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A Multidisciplinary Treatment Of Congenitally Missing Maxillary Lateral Incisors: A 14-Year Follow-Up Case Report, Renato Rodrigues De Almeida, Ana Carolina Morandini, Renata Rodrigues De Almeida-Pedrin, Marcio Rodrigues De Almeida, Renata Cristina Faria Ribeiro Castro, Natalia Martins Insabralde

All Dugoni School of Dentistry Faculty Articles

Absence of the maxillary lateral incisor creates an aesthetic problem which can be managed in various ways. The condition requires careful treatment planning and consideration of the options and outcomes following either space closure or prosthetic replacement. Recent developments in restorative dentistry have warranted a re-evaluation of the approach to this clinical situation. Factors relating both to the patient and the teeth, including the presentation of malocclusion and the effect on the occlusion must be considered. The objective of this study was to describe the etiology, prevalence and alternative treatment modalities for dental agenesis and to present a clinical case …

Wrl Newsletter September 2014, Rebecca Seipp

WRL Newsletters

No abstract provided.

Mir-103a-3p Targets The 5' Utr Of Gprc5a In Pancreatic Cells., Honglei Zhou, Isidore Rigoutsos

Computational Medicine Center Faculty Papers

MicroRNAs (miRNAs) are short noncoding RNAs that regulate the expression of their targets in a sequence-dependent manner. For protein-coding transcripts, miRNAs regulate expression levels through binding sites in either the 3' untranslated region (3' UTR) or the amino acid coding sequence (CDS) of the targeted messenger RNA (mRNA). Currently, for the 5' untranslated region (5' UTR) of mRNAs, very few naturally occurring examples exist whereby the targeting miRNA down-regulates the expression of the corresponding mRNA in a seed-dependent manner. Here we describe and characterize two miR-103a-3p target sites in the 5' UTR of GPRC5A, a gene that acts as a …

Snf1 Mediated Phosphorylation And Activation Of Pas Kinase, Bryan D. Badal

Theses and Dissertations

Nutrient sensing kinases sense available nutrients and regulate cell activity accordingly. Three of these enzymes are AMP regulated kinase (AMPK, or Snf1 in yeast), PAS kinase, and target of rapamycin (TOR), are conserved from yeast to man and have overlapping function. AMPK and Snf1 are important in sensing when nutrient status in the cell is low and down regulating energy consuming pathways. PAS kinase is required for glucose homeostasis in the cell, and responds to glucose levels. TOR senses nutrients such as amino acids and upregulates cell growth pathways primarily through protein synthesis. Due to the varying nature of these …

A Multi-Tactical Approach To Managing Tarnished Plant Bugs In The Mississippi Delta Region, A. L. Catchot, D. Gore, F. Musser

Midsouth Entomologist

Tarnished plant bug (TPB) is the most economically important insect pest of cotton grown in the Mississippi Delta Region. Many factors contribute to the status of TPB as the number one pest producers face annually in cotton such as elimination of foliar sprays due to successful boll weevil eradication and wide spread resistance to several classes of insecticides. Successful management of TPB cannot be achieved unless producers utilize the full complement of tools available. Only an integrated approach to pest management has proven successful in recent years. The following discussion highlights some of the more commonly used approaches employed by …

Current Scientific Literature On Tarnished Plant Bug, Lygus Lineolaris (Palisot De Beauvois) Ecology In Mississippi And Critical Information Needs, K. A. Parys

Midsouth Entomologist

Implementing a successful integrated pest management program requires understanding basic ecologic patterns of the tarnished plant bug (TPB), Lygus lineolaris (Palisot de Beauvois). As the primary pest of cotton in Mississippi and across the mid-south, L. lineolaris is a highly polyphagous mirid that moves among host plants throughout the year. Most major crops in this area, as well as many common weeds, are considered host plants and contribute to the population.

Tarnished Plant Bug Control Technologies: Diversity, Resistance, And Sustainable Management In Mississippi, J. Gore, D. Cook, A. Catchot, F. Musser

Midsouth Entomologist

No abstract provided.

Survival Advantage Associated With Decrease In Stage At Detection From Stage Iiic To Stage Iiia Epithelial Ovarian Cancer, John Hoff, Lauren Baldwin, Jason Lefringhouse, Edward J. Pavlik, Rachel Miller, Christopher Desimone, Frederick Ueland, Thomas Tucker, Richard Kryscio, John R. Van Nagell Jr.

Markey Cancer Center Faculty Publications

Objective. The aim of this study was to document the survival advantage of lowering stage at detection from Stage IIIC to Stage IIIA epithelial ovarian cancer. Methods. Treatment outcomes and survival were evaluated in patients with Stage IIIA and Stage IIIC epithelial ovarian cancer treated from 2000 to 2009 at the University of Kentucky Markey Cancer Center (UKMCC) and SEER institutions. Results. Cytoreduction to no visible disease (P < 0.0001) and complete response to platinum-based chemotherapy (P < 0.025) occurred more frequently in Stage IIIA than in Stage IIIC cases. Time to progression was shorter in patients with Stage IIIC ovarian cancer (17 ± 1 months) than in those with Stage II1A disease (36 ± 8 months). Five-year overall survival (OS) improved from 41% in Stage IIIC patients to 60% in Stage IIIA patients treated at UKMCC and from 37% to 56% in patients treated at SEER institutions for a survival advantage of 19% in both data sets. 53% of Stage IIIA and 14% of Stage IIIC patients had NED at last followup. Conclusions. Decreasing stage at detection from Stage IIIC to stage IIIA epithelial ovarian cancer is associated with a 5-year survival advantage of nearly 20% in patients treated by surgical tumor …

Turkey's New Regional Security Role: Implications For The United States, Richard Weitz Dr.

Books, Monographs & Collaborative Studies

View the Executive Summary

Until a few years ago, the relationship between Washington and Ankara was perennially troubled and occasionally terrible. Turkey opposed the 2003 U.S. invasion of Iraq and complained that the Pentagon was allowing Iraqi Kurds too much autonomy, leading to deteriorating security along the Iraq-Turkish border. Disagreements over how to respond to Iran’s nuclear program; U.S. suspicions regarding Turkey’s outreach efforts to Iran and Syria; and differences over Armenia, Palestinians, and the Black Sea further strained ties. However, Turkey is now seen as responding to its local challenges by moving closer to the West. The United States …

Across-Speaker Articulatory Normalization For Speaker-Independent Silent Speech Recognition, Jun Wang, Ashok Samal, Jordan Green

School of Computing: Conference and Workshop Papers

Silent speech interfaces (SSIs), which recognize speech from articulatory information (i.e., without using audio information), have the potential to enable persons with laryngectomy or a neurological disease to produce synthesized speech with a natural sounding voice using their tongue and lips. Current approaches to SSIs have largely relied on speaker-dependent recognition models to minimize the negative effects of talker variation on recognition accuracy. Speaker-independent approaches are needed to reduce the large amount of training data required from each user; only limited articulatory samples are often available for persons with moderate to severe speech impairments, due to the logistic difficulty of …

The Trehalose Pathway In Maize: Conservation And Gene Regulation In Response To The Diurnal Cycle And Extended Darkness, Clémence Henry, Samuel W. Bledsoe, Allison Siekman, Alec Kollman, Brian M. Waters, Regina Feil, Mark Stitt, L. Mark Lagrimini

Department of Agronomy and Horticulture: Faculty Publications

Energy resources in plants are managed in continuously changing environments, such as changes occurring during the day/night cycle. Shading is an environmental disruption that decreases photosynthesis, compromises energy status, and impacts on crop productivity. The trehalose pathway plays a central but not well-defined role in maintaining energy balance. Here, we characterized the maize trehalose pathway genes and deciphered the impacts of the diurnal cycle and disruption of the day/night cycle on trehalose pathway gene expression and sugar metabolism. The maize genome encodes 14 trehalose-6-phosphate synthase (TPS) genes, 11 trehalose-6-phosphate phosphatase (TPP) genes, and one trehalase gene. Transcript abundance of most …

Sensitivity Analysis Of Biological Boolean Networks Using Information Fusion Based On Nonadditive Set Functions, Naomi Kochi, Tomáš Helikar, Laura Allen, Jim A. Rogers, Zhenyuan Wang, Mihaela T. Matache

Department of Biochemistry: Faculty Publications

Background: An algebraic method for information fusion based on nonadditive set functions is used to assess the joint contribution of Boolean network attributes to the sensitivity of the network to individual node mutations. The node attributes or characteristics under consideration are: in-degree, out-degree, minimum and average path lengths, bias, average sensitivity of Boolean functions, and canalizing degrees. The impact of node mutations is assessed using as target measure the average Hamming distance between a non-mutated/wild-type network and a mutated network.

Results: We find that for a biochemical signal transduction network consisting of several main signaling pathways whose nodes …

Use Of Cysteine-Reactive Crosslinkers To Probe Conformational Flexibility Of Human Dj-1 Demonstrates That Glu18 Mutations Are Dimers, Janani Prahlad, David N. Hauser, Nicole M. Milkovic, Mark R. Cookson, Mark A. Wilson

Department of Biochemistry: Faculty Publications

The oxidation of a key cysteine residue (Cys106) in the parkinsonism-associated protein DJ-1 regulates its ability to protect against oxidative stress and mitochondrial damage. Cys106 interacts with a neighboring protonated Glu18 residue, stabilizing the Cys106-SO₂ ⁻ (sulfinic acid) form of DJ-1. To study this important post-translational modification, we previously designed several Glu18 mutations (E18N, E18D, E18Q) that alter the oxidative propensity of Cys106. However, recent results suggest these Glu18 mutations cause loss of DJ-1 dimerization, which would severely compromise the protein’s function. The purpose of this study was to conclusively determine the oligomerization state of these mutants using X-ray …

Natural Infections Of Tetrathyridia Of Mesocestoides Species In Deer Mice, Peromyscus Maniculatus, From New Mexico, John E. Ubelaker, Nora Abdullah, Aya Mouhaffel, Rashmi Ananadampillair, Caitlyn Emigh, Scott Lyell Gardner

Papers in Parasitology

At Southern Methodist University campus about 6 miles south of Taos, New Mexico, we recovered tetrathyridia of Mesocestoides in five Peromyscus maniculatus in the summers of 2008 (3 of 129, 0.023%), 2009 (0 of 98, 0%), 2010 (1 of 112, 0.008%), 2011 (0 of 88, 0%), and 2012 (1 of 86, 0.011%). Tetrathyridia from the body cavity of one of the five infected mice were injected into the peritoneal cavity of laboratory white mice, Mus musculus. Our later examination of the laboratory mice revealed heavy infections of tetrathyridia continuing to reproduce asexually. Here we provide important new information on …

The Quarterly Review Of Biology: Population And Community Ecology Of Onto- Genetic Development. Monographs In Population Biology, Volume 51., Chad Brassil

School of Biological Sciences: Faculty Publications

The authors present a derivation, synthesis, and exposition of the consequences of juvenile-adult stage-structured models leading to biomass overcompensation with increasing mortality rates. They compile and elaborate upon their previous work, using the space afforded to provide a thorough explanation and examination of model variants.

They argue the most important stage-structure element to include is, minimally, a model with juveniles and adults. Fundamentally, these elements are linked by maturation of juveniles to adults and the reproduction of adults to produce more juveniles. The major result is that, for the empirically justified set of parameters presented in the book, increasing the …

Natural Infections Of Tetrathyridia Of Mesocestoides Species In Deer Mice, Peromyscus Maniculatus, From New Mexico, John E. Ubelaker, Norah Abdullah, Aya Mouhaffel, Rashmi Ananadampillair, Caitlyn Emigh, Scott Lyell Gardner

Harold W. Manter Laboratory of Parasitology: Faculty Publications

At Southern Methodist University campus about 6 miles south of Taos, New Mexico, we recovered tetrathyridia of Mesocestoides in five Peromyscus maniculatus in the summers of 2008 (3 of 129, 0.023%), 2009 (0 of 98, 0%), 2010 (1 of 112, 0.008%), 2011 (0 of 88, 0%), and 2012 (1 of 86, 0.011%). Tetrathyridia from the body cavity of one of the five infected mice were injected into the peritoneal cavity of laboratory white mice, Mus musculus. Our later examination of the laboratory mice revealed heavy infections of tetrathyridia continuing to reproduce asexually. Here we provide important new information on the …

Radix Angelicae Sinensis And Radix Hedysari Enhance Radiosensitivity Of 12c6+ Radiation In Human Liver Cancer Cells By Modulating Apoptosis Protein, Wei Kou, Ying-Dong Li, Kai Liu, Shao-Bo Sun, Yu-Mei Dong, Zhen-Hua Wu

Saudi Medical Journal

OBJECTIVES: To investigate the radiosensitizing effects of Radix Angelicae Sinensis-Radix Hedysari (RAS-RH [an ultra-filtration extract]) and its underlying mechanisms in human liver cancer cells H22. METHODS: This study was conducted between September 2010 and August 2012 in the Gansu University of Traditional Chinese Medicine, Lanzhou, China. The groups were assigned as the control group, drug (RAS-RH) group, 12C6+ radiation group, and combination group. The cell counting kit-8 assay, colony formation assay, cell cycle changes, and apoptosis analysis were carried out, and survivin and casepase-9 were evaluated by reverse transcription polymerase chain reaction and Western blot analyses in the 4 groups. …

Protective Effect Of Seed Oil Of Herpetospermum Pedunculosum Against Carbon Tetrachloride-Induced Liver Injury In Rats, Gang Li, Xiao-Yan Wang, You-Rui Suo, Hong-Lun Wang

Saudi Medical Journal

OBJECTIVES: To investigate the protective effect of Herpetospermum pedunculosum (H. pedunculosum) seed oil against carbon tetrachloride (CCl4)-induced liver damage. METHODS: This experimental study was conducted at the Northwest Institute of Plateau Biology, Chinese Academy of Sciences, and Yantai University, China from November 2012 to May 2013. The H. pedunculosum seed oil was extracted using supercritical carbon dioxide. The antioxidant activities of H. pedunculosum seed oil were assayed in vitro by 2,2-diphenyl-1-picrylhydrazyl assay, lipid peroxidation assay, and antihemolytic assay. Adult Sprague Dawley rats were randomly divided into 6 groups (10 rats/group) including control, CCl4, CCl4+bifendate, and CCl4+H. pedunculosum seed oil (3 …

Seroprevalence Of Toxoplasma Gondii In Women In Najran City, Saudi Arabia, Ismail S. El-Shahawy, Mokhtar I. Khalil, Mosa M. Bahnass

Saudi Medical Journal

OBJECTIVES: To evaluate the seroprevalence of Toxoplasma gondii among Saudi pregnant women in Najran City, as well as to measure the performance of the diagnostic tests used. METHODS: A total of 96 women attending prenatal special clinics (Oteafyn special clinic) in Najran Province, Saudi Arabia, over a one year period, from September 2012 to September 2013 were screened for the presence of Toxoplasma antibody in their blood serum using an indirect hemagglutination assay (IHA). Specific immunoglobulin (Ig) G and IgM antibodies were evaluated using an enzyme-linked immunosorbent assay (ELISA). RESULTS: Out of the 96 samples of sera tested using IHA, …

A 10-Year Experience With Hepatic Trauma In A Chinese Level One Trauma Center, Zhi-Qiang Tian, Xiao-Fang Su, Feng Yu, Hong Liu, Zheng Fang, Kun-Lun Luo

Saudi Medical Journal

OBJECTIVES: To analyze strategies of operative management (OM) and non-operative management (NOM), mortality, and morbidity of hepatic trauma patients. METHODS: We retrospectively reviewed 296 consecutive patients with hepatic trauma at the Department of Hepatobiliary Surgery, 101st Hospital of PLA, Wuxi, Jiangsu, China a single level one trauma center between January 2003 and December 2012. Data on demographics, mechanism of trauma, American Association for the Surgery of Trauma grade, initial management, and outcome were collected for this study. RESULTS: A total of 101 (34%) patients were of low-grade, while 195 (66%) were of high-grade. Hepatic trauma with associated injury of other …

Woman With A 3-Month History Of Left Ulcerative Bulbar Conjunctiva Accompanied By Severe Scleral Irritation And Soreness, Hui Wu, Yuan Hu, Xiaoru Shi, Hui Jia

Saudi Medical Journal

[No abstract available]

Virus-Host Mucosal Interactions During Early Siv Rectal Transmission, Wuxun Lu, Fangrui Ma, Alexander Churbanov, Yanmin Wan, Yue Li, Guobin Kang, Zhe Yuan, Dong Wang, Chi Zhang, Jianqing Xu, Mark Lewis, Qingsheng Li

Nebraska Center for Biotechnology: Faculty and Staff Publications

To deepen our understanding of early rectal transmission of HIV-1, we studied virus-host interactions in the rectal mucosa using simian immunodeficiency virus (SIV)-Indian rhesus macaque model and mRNA deep sequencing. We found that rectal mucosa actively responded to SIV as early as 3 days post-rectal inoculation (dpi) and mobilized more robust responses at 6 and 10 dpi. Our results suggests that the failure of the host to contain virus replication at the portal of entry is attributable to both a high-level expression of lymphocyte chemoattractant, proinflammatory and immune activation genes, which can recruit and activate viral susceptible target cells into …

Does Lethal Control Of Top-Predators Release Mesopredators? A Re-Evaluation Of Three Australian Case Studies, Benjamin L. Allen, Geoff Lundie-Jenkins, Neil D. Burrows, Richard M. Engeman, Peter J.S. Fleming, Luke K.-P. Leung

United States Department of Agriculture Wildlife Services: Staff Publications

Top-predators can sometimes be important for structuring fauna assemblages in terrestrial ecosystems. Through a complex trophic cascade, the lethal control of top-predators has been predicted to elicit positive population responses from mesopredators that may in turn increase predation pressure on prey species of concern. In support of this hypothesis, many relevant research papers, opinion pieces and literature reviews identify three particular case studies as supporting evidence for top-predator controlinduced release of mesopredators in Australia. However, many fundamental details essential for supporting this hypothesis are missing from these case studies, which were each designed to investigate alternative aims. Here, we re-evaluate …

Surface Soil Quality In Five Midwestern Cropland Conservation Effects Assessment Project Watersheds, Douglas Karlen, Diane E. Stott, Cynthia A. Cambardella, Robert J. Kremer, Greg W. Mccarty

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Soil quality (SQ) assessment is a proactive process for evaluating soil and crop management effects on biological, chemical, and physical indicators of soil health. Our objectives were to evaluate several SQ indicators within five Agricultural Research Service (ARS) experimental watersheds (WS) and determine if those indicators were affected by manure, tillage, or crop rotation histories. Ten soil quality indicators were measured within each of 600 0 to 5 cm (0 to 2 in) depth and 398 5 to 15 cm (2 to 6 in) depth increment samples, evaluated statistically, and then scored using the Soil Management Assessment Framework. Except for …

Persistence And Stability Of Eastern Afromontane Forests: Evidence From Brevicipitid Frogs, Simon P. Loader, F. Sara Ceccarelli, Michele Menegon, Kim M. Howell, Roman Kassahun, Abebe A. Mengistu, Samy A. Saber, Fikirte Gebresenbet, Rafael O. De Sá, Et Al.

Biology Faculty Publications

Aim: The persistence and stability of habitats through time are considered predictors of high levels of biodiversity in some environments. Long-term habitat persistence and stability may explain the species-rich, endemic forest fauna and flora of the Eastern Afromontane Biodiversity Region (EABR). Using comple- mentary phylogenetic and biogeographical approaches, we examine evolution- ary patterns in EAR brevicipitid frogs. Using these data, we test whether brevicipitid history reflects patterns of long-term forest persistence and/or sta bility across the EABR.

Location: East Africa.

Methods: A dated phylogeny for brevicipitids was constructed using two nuclear and three mitochondrial markers. Alternative diversification modes were used …

Theoretical Prediction Of Experimental Jump And Pull-In Dynamics In A Mems Sensor, Laura Ruzziconi, Abdallah H. Ramini, Mohammad I. Younis, Stefano Lenci

Mechanical Engineering Faculty Scholarship

The present research study deals with an electrically actuated MEMS device. An experimental investigation is performed, via frequency sweeps in a neighbourhood of the first natural frequency. Resonant behavior is explored, with special attention devoted to jump and pull-in dynamics. A theoretical single degree-of-freedom spring-mass model is derived. Classical numerical simulations are observed to properly predict the main nonlinear features. Nevertheless, some discrepancies arise, which are particularly visible in the resonant branch. They mainly concern the practical range of existence of each attractor and the final outcome after its disappearance. These differences are likely due to disturbances, which are unavoidable …

Saliency Detection With Flash And No-Flash Image Pairs, Shengfeng He, Rynson W.H. Lau

Research Collection School Of Computing and Information Systems

In this paper, we propose a new saliency detection method using a pair of flash and no-flash images. Our approach is inspired by two observations. First, only the foreground objects are significantly brightened by the flash as they are relatively nearer to the camera than the background. Second, the brightness variations introduced by the flash provide hints to surface orientation changes. Accordingly, the first observation is explored to form the background prior to eliminate background distraction. The second observation provides a new orientation cue to compute surface orientation contrast. These photometric cues from the two observations are independent of visual …

Crossnavi: Enabling Real-Time Crossroad Navigation For The Blind With Commodity Phones, Longfei Shangguan, Zheng Yang, Zimu Zhou, Xiaolong Zheng, Chenshu Wu, Yunhao Liu

Research Collection School Of Computing and Information Systems

Crossroad is among the most dangerous parts outside for the visually impaired people. Numerous studies have exploited navigating systems for the visually impaired community, providing services ranging from block detection, route planning to realtime localization. However, none of them have addressed the safety issue in crossroad and integrated three key factors necessary for a practical crossroad navigation system: detecting the crossroad, locating zebra patterns, and guiding the user within zebra crossing when passing the road. Our CrossNavi application responds to these needs, providing an integrated crossroad navigation service that incorporates all the essential functionalities mentioned above. The overall service is …

The Prohibition Of Moonshine: A Consumer Protection Analysis Of Raw Milk In Interstate Commerce, Whitney R. Morgan

West Virginia Law Review

No abstract provided.

Child Maltreatment: What Attitudinal Factors Of Commitment, Confidence, And Concern Predict Reporting Practices Of Preservice Speech-Language Pathologists?, Alan Smith

Doctoral Dissertations and Projects

The pervasiveness of child maltreatment is a global issue, although its impact on the United States is markedly severe. The mortality rate for children four years of age and younger continues to rise annually, with an especially alarming increase present for children with disabilities. Although inservice and preservice educators, including speech-language pathologists, are mandated to report suspected maltreatment, several obstacles appear to hinder their actions. Understanding the factors that predict an individuals' likelihood of reporting malfeasance may help minimize maltreatment occurrence and child mortality. Preservice speech- language pathologists attending accredited programs in the United States were surveyed regarding their attitudes …