Digital Commons Network^™

Journey To The Neighborhood: An Analysis Of Fred Rogers And His Lessons For Educational Leaders, Jeana Lietz

Dissertations

Millions of children worldwide grew up watching Fred Rogers, aka “ Rogers,” as their childhood neighborhood friend on the television show Mister Rogers’ Neighborhood . How was a man able to produce one of the most successful, longest running children’s television programs and stay true to his moral principles? This study examines the life and work of Fred Rogers, and identifies the leadership attributes of Fred Rogers and the implications for educational leaders, through the lens of the five sources of authority described in Moral Leadership: Getting to the Heart of School Improvement by Thomas Sergiovanni (1992).

The central research …

Investigating The Biochemical And Catalytic Properties Of Nitrile Hydratases, Salette Martinez

Dissertations

Chemical and pharmaceutical industries make extensive use of amide compounds for the manufacture of commodity chemicals (e.g., acrylamide) and drug intermediates (e.g., nicotinamide). Production of amide compounds is typically achieved by the hydration of nitrile compounds under acidic or basic conditions, high temperatures, and copper catalysts. However, the use of such chemical methods leads to the generation of unwanted by-products and toxic wastes, in addition to low product yields and high production costs. An alternative route for amide production is the use of a natural catalyst, for example nitrile hydratases (NHase, E.C. 4.2.1.84). NHase is a metalloenzyme that efficiently converts …

Sorority Women & Eating Pathology: Communities Of Unhealthy Body Standards?, Ashley Marie Rolnik

Dissertations

The present study examines disordered eating, sorority social norms regarding the body and thinness, personal values regarding the body and thinness, body dissatisfaction, thin ideal internalization, fat talk, negative affect, and positive affect among sorority and non-sorority women. The aims of this study are to discern the underlying factor structures of the sorority/group social norms questionnaires and the personal values regarding the body and thinness questionnaire, investigate disordered eating among sorority and non-sorority women over time, and further examine the impact of social norms on sorority women's body and eating attitudes and behaviors. The results of this research illustrated three …

Mutations In Phospholamban Alter The Structure And Function Of The Calcium Atpase Regulatory Complex, Neha Abrol

Dissertations

Phospholamban (PLB) is an integral membrane protein that plays an important role in regulation of cardiac calcium handling and contractility. PLB exists as a homopentamer in the membrane, which upon deoligomerization into active monomers reversibly inhibits sarco/endoplasmic reticulum calcium ATPase (SERCA). Mutations in PLB that change the PLB monomer-pentamer equilibrium result in dysregulation of SERCA. To determine the structural and regulatory role of the C-terminal residues of PLB in the membranes of living cells, we fused fluorescent protein tags to PLB and SERCA. We then studied the effect of C-terminal alanine substitutions and truncation mutations on PLB oligomerization and SERCA …

The Role Of Spirituality/Religion As A Coping Mechanism During Treatment For Disordered Eating, David Franczyk

Dissertations

The purpose of this study was to investigate the role of spirituality/religion used as a coping mechanism during treatment for disordered eating. Given the mixed outcome results of current therapeutic and pharmacological treatment methods for disordered eating, it is important to investigate other factors which may influence the treatment process. This study evaluated the role of spirituality/religion used as a coping mechanism among 61 patients who were admitted into an eating disorder treatment program and then discharged over a period of 15 months. In this quantitative study, the Brief RCOPE measure was self-administered at admission to determine the levels of …

Investigation Of Pharmaceutical Mass Transfer Phenomena Using Molecular Dynamics Simulations, Yi Gao

Dissertations

Molecular dynamics (MD) simulation has been widely used in understanding the physical basis of the structure and function of biological macromolecules. However, its application in pharmaceutical research is still at an early stage. This dissertation attempts to establish the use of MD simulation in studying several important pharmaceutical mass transfer processes. The three-series study included (1) the understanding of drug crystal dissolution at molecular level, (2) the elucidation of an unique mechanism for facile polymorphic transformation of crystalline drugs in solutions, and (3) the determination of drug-polymer interactions at water-crystal interface and the implications to crystallization inhibition.

A drug crystal …

Re-Thinking Anthropomorphism Through A Genetic Philosophy Of Time, Carolyn Jo Love

Dissertations

In the classical Christian theological understanding, God and time are tightly interwoven (e.g. time and eternity, the Incarnation, and liturgy) and inform how we comprehend the presence and absence of the Incomprehensible in our day-to-day lives. Yet the classical Christian understanding does not take into account scientific discoveries pertaining to time and how this influences our experience of time. It is within the fabric of God and time that this dissertation will argue that the concept of time contained within contemporary genetics provides a significant and innovative way of considering the Classical Christian theological notion of the presence and absence …

He Seems Like A Good Kid Lessons In Informal Social Control From A Midwestern Peer Court Program, Patricia Lee Maddox

Dissertations

This study examines how peer court jurors make meaning out of the sanctioning trials of youth offenders. In particular, it focuses on how peer court jurors understand juvenile delinquency, deterrence and punishment. Data was collected utilizing ethnographic field observation methods while attending a Midwestern County's peer court program between the end of the 2011-2012 school year and the 2012-2013 school year. Thirteen interviews were conducted after the sessions with willing peer court jurors in order to supplement the field work data.

During the peer court sessions the youth jurors tried to understand the nature of the offenses and how to …

Functional Importance Of Oxidative Post-Translational Modifications Of Ryanodine Receptor In Cardiac Sarcoplasmic Reticulum Ca2+ Handling During Oxidative Stress, Stefan R. Mazurek

Dissertations

Free ionic calcium (Ca2+) plays an essential role as a second messenger that initiates muscle contraction in the heart. Ryanodine receptor (RyR2) acts as the primary Sarcoplasmic Reticulum (SR) Ca2+ release channel in the heart. In the event that intracellular SR Ca2+ handling is compromised, both the contractility and electrical excitability of the heart can be altered. As a consequence, heart function may not be able to maintain the necessary cardiac output to meet the metabolic demand of the body.

Increased oxidation of RyR2 has been implicated in abnormal Ca2+ handling that promotes the onset and progression of cardiovascular disease. …

Internalization Of Race Messages Among Mixed Race Individuals, Jennifer Moulton

Dissertations

The present study used grounded theory qualitative methodology to explore mixed race individuals' experiences within specific racial socialization contexts of family, friends, community, and society, to identify messages received within these contexts. How messages influence both their understandings of mixed race identity and how they racially identify themselves was also examined. Mixed race identity development was found to follow an ecological framework, in which racial socialization messages serve as a mechanism through which experiences within contexts may be interpreted, to then inform conceptions of racial identity and identification choices. Common themes of experiences emerged within contexts, including disownments/disapproval, sibling differences, …

The Dape-Encoded N-Succinyl-L,L-Diaminopimelic Acid Desuccinylase (Dape) From Haemophilus Influenzae As A Prospective Target For The Development Of Novel Antibiotics, Anna Starus

Dissertations

The rapid emergence of bacteria that are resistant to todayfs antibiotics makes them more and more ineffective. Consequently, the need for a novel class of antibacterial agents is rapidly increasing. The importance of this project is emphasized by the emergence of several pathogenic bacterial strains that are resistant to all currently available antibiotics on the market today. One way to approach this problem is to develop drugs that target essential bacterial biosynthetic pathways. Based on bacterial genetic information, the meso]diaminopimelate (mDAP)/lysine biosynthetic pathway offers several potential anti]bacterial targets that have not been yet explored. One of these, the dapE-encoded N-succinyl-L,L-diaminopimelic …

Neuroscience And Galen: Body, Selfhood And The Materiality Of Emotions On The Early Modern Stage, Devon Wallace

Dissertations

From antiquity until the turn of the nineteenth century, temperament, mood and personality were believed to exist within, be managed by, and interact with material substance. Before the medical revolution of the late seventeenth century, early modern theories of anatomy and medicine were primarily based on the writings of Galen, who lived in the second century but was him influenced by a much older medical and philosophical tradition. In this period, the playwrights raise the same central question that now appears in so many reactions to the increasingly accepted "neurocentric" world view: "to what extent do I have an emotional …

Profiles Of Neuropsychological Functioning In Children And Adolescents With Spina Bifda, Rachel Wasserman

Dissertations

The current study examined neuropsychological performance among children with spina bifida (SB) to determine if there are distinct subgroups or "profiles" of cognitive functioning. 96 children with SB myelomeningocele (ages 8-15) completed a brief assessment battery. Hierarchical and non-hierarchical cluster analyses were used to identify and confirm a cluster solution. Hypothesized predictors of cluster membership included lesion level, number of shunt surgeries, history of seizures, age, ethnicity, socio-economic status, family stress, and family environment. Outcomes included independence, academic success, expectations for the future, and quality of life.

Ward's cluster method indicated a 3-cluster solution, and was replicated with 2 other …

Final Report To Ospar Of The Joint Ospar/Ices Ocean Acidification Study Group (Sgoa), E Mcgovern, Jm Hall-Spencer

School of Biological and Marine Sciences

No abstract provided.

Variable Response Of Three Trifolium Repens Ecotypes To Soil Flooding By Seawater., Anissia C. White, Timothy D. Colmer, Greg R. Cawthray, Mick E. Hanley

School of Biological and Marine Sciences

BACKGROUND AND AIMS: Despite concerns about the impact of rising sea levels and storm surge events on coastal ecosystems, there is remarkably little information on the response of terrestrial coastal plant species to seawater inundation. The aim of this study was to elucidate responses of a glycophyte (white clover, Trifolium repens) to short-duration soil flooding by seawater and recovery following leaching of salts. METHODS: Using plants cultivated from parent ecotypes collected from a natural soil salinity gradient, the impact of short-duration seawater soil flooding (8 or 24 h) on short-term changes in leaf salt ion and organic solute concentrations was …

Differential Responses Of Emergent Intertidal Coral Reef Fauna To A Large-Scale El-Niño Southern Oscillation Event: Sponge And Coral Resilience., Francisco Kelmo, James J. Bell, Simone Souza Moraes, Rilza Da Costa Tourinho Gomes, Eduardo Mariano-Neto, Martin J. Attrill

School of Biological and Marine Sciences

There is a paucity of information on the impacts of the 1997-8 El Niño event and subsequent climatic episodes on emergent intertidal coral reef assemblages. Given the environmental variability intertidal reefs experience, such reefs may potentially be more resilient to climatic events and provide important insights into the adaptation of reef fauna to future ocean warming. Here we report the results of a 17-year (1995-2011) biodiversity survey of four emergent coral reef ecosystems in Bahia, Brazil, to assess the impact of a major El Niño event on the reef fauna, and determine any subsequent recovery. The densities of two species …

The Impact Of Changing Surface Ocean Conditions On The Dissolution Of Aerosol Iron, Matthew P. Fishwick, Peter N. Sedwick, Maeve C. Lohan, Paul J. Worsfold, Kristen N. Buck, Thomas M. Church, Simon J. Ussher

School of Geography, Earth and Environmental Sciences

The proportion of aerosol iron (Fe) that dissolves in seawater varies greatly and is dependent on aerosol composition and the physicochemical conditions of seawater, which may change depending on location or be altered by global environmental change. Aerosol and surface seawater samples were collected in the Sargasso Sea and used to investigate the impact of these changing conditions on aerosol Fe dissolution in seawater. Our data show that seawater temperature, pH, and oxygen concentration, within the range of current and projected future values, had no significant effect on the dissolution of aerosol Fe. However, the source and composition of aerosols …

Combining Motion Analysis And Microfluidics--A Novel Approach For Detecting Whole-Animal Responses To Test Substances., Tabitha S. Rudin-Bitterli, Oliver Tills, John I. Spicer, Phil F. Culverhouse, Eric M. Wielhouwer, Michael K. Richardson, Simon D. Rundle

School of Biological and Marine Sciences

Small, early life stages, such as zebrafish embryos are increasingly used to assess the biological effects of chemical compounds in vivo. However, behavioural screens of such organisms are challenging in terms of both data collection (culture techniques, drug delivery and imaging) and data evaluation (very large data sets), restricting the use of high throughput systems compared to in vitro assays. Here, we combine the use of a microfluidic flow-through culture system, or BioWell plate, with a novel motion analysis technique, (sparse optic flow - SOF) followed by spectral analysis (discrete Fourier transformation - DFT), as a first step towards automating …

Atomic Spectrometry Updates. Review Of Advances In Elemental Speciation, Robert Clough, Chris F. Harrington, Steve J. Hill, Yolanda Madrid, Julian F. Tyson

School of Geography, Earth and Environmental Sciences

No abstract provided.

Parameterization Of Pharmaceutical Emissions And Removal Rates For Use In Uk Predictive Exposure Models: Steroid Estrogens As A Case Study., J. D. Heffley, S. D.W. Comber, B. W. Wheeler, C. H. Redshaw

School of Geography, Earth and Environmental Sciences

Newly available prescription data has been used along with census data to develop a localised method for predicting pharmaceutical concentrations in sewage influent and effluent for England, and applied to a case study: the steroid estrogens estrone, 17β-estradiol, and 17α-ethinylestradiol in a selected catchment. The prescription data allows calculation of the mass consumed of synthetic estrogens, while use of highly localised census data improves predictions of naturally excreted estrogens by accounting for regional variations in population demographics. This serves two key purposes; to increase the accuracy of predictions in general, and to call attention to the need for more accurate …

Factors Affecting The Levels Of Protection Transferred From Mother To Offspring Following Immune Challenge, Christina M. Coakley, Vincent Staszewski, Katherine A. Herborn, Emma J.A. Cunningham

School of Biological and Marine Sciences

No abstract provided.

Rocky Shores: From Habitat Threat To Marine Awareness & Well-Being Benefits, Kayleigh Wyles

School of Psychology Theses

Previous psychological research has demonstrated the benefits of visiting natural environments, especially coastal areas. However, research within Marine Biology has shown that such visits can harm natural habitats. Consequently, this thesis uses an integrative approach to examine both the risks to the environment and benefits to the human visitors in the context of rocky shores (intertidal areas where solid rock predominates). This was investigated using seven studies that involved a range of methods. Perception-based surveys (Studies 1 & 2) explored the perceived impacts on the visitor, and the potential impacts these visits can have on the rocky shore. Study 3 …

Put Him In Grandma's House: Investigating Variation In Kinship Policy And Procedure Across Ohio's County-Based Child Welfare System, Andreja M. Siliunas

Senior Independent Study Theses

Since 1980, the U.S. child welfare system has exhibited an increasing reliance upon kinship caregivers as a resource for children who have been removed from the homes of their birthparents due to allegations of abuse or neglect. Literature suggests that agencies differ considerably in their treatment of kinship care providers; however, limited research has been conducted examining the causes and implications of this variation, especially in the case of Ohio’s county-based system. The current study thus aims to define the distinguishing characteristics of kinship policies and procedures of child welfare agencies across Ohio, and to consider the impact of various …

Normalizing Abnormality: An Exploration Of Social Forces Driving Gendered Disparity In Rates Of Anxiety Disorder Diagnoses, Sara Tebeau

Senior Independent Study Theses

According to recent statistics provided by the National Institute of Mental Health (2013), American women are twice as likely as men to face diagnosis with an anxiety disorder. While there are existing bodies of sociological and feminist work theorizing both the social construction of mental illness categories and the historical pathologization of women, there is no contemporary dialogue centered on gendered disparity in anxiety diagnosis rates. In this paper, I contribute to ongoing discussion of neoliberal influence on the gendering of mental illness through an exploration of the forces contributing to disparity in rates of diagnosis with anxiety disorders. In …

Valuing The Arctic National Wildlife Refuge: A Defense Of Countercultural Environmentalism, Mae Manupipatpong

Senior Independent Study Theses

No abstract provided.

Generalist And Specialist Pollination Syndromes: When Are They Favoured? A Theoretical Approach To Predict The Conditions Under Which A Generalist Or Specialist Pollination Syndrome Is Favoured., Tyler L. Poppenwimer

Senior Independent Study Theses

No abstract provided.

Lineage Ii Of Southeast Asian/American Denv-2 Is Associated With A Severe Dengue Outbreak In The Peruvian Amazon, Maya Williams, Sandra V. Mayer, William L. Johnson, Rubing Chen, Evgeniya Volkova, Stalin Vilcarromeor, Steven G. Widen, Thomas G. Wood, Luis Suarez-Ognio, Kanya C. Long, Katherine A. Hanley, Amy C. Morrison, Nikos Vasilakis, Eric S. Halsey

Faculty Publications

During 2010 and 2011, the Loreto region of Peru experienced a dengue outbreak of unprecedented magnitude and severity for the region. This outbreak coincided with the reappearance of dengue virus-2 (DENV-2) in Loreto after almost 8 years. Whole-genome sequence indicated that DENV-2 from the outbreak belonged to lineage II of the southeast Asian/American genotype and was most closely related to viruses circulating in Brazil during 2007 and 2008, whereas DENV-2 previously circulating in Loreto grouped with lineage I (DENV-2 strains circulating in South America since 1990). One amino acid substitution (NS5 A811V) in the 2010 and 2011 isolates resulted from …

She Saves Us From Monsters: The Navajo Creation Story And Modern Tribal Justice, Heidi J. Todacheene

Tribal Law Journal

The goal of this paper is to attempt to provide a general social and political framework of the Navajo tribe using the creation story and journey narrative. This will provide a comprehensive insight into the history and modern functioning of the tribe for someone who may not understand traditional Navajo thought. Modern legal cases have been integrated into this paper to demonstrate how Navajo courts use and preserve traditional concepts in current legal analysis. This paper will try to convey a traditional Navajo perspective whose ideology is deeply rooted in the creation story and illustrated through the Holy Beings, especially …

'It's All A Question Of Business': Investment Identities, Networks And Decision-Making In The Cleantech Economy, Lucien Georgeson, Federico Caprotti, Ian Bailey

School of Geography, Earth and Environmental Sciences

No abstract provided.

The Green Economy: Functional Domains And Theoretical Directions Of Enquiry, Ian Bailey, Federico Caprotti

School of Geography, Earth and Environmental Sciences

No abstract provided.