Digital Commons Network^™

Bioh 104.N.H50: Basic Human Biology, Eric Gren

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Bioh 105n.02: Basic Human Biology Laboratory, Kins W. Loree

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Bioh 105n.H50: Basic Human Biology Laboratory - Hamilton, Eric Gren

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Bioh 201n.Vh1: Human Anatomy And Physiology - Hamilton, Eric Gren

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Psyx 100s.51: Introduction To Psychology, Katie Smith

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Psyx 100s.52: Introduction To Psychology, Katie Smith

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Ot 510.01: Applied Clinical Anatomy, Andrew J. Kittelson, Phillip J. Nordeck

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Ahst 200.01: Operating Room Techniques, Katherine E. Geiger

University of Montana Course Syllabi, 2021-2025

No abstract provided.

Reliability And Spatial Consistency Of Mr Diffusion Tensor Imaging Measures Along The Cerebral Perivascular Space, Enchao Qiu, Joga Chaganti, Phillip Phan, M. Alizadeh, Devon Middleton, Kiran Talekar, Prabath Mondel, Scott H. Faro, Feroze Mohamed, Hsiangkuo Yuan

Department of Radiology Faculty Papers

BACKGROUND AND PURPOSE: Diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) has emerged as a promising noninvasive method for evaluating water motion that may reflect glymphatic system function. However, the reliability of DTI-ALPS measurements across different region-of-interest (ROI) selection methods remains underinvestigated. This study aimed to assess the interrater reliability among three neuroradiologists in native space and compare DTI-ALPS indices derived from ROIs placed in subjects' native space versus standardized Montreal Neurological Institute (MNI) space.

METHODS: DTI-ALPS indices from 16 healthy subjects were calculated from both left and right hemispheres using two ROI placement approaches: (1) native space ROIs …

Aberrant Expression Of Nuclear Prothymosin Α Contributes To Epithelial-Mesenchymal Transition In Lung Cancer, Liyun Chen, Chung-Teng Wang, Jia-Ming Chang, Ai-Li Shiau, Gia-Shing Shieh, Yau-Lin Tseng, Yi-Ting Yen, Tang-Hsiu Huang, Li-Hsin Cheng, Yu-Chih Wu, Chao-Liang Wu, Bing-Hua Su, Pensee Wu

2020-Current year OA Pubs

Elevated expression of prothymosin α (ProT) is frequently observed in cancers, but the underlying molecular mechanism remains poorly understood. Here, we report the clinical relevance of ProT expression and its correlation with lung cancer progression. We have shown that ProT was highly expressed in early-stage lung cancer, exhibiting nuclear localization; on the contrary, a loss of nuclear ProT expression was detected in late-stage tumor specimens. Furthermore, the expression of nuclear ProT impaired lung cancer cell migration, suppressed TGF-β-induced epithelial-to-mesenchymal transition (EMT)-associated transcription factor expression, and inhibited in vivo tumor metastasis. The suppressive effect of ProT was further found to trigger …

Effect Of Short-Chain Polymer Binders On The Mechanical And Electrochemical Performance Of Silicon Anodes, Fei Sun, L. Zurita-Garcia, Dean R. Wheeler

Faculty Publications

Polymer binders are crucial components in providing both mechanical support and chemical stability to the structure of porous Li-ion electrodes. Particularly in silicon anodes, the active material undergoes substantial volume expansion of up to 275%. Due to the mechanical constraint of the current collector, these silicon materials tend to expand in the normal direction while exhibiting substantial particle rearrangement and plastic deformation. Conventional rigid binders such as polyacrylic acid (PAA) and polyimide (PI), while providing satisfactory initial capacity, do not eliminate diminished long-term performance. Our research attempts to develop binder formulations that can accommodate sufficient flexibility for the substantial volume …

Self-Colonization In American Law: The Internet And Personal Information Example, Daniel J.H. Greenwood

Hofstra Law Faculty Scholarship

Since the Reagan era, American economic policy has amounted to self-colonization. Democratic majorities have consistently supported legal regimes that have enabled corporations to extract the lion’s share of the gains from trade from the public. For example, they have supported a corporate law regime that denies the public democratic control over the behavior of corporations and instead gives dictatorial powers to shareholders and managers. The Internet has made it even easier for firms to extract surpluses from consumers through surveillance and algorithmic pricing. One small contribution toward a project of decolonizing the public would be for consumers to obtain a …

Enhancing Preparedness: A Genetic Study Of Sar-Cov-2 And Other Microbial Public Health Threats In Wastewater From A College Town, Christian N. Hutchinson

Master's Theses

Problem

The SARS-CoV-2 (COVID-19) pandemic revealed both the systemic vulnerabilities of our healthcare system as well as the importance of timely, localized data for informing public health responses. Traditional testing approaches were essential but often failed to capture the full extent of viral spread, especially in those with mild or asymptomatic conditions that relied on at home testing. This underreporting hindered effective allocation of resources and made developing effective intervention strategies difficult. We also realized the potential for wastewater surveillance to be applied to tracking antimicrobial resistance gene markers. Taken together, this approach should have important implications for improving public …

An Evaluation Of The Relationship Between Beef Cattle Grazing Activity Traits And Conception Methods During The Breeding Season, Jason Dubowsky

Master's Theses

Efficient use of native rangelands and improved reproductive success are primary objectives in beef cattle production. Grazing behavior during the breeding season may be influenced by pasture characteristics, including size and water availability, as well as physiological differences due to reproductive status. This study aimed to evaluate the relationship between grazing activity and conception method in crossbred Angus cows over a 2-year period. The study was conducted during the winter months (December – February) on the Central Coast of California with a mean temperate of 53 degrees Fahrenheit. Cows (n = 76) were blocked by age and then randomly assigned …

2024-25 Lender Report -- Report, Lender Center For Social Justice

The Lender Center for Social Justice

The 2024-25 Lender Report, encompassing the year's events and research.

Lung Injury Risk Curves From Behind Armor Blunt Trauma Using A Live Swine Model, Narayan Yoganandan, Lewis Somberg, Danielle Wilson, Alok Shah, Jared Michael Koser, Brian D. Stemper, Valeta Carol Chancey, Joseph Mcentire

Biomedical Engineering Faculty Research and Publications

Introduction

From structural, anatomical, and functional perspectives, components of the thoracoabdominal region are heterogeneous and physiologically and functionally different. Although their tolerances to injury are expected to be different, the current Roma Plastilina No. 1 clay penetration criterion for behind armor blunt trauma (BABT) is not specific to the body region. It is important to develop regional injury criteria to ensure its specificity. The objective of the study is to conduct impact tests on the lung region using a live animal model and develop injury risk curves using velocity and deflection metrics via parametric survival analysis.

Materials and Methods

Live …

Linking Core Concepts And Competencies In General Chemistry Via Gowin’S Theory Of Learning And Vee Heuristic, Vijay Vyas, Scott A. Reid

Chemistry Faculty Research and Publications

The content in introductory science courses has often been criticized as “miles wide and inches deep”. In general chemistry, several revisions have focused on framing around a set of core or anchoring concepts, and we recently adapted the anchoring concepts content map (ACCM) of the American Chemical Society (ACS) to develop an anchoring concept-based curriculum for our general chemistry courses. In this article, we describe efforts to connect this curriculum with laboratory learning using Gowin’s theory of learning and the associated knowledge Vee heuristic. Within this framework, the laboratories themselves become events connecting the conceptual and methodological domains, …

Kegamangan Sistem Perlindungan Dan Pengelolaan Lingkungan: Melihat Uu Ciptaker Dari Perspektif Prinsip Non-Regresi, Andri G. Wibisana

Jurnal Hukum & Pembangunan

This article evaluates the Environmental Protection and Management Law (UUPPLH) as amended by the Omnibus Law on Job Creation (UUPPLH-Ciptaker) and its implementing regulations. The evaluation uses the normative framework of the principle of non-regression to assess whether the provisions of the UUPPLH-Ciptaker and its implementing regulations represent a setback compared to the legal conditions prior to the enactment of the Omnibus Law. This paper argues that the changes introduced by the UUPPLH-Ciptaker indicate several regressions in Indonesia’s environmental law, particularly in the following areas: a) the weakening of provisions on Environmental Impact Assessment (AMDAL) and Environmental Management and Monitoring …

Differences In Physician Electronic Health Record Use By Telemedicine Intensity: Evidence From 2 Academic Medical Centers, Seunghwan Kim, Robert Thombley, Elise Eiden, Sunny Lou, Julia Adler-Milstein, Thomas Kannampallil, A Jay Holmgren

2020-Current year OA Pubs

OBJECTIVE: Evaluate the association between telemedicine intensity and ambulatory physician electronic health record (EHR) use following the COVID-19 pandemic.

MATERIALS AND METHODS: This retrospective study included ambulatory physicians in 11 specialties at 2 large academic medical centers (Washington University in St Louis [WashU], University of California San Francisco [UCSF]). EHR use measures, including time-based and frequency-based, were analyzed in the post-COVID-19 period (March 1, 2021, through March 7, 2022). Multivariable regression models with 2-way fixed effects were used to assess the association between telemedicine intensity and EHR use.

RESULTS: Fully telemedicine physician-weeks were associated with higher EHR (hours per 8 …

Acad10 And Acad11 Enable Mammalian 4-Hydroxy Acid Lipid Catabolism, Edrees H Rashan, Abigail K Bartlett, Jingying Zhang, Andrew J Smith, Zakery N Baker, Patrick Forny, Peng Yuan, David J Pagliarini, Et Al.

2020-Current year OA Pubs

Fatty acid β-oxidation is a central catabolic pathway with broad health implications. However, various fatty acids, including 4-hydroxy acids (4-HAs), are largely incompatible with β-oxidation machinery before being modified. Here we reveal that two atypical acyl-CoA dehydrogenases, ACAD10 and ACAD11, drive 4-HA catabolism in mice. Unlike other ACADs, ACAD10 and ACAD11 feature kinase domains that phosphorylate the 4-hydroxy position as a requisite step in converting 4-hydroxyacyl-CoAs into conventional 2-enoyl-CoAs. Through cryo-electron microscopy and molecular modeling, we identified an atypical dehydrogenase binding pocket capable of accommodating this phosphorylated intermediate. We further show that ACAD10 is mitochondrial and necessary for catabolizing shorter-chain …

Machine Learning Feasibility In Cochlear Implant Speech Perception Outcomes-Moving Beyond Single Biomarkers For Cochlear Implant Performance Prediction, Matthew A. Shew, Cole Pavelchek, Andrew Michelson, Amanda Ortmann, Shannon Lefler, Amit Walia, Nedim Durakovic, Alisa Phillips, Ayna Rejepova, Jacques A. Herzog, Phillip Payne, Jay F. Piccirillo, Craig A. Buchman

2020-Current year OA Pubs

OBJECTIVES: Machine learning (ML) is an emerging discipline centered around complex pattern matching and large data-based prediction modeling and can improve precision medicine healthcare. Cochlear implants (CI) are highly effective, however, outcomes vary widely, and accurately predicting speech perception performance outcomes between patients remains a challenge. This study aims to evaluate the ability of ML to predict speech perception performance among CI recipients at 6-month post-implantation using only preoperative variables on one of the largest CI datasets to date, with an emphasis placed on identification of poor performers.

DESIGN: All patients enrolled in the national CI outcome tracking database, HERMES, …

Associations Of Biomarkers Of Systemic Inflammation, Angiogenesis, And Cell-To-Cell Adhesion With Tumor Budding Among Early-Onset And Later-Onset Colorectal Cancer Patients, Oda Hausmann, Adetunji T Toriola, Et Al.

2020-Current year OA Pubs

BACKGROUND: High tumor budding and elevated systemic inflammation are adverse prognostic indicators in colorectal cancer. Its underlying mechanisms remain poorly understood. It is unclear whether systemic inflammation, angiogenesis, and cell-to-cell adhesion influence tumor budding.

METHODS: We investigated n = 132 stage I-III colorectal cancer patients recruited at Huntsman Cancer Institute enrolled in the ColoCare Study. Tumor budding was evaluated using an evidence-based scoring system, and patient sera were analyzed for nine circulating biomarkers using the Meso Scale Discovery platform. We examined associations between biomarkers and tumor budding using multivariable linear regression models adjusted for age, sex, neoadjuvant treatment, stage, and …

Minimally Invasive, Bioadaptive Multimodal Sensor Probe With Safe Deployment For Real-Time Acute Compartment Syndrome Diagnosis, Seung Gi Seo, Amanda M Westman, William Moritz, Joseph Ribaudo, Mitchell A Pet, Et Al.

2020-Current year OA Pubs

Acute Compartment Syndrome (ACS) is a serious medical condition that arises from increased pressure within osteofascial compartments, leading to impaired blood flow and potential tissue damage. Early and accurate diagnosis is critical for preventing permanent damage. Current methods rely largely on qualitative assessments with limited accuracy, and those that exploit invasive pressure measurements often prove inadequate. Herein, a soft materials-based multimodal sensor probe is introduced, as well as the mechanical and thermal influences to monitor intra-compartmental pressure, tissue oxygen saturation (StO

Characterization Of A Mouse Model Of Osteoarticular Infection Using Clinical Isolates Of Staphylococcus Aureus, Philip M Roper, Jessica Beetner, Jennifer L Davis, Christine Shao, Jason Zhang, Linda Cox, Nitin Kumar Pokhrel, James E Cassat, Javier Rangel-Moreno, Gowrishankar Muthukrishnan, Deborah J Veis

2020-Current year OA Pubs

Osteoarticular infection, most commonly due to

S1pr1 Regulates Lymphatic Valve Development And Tertiary Lymphoid Organ Formation In The Ileum, Xin Geng, Gwendalyn J Randolph, Et Al.

2020-Current year OA Pubs

Efficient lymph flow is ensured by lymphatic valves (LVs). The mechanisms that regulate LV development are incompletely understood. Here, we show that the deletion of the GPCR sphingosine 1-phosphate receptor-1 (S1PR1) from lymphatic endothelial cells (LECs) results in fewer LVs. Interestingly, LVs that remained in the terminal ileum-draining lymphatic vessels were specifically dysfunctional. Furthermore, tertiary lymphoid organs (TLOs) formed in the terminal ileum of the mutant mice. TLOs in this location are associated with ileitis in humans and mice. However, mice lacking S1PR1 did not develop obvious characteristics of ileitis. Mechanistically, S1PR1 regulates shear stress signaling and the expression of …

Bacterial Vaginosis Toxins Impair Sperm Capacitation And Fertilization, Shweta Bhagwat, Leila Asadi, Ronald Mccarthy, Juan Ferreira, Ping Li, Ethan Li, Sariela Spivak, Ariana Gaydon, Vaka Reddy, Christy Armstrong, Sydney R Morrill, Hillary Zhou, Amanda L Lewis, Warren G Lewis, Celia M Santi

2020-Current year OA Pubs

STUDY QUESTION: What effect do toxins produced by bacterial vaginosis (BV) bacteria have on sperm function?

SUMMARY ANSWER: BV toxins dysregulate sperm capacitation and intracellular calcium homeostasis, and impair the ability of sperm to fertilize oocytes.

WHAT IS KNOWN ALREADY: In BV, which is linked to infertility, overgrowth of Prevotella and Gardnerella in the vagina is accompanied by elevated concentrations of the toxins lipopolysaccharide (LPS) and vaginolysin (VLY).

STUDY DESIGN, SIZE, DURATION: This was a laboratory study in which human semen samples were collected from consenting healthy donors with normal semen parameters. Mouse sperm samples were obtained from the caudal …

Coupling Category Alignment For Graph Domain Adaptation, Nan Yin, Xiao Teng, Zhiguang Cao, Mengzhu Wang

Research Collection School Of Computing and Information Systems

Graph domain adaptation (GDA), which transfers knowledge from a labeled source domain to an unlabeled target graph domain, attracts considerable attention in numerous fields. However, existing methods commonly employ message-passing neural networks (MPNNs) to learn domain-invariant representations by aligning the entire domain distribution, inadvertently neglecting category-level distribution alignment and potentially causing category confusion. To address the problem, we propose an effective framework named Coupling Category Alignment (CoCA) for GDA, which effectively addresses the category alignment issue with theoretical guarantees. CoCA incorporates a graph convolutional network branch and a graph kernel network branch, which explore graph topology in implicit and explicit …

Covid-19 Adolescent Technology Use And Physical Activities: Cluster Analysis For Mental Health, Chunling Niu, Rui Jin, Ashley Love, Sohelia Sadeghi, Loren Cossette, Marissa Molina

Journal of Youth Development

This study examined how COVID-19 disrupted adolescent education, social interactions, and mental health by conducting exploratory cluster analysis to identify distinct profiles of technology use and physical activities, then comparing resulting clusters on demographics, social support, and mental health dimensions. Using the first wave of the longitudinal Oxford Achieving Resilience during COVID-19 (ARC) study of 1,196 United Kingdom adolescents aged 13-18, three clustering algorithms (k-means, k-medoids, and agglomerative hierarchical) identified optimal groupings validated both statistically and empirically. Three distinct clusters emerged: Cluster 1 (n = 380) characterized by low media use and moderate activity; Cluster 2 (n = 153) showing …

Best Practices For Hybrid Positive Youth Development Programming, William Wilton, Claudia Mincemoyer, Jill Lingard, Maria Walker

Journal of Youth Development

CLOVER by 4-H is an online learning platform that creates a space for youth to explore interactive learning experiences across a range of 4-H program areas. This article provides an overview of a pilot conducted around the implementation of CLOVER by 4-H to provide positive youth-development experiences in 4-H programming. As a result of the pilot, three distinct models for hybrid program delivery and a set of seven best practices for hybrid positive youth development have been identified. This article outlines the hybrid models that were examined and discusses the best practices for hybrid PYD with examples from the pilot …

Getting To Court Is The Hard Part, Michael B. Gerrard, Jessica A. Wentz

Faculty Scholarship

The article by Quilcaille and colleagues makes a convincing case that heatwaves around the world have been worsened by the combustion of fossil fuels produced mostly by a limited number of companies. This is the latest in a series of climate-attribution studies5 that are demonstrating — with increasing precision — the link between greenhouse-gas emissions and climate impacts.