Digital Commons Network^™

Comparative Molecular Docking Studies With Abcc1 And Aquaporin 9 In The Arsenite Complex Efflux, Shiv Poojan, Anupam Dhasmana, Qazi Mohammad Sajid Jamal, Mohd Haneef, Mohtashim Lohani

School of Medicine Publications

Arsenic is the most toxic metalloid present in the natural environment in both organic and inorganic arsenic forms. Inorganic arsenic is often more hazardous than the organic form. Arsenite and arsenate compounds are the major inorganic forms which are toxic causing severe human health dysfunction including cancer. Excretion of arsenic from the system is found elusive. Therefore, it is of interest to screen channel proteins with the arsenic complex in the different combination of arsenic, GSH (glutathione) and arsenic, selenium using docking methods. The mode of arsenic removal. The complex structure revealed the mode of arsenic binding efficiency with the …

Adam10 Mediates Trastuzumab Resistance And Is Correlated With Survival In Her2 Positive Breast Cancer, K Feldinger, D Generali, G Kramer-Marek, M Gijsen, Et Al

School of Biomedical Sciences

Trastuzumab prolongs survival in HER2 positive breast cancer patients. However, resistance remains a challenge. We have previously shown that ADAM17 plays a key role in maintaining HER2 phosphorylation during trastuzumab treatment. Beside ADAM17, ADAM10 is the other well characterized ADAM protease responsible for HER ligand shedding. Therefore, we studied the role of ADAM10 in relation to trastuzumab treatment and resistance in HER2 positive breast cancer. ADAM10 expression was assessed in HER2 positive breast cancer cell lines and xenograft mice treated with trastuzumab. Trastuzumab treatment increased ADAM10 levels in HER2 positive breast cancer cells (p ≤ 0.001 in BT474; p ≤ …

August 29, 2014, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

The Effect Of The Victim-Offender Relationship And Pre-Assault Intoxication On Ptsd Symptom Severity, Diandra Meloni

Theses and Dissertations

College-aged women are at an increased risk for experiencing non-consensual sexual contact (i.e. sexual assault) relative to the general population. Women who endure a sexual assault are at an increased risk for developing Post-traumatic Stress Disorder (PTSD). Intoxication by drugs and/or alcohol during an assault is linked to victims experiencing less severe PTSD symptoms; however, little is known about how the victim-offender relationship relates to PTSD symptom severity. The current study sampled 125 university women on measures that assessed degree of sexual victimization and resulting PTSD symptoms. It was hypothesized that both intoxication and the victim-offender relationship would affect PTSD …

The Bg News August 29, 2014, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. August 29, 2014. Volume 94-Issue 4.

An Intronic Picalm Polymorphism, Rs588076, Is Associated With Allelic Expression Of A Picalm Isoform, Ishita Parikh, Christopher Medway, Steven Younkin, David Fardo, Steven Estus

Physiology Faculty Publications

BACKGROUND: Although genome wide studies have associated single nucleotide polymorphisms (SNP)s near PICALM with Alzheimer's disease (AD), the mechanism underlying this association is unclear. PICALM is involved in clathrin-mediated endocytosis and modulates Aß clearance in vitro. Comparing allelic expression provides the means to detect cis-acting regulatory polymorphisms. Thus, we evaluated whether PICALM showed allele expression imbalance (AEI) and whether this imbalance was associated with the AD-associated polymorphism, rs3851179.

RESULTS: We measured PICALM allelic expression in 42 human brain samples by using next-generation sequencing. Overall, PICALM demonstrated equal allelic expression with no detectable influence by rs3851179. A single sample demonstrated …

A Scientometric Study Of Journal Of Bio-Chemistry And Bio-Physics (Ijbb), Madhu Bala, Mahender Pratap Singh

Library Philosophy and Practice (e-journal)

Abstract:

Scientometric is branch of Science. Scientometric explain about input and output resources in term of organisational structure. Scientometric is the Science of measuring and analyzing Science. Modern Scientometric is mostly based on the work of Derek J.de Solla Price and Eugene Garfield. This paper critically analyses 316 scholarly communications published in the Indian Journal of Biochemistry & Bio-Physics. Indian Journal of Bio-Chemistry and Bio-Physics, formerly known as IJBB. It is a peer reviewed, open access bio-monthly Journal published by NISCAIR. The analysis cover mainly the number of articles, form of document cited, most cited Journals etc. Study reveals that …

August 29, 2014 Minutes, Swosu Faculty Senate

Faculty Senate Minutes

SWOSU Faculty Senate August 29, 2014 Approved Minutes

Jannie B. Emery

African American Funeral Programs

No abstract provided.

100th Convocation 2014 Address - Amazing Mice Light Up The Liberal Arts, Marc Zimmer

Convocation Addresses

Connecticut College Professor of Chemistry Marc Zimmer states, "I like to think of our educational system as an intellectual maze. New students, you are standing at the entrance of this fantastic maze, a lush and verdant garden maze..."

He concludes: "We are all, faculty, students and staff tremendously privileged to be sitting here at the entrance of the amazing maze of learning."

Identification Of Srnas Expressed By The Human Pathogen Neisseria Gonorrhoeae Under Disparate Growth Conditions, Ryan Mcclure, Brian Tjaden, Caroline Genco

Faculty Research and Scholarship

In the last several years, bacterial gene regulation via small RNAs (sRNAs) has been recognized as an important mechanism controlling expression of essential proteins that are critical to bacterial growth and metabolism. Technologies such as RNA-seq are rapidly expanding the field of sRNAs and are enabling a global view of the “sRNAome” of several bacterial species. While numerous sRNAs have been identified in a variety of both Gram-negative and Gram-positive bacteria, only a very small number have been fully characterized in the human pathogen Neisseria gonorrhoeae, the etiological agent of the STD gonorrhea. Here we present the first analysis …

Paternal Incarceration And Children's Food Insecurity: A Consideration Of Variation And Mechanisms, Kristen Turney

University of Kentucky Center for Poverty Research Discussion Paper Series

Despite growing attention to the unintended consequences of paternal incarceration for children’s wellbeing across the life course, little is known about whether and how paternal incarceration is related to food insecurity among children, an especially acute and severe form of deprivation. In this article, I use data from the Fragile Families and Child Wellbeing Study, a cohort of children born to mostly unmarried mothers, to examine the relationship between paternal incarceration and three indicators of food insecurity among young children: current food insecurity (at age five), onset of food insecurity (between ages three and five), and exit from food insecurity …

Cyclic Peptide-Capped Gold Nanoparticles For Enhanced Sirna Delivery, Amir Nasrolahi Shirazi, Karissa L. Paquin, Niall G. Howlett, Dindyal Mandal, Keykavous Parang

Cell and Molecular Biology Faculty Publications

Previously, we have reported the synthesis of a homochiral l-cyclic peptide [WR]₅ and its use for delivery of anti-HIV drugs and biomolecules. A physical mixture of HAuCl₄ and the peptide generated peptide-capped gold nanoparticles. Here, [WR]₅ and [WR]₅-AuNPs were tested for their efficiency to deliver a small interfering RNA molecule (siRNA) in human cervix adenocarcinoma (HeLa) cells. Flow cytometry investigation revealed that the intracellular uptake of a fluorescence-labeled non-targeting siRNA (200 nM) was enhanced in the presence of [WR]₅ and [WR]₅-AuNPs by 2- and 3.8-fold when compared with that of siRNA alone …

August 28, 2014, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

The Genomic Architecture Of Population Divergence Between Subspecies Of The European Rabbit, Miguel Carneiro, Frank W. Albert, Sandra Afonso, Ricardo J. Pereira, Hernan Burbano, Rita Campos, Jose Melo-Ferreira, Jose A. Blanco-Aguiar, Rafael Villafuerte, Michael W. Nachman, Jeffrey M. Good, Nuno Ferrand

Biological Sciences Faculty Publications

The analysis of introgression of genomic regions between divergent populations provides an excellent opportunity to determine the genetic basis of reproductive isolation during the early stages of speciation. However, hybridization and subsequent gene flow must be relatively common in order to localize individual loci that resist introgression. In this study, we used next-generation sequencing to study genome-wide patterns of genetic differentiation between two hybridizing subspecies of rabbits (Oryctolagus cuniculus algirus and O. c. cuniculus) that are known to undergo high rates of gene exchange. Our primary objective was to identify specific genes or genomic regions that have resisted …

2014-08-28, Board Of Regents, Murray State University

Board of Regents Meeting Minutes

No abstract provided.

The Tiger Vol. 108 Issue 17 2014-08-28, Clemson University

Tiger Newspapers

No abstract provided.

Impulsivity Traits As Determinants For Smoking Behavior, Stacey Munyon

Theses and Dissertations

The notion that smoking is in direct relation to the character trait of impulsivity is widely agreed upon. This study examines the individual character traits of the UPPS-P impulsivity scale that comprise the construct of impulsivity as they relate to cigarette smoking. This study seeks to illustrate whether or not there is determination of smoking behavior as a result of high levels of one or more of these impulsive traits. Analysis will be evaluated through means of several different analyses of variance to determine if any relationships are present.

Daily Eastern News: August 28, 2014, Eastern Illinois University

August

No abstract provided.

High Sensitive Detection Of Cd(Ii) And Pb(Ii) Based On Antimony-Film Covered Pencil Core Electrodes, Shan Chen, Zhao-Yan Zheng, Yi-Min Fang, Li-Qing Zheng, Jian-Jun Sun

Journal of Electrochemistry

In this paper, a pencil core was used as the substrate for an antimony-film electrode for simultaneous detection of Cd(II) and Pb(II) by square-wave anodic stripping voltammetry (SWASV). With the deposition time of 180 s, the low limit of detection (LOD) for the electrode was determined to be 0.075·g?L-1 for Cd(II), while 0.13·g·L-1 for Pb(II) with good reproducibility in low pH solutions (pH = 2). The results show a much lower LOD than that of bismuth-film pencil core electrode. Finally, this antimony-film electrode was successfully applied to determine Cd(II) and Pb(II) in tap water.

A Sensitive And Label-Free Electrochemical Aptasensor Based On Signal Amplification Of Carbon Nanotubes, Chun-Yan Deng, Hui-Min Fan, Juan Xiang, Yuan-Jian Li

Journal of Electrochemistry

A label-free electrochemical sensing electrode for highly sensitive detection of adenosine was constructed based on the signal amplification of carbon nanotubes (CNTs). The change in the interfacial feature of the modified electrode was characterized by electrochemical impedance spectroscopy. Using [Ru(NH₃)₆]³⁺ as the signaling moiety, adenosine with concentrations as low as 0.027 nmol·L^-1 can be selectively detected. Additionally, the fabrication of this present aptasensor was simple, time-saving and cost-effective. Compared with other reported aptasensors, the proposed aptasensor had advantages of excellent sensitivity, selectivity and simplicity, which plays a potential role in development of aptasensor.

Seeing The Results Of A Mutation With A Vertex Weighted Hierarchical Graph, Debra J. Knisley, Jeff R. Knisley

ETSU Faculty Works

We represent the protein structure of scTIM with a graph-theoretic model. We construct a hierarchical graph with three layers - a top level, a midlevel and a bottom level. The top level graph is a representation of the protein in which its vertices each represent a substructure of the protein. In turn, each substructure of the protein is represented by a graph whose vertices are amino acids. Finally, each amino acid is represented as a graph where the vertices are atoms. We use this representation to model the effects of a mutation on the protein. Methods: There are 19 vertices …

The Alestle - Vol. 67 No. 3 - 08/28/2014, Southern Illinois University Edwardsville

The Alestle

Vol. 67. No. 3

State V. Oldham Appellant's Brief Dckt. 41820

Not Reported

No abstract provided.

Development Of Novel Tools For Radial Glia Lineage Tracing And Modeling Central Nervous System Tumor, Fuyi Chen

Doctoral Dissertations

In this dissertation, I first established a novel non viral piggyBac transposon mediated transgenesis approach delivered by in utero electroporation for radial glia lineage tracing. Furthermore, I developed a novel central nervous system tumor model in rat using piggyBac IUE. By directing expression of oncogenic HRasV12/AKT in radial glia, astrocytes and oligodendrocytes, glioblastoma multiforme and anaplastic oligoastrocytoma were induced. Also addition of neurogenic bHLH transcription factors Neurogenin 2 and Neural differentiation 1 to GBM inducing HRasV12/AKT, malignant pediatric atyical teratoid rhabdoid tumor like tumor was induced. These results shad lights on the sources of tumor heterogeneity and indicate that oncogenic …

Orthoclust: An Orthology-Based Network Framework For Clustering Data Across Multiple Species, Koon-Kiu Yan, Daifeng Wang, Joel Rozowsky, Henry Zheng, Chao Cheng, Mark Gerstein Gerstein

Dartmouth Scholarship

Increasingly, high-dimensional genomics data are becoming available for many organisms.Here, we develop OrthoClust for simultaneously clustering data across multiple species. OrthoClust is a computational framework that integrates the co-association networks of individual species by utilizing the orthology relationships of genes between species. It outputs optimized modules that are fundamentally cross-species, which can either be conserved or species-specific. We demonstrate the application of OrthoClust using the RNA-Seq expression profiles of Caenorhabditis elegans and Drosophila melanogaster from the modENCODE consortium. A potential application of cross-species modules is to infer putative analogous functions of uncharacterized elements like non-coding RNAs based on guilt-by-association.

The Inkwell, Armstrong State University

The Inkwell

No abstract provided.

Room Temperature Ionic Liquid Templated Meso-Macroporous Material By Self-Assembled Giant Gold Nanoparticles And Its Enhancement On The Direct Electrochemistry Of Cytochrome C, Pei Li, Dong-Ping Zhan, Yuan-Hua Shao

Journal of Electrochemistry

Room temperature ionic liquid (RTIL) is used as a soft-template to organize a meso-macroporous material constructed by self-assembled giant gold nanoparticles which are capped by L-cysteine. First, L-cysteine capped gold nanoparticles can self-assembly to form nanowires and sub-micrometer spherical giant particles due to the static interaction and/or the condensation reaction between the carboxyl and amino groups at the outer terminal of the ligand. Second, the spherical assembled particles can form a quasi-solid gel when grinding with a hydrophobic RTIL, 1-octyl-3-metyllimidazolium hexafluorophosphate. Finally, when the composite gel is coated on a glassy carbon electrode and then polarized by using cyclic voltammetry …

Targeting Grp78 In Cancer With Nucleic Acid Bioconjugates, Pradeepkumar L. Patel

Seton Hall University Dissertations and Theses (ETDs)

Nucleic acid bioconjugates have gained widespread use in medicinal chemistry research programs aimed at fighting human malignancies such as cancer, diabetes, genetic and infectious diseases. Their popularity stems from their ability to accelerate the drug development process by conjugating chemical functionality that may improve the pharmacology of a bioactive nucleoside. Moreover, this strategy has been proven to be effective with small molecule nucleoside analogs and those derived from lengthy oligonucleotide sequences. Considering these fruitful applications, my research and this thesis aims to explore the synthesis, characterization and therapeutic potential of novel classes of nucleic acid bioconjugates.

These are based on, …

The Pacifican August 28, 2014, University Of The Pacific

All Issues - Student Newspaper, The Pacifican, Pacific Weekly

No abstract provided.