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Status And Trends Of The Rocky Intertidal Community On The Farallon Islands, Jan Roletto, Scott Kimura, Natalie Cosentino-Manning, Ryan Berger, Russell Bradley

Monographs of the Western North American Naturalist

The Farallon Islands in the Gulf of the Farallones National Marine Sanctuary (GFNMS) is a 7-island chain located 48 km west of San Francisco, California. Since 1993, GFNMS biologists and associates have monitored algal and invertebrate species abundances on the intertidal shores of the 2 South Farallon Islands. The monitoring occurred 1–3 times yearly in 6 study areas. In each study area, 3–4 permanent, 0.15-m² quadrats located between the upper and midintertidal zones were sampled for algal and sessile invertebrate cover and invertebrate counts. Taxonomic surveys were also completed to document other species in the vicinity of the sampling …

How The Esa Can Swallow Alaskan Tribal Sovereignty: The Story Of The Iliamna Lake Seals, Charisse Arce

American Indian Law Journal

No abstract provided.

The Influence Of Dx-52-1 And Phosphorylation On The Interactions Of Galectin-3 With Its Binding Partners, Matthew L. Rotondi

Doctoral Dissertations

The Influence of DX-52-1 and Phosphorylation on the Interactions of Galectin-3 with its Binding Partners

Matthew L. Rotondi, PhD

University of Connecticut, 2015

Galectin-3, a member of a large family of animal based β-galactoside-binding lectins has been shown to play a role in a number of cellular and pathogenic processes. This protein has been shown throughout the literature to interact with a diverse multiplicity of proteins, involved in a diverse array of cellular functions, including cell migration and cell proliferation, both of which are of particular in regards to cancer research. Covalent modifications to Galectin-3 that can undermine its binding …

Cyclooxygenase-2, Prostaglandin E2, And Prostanoid Receptor Ep2 In Fluid Flow Shear Stress-Mediated Injury In The Solitary Kidney., Tarak Srivastava, Uri S. Alon, Patricia A. Cudmore, Belal Tarakji, Alexander Kats, Robert E. Garola, R Scott Duncan, Ellen T. Mccarthy, Ram Sharma, Mark L. Johnson, Lynda F. Bonewald, Ashraf El-Meanawy, Virginia J. Savin, Mukut Sharma

Manuscripts, Articles, Book Chapters and Other Papers

Hyperfiltration subjects podocytes to increased tensile stress and fluid flow shear stress (FFSS). We showed a 1.5- to 2.0-fold increase in FFSS in uninephrectomized animals and altered podocyte actin cytoskeleton and increased synthesis of prostaglandin E2 (PGE2) following in vitro application of FFSS. We hypothesized that increased FFSS mediates cellular changes through specific receptors of PGE2. Presently, we studied the effect of FFSS on cultured podocytes and decapsulated isolated glomeruli in vitro, and on solitary kidney in uninephrectomized sv129 mice. In cultured podocytes, FFSS resulted in increased gene and protein expression of cyclooxygenase (COX)-2 but not COX-1, prostanoid receptor EP2 …

Modeling Mussel Mortality: Investigating The Importance Of Swash And The Potential Implications Of Changing Wave Environments, Shadow Leigh Gulledge

Theses and Dissertations

Rising sea level and increases in temperature are causing biogeographic shifts in intertidal zones and can also lead to shifts in the local vertical zonation of organisms due to changes in body temperature during aerial exposure during low tide. Swash is an important determinant of aerial body temperatures, and vulnerability of intertidal zones to changes in climate could potentially depend on how much and how often animals are cooled by waves. While wave heights (and thus swash) are generally expected to increase with climate change, anthropogenic physical structures, such as breakwaters and wave energy converters, can decrease wave height and …

The Effects Of Multiple Gratitude Interventions Among Informal Caregivers Of Persons With Dementia And Alzheimer's Disease, Cristy Degregory

Theses and Dissertations

The purpose of this group randomized intervention trial was to examine the impact of participation in three telephone-based gratitude interventions on the physical, psychological and social functioning of participants in caregiver support groups who are unpaid family caregivers of persons with dementia and Alzheimer’s disease. Fredrickson’s (2001) Broaden-and-Build Theory informed the investigation of the effect of three gratitude interventions on participants’ levels of gratitude, positive aspects of caregiving, subjective well-being, physical health and mental health. This was a randomized, wait-list controlled study involving informal caregivers involved in support groups. The research questions were: 1.) How does gratitude contribute to subjective …

Marine Population Connectivity: Range Boundaries And Climate Change, Rhiannon Leigh Rognstad

Theses and Dissertations

Population connectivity, particularly in open systems, is an important metric for understanding population-level processes on both ecological and evolutionary timescales. In coastal marine systems, adults are typically sedentary and dispersal occurs primarily during a larval stage when individuals are transported in ocean currents. Because coastal marine populations exist as networks of interconnected subpopulations, variation in the magnitude and extent of population connectivity can have profound effects on population dynamics and species distribution limits. Connectivity is a complex process, affected by a multitude of factors, including adult inputs and physical dispersal, which operate at multiple scales and may interact. This dissertation …

Climatic Controls On Organic Matter Decomposition In Boreal Peatlands, Michael J. Philben

Theses and Dissertations

Boreal peatlands currently contain 550 Pg C and are located at high latitudes where mean annual temperatures are expected to increase by as much as 7°C by the end of the century. There is growing concern that warming will stimulate decomposition, transforming peatlands from a sink to a source of atmospheric carbon dioxide and accelerating climate change. A primary goal of this dissertation was to evaluate the effect of climate change on organic matter decomposition in peatlands. This was achieved by developing and employing biochemical tracers to indicate the extent of peat decomposition across a range of naturally occurring climatic …

Young, Southern Women's Perceptions Of Stem Careers: Examining Science, Technology, Engineering And Mathematics As A Gendered Construct, Jessica Elizabeth Quinton

Theses and Dissertations

Career interests develop over a lifetime and tend to solidify during late adolescence and early adulthood (Lent, Brown, and Hackett, 2002). The primary purpose of the present qualitative study, which is framed in Feminist Standpoint Theory (Haraway, 1988; Harding, 2007; Naples, 2007; Richardson, 2007), is to understand how eighthgrade, young women in a suburban, public, southern, middle school the South Carolina County School District (CCSD) (pseudonym) perceive their accessibility to Science, Technology, Engineering, and Mathematics (STEM) courses and careers. The secondary purpose is to understand these young women’s “perceptions and unconscious beliefs about gender in science and mathematics” and how …

Ferric Reductases And Transporters That Contribute To Mitochondrial Iron Homeostasis, Anshika Jain

Theses and Dissertations

Iron (Fe) is the fourth most abundant element in the Earth’s crust, yet the availability of Fe to plants is often limited. This is because in most soil types, Fe precipitates as ferric-oxyhydroxy complexes, making it unavailable for uptake by plants. While the mechanisms involved in Fe uptake from the soil are relatively well understood, the mechanisms involved in its further distribution to the aerial portion of the plant and to subcellular compartments are not fully understood. During Fe deprivation, plants up-regulate root Fe acquisition machinery. How plants sense Fe deprivation and tie the Fe status of the plant to …

Cationic Metallocene-Containing Polymers: From Synthesis To Applications, Jiuyang Zhang

Theses and Dissertations

Metallopolymers, with the combination of metals and polymeric framworks, have attracted a lot of attention during the past decades. The development of metallopolymers has been largely driven by the desire to combine the synthetic efficiency and versatility of an organic polymer framework with the unique redox, responsive and catalytic properties of inorganic metals. Among different kinds of metallopolymers, metallocene-containing polymers， have been widely utilized for applications ranging from electrochemical sensors to templates for advanced inorganic catalysts to battery materials, due to their unique physicochemical properties. In the first part of my thesis, we showed controlled/living polymerization strategies to prepare well-defined …

Metformin Arrests Growth And Induces Apoptosis Of Neuroblastoma Cells, Nadia Al-Sammarraie

Theses and Dissertations

Neuroblastoma is one of the most common solid neoplasms in children, which affects sympathetic neurons with a wide range of genetic abnormalities, especially MYCN amplification, a molecular marker of poor prognosis. Despite advance therapy, still the mortality rate for advance disease is high with frequent relapse and resistance to cytotoxic therapy with evidence of p53 mutation. Metformin, an oral hypoglycemic medication, is a relatively safe and cost effective drug with wide clinical applications, mainly for treatment of Type 2 diabetes. Recent studies have showed promising anticancer effect of metformin on various cancer types, especially on p53 mutant cells. In our …

How School Leadership Develops Parental Involvement Strategies With Social Capital In Four South Carolina Middle Schools, Anthony Neil Boatwright

Theses and Dissertations

Passed in 2001, the No Child Left Behind (NCLB) mandate requires schools to have a comprehensive plan for addressing parental involvement. Identifying successful practices to increase social capital and academic achievement in lower socio-economic schools appears to be the area that is having the most impact. Principals can contribute to higher success rates by generating productive partnerships between the school and parents/guardians. The purpose of this study is to describe the parental involvement strategies that four successful South Carolina (SC) middle school principals used and to identify successful practices being implemented to increase social capital and academic achievement. The researcher …

Novel Biofabrication Technologies To Recapitulate In Vivo Geometries In Collagen Hydrogels, Veronica Rodriguez-Rivera

Theses and Dissertations

Tissue engineering and regenerative medicine aims to restore form and function to tissues that have been lost or damaged due to disease, congenital defect, or trauma. Biomaterials suitable to restore these complex tissues need to provide a balance between chemical and mechanical properties, providing accurate cell-matrix interaction and induce in vivo behaviors such as proliferation, differentiation and migration. It also requires that physical and chemical cues be presented to the body in the proper temporal and spatial pattern. The extracellular matrix exerts forces that are transmitted through focal adhesion causing changes in the cell behavior. The hypothesis for this dissertation …

Understanding The Evolutionary History Of Biochemical Innovation, Madeline Opal St. Julien

Theses and Dissertations

The serine protease (SP) gene family is an ecologically important gene family because of observed involvement in innate immunity, digestive processes, and embryological development of arthropods. In the past decade, all genes of the serine protease family have been classified in a number of arthropods, with the exception of crustacean. Possible evolutionary mechanisms have been observed based off of varying selectional pressures acting on recent SP expansions in respect to varying diets. Daphnia is the first crustacean to have its genome sequenced, and their genomes were analyzed in this study to elucidate the expansion and divergence of the SP gene …

Toward A Theory Of Safe Passage: Agentic Practices Of Women Writers Who Teach, Lillian Gordon Reeves

Theses and Dissertations

Past studies show that narrative is an effective tool for guiding teachers to develop teacher identity, to recognize their practical knowledge, and to engage in teacher transformation, especially during initial teacher training and the early years of their career. Consequently, other researchers have identified how narrative studies inform what we know about teachers’ identities, their practical knowledge, and their transformations during initial training and early career teaching. However, we do not know how narrative functions in the experiences of teachers beyond initial teacher training and early career teaching. This study intends to fill this gap in the research. In this …

Understanding Geo-Social Network Patterns: Computation, Visualization, And Usability, Caglar Koylu

Theses and Dissertations

Geo-social networks are formed by flows of physical entities (e.g., humans, vehicles, sensors, animals), and communication (e.g., information, ideas, innovation) that connect places to places and individuals to individuals. Several major problems remain to be addressed for understanding the complex patterns in geo-social networks. This dissertation makes the following contributions to the theory and methodologies that aim at understanding complex geo-social data by integrating methods of computation, visualization and usability evaluation. Chapter 2 introduces a novel network-based smoothing approach that addresses the size-difference and small area problem in calculating and mapping locational (graph) measures in spatial interaction networks. The new …

Weight-Gain And Energy Balance, Benjamin Thomas Gordon

Theses and Dissertations

Energy balance is the result of a dynamic relationship between energy intake (EI), energy expenditure (EE) and energy storage (ES). These three components of energy balance have extremely complicated associations, and all three major components are consistently influenced by physiologic, psychological, and sociologic factors. Concerted changes between EE and EI result in alterations of the ES. Most often in clinical and research settings, bodyweight is used as marker of body composition (i.e., ES) changes. Traditional measurements of bodyweight do not give an accurate portrayal of ES change or the role it has in energy balance. This dissertation supplies new methods …

Science Fairs Before Sputnik: Adolescent Scientific Culture In Contemporary America, Sarah Michel Scripps

Theses and Dissertations

"Science Fairs before Sputnik: Adolescent Scientific Culture in Contemporary America" traces the formation and evolution of science fairs in America, focusing on the ways in which adolescents established communities of practice by engaging in these competitions. Over the course of the twentieth century, generations of American children conducted their first experiments by crafting science fair projects. The dissertation evaluates this understudied phenomenon against the backdrop of American fascinations and fears of science and evolving notions of adolescence. It argues that science fairs were central to shaping an adolescent scientific culture in the United States during the early to mid twentieth …

Coral Spawning In The Gulf Of Oman And Relationship To Latitudinal Variation In Spawning Season In The Northwest Indian Ocean, E. J. Howells, D. Abrego, G. O. Vaughan, J. A. Burt

All Works

Despite a wealth of information on sexual reproduction in scleractinian corals, there are regional gaps in reproductive records. In the Gulf of the Oman in the Arabian Sea, reproductive timing was assessed in four common species of broadcast spawning corals using field surveys of gamete maturity and aquarium observations of spawning activity. The appearance of mature gametes within the same month for Acropora downingi, A. hemprichii, Cyphastrea microphthalma and Platygyra daedalea (≥ 75% of colonies, n = 848) indicated a synchronous and multi-specific spawning season. Based on gamete disappearance and direct observations, spawning predominantly occurred during April in 2013 (75- …

School-Based Sexuality Education, Gender, And Relationship Self-Efficacy: A Moderated-Mediation Analysis Of Sexual Behavior In First-Year College Students, Sara C. Schmidt

Theses and Dissertations

While the effectiveness at abstinence-only versus comprehensive sexuality education in preventing adolescent risky sexual behavior is widely researched, little is known about whether material learned in secondary school sexuality education classes impacts emerging adult sexual behavior in the college environment. Furthermore, research suggests that self-efficacy – or beliefs in one’s abilities to organize and execute actions – may be more critical than knowledge or skills in terms of how individuals enact behavior. We hypothesized a moderated-mediation effect by which the causal impact of type of sexuality education on four different sexual behaviors during the first year in college is transmitted …

Quantitative Comparison Of Time-Frequency Decomposed Gait Emg Signals, L. Patrick Mitchell

Theses and Dissertations

Falls in the senior population represent an immediate threat to both current and future generations’ quality of life. The results of falls can be disastrous, create a long road to recovery, and in many cases result in death. Hypertension represents a difficult-to-quantify condition which is known to contribute to gait and balance dysfunction. Accurate assessment of conditions such as these represents an area of primary investigative need. In order to meet this need, a new experimental setup is developed which combines time-frequency analysis with surface electromyography (sEMG) signals obtained during ambulation. 3-bit pressure data is acquired using a pressure-sensitive mat, …

An Engineering Approach For The Design Of Archaeological Reburial Systems, Angel Ari Perez Mejia

Theses and Dissertations

Archaeological sites are a non-renewable resource which is often our only link to the past. However, sites are under constant threat of destruction due to construction activities. Civil engineers and archaeologists must the work together to ensure both the continued survival of archaeological sites while allowing for development to continue. Reburial systems, when properly designed and constructed, allow for the protection of archaeological sites while allowing the continued use of the land. However, because reburial as an intentional conservation technique is relatively modern, practice is fragmented and there are no universally accepted guidelines. Current reburial system design relies on prescriptive …

Effect Of Primary Care Physician Density On Late Stage Cervical Cancer Diagnosis, Emily Haanschoten

Theses and Dissertations

INTRODUCTION: Late-stage cervical cancer diagnosis is an important contributing factor to the cervical cancer mortality rate. Screening for cervical cancer is a vital tool in reducing the number of late-stage cases, preventing incident cases and reducing mortality. Access to care is often a significant barrier to receiving these services. Women who have no usual source of care report significantly lower percentages of Pap tests than women who have a usual source. South Carolina ranks 13th in the US in cervical cancer incidence and 7th in cervical cancer mortality. South Carolina also struggles with a primary care physician shortage, ranking 39th …

Examining The Influence Of Healthy Eating Identity On Shopping Behaviors, Jordan Brittingham

Theses and Dissertations

Eating identity is shown to be a promising measure capable of enhancing our understanding of nutrition behavior. Persons with healthy eating identities are less likely to consume the typical American diet and report healthier diets in general. While there are several studies linking healthy eating identity and diet, there is currently no research examining healthy eating identity in relation to food shopping behavior, an important aspect of nutritional intake. The purpose of this study was to examine the influence of healthy eating identity on shopping behaviors including supermarket utilization, supercenter utilization, likelihood of shopping at the nearest store, distance to …

Periodontal Microorganisms, Obesity, Chronic Inflammation, And Type 1 Diabetes, Georges Joseph Nahhas

Theses and Dissertations

Periodontal disease is a low-grade chronic inflammation in the tissues surrounding the teeth caused by multiple, mostly gram-negative pathogens. It is associated with diabetes, obesity, and chronic inflammation. The specific roles that periodontal microorganism play in these conditions are not well-studied. Hereby, we explored how periodontal bacteria from sub gingival plaque clustered in youth with and without type 1 diabetes, and how such patterns related to body-mass-index percentile (BMI percentile), C-reactive protein (CRP) and adiponectin. Cross-sectional data were collected from 105 youth with type 1 diabetes and 71 without diabetes. Participants were between 12 and 19 years of age receiving …

Life Satisfaction And Academic Performance In Early Adolescents: Evidence For Reciprocal Relationships, Zi Jia Ng

Theses and Dissertations

Student well-being remains a relatively neglected topic despite its intimate link to positive school outcomes. As academic achievement is the yardstick of student success and school accountability, school-based mental health research and practice have focused primarily on the assessment and treatment of learning and behavioral problems. This shortterm longitudinal study sought to establish the role of student subjective well-being in academic achievement. Based on the engine model of well-being (Jayawickreme, Forgeard, & Seligman, 2012), the study focused on life satisfaction as a process variable and academic performance as an outcome variable. Using two waves (five months apart) of data, the …

Piezotransistive Iii-V Nitride Microcantilever Based Mems/Nems Sensor For Photoacoustic Spectroscopy Of Chemicals, Abdul Hafiz Ibne Talukdar

Theses and Dissertations

Microcantilevers are highly attractive as transducers for detecting chemicals, explosives, and biological molecules due to their high sensitivity, micro-scale dimensions, and low power consumption. Though optical transduction of the mechanical movement of the microcantilevers into an electrical signal is widely practiced, there is a continuous thrust to develop alternative transduction methods that are more conducive to the development of compact miniaturized sensors. Piezoelectric and piezoresistive transduction methods are two of the most popular ones that have been utilized to develop miniaturized sensor systems. Piezoelectric cantilevers, which are commonly made of PZT film, have demonstrated very high sensitivity; however, they suffer …

Application Of Various Adsorbents To Remove Micro-Pollutants In Aquatic System, Chanil Jung

Theses and Dissertations

Untreated or insufficiently treated pharmaceuticals and endocrine disrupting compounds (EDCs) as well as heavy metals have influenced the ecosystem and their exposures in the water system have threatened human health; causing cancers and adverse health effect to immune system. While various water treatment techniques have been applied to solve this problem, adsorption has been considered as one of the most efficient and manageable water purification techniques. Advanced analysis methods for aqueous contaminants have improved comprehension, allowing proficiency about the fate of trace leveled emerging contaminants, thus allowed to reveal the adsorption mechanisms of each pollutant. This dissertation focuses on the …

Toward The Combinatorial Development Of Hydrophobic-Tagged Antifolate-Directed Degradation Of Human Thymidylate Synthase, Daniel J. Menasco

Theses and Dissertations

Direct post-translational control over a protein of interest (POI) can be exploited by manipulating the cells protein quality-control systems responsible for either intracellular turnover through ubiquitination (POI half-life) or repairing and degrading misfolded proteins.1 In an effort to target and degrade a high value POI we selected the enzyme human thymidylate synthase (TS) for post-translational degradation through ligand-directed ubiquitination and hydrophobic tagging. Thymidylate synthase catalyzes the reductive methylation of 2’-deoxyuridine monophosphate (dUMP) to 2’-deoxythymidine monophosphate (dTMP). As the de novo source of dTMP the regulation of intracellular TS is strictly controlled by ubiquitinindependent proteasomal degradation mediated by an internal TS-degron …