Digital Commons Network^™

Asynchronous Remodeling Is A Driver Of Failed Regeneration In Duchenne Muscular Dystrophy, Sherry Dadgar, Zuyi Wang, Helen Johnston, Akanchha Kesari, Kanneboyina Nagaraju, Yi-Wen Chen, D. Ashley Hill, Terence A. Partridge, Robert J. Freishtat, Javad Nazarian, Jianhua Xuan, Yue Wang, Eric P. Hoffman

Genomics and Precision Medicine Faculty Publications

We sought to determine the mechanisms underlying failure of muscle regeneration that is observed in dystrophic muscle through hypothesis generation using muscle profiling data (human dystrophy and murine regeneration). We found that transforming growth factor β-centered networks strongly associated with pathological fibrosis and failed regeneration were also induced during normal regeneration but at distinct time points. We hypothesized that asynchronously regenerating microenvironments are an underlying driver of fibrosis and failed regeneration. We validated this hypothesis using an experimental model of focal asynchronous bouts of muscle regeneration in wild-type (WT) mice. A chronic inflammatory state and reduced mitochondrial oxidative capacity are …

Measuring The Socio-Economic Characteristics Of A Lionfish Derby Event, Adam Nardelli, Stephanie Green, L. Akins, David W. Kerstetter

Marine & Environmental Sciences Faculty Proceedings, Presentations, Speeches, Lectures

No abstract provided.

Lasting Impressions, Fall 2014, College Of Dental Medicine

Newsletters

No abstract provided.

A Bayesian Approach To Joint Modeling Of Menstrual Cycle Length And Fecundity, Kirsten J. Lum, Rajeshwari Sundaram, Germaine M. Buck-Louis, Thomas A. Louis

Johns Hopkins University, Dept. of Biostatistics Working Papers

Female menstrual cycle length is thought to play an important role in couple fecundity, or the biologic capacity for reproduction irrespective of pregnancy intentions. A complete assessment of the association between menstrual cycle length and fecundity requires a model that accounts for multiple risk factors (both male and female) and the couple's intercourse pattern relative to ovulation. We employ a Bayesian joint model consisting of a mixed effects accelerated failure time model for longitudinal menstrual cycle lengths and a hierarchical model for the conditional probability of pregnancy in a menstrual cycle given no pregnancy in previous cycles of trying, in …

Unity House News Fall 2014, Connecticut College

Unity House News

No abstract provided.

Arboretum Annual Report 2013-2014, Glenn Dreyer

Annual Reports

No abstract provided.

Law & Healthcare Newsletter, V. 22, No. 1, Fall 2014

Law & Health Care Newsletter

No abstract provided.

Mid-Atlantic Ethics Committee Newsletter, Fall 2014

Mid-Atlantic Ethics Committee Newsletter

No abstract provided.

The Healthy Scoop, Lehigh Valley Health Network

The Healthy Scoop

No abstract provided.

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.

Scholarworks Statistics - October 2014, Scholarworks

ScholarWorks Reports

For the month of October 2014, ScholarWorks recorded a total of 31,709 full-text downloads and 12,337 page views.

2014-2015 Boise State University Undergraduate Catalog, Boise State University Office Of The Registrar

University Catalogs

No abstract provided.

Kaelin Rapport - Histological Techniques For The Sex Determination Of Skeletonized Human Remains, Kaelin Rapport

Ronald E. McNair Scholars Program 2014

Determining the sex of skeletons is problematic in forensic and bio-archaeological research. Past studies demonstrate that bone cells can sometimes contain preserved sex chromosomal material in ancient samples. The sex chromosomes in skeletal remains may allow determination of sex in non-adults. The problem is explored by making 20μ thin sections stained with hematoxylin eosin. The dye highlights inactive X chromosomes (Barr Bodies) of females. The presence of the Barr Body is an indicator of female with an accuracy of greater than 99.9. This approach to identification of sex in unknown skeletons has been demonstrated with remains of individuals deceased as …

Rawan Atari - The Influence Of Multi-Sensory Environment On Physiological Response In Children With Autism Spectrum Disorders And Children With Special Health Care Needs, Rawan Atari

Ronald E. McNair Scholars Program 2014

A research study based on the sensory integration theory was conducted to examine the effects of multi-sensory environment (MSE) on physiological arousal in children with autism spectrum disorder (ASD) and special health care needs. Adapted environments may serve as a mechanism to treat anxiety levels in a population of children who experience more severe generalized anxiety symptoms than typically developing children. The sample consisted of children with community-based diagnoses of ASD and children with special health care needs, primarily children diagnosed with cerebral palsy (CP) from the Milwaukee Center for Independence (MCFI). Treatment for the autism sample was carried out …

Brazen (Fall 2014), Hollins University

Brazen - Gender & Women's Studies Department Newsletters

No abstract provided.

Olfactory Dysfunction Predicts 5-Year Mortality In Older Adults, Jayant M. Pinto, Kristen E. Wroblewski, David W. Kern, L Phillip Schumm, Martha K. Mcclintock

Psychology & Gerontology Faculty Publications

Prediction of mortality has focused on disease and frailty, although antecedent biomarkers may herald broad physiological decline. Olfaction, an ancestral chemical system, is a strong candidate biomarker because it is linked to diverse physiological processes. We sought to determine if olfactory dysfunction is a harbinger of 5-year mortality in the National Social Life, Health and Aging Project [NSHAP], a nationally representative sample of older U.S. adults. 3,005 community-dwelling adults aged 57–85 were studied in 2005–6 (Wave 1) and their mortality determined in 2010–11 (Wave 2). Olfactory dysfunction, determined objectively at Wave 1, was used to estimate the odds of 5-year, …

Two Approaches To Collaborative Information Literacy Instruction At A Small Engineering School, Conor Cote, Scott Juskiewicz

Library

Two librarians at a small STEM academic library have partnered with professors to develop and teach chemistry and writing courses. These librarians have successfully worked with professors to serve as an active presence within the classroom. This article describes the challenges of navigating the typical obstacles librarians face when attempting to integrate information literacy into the curriculum, reflects on the benefits of these collaborations, and touches on strategies for implementing similar programs at other institutions. It outlines two distinct approaches to collaborating with professors on credit-bearing information literacy courses, along with the key steps involved in planning and implementing these …

Marshall Magazine Autumn 2014, Marshall University

Marshall Magazine

No abstract provided.

The Scientist, Fall 2014, San Jose State University, College Of Science

The Scientist (College of Science)

No abstract provided.

Chemistry Department Newsletter 2014, Ken Overway

Chemistry Department Newsletters

This document contains a summary of news and events from the chemistry department from the 2013-2014 academic year.

Engineering News, Fall 2014, School Of Engineering

Engineering News

No abstract provided.

Neural Transcription Factors: From Embryos To Neural Stem Cells, Hyun-Kyung Lee, Hyun-Shik Lee, Sally Ann Moody

Anatomy and Regenerative Biology Faculty Publications

The early steps of neural development in the vertebrate embryo are regulated by sets of transcription factors that control the induction of proliferative, pluripotent neural precursors, the expansion of neural plate stem cells, and their transition to differentiating neural progenitors. These early events are critical for producing a pool of multipotent cells capable of giving rise to the multitude of neurons and glia that form the central nervous system. In this review we summarize findings from gain- and loss-of-function studies in embryos that detail the gene regulatory network responsible for these early events. We discuss whether this information is likely …

Tps Mutational Status Is A Potential Marker For Risk Stratification In Wilms Tumour With Diffuse Anaplasia, Mariana Maschietto, Richard D. Williams, Tasnim Chagtai, Sergey D. Popov, Neil J. Sebire, Gordan Vujanic, Elizabeth Perlman, James R. Anderson, Paul Grundy, Jeffrey S. Dome, Kathy Pritchard-Jones

Pediatrics Faculty Publications

Purpose

The presence of diffuse anaplasia in Wilms tumours (DAWT) is associated with TP53 mutations and poor outcome. As patients receive intensified treatment, we sought to identify whetherTP53 mutational status confers additional prognostic information.

Patients and Methods

We studied 40 patients with DAWT with anaplasia in the tissue from which DNA was extracted and analysed for TP53 mutations and 17p loss. The majority of cases were profiled by copy number (n = 32) and gene expression (n = 36) arrays. TP53 mutational status was correlated with patient event-free and overall survival, genomic copy number instability and gene expression profiling. …

Management Of A Dka Patient With Severe Metabolic And Ketoacidosis With Chronic Renal Insufficiency, Brian Albany

Nursing Student Class Projects (Formerly MSN)

Diabetic ketoacidosis (DKA) serves as one the leading causes of mortality in diabetic patients [14]. The mortality has decreased over the past several decades due to the rapid recognition of the disease state and the improvement of management of DKA [14]. Despite a decline in mortality rates over the past twenty years from 7.96% to 0.67%, errors in management of the disease state are associated with significant morbidity and mortality [2]. Utilization of DKA protocols in the acute care setting have allowed congruency in care and delivery of effective lifesaving treatment. Despite advances in standardized DKA protocols, there still remains …

The Pathophysiology Of Tumor Lysis Syndrome In Oncology Patients, Jessica Richardson

Nursing Student Class Projects (Formerly MSN)

Patients with oncological conditions are at an increased risk of developing a wide variety of complications from chemotherapy that they would not otherwise be exposed too. One such life threatening complication is tumor lysis syndrome, which is an oncology emergency that frequently lands patients in the intensive care unit. Tumor lysis syndrome (TLS) occurs most frequently after the initiation of chemotherapy or other chemotoxic drugs during the patients’ treatment course [8]. It causes faster than normal tumor cell breakdown and release of intracellular contents into the general circulation. [8]. This leads to a very predictable development of electrolyte imbalances to …

Understanding The Mystery Of Brain Death, Natalie A. Felter

Nursing Student Class Projects (Formerly MSN)

Lack of understanding of brain death has contributed to recent controversial cases (Copnell, 2014). The cases of Jahi McMath and Marlise Munoz were the focus of national news, causing an intense debate among the public and healthcare professionals (Copnell, 2014). The concept of brain death is a mystery to the public (Powell, 2014). Copnell (2014) found that 60% of family members who had been told their loved one was brain dead believed that they were still alive. Health professionals not having a clear grasp of brain death’s definition and assessment can lead to increased confusion in family members (Powell, 2014).

Ummra Info: Volume Xvii, Number 2, University Of Minnesota, Morris Retirees' Association

UMMRA Info

This newsletter includes: a letter from the UMMRA president, upcoming events, sad news, faculty and staff news, a section titled "Hats off to UMM!", information regarding Homecoming 2014, and articles titled "Opening Convocation remarks by Chancellor Jacqueline Johnson" and "Visit the courtyards behind the Welcome Center."

Vol. 90, No. 1 | Fall 2014, Bridgewater College

Bridgewater Magazine

Excellence: The Tradition Continues

Dietary Carbohydrates Influence The Structure And Function Of The Intestinal Alpha-Glucosidases, Mohammad Chegeni

Open Access Dissertations

As the primary products of starch digestion by pancreatic α-amylase, maltooligosaccharides (including maltose) are the main substrates for the α-glucosidases at the intestinal brush border. Here, maltose was shown to induce the formation of a higher molecular weight (HMW) sucrase-isomaltase (SI) species in Caco-2 cells that sorts more quickly to the enterocyte surface to act as a digestive enzyme. As this finding suggested a maltose sensing ability of small intestinal enterocytes, molecular mechanisms associated with the maturation and trafficking of HMW SI were further investigated. A pulse-chase experiment using [ ³⁵S]-methionine revealed a higher rate of early trafficking and …

Afterschool Matters Fall 2014, National Institute For Out-Of-School Time

Afterschool Matters

In this issue:

Curriculum and Professional Development for OST Science Education: Lessons Learned from California 4-H
By Steven M. Worker and Martin H. Smith

Keeping Children Safe: Afterschool Staff and Mandated Child Maltreatment Reporting
By Maria Gandarilla and Julie O'Donnell

Long-Term Participants: A Museum Program Enhances Girls’ STEM Interest, Motivation, and Persistence
By Jennifer D. Adams, Preeti Gupta, and Alix Cotumaccio

Paper Copters and Potential: Leveraging Afterschool and Youth Development Trainers to Extend the Reach of STEM Programs
By Stephanie A. Lingwood and Jennifer B. Sorensen

The Quest for Mastery
By Diane Gruber, M.A.

The Role of Out-of-School Time in …