Digital Commons Network^™

Patent Claim Interpretation Review: Deference Or Correction Driven?, Christopher A. Cotropia

Law Faculty Publications

This Article examines the Federal Circuit's review of claim constructions by lower tribunals to determine whether the Federal Circuit defers to lower court constructions or is making its own, independent determination as to the "correct" construction and ultimate result in the case.

Comments: What's Yours Is Ours? Gamete Donation In The Marital Context: Why Courts And Legislatures Should Not Interfere With An Individual's Fundamental Right To Privacy, Emily K. Alt

University of Baltimore Law Review

No abstract provided.

Characterization Of The Disulfide In The Ectodomain Of Anthrax Toxin Receptor 2, Pedro Raymundo Jacquez

Open Access Theses & Dissertations

Anthrax toxin receptors act as molecular clamps or switches that control anthrax toxin entry, pH-dependent pore formation, and translocation of enzymatic moieties across the endosomal membranes. The ectodomain of anthrax toxin receptor 2 (ANTXR2) is composed of a von Willebrand factor A (VWA) domain that binds to anthrax toxin protective antigen (PA) and a newly defined immunoglobulin-like (Ig) domain, in which the disulfide bonds are required for PA pore formation and for the folding of ANTXR2. While the VWA domain has been well characterized, the structure and function of the whole ectodomain (VWA-Ig) are poorly defined, this is mainly due …

Biochemical Characterization Of Four Distinct Proteins, Gustavo A. Avila

Open Access Theses & Dissertations

Proteins are ubiquitous in all living organisms, executing the majority of cellular functions in distinct ways. Understanding a protein's role necessitates investigating its structure and function, which are closely related. My research couples these two aspects by delving into the biochemical and structural characterization of proteins in four distinct systems, all playing central roles in numerous significant disease progressions. These four original research endeavors were all targeted for structural studies with a unifying relationship to establish our new structural biochemistry lab. These four systems are: (1) Gam1, an early adenovirus protein globally inhibiting host SUMOylation; (2) Anthrax toxin complexed with …

The Sumoylation Of The Non-Structural Protein 1 Of The Influenza A Virus Plays A Dual Role During Viral Infection, Jason Michael Chacon

Open Access Theses & Dissertations

The potential for a highly pathogenic influenza pandemic remains a concern for global health. The ability of the influenza virus to undergo antigenic shift and genetic drift give circulating strains of influenza the high probability of developing resistance to current antiviral therapies. Emerging strains of higher virulence, to which the infected person has not had any previous exposure to viral antigens, pose a greater threat of serious illness and death. Currently, there is no antiviral therapy that is effective against all strains of influenza, emphasizing the need to develop new strategies that target cellular systems required for viral replication to …

Language Difference Between Peer And Professional Drug And Substance Abuse Counselors: What Can It Tell Us?, Lizzeth Celeste Jensen

Open Access Theses & Dissertations

Language studies that explore the human mind are not new. In recent years new techniques have opened new areas of investigation. One such is whether different professional groups do not merely use language in different ways, but a) "think" differently, or b) may be professionally more effective.

This is an exploratory study that uses secondary data analysis to see if difference in approach to providing help by Peer versus Professional substance use counselors, are reflected in differences of language use. For the purpose of this study Peer will stand for those counselors which, during the interview, stated they were ex-addicts …

Super Resolution Pump-Probe Microscopy With Point Spread Function Engineering, Farzaneh Mohajerani

Open Access Theses & Dissertations

Since the last decade, new techniques have made optical microscopy break the diffraction barrier of resolution where all of them are based on molecular fluorescence. Among them, stimulated emission depletion microscopy (STED) has reached less than 25 nm resolution by engineering the point spread function. However, the existing obstacles associated with fluorescence tagging makes it desirable to achieve label-free imaging. Recently the pump-probe method has made it possible to obtain image contrast from molecular absorption and vibration signatures that do not depend on fluorescence. We introduce Super Resolution Pump-Probe Microscopy (SRPPM), in which we combine both PSF engineering method and …

Master's In Electrical Engineering, Ricardo Xavier Rodriguez

Open Access Theses & Dissertations

This project is a focus on characterizing the process for actualizing three dimensional structures out of a carbon nanostructure composite via a direct print additive manufacturing process. Manufacturing parts additively enables for realization of geometrically complex shapes that often times cannot be manufactured any other way. The specificity of a material's properties have to be such, that the processing method can precisely place and bond material to itself in a highly repeatable manner. Commercial materials for additive manufacturing are have been optimized with these goals in mind and, therefore, often times lack the rigor and robustness for many applications.

The …

Identification And Characterization Of Novel Anti-Leukemia And Anti-Lymphoma Compounds, Yahaira Santiago

Open Access Theses & Dissertations

The anti-cancer properties of curcumin, the natural yellow pigment in the roots of turmeric (Curcuma longa), have been extensively described over the last century. It has been shown to interfere with multiple cell signaling pathways, including execution of apoptosis, anti-proliferation, anti-angiogenic, and anti-inflammatory properties. However, curcumin's cytotoxic potential is limited when administered in vivo. With the idea of preserving curcumin's characteristics, but improving its bioavailability, analogues have been developed and evaluated in the last decade. Most of the analogues have shown very good anti-cancer activity in various cell lines and one analogue is now in a clinical trial. Nonetheless, this …

An Avian Survey Conducted At Five Water Sources Within The Northern Chihuahuan Desert On Indio Mountains Research Station, Texas, Geoffrey Hugh Wiseman

Open Access Theses & Dissertations

The objective of this study was to conduct an avian survey of five water sources (four ephemeral former cattle tanks and one perennial spring), determine how many species inhabit or use Indio Mountains Research Station, and show a hierarchal similarity between the survey sites. This survey was conducted in a Chihuahuan Desert scrub landscape on Indio Mountains Research Station (IMRS) in Hudspeth County, Texas. There have been no previous formal studies of the avifauna at IMRS. All species accounts or sightings have been from casual sightings.

Eighty-five avian species were recorded during this project bringing the total of avian species …

Gbetagamma-Microtubule Mediated Mechanism Of Neuronal Differentiation, Jorge Anibal Sierra Fonseca

Open Access Theses & Dissertations

Neurodegeneration, a progressive loss of nerve cells (neurons), occurs in many neurological disorders, including Alzheimer's and Parkinson's diseases, as well as in the aging brain. Disruption of microtubules in neurons and the aggregation of proteins associated with them is the hallmark of neurodegeneration. Nevertheless, the cause of this disorder is largely unknown, and no effective drugs are available to treat the disease processes. Therefore, there is a need to understand the molecular mechanisms that drive the assembly and disassembly of microtubules during neurite outgrowth and differentiation. Evidence suggests that nerve growth factor (NGF) induces neurite outgrowth from PC12 cells by …

Gphy 433.01: Cultural Geography, Jeffrey Allman Gritzner

University of Montana Course Syllabi

No abstract provided.

Pubh 595.51: Issues In Maternal And Child Health, Julie M. Stevens

University of Montana Course Syllabi

No abstract provided.

Psyx 385.90: Psychology Of Personality- Methodology, Theories, And Application, Desiree Fox

University of Montana Course Syllabi

No abstract provided.

Psyx 362.01: Multicultural Psychology, Gyda Swaney

University of Montana Course Syllabi

No abstract provided.

Pubh 595.50: Tobacco And Public Health, Kari J. Harris

University of Montana Course Syllabi

No abstract provided.

Psyx 230.02: Developmental Psychology, Nicole Mccray

University of Montana Course Syllabi

No abstract provided.

Psyx 100s.07: Introduction To Psychology, Priya Loess

University of Montana Course Syllabi

No abstract provided.

Optimized Analysis Of Variable Chlorophyll Fluorescence In Algal Physiology Under Stress Conditions : Measuring Nothing With Confidence, Nicole Bobco

Capstone Projects and Master's Theses

The detection and determination of viable phytoplankton are fundamental assays in oceanographic and limnological fields. Assessing phytoplankton physiology allows for insight into how cells might respond to different environmental or physical stressors, making it an important subject for ecological research and applied sciences, where the physiological status of photautotrophs must be known. In particular, maritime operations have been identified as major vectors in the spread of aquatic invasive species through ballast water transport. To mitigate this environmental hazard, shipborne systems are required to effectively sterilize ballast water to comply with emerging regulations regarding the transport of ballast water. Common oceanographic …

Analysis Of Vesicular Porosity In Soils Using High-Resolution X-Ray Computed Tomograpy, Judith K. Turk, Robert C. Graham

Conservation and Survey Division: Faculty and Staff Publications

Vesicular horizons are common at the surface of arid and semiarid soils and play a critical role in regulating infiltration. Most methods for examining pore morphology in the vesicular horizon involve physical sectioning of the sample and individual measurement of pores, which is time-consuming and provides an incomplete view of the pores. The objectives of this study were to (i) develop methods for the classification and characterization of pores in the vesicular horizon using high resolution X-ray computed tomography (HRXCT) and (ii) use these methods to examine the distribution of pores within vesic-ular peds. Three intact peds were scanned by …

Health Law As Social Justice, Lindsay Wiley

Scholarly Articles in Law Reviews & Journals

Health law is in the midst of a dramatic transformation. From a relatively narrow discipline focused on regulating relationships among individual patients, health care providers, and third-party payers, it is expanding into a far broader field with a burgeoning commitment to access to health care and assurance of healthy living conditions as matters of social justice. Through a series of incremental reform efforts stretching back decades before the Affordable Care Act and encompassing public health law as well as the law of health care financing and delivery, reducing health disparities has become a central focus of American health law and …

From Third Parties To Parents: The Case Of Lesbian Couples And Their Children, Nancy Polikoff

Scholarly Articles in Law Reviews & Journals

No abstract provided.

Biob 547.01a: Experimental Molecular, Cellular, And Chemical Biology, Jesse C. Hay

University of Montana Course Syllabi

No abstract provided.

Still Unconstitutional: Our Nation's Experiment With State-Sponsored Sex Segregation In Education, David S. Cohen, Nancy Levit

Faculty Works

Since federal regulations authorized single-sex education in 2006, there has been an explosion of single-sex schools and classes. Although the Supreme Court has not ruled, three federal court decisions have addressed the constitutionality of single-sex classes, and the issue will percolate toward Supreme Court review soon. The arguments are that parents should have choices and “diversity” of educational options, that “brain research” shows that boys and girls are so biologically different to need sex-specific educational environments, that educational outcomes are better, and single-sex learning environments allows boys and girls to break through gender stereotypes. This article dissects these arguments within …

Glyco-Modification Of Protein With O-Cyanate Chain-End Functionalized Glycopolymer Via Isourea Bond Formation, Valentinas Gruzdys, Hailong Zhang, Xue-Long Sun

Chemistry Faculty Publications

Glycoengineering aimed at addition of carbohydrates to proteins is an attractive approach to alter pharmacokinetic properties of proteins such as enhancing stability and prolonging the duration of action. We report a novel protein glyco-modification of BSA and recombinant thrombomodulin with O-cyanate chain-end functionalized glycopolymer via isourea bond formation. The protein glycoconjugates were confirmed by SDS-PAGE, western blot, and MALDI-TOF Mass Spectrometry. Protein C activation activity of the glyco-modified recombinant thrombomodulin was confirmed, proving no interference to activity from the glycopolymer modification. The isourea bond formation under mild conditions was demonstrated as an alternative method for protein modification with polymers.

Greater Polar Moment Of Inertia At The Tibia In Athletes Who Develop Stress Fractures, Lee A. Weidauer, Teresa Binkley, Matthew Vukovich, Bonny Specker

Health and Nutritional Sciences Faculty Publications

Background: Several previous investigations have determined potential risk factors for stress fractures in athletes and military personnel.
Purpose: To determine factors associated with the development of stress fractures in female athletes.
Study Design: Case-control study; Level of evidence, 3.
Methods: A total of 88 female athletes (cross-country, n ¼ 29; soccer, n ¼ 15; swimming, n ¼ 9; track and field, n ¼ 14; volleyball, n ¼ 12; and basketball, n ¼ 9) aged 18 to 24 years were recruited to participate in a longitudinal bone study and had their left distal tibia at the 4%, 20%, and 66% sites …

Salute To Faculty Scholarship 2014, Clark University

Faculty Works

No abstract provided.

Outlook Magazine, Autumn 2014

Outlook Magazine

No abstract provided.

Search Strategies From: Libraries And Genomics: Providing Support To Healthcare Providers And Consumers, Karen E. Gutzman, Marcy L. Vana, Kristi L. Holmes

Becker Library Publications and Presentations

No abstract provided.

Average Budgeted Salaries Of Faculty Staff 2014-2015, University Of Northern Iowa

Institutional Effectiveness & Planning Documents

Gives the average salaries of faculty broken down by rank and college and the distribution of salaries of the professional and scientific category.