Digital Commons Network^™

Genetic Variation In Iron Metabolism Is Associated With Neuropathic Pain And Pain Severity In Hiv-Infected Patients On Antiretroviral Therapy, David B. Clifford, Et Al.

Open Access Publications

No abstract provided.

An Animal Model With A Cardiomyocyte-Specific Deletion Of Estrogen Receptor Alpha: Functional, Metabolic, And Differential Network Analysis, Sriram Devanathan, Timothy Whitehead, George G. Schweitzer, Nicole Fettig, Attila Kovacs, Kenneth S. Korach, Brian N. Finck, Kooresh I. Shoghi

Open Access Publications

No abstract provided.

Metagenomic Analysis Of Double-Stranded Dna Viruses In Healthy Adults, Kristine M. Wylie, Kathie A. Mihindukulasuriya, Yanjiao Zhou, Erica Sodergren, Gregory A. Storch, George M. Weinstock

Open Access Publications

No abstract provided.

Pharmacologic Blockade Of Jak1/Jak2 Reduces Gvhd And Preserves The Graft-Versus-Leukemia Effect, Jaebok Choi, Matthew L. Cooper, Bader Alahmari, Julie Ritchey, Lynne Collins, Matthew Holt, John F. Dipersio

Open Access Publications

No abstract provided.

Mitochondrial Genome Linearization Is A Causative Factor For Cardiomyopathy In Mice And Drosophila, Yun Chen, Megan Sparks, Poonam Bhandari, Scot J. Matkovich, Gerald W. Dorn

Open Access Publications

No abstract provided.

Il-6 Stimulates Intestinal Epithelial Proliferation And Repair After Injury, Kristine A. Kuhn, Nicholas A. Manieri, Ta-Chiang Liu, Thaddeus S. Stappenbeck

Open Access Publications

No abstract provided.

Aligning Objectives And Assessment In Responsible Conduct Of Research Instruction, Alison Antes, James M. Dubois

Open Access Publications

No abstract provided.

Alzheimer’S Therapeutics Targeting Amyloid Beta 1–42 Oligomers Ii: Sigma-2/Pgrmc1 Receptors Mediate Abeta 42 Oligomer Binding And Synaptotoxicity, Jinbin Xu, Chenbo Zeng, Carlos Cruchaga, Alison Goate, Robert H. Mach, Et Al

Open Access Publications

No abstract provided.

Loss Of Trop2 Causes Erbb3 Activation Through A Neuregulin-1-Dependent Mechanism In The Mesenchymal Subtype Of Hnscc, Kaihua Zhang, Lamont Jones, Sora Lim, Christopher A. Maher, Douglas Adkins, James Lewis, Randall J. Kimple, Elana J. Fertig, Christine H. Chung, Brian A. Van Tine, Matthew J. Ellis, Andreas Herrlich, Loren S. Michel

Open Access Publications

No abstract provided.

Distinct Lysosome Phenotypes Influence Inflammatory Function In Peritoneal And Bone Marrow-Derived Macrophages, Kassandra Weber, Joel D. Schilling

Open Access Publications

No abstract provided.

Evaluating The Application Of Multipollutant Exposure Metrics In Air Pollution Health Studies, Michelle Oakes, Lisa Baxter, Thomas C. Long

United States Environmental Protection Agency: Publications

Background: Health effects associatedwith air pollution are typically evaluated using a single pollutant approach, yet people are exposed to mixtures consisting of multiple pollutants that may have independent or combined effects on human health. Development of exposure metrics that represent the multipollutant environment is important to understand the impact of ambient air pollution on human health. Objectives:We reviewed existing multipollutant exposure metrics to evaluate howthey can be applied to understand associations between air pollution and health effects. Methods: We conducted a literature search using both targeted search terms and a relational search in Web of Science and PubMed in April …

Microbial Diversities (16s And 18s Rrna Gene Pyrosequencing) And Environmental Pathogens Within Drinking Water Biofilms Grown On The Common Premise Plumbing Materials Unplasticized Polyvinylchloride And Copper, Helen Buse, Jingrang Lu, Xiaozhen Mou, Nicholas Ashbolt

United States Environmental Protection Agency: Publications

Drinking water (DW) biofilm communities influence the survival of opportunistic pathogens, yet knowledge about the microbial composition of DW biofilms developed on common in-premise plumbing material is limited. Utilizing 16S and 18S rRNA gene pyrosequencing, this study characterized the microbial community structure within DW biofilms established on unplasticized polyvinyl chloride (uPVC) and copper (Cu) surfaces and the impact of introducing Legionella pneumophila (Lp) and Acanthamoeba polyphaga. Mature (> 1 year old) biofilms were developed before inoculation with sterilized DW (control, Con), Lp, or Lp and A. polyphaga (LpAp). Comparison of uPVC and Cu biofilms indicated significant differences between bacterial (P …

Institutionalized Cooperation And Resilience In Transboundary Freshwater Allocation, Olivia Odom Green, Charles Perrings

United States Environmental Protection Agency: Publications

Of all the expected impacts of climate change, the most significant is likely to be the change in the availability of freshwater associated with changing precipitation. The most recent Intergovernmental Panel on Climate Change (IPCC) report notes that all regions of the world are expected to experience a net negative impact on water resources and freshwater ecosystems. The impact is likely to be highly variable, with some regions experiencing declining runoff and others experiencing increasing runoff. Many areas are projected to experience increased variability in precipitation and hence. in water supply, water quality, and flood risks (IPCC 2007). Individual countries …

An Inexpensive, Temporally Integrated System For Monitoring Occurrence And Biological Effects Of Aquatic Contaminants In The Field, Michael D. Kahl, Daniel L. Vileneuve, Kyle Stevens, Anthony Schroeder, Elizabeth A. Makynen, Carlie A. Lalone, Kathleen M. Jensen, Meagan Hughes, Bruce A. Holmen, Evan Eid, Elizabeth J. Durhan, Jenna E. Cavallin, Jason Berninger, Gerald T. Ankley

United States Environmental Protection Agency: Publications

Assessment of potential risks of complex contaminant mixtures in the environment requires integrated chemical and biological approaches. In support of the US Great Lakes Restoration Initiative, the US Environmental Protection Agency lab in Duluth, MN, is developing these types of methods for assessing possible risks of aquatic contaminants in near-shore Great Lakes (USA) sites. One component involves an exposure system for caged fathead minnow (Pimephales promelas) adults suitable for the wide range of habitat and deployment situations encountered in and around the Great Lakes. To complement the fish exposure system, the authors developed an automated device for collection of composite …

Beta‐Thymosin Gene Polymorphism Associated With Freshwater Invasiveness Of Alewife (Alosa Pseudoharengus), Katarzyna Michalak, Serguisz Czesny, John Epifanio, Randal Snyder, Eric Schultz, Jonathan Velotta, Stephen Mccormick, Bonnie Brown, Graciela Santopietro, Pawel Michalak

United States Geological Survey: Staff Publications

Predicting the success of a species' colonization into a novel environment is routinely considered to be predicated on niche‐space similarity and vacancy, as well as propagule pressure. The role genomic variation plays in colonization success (and the interaction with environment) may be suggested, but has not rigorously been documented. To test an hypothesis that previously observed ecotype‐specific polymorphisms between anadromous and landlocked alewife (Alosa pseudoharengus) populations are an adaptive response to osmoregulatory challenges rather than a result of allele sampling at founding, we examined multiple anadromous and landlocked (colonized) populations for their allelic profiles at a conserved region (3’‐UTR end) …

Projecting Future Grassland Productivity To Assess The Sustainability Of Potential Biofuel Feedstock Areas In The Greater Platte River Basin, Yingxin Gu, Bruce K. Wylie, Stephen Boyte, Khem Phuyal

United States Geological Survey: Staff Publications

This study projects future (e.g., 2050 and 2099) grassland productivities in the Greater Platte River Basin (GPRB) using ecosystem performance (EP, a surrogate for measuring ecosystem productivity) models and future climate projections. The EP models developed from a previous study were based on the satellite vegetation index, site geophysical and biophysical features, and weather and climate drivers. The future climate data used in this study were derived from the National Center for Atmospheric Research Community Climate System Model 3.0 ‘SRES A1B’ (a ‘middle’ emissions path). The main objective of this study is to assess the future sustainability of the potential …

Anatomy Of The Lamprey Ear: Morphological Evidence For Occurrence Of Horizontal Semicircular Ducts In The Labyrinth Of Petromyzon Marinus, Adel Maklad, Caitlyn Reed, Nicolas Johnson, Bernd Fritzsch

United States Geological Survey: Staff Publications

In jawed (gnathostome) vertebrates, the inner ears have three semicircular canals arranged orthogonally in the three Cartesian planes: one horizontal (lateral) and two vertical canals. They function as detectors for angular acceleration in their respective planes. Living jawless craniates, cyclostomes (hagfish and lamprey) and their fossil records seemingly lack a lateral horizontal canal. The jawless vertebrate hagfish inner ear is described as a torus or doughnut, having one vertical canal, and the jawless vertebrate lamprey having two. These observations on the anatomy of the cyclostome (jawless vertebrate) inner ear have been unchallenged for over a century, and the question of …

Wildfire Effects On Extractable Elements In Ash From A Pinus Pinaster Forest In Portugal, Paulo Pereira, Xavier Ubeda, Deborah Martin, Jorge Mataix-Solera, Artemi Cerda, Maria Burguet

United States Geological Survey: Staff Publications

The aim of this work is to study the effects of a wildfire on water-extractable elements in ash from a Pinus pinaster forest located in Portugal. The pH, electrical conductivity (EC), calcium (Ca²⁺), magnesium (Mg²⁺), sodium (Na⁺), potassium (K⁺), sodium and potassium adsorption ratio (SPAR), aluminium (Al³⁺), manganese (Mn²⁺), iron (Fe²⁺), zinc (Zn²⁺), sulphur (S), silica (Si) and phosphorous (P) were analysed in ash sampled from a sloped area burned in a wildfire and from litter from a contiguous unburned area, with similar morphological …

Net Ecosystem Productivity Of Temperate Grasslands In Northern China: An Upscaling Study, Li Zhang, Huadong Guo, Gensou Jia, Bruce K. Wylie, Tagir Gilmanov, Danny Howard, Lei Ji, Jingfeng Xiao, Jing Li, Wenping Yuan, Tianbao Zhao, Shiping Chen, Guangsheng Zhou, Tomomichi Kato

United States Geological Survey: Staff Publications

Grassland is one of the widespread biome types globally, and plays an important role in the terrestrial car-bon cycle. We examined net ecosystem production (NEP) for the temperate grasslands in northern China from 2000 to 2010. We combined flux observations, satellite data, and climate data to develop a piece-wise regression model for NEP, and then used the model to map NEP for grasslands in northern China. Over the growing season, the northern China’s grassland had a net carbon uptake of 158 ± 25 g C m−2during 2000–2010 with the mean regional NEP estimate of 126 Tg C. Our results showed …

Fitting Statistical Distributions To Sea Duck Count Data: Implications For Survey Design And Abundance Estimation, Elise Zipkin, Jeffrey Leirness, Brian Kinlan, Allan O'Connell, Emily Silverman

United States Geological Survey: Staff Publications

Determining appropriate statistical distributions for modeling animal count data is important for accurate estimation of abundance, distribution, and trends. In the case of sea ducks along the U.S. Atlantic coast, managers want to estimate local and regional abundance to detect and track population declines, to define areas of high and low use, and to predict the impact of future habitat change on populations. In this paper, we used a modified marked point process to model survey data that recorded flock sizes of Common eiders, Long-tailed ducks, and Black, Surf, and White-winged scoters. The data come from an experimental aerial survey, …

Adverse Outcome Pathway And Risks Of Anticoagulant Rodenticides To Predatory Wildlife, Barnett A. Rattner, Rebecca S. Lazarus, John E. Elliott, Richard F. Shore, Nico Van Den Brink

United States Geological Survey: Staff Publications

Despite a long history of successful use, routine application of some anticoagulant rodenticides (ARs) may be at a crossroad due to new regulatory guidelines intended to mitigate risk. An adverse outcome pathway for ARs was developed to identify information gaps and end points to assess the effectiveness of regulations. This framework describes chemical properties of ARs, established macromolecular interactions by inhibition of vitamin K epoxide reductase, cellular responses including altered clotting factor processing and coagulopathy, organ level effects such as hemorrhage, organism responses with linkages to reduced fitness and mortality, and potential consequences to predator populations. Risk assessments have led …

Novel Gammaherpesvirus Functions 1 Encoded By Bovine Herpesvirus (Bovine Lymphotropic Virus), J. Jia, G. Delhon, E. R. Tulman, D. G. Diel, Fernando A. Osorio, X. Wen, G. F. Kutish, D. L. Rock

School of Veterinary and Biomedical Sciences: Faculty Publications

The genus Macavirus of the subfamily Gammaherpesvirinae includes viruses that infect lymphoid cells of domestic and wild ruminants and swine, causing asymptomatic latent infections in reservoir hosts. Here, we describe the genome of bovine herpesvirus 6 (BoHV-6), a

macavirus ubiquitous in healthy cattle populations. The BoHV-6 genome exhibited architecture conserved in macaviruses, including a repetitive H-DNA region and unique, 141 kilobase pair L

DNA region predicted to encode 77 genes. BoHV-6 encoded in variable genomic regions a novel complement of genes relative to other characterized macaviruses, likely contributing to distinctive aspects of BoHV-6 infection biology and host range. Most notably, …

Chronic Wasting Disease Detection In The Lymph Nodes Of Free-Ranging Cervids By Real Time Quaking-Induced Conversion, Nicholas J. Haley, Scott Carver, Laura Hoon-Hanks, Davin M. Henderson, Kristen A. Davenport, Elizabeth Bunting, Shawn Gray, Judith Galeota, Ivy Levan, Tracy Dubovos, Paul Shelton, Edward A. Hoover, Bruce Trindle

School of Veterinary and Biomedical Sciences: Faculty Publications

Chronic wasting disease (CWD), a transmissible spongiform encephalopathy of deer, elk and moose, is the only prion disease affecting free-ranging animals. First identified in northern Colorado and southern Wyoming in 1967, new epidemic foci of the disease have since been identified in additional states, as well as two Canadian provinces and the Republic of South Korea. Identification of CWD-affected animals currently requires post-mortem analysis of brain or lymphoid tissues using immunohistochemistry (IHC) or an enzyme linked immunosorbent assay (ELISA), with no practical way to evaluate potential strain types or investigate the epidemiology of existing or novel foci of disease. Using …

Radioprotective Efficacy Of Delta-Tocotrienol, A Vitamin E Isoform, Is Mediated Through Granulocyte Colony-Stimulating Factor, Vijay Singh, Stephen Y. Wise, Jessica R. Scott, Patricia L.P. Romaine, Victoria L. Newman, Oluseyi O. Fatanmi

Uniformed Services University of the Health Sciences

Aims: The objectives of this study were to determine the cytokine induction by delta tocotrienol (DT3, a promising radiation countermeasure) and to investigate the role of granulocyte colony-stimulating factor (G-CSF) in its radioprotective efficacy against ionizing radiation in mice. Main methods: Multiplex Luminex was used to analyze cytokines induced by DT3 and other tocols (gammatocotrienol and tocopherol succinate) in CD2F1 mice. Mice were injected with an optimal dose of DT3 and a G-CSF antibody, and their 30-day survival against cobalt-60 gamma-irradiation was monitored. The neutralization of G-CSF by the administration of a G-CSF-specific antibody in DT3-injected mice was investigated by …

Test 2096a: New Holland T9.600, Nebraska Tractor Test Lab

Nebraska Tractor Tests

ABOUT THE TEST REPORT AND USE OF THE DATA The test data contained in this report are a tabulation of the results of a series of tests. Due to the restricted format of these pages, only a limited amount of data and not all of the tractor specifications are included. The full OECD report contains usually about 30 pages of data and specifications. The test data were obtained for each tractor under similar conditions and therefore, provide a means of comparison of performance based on a limited set of reported data. EXPLANATION OF THE TEST PROCEDURES Purpose The purpose of …

University Of Nebraska- Lincoln: Fact Book 2013-2014

University of Nebraska-Lincoln Administration: Reports, Papers, Publications, and Presentations

Fact Book Table of Contents

Cover Photo Captions................................................. 1

Introduction................................................................................................. 2

Table of Contents................................................... 3

General Information

University of Nebraska-Lincoln Core Values (LEADERS)................................... 6

The Role of the University of Nebraska-Lincoln .............................................. 7

The Missions of the University of Nebraska-Lincoln ......................................... 7

Teaching..................................................................................... 8

Research............................................................................ 9

Service................................................................................................... 9

Institutional and Professional Accreditations ................................................. 10

University of Nebraska-Lincoln Administrative Organization Chart ................. 13

Student Credit Hours (SCH)

Total SCH: Fall Semester Since 1979 ............................................................ 14

Total SCH: Spring Semester Since 1993 ....................................................... 15

SCH by College and Course Level, Fall and Spring Semester, 5 Year Trend ..... 16

SCH by College …

Agricultural Research Magazine, Vol. 62, No. 7, August 2014, United States Department Of Agriculture

Agricultural Research Magazine

Forum-Breeding Rootstocks to Help Apple Growers Rooting Out the Best in Apple Rootstcks Mosquitoes Reveal a Taste for Repellents Switchgrass for Ethanol: Where It Came From--and Where It's Going Developing Tool to Fight Marek's Disease Treasure of the National Agricultural Library: Timeless Works of Fungi The Ins and Outs of Beneficial Nematode Movement Moisture Meter Technology for In-shell Peanuts Licensed Up Close and Personal with Tiny Beneficial Wasps New Lure May Help Growers Combat Almond's No.1 Insect Navel Orangeworm Locations Featured in This Magazine Issue

Nebraska Water Center Annual Report 2014, Nebraska Water Center

Nebraska Water Center: Administrative Materials

Letter from the Director

I am pleased to present this annual report on the activities, finances and many accomplishments of the Nebraska Water Center (NWC) during 2013 and 2014, a time when the NWC is celebrating its Golden Anniversary. More than being a simple look back at where we’ve been and what we have accomplished over the past year, this report looks forward to the complex challenges and exciting opportunities that lie ahead of us. We are now an integral part of the Robert B. Daugherty Water for Food Institute (DWFI), a growing global institute focused on one of the …

Evidence For A Transketolase-Mediated Metabolic Checkpoint Governing Biotrophic Growth In Rice Cells By The Blast Fungus Magnaporthe Oryzae, Jessie Fernandez, Margarita Marroquin-Guzman, Richard A. Wilson

Department of Plant Pathology: Faculty Publications

The blast fungus Magnaporthe oryzae threatens global food security through the widespread destruction of cultivated rice. Foliar infection requires a specialized cell called an appressorium that generates turgor to force a thin penetration hypha through the rice cuticle and into the underlying epidermal cells, where the fungus grows for the first days of infection as a symptomless biotroph. Understanding what controls biotrophic growth could open new avenues for developing sustainable blast intervention programs. Here, using molecular genetics and live-cell imaging, we dismantled M. oryzae glucose-metabolizing pathways to reveal that the transketolase enzyme, encoded by TKL1, plays an essential role …

Eastern Michigan University Undergraduate Catalog, 2014-2015, Office Of The Registrar

Undergraduate Catalogs

No abstract provided.