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2014

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Articles 25321 - 25350 of 25847

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Reporting On The Seminar - Risk Interpretation And Action (Ria): Decision Making Under Conditions Of Uncertainty, Emma E. Doyle, Shabana Khan, Carolina Adler, Ryan C. Alaniz, Simone Athayde, Kuan H. Lin, Wendy Saunders, Todd Schenk, Fabiola Sosarodriguez, Victoria Sword-Daniels, Olayinka Akanle, Marie A. Baudoin, Chiung T. Chang, Karianne D. De Bruin, Riyanti Djalante, Christine Eriksen, Hsiang C. Lee, Jyoti Mishra, Victor O. Okorie, David R. Olanya, Goda Perlaviciute, Naxhelli Ruizrivera, Suzanne Vallance, Xinlu Xie, Lun Yin, Sarah Beaven, Charles Ebikeme, Richard Eiser, David Johnston, Christine Kenney, Douglas Paton, Sarah Schweizer, Vivi Stavrou Jan 2014

Reporting On The Seminar - Risk Interpretation And Action (Ria): Decision Making Under Conditions Of Uncertainty, Emma E. Doyle, Shabana Khan, Carolina Adler, Ryan C. Alaniz, Simone Athayde, Kuan H. Lin, Wendy Saunders, Todd Schenk, Fabiola Sosarodriguez, Victoria Sword-Daniels, Olayinka Akanle, Marie A. Baudoin, Chiung T. Chang, Karianne D. De Bruin, Riyanti Djalante, Christine Eriksen, Hsiang C. Lee, Jyoti Mishra, Victor O. Okorie, David R. Olanya, Goda Perlaviciute, Naxhelli Ruizrivera, Suzanne Vallance, Xinlu Xie, Lun Yin, Sarah Beaven, Charles Ebikeme, Richard Eiser, David Johnston, Christine Kenney, Douglas Paton, Sarah Schweizer, Vivi Stavrou

Research outputs 2014 to 2021

The paper reports on the World Social Science (WSS) Fellows seminar on Risk Interpretation and Action (RIA), undertaken in New Zealand in December, 2013. This seminar was coordinated by the WSS Fellows program of the International Social Science Council (ISSC), the RIA working group of the Integrated Research on Disaster Risk (IRDR) program, the IRDR International Center of Excellence Taipei, the International START Secretariat and the Royal Society of New Zealand. Twenty-five early career researchers from around the world were selected to review the RIA framework under the theme of 'decision-making under conditions of uncertainty', and develop novel theoretical approaches …

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Biomarkers Of Alzheimer's Disease Risk In Peripheral Tissues; Focus On Buccal Cells, Maxime François, Wayne Leifert, Ralph Martins, Philip Thomas, Michael Fenech Jan 2014

Biomarkers Of Alzheimer's Disease Risk In Peripheral Tissues; Focus On Buccal Cells, Maxime François, Wayne Leifert, Ralph Martins, Philip Thomas, Michael Fenech

Research outputs 2014 to 2021

Alzheimer's disease (AD) is a progressive degenerative disorder of the brain and is the most common form of dementia. To-date no simple, inexpensive and minimally invasive procedure is available to confirm with certainty the early diagnosis of AD prior to the manifestations of symptoms characteristic of the disease. Therefore, if population screening of individuals is to be performed, more suitable, easily accessible tissues would need to be used for a diagnostic test that would identify those who exhibit cellular pathology indicative of mild cognitive impairment (MCI) and AD risk so that they can be prioritized for primary prevention. This need …

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Leaf Gas Films Delay Salt Entry And Enhance Underwater Photosynthesis And Internal Aeration Of Melilotus Siculus Submerged In Saline Water, Natasha Lea Teakle, Timothy David Colmer, Ole Pedersen Jan 2014

Leaf Gas Films Delay Salt Entry And Enhance Underwater Photosynthesis And Internal Aeration Of Melilotus Siculus Submerged In Saline Water, Natasha Lea Teakle, Timothy David Colmer, Ole Pedersen

Research outputs 2014 to 2021

A combination of flooding and salinity is detrimental to most plants. We studied tolerance of complete submergence in saline water for Melilotus siculus, an annual legume with superhydrophobic leaf surfaces that retain gas films when under water. M.siculus survived complete submergence of 1 week at low salinity (up to 50molm-3 NaCl), but did not recover following de-submergence from 100molm-3 NaCl. The leaf gas films protected against direct salt ingress into the leaves when submerged in saline water, enabling underwater photosynthesis even after 3d of complete submergence. By contrast, leaves with the gas films experimentally removed suffered from substantial Na+ and …

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Decision Support System Data For Farmer Decision Making, Pornchai Taechatanasat, Leisa Armstrong Jan 2014

Decision Support System Data For Farmer Decision Making, Pornchai Taechatanasat, Leisa Armstrong

Research outputs 2014 to 2021

The capacity of farmers and agricultural scientists to be able to make in-season decisions is dependent on accurate climate, soil and plant data. This paper will provide a review of the types of environmental and crop data that can be collected by sensors which can used for decision support systems (DSS) or be further interrogated for real time data mining and analysis. This paper also presents a review of the data requirements for agricultural decision making by firstly reviewing decision support frameworks and agricultural DSSs, data acquisition, sensors for data acquisition and examples of data incorporation for agricultural DSSs.

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Genetic Algorithm With Logistic Regression For Prediction Of Progression To Alzheimer's Disease, Piers Johnson, Luke Vandewater, William Wilson, Paul Maruff, Greg Savage, Petra Graham, Lance S. Macaulay, Kathryn A. Ellis, Cassandra Szoeke, Ralph N. Martins, Christopher Rowe, Colin L. Masters, David Ames, Ping Zhang Jan 2014

Genetic Algorithm With Logistic Regression For Prediction Of Progression To Alzheimer's Disease, Piers Johnson, Luke Vandewater, William Wilson, Paul Maruff, Greg Savage, Petra Graham, Lance S. Macaulay, Kathryn A. Ellis, Cassandra Szoeke, Ralph N. Martins, Christopher Rowe, Colin L. Masters, David Ames, Ping Zhang

Research outputs 2014 to 2021

Assessment of risk and early diagnosis of Alzheimer's disease (AD) is a key to its prevention or slowing the progression of the disease. Previous research on risk factors for AD typically utilizes statistical comparison tests or stepwise selection with regression models. Outcomes of these methods tend to emphasize single risk factors rather than a combination of risk factors. However, a combination of factors, rather than any one alone, is likely to affect disease development. Genetic algorithms (GA) can be useful and efficient for searching a combination of variables for the best achievement (eg. accuracy of diagnosis), especially when the search …

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Integrating Soil And Plant Tissue Tests And Using An Artificial Intelligence Method For Data Modelling Is Likely To Improve Decisions For In-Season Nitrogen Management, Andreas Neuhaus, Leisa Armstrong, Jinsong Leng, Dean Diepeveen, Geoff Anderson Jan 2014

Integrating Soil And Plant Tissue Tests And Using An Artificial Intelligence Method For Data Modelling Is Likely To Improve Decisions For In-Season Nitrogen Management, Andreas Neuhaus, Leisa Armstrong, Jinsong Leng, Dean Diepeveen, Geoff Anderson

Research outputs 2014 to 2021

This paper hypothesizes that there is value in combining soil, climate and plant tissue data to give more reliable advice on nitrogen top-ups in-season when compared with models that are currently available. The benefit of soil and climate data is to factor in N mineralisation and potential yield while plant test data is a more direct approach of yield estimates when considering firstly plant N uptake from the whole soil profile and secondly biomass (important yield component). Plant test data are closer to yield in time and space than soil test data, shortening the time period for any yield prognosis …

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Are We Approaching Pit Lake Closure From The Wrong Perspective?, Mark A. Lund, Melanie L. Blanchette Jan 2014

Are We Approaching Pit Lake Closure From The Wrong Perspective?, Mark A. Lund, Melanie L. Blanchette

Research outputs 2014 to 2021

Pit lakes are similar to natural lakes formed by faulting, glacial action, volcanic action and asteroid collisions. These natural lakes have, after thousands of years, developed into environmentally significant ecosystems. As artificial constructs, pit lakes can be modified prior to filling to enhance lake attributes, such as modification of catchment size, creation of littoral zones and addition of organic matter. Significant advances could be made in successful closure and relinquishment of pit lakes, by 1) choosing appropriate model lakes, 2) understanding successional processes, 3) designing pit lakes to enhance ecological values, and 4) recognizing that it will take time to …

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What Do Elevated Background Contaminant Concentrations Mean For Amd Risk Assessment And Management In Western Australia?, C. D. Mccullough, J. J Pearce Jan 2014

What Do Elevated Background Contaminant Concentrations Mean For Amd Risk Assessment And Management In Western Australia?, C. D. Mccullough, J. J Pearce

Research outputs 2014 to 2021

Water quality contaminants include a range of naturally occurring chemicals that can cause degradation of aquatic ecosystem water values when concentration ranges exceed biological tolerances. Both acid and metalliferous drainage (AMD) and acid sulfate soil (ASS) can increase contaminant concentrations through reduced pH and increased solute concentrations especially of toxic metals and metalloids. Water quality guideline criteria are typically used to maintain existing end use value objectives when managing AMD/ASS-affected waters. However, surface and ground waters of catchments comprising mining resources often show elevated solute concentrations in baseline conditions due to their unique geologies. From an AMD and ASS risk …

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Student Perceptions Of Online Interactive Versus Traditional Lectures; Or How I Managed Not To Fall Asleep With My Eyes Open, John A. O'Rourke, Susan J. Main, Martin G. Cooper Jan 2014

Student Perceptions Of Online Interactive Versus Traditional Lectures; Or How I Managed Not To Fall Asleep With My Eyes Open, John A. O'Rourke, Susan J. Main, Martin G. Cooper

Research outputs 2014 to 2021

Universities are increasingly experimenting with the online domain to connect with busy and digital-savvy students and counter the decline in face-to-face lecture attendance More often than not universities are offering videoed lectures or PowerPoints with lecturer voice-overs as a way of delivering content. Evidence suggests that while these techniques may provide the flexibility required, some content needs more personalised delivery. In this article the authors explore the development and delivery of an online lecture format. Using a combination of video, text and interactive cell technology, this online offering was trialed in a unit focused on the education of students with …

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Influence Of Age And Sex On Pacing During Sprint, Olympic, Half-Ironman And Ironman Triathlons. Part B, Sam Shi Xuan Wu, Jeremiah J. Peiffer, Jeanick Brisswalter, Wing Y. Lau, Kazunori Nosaka, Christopher Abbiss Jan 2014

Influence Of Age And Sex On Pacing During Sprint, Olympic, Half-Ironman And Ironman Triathlons. Part B, Sam Shi Xuan Wu, Jeremiah J. Peiffer, Jeanick Brisswalter, Wing Y. Lau, Kazunori Nosaka, Christopher Abbiss

Research outputs 2014 to 2021

The aim of this study was to investigate the influence of biological sex and age on the pacing strategies adopted by non-drafting top triathletes during the cycle and run disciplines of a Sprint, Olympic, half-Ironman and Ironman triathlon. Split times of the top 20% non-elite males (n=468) and females (n=146) were determined using official race transponders and a video capture system for pre-determined sections of the cycle and run disciplines of four triathlon distances. Indices of pacing were calculated to compare between sexes and age-groups. Results of this study indicated that different pacing strategies were adopted between athletes of different …

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Influence Of Race Distance And Biological Sex On Age-Related Declines In Triathlon Performance. Part A, Sam Shi Xuan Wu, Jeremiah Peiffer, Jeanick Brisswalter, Wing Y. Lau, Kazunori Nosaka, Chris R. Abbiss Jan 2014

Influence Of Race Distance And Biological Sex On Age-Related Declines In Triathlon Performance. Part A, Sam Shi Xuan Wu, Jeremiah Peiffer, Jeanick Brisswalter, Wing Y. Lau, Kazunori Nosaka, Chris R. Abbiss

Research outputs 2014 to 2021

This study examined the effect of biological sex and race distance on the age-related declines in swimming, cycling, running and overall performances of the sprint, Olympic, Half-Ironman and Ironman triathlons. Individual discipline and overall performance time of the top 20% non-elite males (n=468) and females (n=146) were compared by categorizing into four 10-year age-groups (20-29, 30-39, 40-49, 50+ years) and normalising to the mean performance time of the fastest age-group for each race. An earlier, larger and faster rate of decline (p=0.01) in performance with ageing was observed in females (≥30 years, 9.3%, 3.0% per decade respectively) and males (≥40 …

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On The Application Of Genetic Probabilistic Neural Networksand Cellular Neural Networks In Precision Agriculture, Oluleye H. Babatunde, Leisa Armstrong, Jinsong Leng, Dean Diepeveen Jan 2014

On The Application Of Genetic Probabilistic Neural Networksand Cellular Neural Networks In Precision Agriculture, Oluleye H. Babatunde, Leisa Armstrong, Jinsong Leng, Dean Diepeveen

Research outputs 2014 to 2021

This article details the effect of Gaussian smoothing parameter (spread) on the performance of Probabilistic Neural Networks (PNN). Two (2) different Genetic Algorithms (GAs) were used to optimize the PNN spread in order to avoid under and over fitting. In this work there is a novel combination of Cellular Neural Networks (CNN), Probabilistic Neural Networks (PNN) and GA to address the present challenges on automatic identification of plant species. Such problems include misclassification species of plants that are similar in shapes and image segmentation speed. In this work, GA was used in both feature selection and PNN parameter optimization. The …

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Educational Innovations And Pedagogical Beliefs: The Case Of A Professional Development Program For Indonesian Teachers, Cher Ping Lim, Jo Tondeur, Hendrati Nastiti, Jeremy E. Pagram Jan 2014

Educational Innovations And Pedagogical Beliefs: The Case Of A Professional Development Program For Indonesian Teachers, Cher Ping Lim, Jo Tondeur, Hendrati Nastiti, Jeremy E. Pagram

Research outputs 2014 to 2021

This study aimed to explore the impact of a professional development program on the teachers’ pedagogical beliefs and practices. More specifically, the program endeavoured to design a prototype for teacher professional development in Indonesia that was sustainable and scalable. This one-year program built upon the participating teachers’ existing practices, reinforced with the concept of reflection as a tool for ongoing inquiry of their own practices. The three major components of this program were: action research, peer-coaching and leadership support. By using a mixed method of quantitative and qualitative data collection, this study examined the changes in the participating teachers’ beliefs …

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Bastard Immigrants: Asylum Seekers Who Arrive By Boat And The Illegitimate Fear Of The Other, Lelia R. Green, Anne Aly Jan 2014

Bastard Immigrants: Asylum Seekers Who Arrive By Boat And The Illegitimate Fear Of The Other, Lelia R. Green, Anne Aly

Research outputs 2014 to 2021

The human capacity to marginalise and discriminate against others on the basis of innate and constructed characteristics is evident from the long history of discrimination against people whose existence is ‘illegitimate’, defined as being outside the law. What is inside or outside the law depends upon the context under consideration. For example, in societies such as ancient Greece and the antebellum United States, where slavery was legal, people who were constructed as ‘slaves’ could legitimately be treated very differently from ‘citizens’: free people who benefit from a range of human rights (Northup). The discernment of what is legitimate from that …

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Principles Of Practice In Mental Health Assessment With Aboriginal Australians, Yolonda Adams, Neil M. Drew, Roz Walker Jan 2014

Principles Of Practice In Mental Health Assessment With Aboriginal Australians, Yolonda Adams, Neil M. Drew, Roz Walker

Research outputs 2014 to 2021

In this chapter, concepts and history of assessment and testing in the context of Aboriginal and Torres Strait Islander social and emotional wellbeing and mental health are discussed. Importantly, recently revised diagnostic guidelines and the National Practice Standards for the Mental Health Workforce 20131 and their appropriateness for meeting the distinctive needs of Aboriginal people are reviewed. Various assessment tools and measures that have been validated or proved appropriate for use with particular Aboriginal populations, i.e. youth, women and older people, are described. We conclude that practitioners need to be critically reflective in their role in assessment, and position themselves …

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Links Between Insulin Resistance, Lipoprotein Metabolism And Amyloidosis In Alzheimer's Disease, Ian J. Martins, Rhona Creegan Jan 2014

Links Between Insulin Resistance, Lipoprotein Metabolism And Amyloidosis In Alzheimer's Disease, Ian J. Martins, Rhona Creegan

Research outputs 2014 to 2021

The origins of premature brain aging and chronic disease progression are associated with atherogenic diets and sedentary lifestyles in Western communities. Interests in brain aging that involves non alcoholic fatty liver disease (NAFLD), the global stroke epidemic and neurodegeneration have become the focus of nutritional research. Atherogenic diets have been linked to plasma ceramide dysregulation and insulin resistance actively promoting chronic diseases and neurodegeneration in developed countries. Abnormal lipid signaling as observed in chronic diseases such as hypothyroidism, obesity and diabetes is connected to stroke and neurodegenerative diseases in man. Lipids that are involved in calcium and amyloid betahomeostasis are …

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High Fibre Diets And Alzheimer's Disease, Ian J. Martins, Warnakulasuriya M. Fernando Jan 2014

High Fibre Diets And Alzheimer's Disease, Ian J. Martins, Warnakulasuriya M. Fernando

Research outputs 2014 to 2021

The convergence of diet and AD may be related to the effects of phytosterols since plasma cholesterol is closely linked and regulated by phytosterols. Dietary fibre modifications that are low in fat and glucose reduce the risk for AD by not only effecting cell membranes and nutrient sensing G coupled receptors but also by regulating number of nuclear receptors such as histone deacetylases (HDAC) and peroxisome proliferator activated receptors (PPAR) that control glucose, fatty acids and cholesterol and have significant effects on the brain cholesterol homeostasis and amyloidosis. The peripheral sink Aβ hypothesis indicates that the peripheral clearance of Aβ …

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Induction Of Nafld With Increased Risk Of Obesity And Chronic Diseases In Developed Countries, Ian J. Martins Jan 2014

Induction Of Nafld With Increased Risk Of Obesity And Chronic Diseases In Developed Countries, Ian J. Martins

Research outputs 2014 to 2021

The susceptibility of individuals to obesity has been reported in many developed countries with predisposition of humans to obesity associated with high calorie diets and unhealthy lifestyles. Obesity may closely be involved in cell suicide in various organ diseases with the importance of accelerated aging that requires early intervention with drug therapy to prevent diseases such as non alcoholic fatty liver disease (NAFLD) that has increased in children and reached to approx. 40% of the global population. Obesity is induced by various diets and lifestyle factors such as stress, anxiety and depression which are important to consider with the global …

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Changes In Muscle Damage Markers In Female Basketball Players, A Moreira, Kazunori Nosaka, Ja Nunes, L Viveiros, A.Z. Jamurtas, M.S. Aoki Jan 2014

Changes In Muscle Damage Markers In Female Basketball Players, A Moreira, Kazunori Nosaka, Ja Nunes, L Viveiros, A.Z. Jamurtas, M.S. Aoki

Research outputs 2013

The aim of the present study was to investigate changes in muscle soreness, blood muscle damage markers, muscle strength and agility following an official basketball match. Eleven elite female professional basketball players (27.4 ± 4.8 years, 179.5 ± 5.5 cm, 72.0 ± 7.8 kg) of a team participated in this study. The official match was the seventh match of the season in the first phase of the Brazilian National Female Basketball Championship. Muscle soreness, plasma creatine kinase activity (CK), and myoglobin concentration (Mb) were determined before and after the match (post-match, 24 and 48 hours after the match). The 1RM …

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Shades Of Grey: The Need For A Multi-Disciplinary Approach To Research Investigating Alcohol And Ageing, Celia Wilkinson, Julie Dare Jan 2014

Shades Of Grey: The Need For A Multi-Disciplinary Approach To Research Investigating Alcohol And Ageing, Celia Wilkinson, Julie Dare

Research outputs 2014 to 2021

This paper calls for an increase in multi-disciplinary research on the issue of alcohol and ageing, to ensure public health interventions reflect the complex and diverse needs of older drinkers. Older people (65+ years) represent a unique segment of the population; compared to adolescents and younger people, they are more likely to have a range of co-morbid conditions and be taking prescribed medication, and are more physiologically vulnerable to the effects of alcohol. This suggests that from a public health perspective, alcohol use by older people is problematic. However, as with younger people, alcohol use is closely associated with socialisation …

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Tego - A Framework For Adversarial Planning, Daniel Ashlock, Philip Hingston Jan 2014

Tego - A Framework For Adversarial Planning, Daniel Ashlock, Philip Hingston

Research outputs 2014 to 2021

This study establishes a framework called ∗-Tego for a situation in which two agents are each given a set of players for a competitive game. Each agent places their players in an order. Players on each side at the same position in the order play one another, with the agent's score being the sum of their player's scores. The planning agents are permitted to simultaneous reorder their players in each of several stages. The reordering is termed competitive replanning. The resulting framework is scalable by changing the number of players and the complexity of the replanning process. The framework is …

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Remote Beehive Monitoring Using Acoustic Signals, Amro Qandour, Iftekhar Ahmad, Daryoush Habibi, Mark Leppard Jan 2014

Remote Beehive Monitoring Using Acoustic Signals, Amro Qandour, Iftekhar Ahmad, Daryoush Habibi, Mark Leppard

Research outputs 2014 to 2021

Recent developments in Wireless Sensor Networks (WSNs) have led to their use in remote data acquisition and automatic data analysis applications, which have proven to be an invaluable tool in a diverse range of fields including biosecurity. Further indications have been found that honeybee health can be monitored and determined through the use of acoustic analysis. In this paper, we present a system that has the ability to remotely detect the presence of pest infestation on a colony of honeybees by comparing the acoustic fingerprint of a hive to a fingerprint of known status. This will aid the goals of …

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Regulation Of Human Pax6 Expression By Mir-7, M Needhamsen, Robert B. White, Keith M. Giles, Sarah A. Dunlop, Meghan G. Thomas Jan 2014

Regulation Of Human Pax6 Expression By Mir-7, M Needhamsen, Robert B. White, Keith M. Giles, Sarah A. Dunlop, Meghan G. Thomas

Research outputs 2014 to 2021

The paired box gene 6 (PAX6) is a powerful mediator of eye and brain organogenesis whose spatiotemporal expression is exquisitely controlled by multiple mechanisms, including post-transcriptional regulation by microRNAs (miRNAs). In the present study, we use bioinformatic predictions to identify three candidate microRNA-7 (miR-7) target sites in the human PAX6 3′ untranslated region (3′-UTR) and demonstrate that two of them are functionally active in a human cell line. Furthermore, transient transfection of cells with synthetic miR-7 inhibits PAX6 protein expression but does not alter levels of PAX6 mRNA, suggesting that miR-7 induces translational repression of PAX6. Finally, a comparison of …

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Setting Goals And Choosing Appropriate Reference Sites For Restoring Mine Pit Lakes As Aquatic Ecosystems: Case Study From South West Australia, Eddie J. Van Etten, C. D. Mccullough, Mark A. Lund Jan 2014

Setting Goals And Choosing Appropriate Reference Sites For Restoring Mine Pit Lakes As Aquatic Ecosystems: Case Study From South West Australia, Eddie J. Van Etten, C. D. Mccullough, Mark A. Lund

Research outputs 2014 to 2021

Pit lakes may form when open cut mining leaves a pit void behind that fills with ground and surface water. Often replacing terrestrial ecosystems that existed prior to mining, the pit lake may offer an alternative ecosystem with aquatic biodiversity values that can be realised through planned restoration. Restoration theory and mine closure regulatory requirements guides us toward restoring disturbed systems towards landscapes that are of regional value and relevance. However, how do we identify a restoration target for a novel aquatic habitat that did not exist prior to the new post-mining landscape? This paper presents a process of first …

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Overexpression Of Phospholipase A2 Group Iia In Esophageal Squamous Cell Carcinoma And Association With Cyclooxygenase-2 Expression, Yan Chun Zhai, Bin Dong, Wen Qiang Wei, Yan He, Xin Qing Li, Robert T. Cormier, Wei Wang, Fen Liu Jan 2014

Overexpression Of Phospholipase A2 Group Iia In Esophageal Squamous Cell Carcinoma And Association With Cyclooxygenase-2 Expression, Yan Chun Zhai, Bin Dong, Wen Qiang Wei, Yan He, Xin Qing Li, Robert T. Cormier, Wei Wang, Fen Liu

Research outputs 2014 to 2021

Background: Esophageal cancer is one of the most frequently occurring malignancies and the seventh leading cause of cancer-related deaths in the world. The esophageal squamous cell carcinoma (ESCC) is the most common histological type of esophageal cancer worldwide. Materials and Methods: Our goal in this study was to detect phospholipase A2 Group IIA (PLA2G2A) and cyclooxygenase-2 (COX-2) immuno-expression in ESCC in a high-risk population in China. Results: Positive expression of PLA2G2A protein was observed in 57.2% (166/290) of the cases, while COX-2 was found in 257 of 290 samples (88.6%), both PLA2G2A and COX-2 being expressed in 153 cases (52.8%), …

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Pax Genes: Regulators Of Lineage Specification And Progenitor Cell Maintenance, Judith A. Blake, Mel R. Ziman Jan 2014

Pax Genes: Regulators Of Lineage Specification And Progenitor Cell Maintenance, Judith A. Blake, Mel R. Ziman

Research outputs 2014 to 2021

Pax genes encode a family of transcription factors that orchestrate complex processes of lineage determination in the developing embryo. Their key role is to specify and maintain progenitor cells through use of complex molecular mechanisms such as alternate RNA splice forms and gene activation or inhibition in conjunction with protein co-factors. The significance of Pax genes in development is highlighted by abnormalities that arise from the expression of mutant Pax genes. Here, we review the molecular functions of Pax genes during development and detail the regulatory mechanisms by which they specify and maintain progenitor cells across various tissue lineages. We …

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Prevalence And Risk Factors For Cervical Neoplasia: A Cervical Cancer Screening Program In Beijing, Lixin Tao, Lili Han, Xia Li, Qi Gao, Lei Pan, Lijuan Wu, Yanxia Luo, Wei Wang, Zihe Zheng, Xiuhua Guo Jan 2014

Prevalence And Risk Factors For Cervical Neoplasia: A Cervical Cancer Screening Program In Beijing, Lixin Tao, Lili Han, Xia Li, Qi Gao, Lei Pan, Lijuan Wu, Yanxia Luo, Wei Wang, Zihe Zheng, Xiuhua Guo

Research outputs 2014 to 2021

Cervical cancer is the second most common cancer and cause of cancer-related death for women worldwide. The aims of this study were to investigate the prevalence of cervical neoplasia and examine factors associated with high-grade cervical squamous intraepithelial lesions (HSIL) among women taking part in a cervical cancer screening program in Beijing.

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Dystonia Type 6 Gene Product Thap1: Identification Of A 50 Kda Dna-Binding Species In Neuronal Nuclear Fractions, Maitane Ortiz-Virumbrales, Marta Ruiz, Eugene Hone, Georgia Dolios, Rong Wang, Andrika Morant, Jessica Kottwitz, Laurie J. Ozelius, Sam Gandy, Michelle Ehrlich Jan 2014

Dystonia Type 6 Gene Product Thap1: Identification Of A 50 Kda Dna-Binding Species In Neuronal Nuclear Fractions, Maitane Ortiz-Virumbrales, Marta Ruiz, Eugene Hone, Georgia Dolios, Rong Wang, Andrika Morant, Jessica Kottwitz, Laurie J. Ozelius, Sam Gandy, Michelle Ehrlich

Research outputs 2014 to 2021

Mutations in THAP1 result in dystonia type 6, with partial penetrance and variable phenotype. The goal of this study was to examine the nature and expression pattern of the protein product(s) of the Thap1 transcription factor (DYT6 gene) in mouse neurons, and to study the regional and developmental distribution, and subcellular localization of Thap1 protein. The goal was accomplished via overexpression and knock-down of Thap1 in the HEK293T cell line and in mouse striatal primary cultures and western blotting of embryonic Thap1-null tissue. The endogenous and transduced Thap1 isoforms were characterized using three different commercially available anti-Thap1 antibodies and validated …

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Urinary And Breast Milk Biomarkers To Assess Exposure Ro Naphthalene In Pregnant Women: An Investigation Of Personal And Indoor Air Sources, Amanda J. Wheeler, Nina A. Dobbin, Marie-Eve Heroux, Mandy Fisher, Liu Sun, Cheryl F. Khoury, Russ Hauser, Mark Walker, Tim Ramsay, Jean-Francois Bienvenu, Alain Leblanc, Eric Daigle, Eric Gaudreau, Patrick Belanger, Mark Feeley, Pierre Ayotte, Tye E Arbuckle Jan 2014

Urinary And Breast Milk Biomarkers To Assess Exposure Ro Naphthalene In Pregnant Women: An Investigation Of Personal And Indoor Air Sources, Amanda J. Wheeler, Nina A. Dobbin, Marie-Eve Heroux, Mandy Fisher, Liu Sun, Cheryl F. Khoury, Russ Hauser, Mark Walker, Tim Ramsay, Jean-Francois Bienvenu, Alain Leblanc, Eric Daigle, Eric Gaudreau, Patrick Belanger, Mark Feeley, Pierre Ayotte, Tye E Arbuckle

Research outputs 2014 to 2021

Naphthalene exposures for most non-occupationally exposed individuals occur primarily indoors at home. Residential indoor sources include pest control products (specifically moth balls), incomplete combustion such as cigarette smoke, woodstoves and cooking, some consumer and building products, and emissions from gasoline sources found in attached garages. The study aim was to assess naphthalene exposure in pregnant women from Canada, using air measurements and biomarkers of exposure.

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Factors Influencing Pacing In Triathlon, Sam Shi Xuan Wu, Jeremiah P. Peiffer, Jeanick Brisswalter, Kazunori Nosaka, Chris Abbiss Jan 2014

Factors Influencing Pacing In Triathlon, Sam Shi Xuan Wu, Jeremiah P. Peiffer, Jeanick Brisswalter, Kazunori Nosaka, Chris Abbiss

Research outputs 2014 to 2021

Triathlon is a multisport event consisting of sequential swim, cycle, and run disciplines performed over a variety of distances. This complex and unique sport requires athletes to appropriately distribute their speed or energy expenditure (ie, pacing) within each discipline as well as over the entire event. As with most physical activity, the regulation of pacing in triathlon may be influenced by a multitude of intrinsic and extrinsic factors. The majority of current research focuses mainly on the Olympic distance, whilst much less literature is available on other triathlon distances such as the sprint, half-Ironman, and Ironman distances. Furthermore, little is …

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