Digital Commons Network^™

Bioh 461.80: Tutoring Human Anatomy And Physiology I - Honors, Laurie A. Minns

University of Montana Course Syllabi

No abstract provided.

Biob 547.01a: Experimental Molecular, Cellular, And Chemical Biology, Jesse C. Hay

University of Montana Course Syllabi

No abstract provided.

Biob 291.01: Special Topics - Conservation Ecology, John L. Maron

University of Montana Course Syllabi

No abstract provided.

Biob 260.00: Cellular And Molecular Biology, D. Scott Samuels, Mark L. Grimes

University of Montana Course Syllabi

No abstract provided.

Biob 160n.00: Principles Of Living Systems, H. Arthur Woods, Scott R. Miller

University of Montana Course Syllabi

No abstract provided.

Biob 101n.50: Discover Biology - Online, Evgueny Kroll

University of Montana Course Syllabi

No abstract provided.

Biob 101n.00: Discover Biology, Kevin J. Murray

University of Montana Course Syllabi

No abstract provided.

Bioh 365.80: Human Anatomy And Physiology For Health Professions I - Honors, Heather D. Labbe

University of Montana Course Syllabi

No abstract provided.

Enst 225.01: Community And Environment, Brianna M. Ewert

University of Montana Course Syllabi

No abstract provided.

Anty 510.01: Seminar In Human Variation And Evolution, Meradeth H. Snow

University of Montana Course Syllabi

No abstract provided.

Chmy 141n.00: College Chemistry I, Mark S. Cracolice

University of Montana Course Syllabi

No abstract provided.

Biom 427.01: General Parasitology, Willard O. Granath

University of Montana Course Syllabi

No abstract provided.

Bioh 423.80: Human Form And Function Teaching Assistant I - Honors, Heather D. Labbe

University of Montana Course Syllabi

No abstract provided.

Fors 349.01: Practice Of Silviculture, John Goodburn

University of Montana Course Syllabi

No abstract provided.

Oncolog, Volume 59, Number 09, September 2014, Stephanie Deming, Bryan Tutt, Joe Munch, Jill Delsigne

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Biomarker-Driven Clinical Trials may Improve Personalized Treatment for Patients With Lung Cancer: Innovative clinical trials that assign patients to treatment arms based on tumor biomarkers could lead to increase treatment options for patients with lung cancer
• New Antibody-Chemotherapy Combinations Show Promise Against Acute Lymphoblastic Leukemia: Two investigational agents-inotuzumab and ofatumumab-shows promise when combined with cytotoxic chemotherapy drugs for the treatment of acute lymphoblastic leukemia (ALL) in adults
• Deep Inspiration Breath Hold Protects Against Radiation-Induced Cardiotoxicity in Patients With Left-Sided Breast cancers: Patients with lest-sided breast cancers have an increased risk of heart damage from adjuvant radiation therapy given after lumpectomy …

Range Maps For The Terrestrial Natural Communities Of Nebraska, Steven B. Rolfsmeier, Gerry Steinauer, Rachel Simpson

Nebraska Game and Parks Commission: White Papers, Conference Presentations, and Manuscripts

This document includes range maps for the 83 terrestrial natural (plant) communities described in Terrestrial Ecological Systems and Natural Communities of Nebraska (Version IV - March 9, 2010) by Rolfsmeier and Steinauer 2010. Each map includes the known range and potential range for individual community types. The known range includes areas where a community has been documented and areas where it has not been documented but thought very likely to occur. The potential range includes areas where the community has not been documented but is thought to have some potential to occur. The maps should be considered approximations of the …

Reclaiming The Spiritual Leadership Role Of Christian Parents In Family Life: Coaching And Markers, Cindy Hayes

Doctoral Dissertations and Projects

Christians in the Western culture often struggle to pass on their faith to the next generation and as a result, the way God designed the family to function is being unwittingly abandoned. Countless parents today are leaving genuine faith and reliance on God behind. Though God's Word gives specific instructions on how to maintain and pass on faith, many have abdicated this injunction. In an effort to encourage authentic faith within the family, the local church can come alongside parents to help them understand and share their faith by offering training and coaching to embrace their own faith and pass …

Antisense Reduction Of The Protein Tau Attenuates Neuronal Hyperexcitability And Permits Clearance Of Intraneuronal Tau Accumulations In Vivo, Sarah Lorraine Devos

All Theses and Dissertations (ETDs)

The protein tau is a major contributor in some of the most prevalent neurodegenerative diseases, including the most common form of dementia, Alzheimer's Disease (AD). As a member of the microtubule-associated protein family, tau in enriched in the axons of mature and growing neurons, though under certain conditions, can become hyperphosphorylated and accumulate into toxic oligomeric species and aggregates. In the studies outlined here, we sought to directly target the protein tau using Antisense Oligonucleotides (ASOs) to reduce total expression of tau in vivo and assess if such a reduction could be therapeutically beneficial. To first test the feasibility of …

The Role Of Hspa9 In Mouse Hematopoiesis And Il-7 Receptor Signaling, Kilannin Krysiak

All Theses and Dissertations (ETDs)

HSPA9 was previously identified as a candidate gene in a commonly deleted region (CDR) associated with myelodysplastic syndrome (MDS), a clonal hematopoietic stem cell disorder. Cytogenetic abnormalities occur in ~50% of MDS patients and an interstitial deletion or loss of chromosome 5 containing HSPA9 is the most common, occurring in up to 25% of patients. In order to understand the role of HSPA9 in hematopoiesis and disease development, we created an Hspa9 knockout mouse model. We characterized hematopoiesis of heterozygous mice (Hspa9+/-), which have a 50% reduction in Hspa9 expression, modeling the heterozygous loss of HSPA9 and 50% reduction in …

Characterization Of Fasting-Induced P21 Expression And Protection Of Intestinal Stem Cells, Kelsey Lynn Tinkum

All Theses and Dissertations (ETDs)

The cyclin dependent kinase inhibitor, p21, plays a key role in cell cycle. Additionally, the p21 gene, Cdkn1a (hereafter p21) is often used as a marker of cellular stress. To investigate p21 promoter activity under basal conditions and in response to various forms of stress, we generated knock-in imaging reporter mice that express firefly luciferase (FLuc) under the control of the endogenous p21 promoter. I demonstrated that FLuc expression and bioluminescence detection mirrored endogenous p21 protein levels and promoter activity in vivo. Contrary to previously known roles for p53-mediate expression of p21, imaging of reporter cells demonstrated that p53 prevented …

Investigation And Optimization Of Extraordinary Electroconductance (Eec) Sensors & The Role Of Magnetic Disorder In The Formation Of Spin Glasses, Fletcher M. Werner

All Theses and Dissertations (ETDs)

PART I: Investigation and Optimization of Extraordinary Electroconductance (EEC) Sensors

This thesis presents an investigation and geometric optimization of Extraordinary Electroconductance (EEC) sensors, a member of an established class of sensors that exhibit `extraordinary' phenomenon driven by interfaces that maximize current redistribution under an applied perturbation. EEC sensors are responsive to both applied electrical fields and optical illumination and show promising application in the detection of complex biological signals that can aid in conclusive diagnoses.

The EEC device response to nonuniform illumination establishes greater versatility for EEC devices by allowing for position-dependent light sensing while under local illumination. Additionally, an …

Novel Role Of Chk2 In The Intrinsic And Extrinsic Apoptosis Pathway, Anurag Agarwal

All Theses and Dissertations (ETDs)

In response to genotoxic stress, cells activate DNA damage checkpoint pathways that maintain genetic fidelity, promote cell survival, and prevent malignant transformation. Checkpoint kinase 2 (CHK2) is an evolutionarily conserved serine/threonine protein kinase that is activated in response to DNA double strand breaks. Upon activation by the DNA damage transducer kinase, ATM, CHK2 phosphorylates a wide variety of down stream effectors to promote cell cycle arrest, DNA repair and apoptosis. One of they key downstream substrate of CHK2 is the tumor suppressor protein, p53. CHK2 is considered as a key kinase in DNA damage-induced p53 regulation and thought to mediate …

Making Sense Of Unexpected Preferences, Gordon Alexander Arsenoff

All Theses and Dissertations (ETDs)

This dissertation includes three papers using quantitative models to sensibly describe what kinds of preferences political actors will or actually do hold when existing theory offers no insight. The first two papers use evolutionary game theory to predict ways in which politicians, artificially selected on the basis of good performance to remain in office, will in the long run diverge from instrumental rationality as ordinarily assumed in game theory. The first sets out a general principle for producing models of preference evolution in games as political models, namely, that the information about opponent preferences necessary for evolution of non-rational preferences …

Characterization Of The Role Of R7-Rgs Proteins In Mammalian Retina And Vision, Matthew D. Cain

All Theses and Dissertations (ETDs)

ABSTRACT OF THE DISSERTATION

Characterization of the Role of RGS7-family Proteins in Mammalian Retina and Vision

by

Matthew David Cain

Doctor of Philosophy in Biology and Biomedical Sciences

Molecular Cell Biology

Washington University in St. Louis, 2014

Professor Kendall J. Blumer, Chairperson

GPCR/G protein signaling is a critical component of neuronal signal transduction and function. G protein signaling is regulated by a family of regulator of G protein signaling (RGS) proteins that act as GTPase activating proteins (GAPs) for Gα subunits. In the retina, the R7-RGS family of RGS proteins which specifically act as GAPs toward Gi/o, are critical regulators …

Multi- Modal Characterization Of Left Ventricular Diastolic Filling Physiology, Erina Ghosh

All Theses and Dissertations (ETDs)

Multiple modalities are clinically used to quantify cardiovascular function. Most clinical indexes derived from these modalities are empirically derived or correlation- based rather than causality based. Hence these indexes don't provide insight into cardiac physiology and the mechanism of dysfunction. Our group has previously developed and validated a mathematical model using a kinematic paradigm of suction- initiated ventricular filling to understand the mechanics of early transmitral flow and the associated physiology/ pathophysiology. The model characterizes the kinematics of early transmitral flow analogous to a damped simple harmonic oscillator with lumped parameters- ventricular stiffness, ventricular viscoelasticity/ relaxation and ventricular load.

The …

Dominant Mechanisms Of Uranium(Vi)‒Phosphate Interactions In Subsurface Environments: An In Situ Remediation Perspective, Vrajesh Sanat Mehta

All Theses and Dissertations (ETDs)

Anthropogenic activities associated with the production of nuclear materials have resulted in uranium contaminated soil and groundwater. The carcinogenic and toxic effects of uranium contamination pose a significant risk to the environment and human health. Phosphate addition to uranium-contaminated subsurface environments has been proposed as a strategy for in situ remediation. Addition of phosphate amendments can result in uranium sequestration in its oxidized +VI state without sustaining reducing conditions as is needed for in situ immobilization via chemical or biological reduction of U(VI) to less soluble U(IV) species. Phosphate addition can be used as a stand-alone process or as a …

Dual Roles Of Interferon Stimulated Gene-15 During Respiratory Virus Infection, David James Morales

All Theses and Dissertations (ETDs)

ISG15 is a diubiquitin-like posttranslational modifier and one of the most rapidly induced genes upon type I interferon stimulation. Hundreds of host proteins have been identified as targets of ISG15 conjugation after interferon stimulation, and a number of viral proteins have been shown to be modified by ISG15 during infection. Given the known importance of posttranslational protein modification in the regulation of cellular biology, understanding how ISG15 affects the interferon response and virus replication has been of considerable interest. ISG15 deficient mice have previously been shown to exhibit increased susceptibility to a number of different viruses, including influenza A and …

How Cd4+ T Cells Recognize Allostimulatory Peptide-Mhc, Peggy Pei-Wen Ni

All Theses and Dissertations (ETDs)

Critical in determining transplantation outcome, whether tolerance is achieved or not, are CD4+ T cells that can recognize peptides presented on allogeneic (non-self) Major Histocompatibility Complex (MHC) molecules in addition to their conventional ligands, peptides presented on self MHC. It is an enigma as to how these alloreactive T cells can bind to allogeneic MHC given that T cells undergo stringent positive selection during development to bind to peptides presented on self MHC. We hypothesize that T cells bind to peptides on non-self MHC using the same properties involved in binding their conventional ligands. We identified allostimulatory peptide-MHC (pMHC) ligands …

Characterization Of A Novel Npc1i1061t Knock-In Mouse Model Of Niemann-Pick Type C1 Disease, Maria A. Praggastis

All Theses and Dissertations (ETDs)

Niemann-Pick Type C (NPC) disease is a fatal pediatric cholesterol storage disease that is caused by mutations in either the npc1 or npc2 genes. Loss of function of either gene results in toxic storage of free cholesterol in the lysosomes due to a cholesterol trafficking defect. In humans the free cholesterol accumulation leads to Purkinje cell loss in the cerebellum and is accompanied by neurodegenerative symptoms that include ataxia, vertical supranuclear gaze palsy, and decreased motor function. Most NPC1 patients succumb to the disease within the first two decades of life.

The most prevalent mutation, NPC1I1061T, resides within the cysteine-rich …

N-Cadherin Regulation Of Bone Anabolic Responses Via Pth And Wnt/Beta-Catenin Signaling, Leila Denise Revollo

All Theses and Dissertations (ETDs)

The main function of parathyroid hormone (PTH) is to regulate serum calcium levels, in part by stimulating osteoclast mediated bone resorption. However, PTH can stimulate bone formation if given in intermittent doses and it is currently used as a bone anabolic agent to treat osteoporosis. The mechanisms by which PTH stimulates new bone formation are not yet completely clarified; PTH targets not only osteoblasts, where PTH receptors are abundantly expressed, but also immune cells. In this thesis, I examined the role of the calcium dependent cell-cell adhesion molecule, N-cadherin, in PTH signaling and bone anabolic responses. The findings presented in …