many microfluidic Coulter Counter designs have utilized a technique termed …

The Walkable Dividend : The Impacts Of Walkability On Housing And Socio-Economic Composition In Louisville, Ky., Wesley Laurance Meares

Electronic Theses and Dissertations

Until 2008, there has not been a reliable measure of the social, health, and economic impact of walkable neighborhoods. This changed dramatically when scholars were able to quantify walkability, which measures how accessible daily living activities are by foot. However, most of these studies focus on mega cities, sections of cities or on random parcel data. Absent from the literature is the impacts of walkability on mid-size cities. This dissertation seeks to fill this void by examining the impacts of walkability on neighborhood housing valuation, foreclosures, vacancy rates and socio-economic composition in Louisville, KY. This dissertation employs ordinary least squares …

Bdnf Maintains Adult Taste Innervation And Is Required For Taste Nerve Regeneration After Injury., Lingbin Meng

Electronic Theses and Dissertations

Brain derived neurotropic factor (BDNF) is required for the gustatory neuron survival,target innervation, and taste bud maintenance during development. However, whether BDNF has any function in the adult gustatory system in normal conditions or after nerve injury is unclear. To address these issues, I inducibly removed BDNF in all cells expressing BDNF in adult mice. In the experimental animals, Bdnf expression decreased to 5% of control mice in the lingual epithelium and geniculate ganglion (p< 0.01) at both two weeks and ten weeks after tamoxifen administration. I found no effect on taste bud morphology at four weeks following Bdnf gene deletion. However, ten weeks following Bdnf gene deletion, P2X3-positive and TUJ1-positive gustatory innervation to individual taste buds was reduced by nearly half (each with p < 0.01) and both taste bud volume and taste cell number decreased 30% (each with p< 0.01). These experiments demonstrate that BDNF is required for maintenance of normal levels of taste innervation and normal taste bud morphology in adulthood. In addition, taste cells expressing PLCß2 (phospholipase C ß2), a marker for taste cells that respond to sweet, bitter and umami, did not decrease after Bdnf gene deletion in the adult. Thus, the missing taste cells are of another type. This indicates that taste cell loss is not uniform across the various taste cell types, even if nearly all taste cell types receive the P2X3 and TUJ1 innervation. Since BDNF is required for initial innervation of the taste system and supports taste bud innervation and size in adulthood, it could also be required for nerve reinnervation after injury. To determine if Bdnf is still expressed following nerve section, the chorda tympani nerve (taste nerve) was sectioned and Bdnf level was detected with Real Time RT-PCR. Bdnf continued to be expressed at normal levels from two days to two months post-surgery in both geniculate ganglion and tongue epithelium. Therefore, BDNF could be involved with chorda tympani regeneration. To determine if this was the case, the Bdnf gene was deleted in adult inducible transgenic mice (under the control of a Ubiquitin promoter) two weeks before chorda tympani nerve section. Taste bud number was reduced by half in all genotypes at two weeks post-surgery (p < 0.01). For the remaining taste buds, gustatory innervation was nearly gone with only a little innervation from the trigeminal nerve remaining in the taste bud (p < 0.01). Taste bud volume (p < 0.01) and taste cell number (p< 0.01) were reduced by half for both control and experimental genotypes. Eight weeks post-surgery, taste bud number recovered in mice without Bdnf gene deletion, but did not recover in mice following Bdnf gene deletion (p < 0.01). Gustatory nerve innervation returned in 70% of the taste buds in control mice (p< 0.01). For those reinnervated taste buds, both taste bud volume and taste cell number increased to normal levels. However, in mice lacking the Bdnf gene, gustatory fibers only reinnervated 7.8% of the taste buds (p < 0.01); for most uninnervated taste buds, both taste bud volume and taste cell number remained small. These experiments demonstrate that BDNF is crucial for promoting regeneration of gustatory nerve fibers in adulthood. Following gustatory nerve section, considerable adult plasticity has been observed on the contralateral side including enlarged taste buds with more cells (Guagliardo and Hill, 2007). To determine if this anatomical change was associated with alter Bdnf expression. I examined Bdnf level in the geniculate ganglion and tongue epithelium on the contralateral side following chorda tympani nerve section. Results showed Bdnf expression increased two fold at two weeks post-surgery in geniculate ganglion on the contralateral side (p < 0.05), indicating BDNF may involve with the observed plastic changes. To determine if the increase in taste bud size was associated with increased innervation and/or regulated by BDNF, the Bdnf gene was then deleted in inducible knockout mice before nerve surgery, and taste bud size and amount of innervation were measured on the contralateral side. The results showed taste bud volume, taste cell number and a marker for nerve fibers all increased on the contralateral side in mice without Bdnf gene deletion at eight weeks post-surgery. This indicates that larger taste buds could be supported by increased TUJ1 positive fibers from trigeminal nerve. In addition, in mice lacking Bdnf, taste bud volume, taste cell number and innervation did not increase on the contralateral side after surgery, which indicates that Bdnf may contribute to larger taste buds on the contralateral side following nerve section by supporting increased innervation to the larger taste buds.

A Novel Diffusion Tensor Imaging-Based Computer-Aided Diagnostic System For Early Diagnosis Of Autism., Mahmoud Mostapha

Electronic Theses and Dissertations

Autism spectrum disorders (ASDs) denote a significant growing public health concern. Currently, one in 68 children has been diagnosed with ASDs in the United States, and most children are diagnosed after the age of four, despite the fact that ASDs can be identified as early as age two. The ultimate goal of this thesis is to develop a computer-aided diagnosis (CAD) system for the accurate and early diagnosis of ASDs using diffusion tensor imaging (DTI). This CAD system consists of three main steps. First, the brain tissues are segmented based on three image descriptors: a visual appearance model that has …

The Second Generation Of The Cccm System For In-Vitro Cardiac Tissue Engineering., Mai-Dung Thi Nguyen

Electronic Theses and Dissertations

Cardiovascular disease is the leading cause of death worldwide. When a myocardial infarction occurs, scar tissue compensates the damaged myocardial tissue. This scar tissue increases the stiffness of the heart tissue, reduces the heart’s function, and finally leads to the heart failure (HF) disease. To have the tissue engraftment, in-vitro cardiac tissue should have the same properties as the native mature cardiac tissue. However, current in-vitro cell culture technologies fail to accurately recreate the in-vivo like mechanically physiological environment for in-vitro cardiac tissue culture, and therefore, fail to regenerate the in-vivo like mature cardiac tissue. Hence, a microfluidic cardiac cell …

A Meta-Analytic Review Of The Relationships Between The Therapeutic Alliance, Empathy, And Genuineness In Individual Adult Psychotherapy., Jacob B. Nienhuis

Electronic Theses and Dissertations

This dissertation explored the relationship between the therapeutic alliance and perceptions of therapist empathy and genuineness through a systematic review and meta-analysis. Alliance, empathy, and genuineness are each integral parts of the therapeutic relationship. Prior meta-analyses demonstrated that alliance, empathy, and genuineness each had a moderate relationship to therapy outcome. No previous analysis has explored how therapist empathy and genuineness contribute to the therapeutic alliance. Studies for this analysis were obtained through a multi-part search strategy. Out of 2,141 obtained abstracts, 46 studies contained enough data for inclusion in the meta-analysis. Thirty-six studies reported alliance/empathy relationships, six studies reported alliance/genuineness …

The Impact Of Preconception Maternal Stress On Fecundability And Adverse Pregnancy Outcomes., Shekufe Akhter

Electronic Theses and Dissertations

It has been commonly hypothesized (and widely believed) that maternal stress either prior to or during pregnancy can adversely affect fertility and pregnancy outcomes. However, surprisingly few epidemiologic studies have rigorously tested these hypotheses. The current study evaluated the effects of pre-conception self-reported stress on fecundability and spontaneous abortion. The study population was derived from the Mount Sinai Study of Woman Office Workers with 487 women included. Women recorded stress (scale from 1 to 4) and covariate information in a daily diary for 12 cycles or until pregnant. Results indicated a significantly increased risk of spontaneous abortion for women with …

Mirna-21 Has Anti-Inflammatory Effects In The Macrophage Response To Peritonitis., Rebecca Elise Barnett

Electronic Theses and Dissertations

This project investigated the role of miRNA-21 in the macrophage response to peritonitis; with the goal of understanding whether the associated mechanism has potential benefits in the clinical treatment of peritonitis. A novel therapeutic intervention in the treatment of peritonitis could modulate the host immune response to decrease an exaggerated pro-inflammatory innate response and then prevent or ameliorate the development of sepsis and organ failure. We found the following: 1. MiRNA-21 expression increases in peritoneal macrophages after lipopolysaccharide (LPS) stimulation. 2. Over expression of miRNA-21 decreases TNF-a secretion from macrophages after LPS stimulation. Suppression of miRNA-21 expression results in increased …

Nanoporous Bi2te3 Thermoelectric Based Knudsen Gas Pump., Abderrazzak Faiz

Electronic Theses and Dissertations

This dissertation reports on the fabrication of a bi-directional Knudsen gas pump using a multifunctional nanoporous thermoelectric material. The integration of the channels into the thermoelectric material has the advantages of reducing heat losses and power consumption, improving the pump efficiency, and reducing the overall pump size. The Knudsen pump operates on the thermal transpiration principle, the phenomenon that gas molecules drift from the cold end to the hot end of a narrow channel. The gas pumping is realized in the transition or free molecular regime. The Knudsen pump is needed in a great number of applications such as gas …

Evaluation Of The Safety And Pharmacokinetic Profile Of The Broad Spectrum Antiviral Lectin Griffithsin., Christopher Lynn Barton

Electronic Theses and Dissertations

Carbohydrate binding agents that target viral envelope glycans are being studied for their potential use as microbicides and antiviral therapeutics. Griffithsin is a lectin originally identified in a red alga Griffithisia sp. Multiple studies have shown that GRFT inhibits HIV-1, Coronaviruses, Hepatitis C, influenza and Ebola virus replication in vitro. This antiviral activity suggests potential uses in chemoprophylaxis and disease treatment. However, safety of GRFT administration has not been extensively studied. In vivo testing--chronic subcutaneous treatment as well as single dose subcutaneous, oral, and intravenous administrations of Griffithsin in Sprague Dawley Rats (Rattus Norvegicus)--was used to assess Griffithsin’s pharmacokinetic properties …

Cholinergic Inhibition Of Lipopolysaccharide Induced Matrix Metalloproteinase In Immune Cells., Harrison Black,

Electronic Theses and Dissertations

Background: Matrix metalloproteinase (MMPs) are proteins that have a unique role in immunity, tissue remodeling, and tumorigenesis. MMPs can break down extracellular components, release bioactive molecules, and act on pro-inflammatory cytokines, chemokines and other proteins to regulate varied aspects of inflammation and immunity. Nicotine (3-(1-methyl-2-pyrrolidinyl) pyridine), a key toxic component of tobacco, is thought to dysregulate matrix metalloproteinase secretion in immune cells. Aim: Examine the effect of nicotine on MMP9 secretion and activity in primary monocytes. Methods: Primary monocytes were stimulated with LPS (1 µg/ml) and Nicotine (100 ng/ml) and MMP9 secretion were studied. Gel zymography and ELISA techniques were …

An Analysis Of The Potential Effects Of Urbanization On The Water Quality Of The Middle Fork Of Beargrass Creek, Louisville, Kentucky., Olivia Brooks

Electronic Theses and Dissertations

This thesis examined whether water quality diminished as a result of increasing pollution downstream along the Middle Fork of Beargrass Creek, Louisville, Kentucky in response to urbanization. Samples of key water quality indicators/pollutants were collected for 12 weeks (November - January) along the Middle Fork of Beargrass Creek at three different stream gauges. A spatial and statistical analysis was performed to verify any significant correlations between the water quality indicators and pollutants, and whether basin wide landcover/sewer outlet numbers led to an increase in these indicators downstream. Following ANOVA and Kruskal-Wallis statistical testing it was established that turbidity significantly increased …

Bone Strength And Architecture : Pharmacological Targeting Of Camkk2 As A Method For Enhancing Bone Quality., Zachary James Pritchard

Electronic Theses and Dissertations

Mice lacking or pharmacologically inhibited for calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) have enhanced bone mass and microarchitecture. This enhanced bone mass and architecture is due to changes in osteoblast and osteoclast numbers as well as activity. Whether the enhanced bone mass translated to increased bone quality and strength was further explored by developing a method to directly test the trabecular strength of the distal femur. Micro computed tomography (CT)-based measurement of the length of the epiphysis of the distal femur, aided in its removal, allowing the exposure of the trabecular bone volume used to determine the microarchitecture parameters. Following …