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Articles 19381 - 19410 of 25859
Full-Text Articles in Entire DC Network
Ethnic Identity, Gender, And Adolescent Attitude Toward School: Adaptive Perspectives In Diverse Settings, Margaret Zoller Booth, Erin M. Curran, Christopher J. Frey, Jean M. Gerard, Bruce Collet, Jennifer Bartimole
Ethnic Identity, Gender, And Adolescent Attitude Toward School: Adaptive Perspectives In Diverse Settings, Margaret Zoller Booth, Erin M. Curran, Christopher J. Frey, Jean M. Gerard, Bruce Collet, Jennifer Bartimole
Mid-Western Educational Researcher
The relationships between adolescent ethnic identity and attitudes toward school and school climate are investigated in a small, multiracial/multiethnic city in the Great Lakes region with ethnically diverse adolescents taught by primarily White teachers. The mixed methods investigation of 986 eighth through eleventh grade students during the 2010-2011 academic year suggests that the relationship between ethnic identity and attitude toward school is a complex interaction among individual characteristics of ethnicity/race, ethnic identity, gender, and ecological context. Quantitative results reveal that White female and Hispanic and African American male students exhibit strong ethnic identity that correlates positively with school attitude; however, …
Nyls Loan Report: 1h2014, New York Law School
Reclaimed Water Use: The Example Of Florida, Chelsea Anderson
Reclaimed Water Use: The Example Of Florida, Chelsea Anderson
University of Florida Journal of Law & Public Policy
No abstract provided.
Boy Or Girl: Who Gets To Decide? Gender-Nonconforming Children In Child Custody Cases, David Alan Perkiss
Boy Or Girl: Who Gets To Decide? Gender-Nonconforming Children In Child Custody Cases, David Alan Perkiss
UC Law SF Journal on Gender and Justice
Transgender youth, especially those in families that express rejecting behavior, are at great risk for physical and psychological harms. These harms can be alleviated by families expressing accepting behavior and by support their children's transition. However, when separated parents disagree about whether to support their gender-nonconforming children in their felt genders, especially as more transgender youth come out at earlier ages, disagreements between the parents leads to harm for the child as well as renewed custody challenges. This disagreement was adjudicated in the custody dispute Smith v. Smith. This Article analyzes Smith and applies to cases involving gender-nonconforming children, regardless …
Karen's Thompson's Role In The Movement For Marriage Equality, D. Kelly Weisberg
Karen's Thompson's Role In The Movement For Marriage Equality, D. Kelly Weisberg
UC Law SF Journal on Gender and Justice
Karen Thompson stands as a pivotal figure in both the gay rights and disability rights movements. In her struggle to give her partner, Sharon Kowalski, better rehabilitative care after a life-altering car accident, Ms. Thompson faced persistent sexual orientation discrimination from her partner's family and medical providers. When Ms. Thompson took her battle to court, she was forced to deal with prejudices and stereotypes about gays and lesbians. It was only after her third attempt years later that she prevailed in her to quest to seek guardianship of her partner. Ms. Weisberg's introduction outlines how Ms. Thompson's story turned from …
A Holistic Aboriginal Framework For Individual Healing, Gus Hill
A Holistic Aboriginal Framework For Individual Healing, Gus Hill
Lyle S. Hallman Social Work Faculty Publications
This paper offers up an holistic Indigenous model of individual healing that utilizes medicine wheel teachings to break down the four aspects (spiritual, emotional, physical, and mental) of individual wellness. Teachings about each direction are presented followed by practice techniques for each aspect of the individual self. It is bookended by an introduction to the historical trauma faced by Indigenous peoples in Canada, and a conclusion that draws implications for healing.
A Strange Kind Of Identity Theft: How Competing Definitions Of "Indian" May Deny Individual Identity, Suzianne D. Painter-Thorne
A Strange Kind Of Identity Theft: How Competing Definitions Of "Indian" May Deny Individual Identity, Suzianne D. Painter-Thorne
Articles
To the extent we think about it all, most of us believe what our parents tell us about where we came from-about who our grandparents are, who our ancestors were, our ethnic background, our family histories. My own family story includes claims to Scottish, Irish, French, and English ancestry. It also includes the Cherokee great-grandmother so popular in American genealogical stories. I have not undertaken an extensive genealogical search to more accurately pinpoint the threads of my ancestral quilt; I have simply accepted the family lore without much thought to whether it was verifiable.
My family's claimed link to the …
The Effects Of Adherence To Asian Values And Extraversion On Cardiovascular Reactivity: A Comparison Between Asian And European Americans, Lindsay K. Yamaoka
The Effects Of Adherence To Asian Values And Extraversion On Cardiovascular Reactivity: A Comparison Between Asian And European Americans, Lindsay K. Yamaoka
Pitzer Senior Theses
This study investigated the effects of personality type and ethnicity on reactivity to stressful stimuli by examining acculturation and adherence to Asian American cultural values as moderators. Twenty-two Asian American and twenty-two European American students performed a mental arithmetic task and a speech task while cardiovascular (CV) reactivity was monitored. Level of extraversion, acculturation, and adherence to Asian American values were assessed. As predicted, Asian Americans exhibited less CV reactivity to stressful stimuli and lower levels of extraversion than European Americans. Support was found for adherence to Asian American values as a moderator of the relationship between level of extraversion …
Evaluating The Potential Risks And Rewards In The Implementation Of A Redd+ Policy In Uganda, Sage Schaftel
Evaluating The Potential Risks And Rewards In The Implementation Of A Redd+ Policy In Uganda, Sage Schaftel
Pitzer Senior Theses
In this thesis, I analyze the potential for a REDD+ program to succeed in Uganda at this time, and I explore why this may or may not be possible. REDD+, which stands for Reducing Deforestation and Forest Degradation, aims to enhance carbon stocks while also conserving and sustainably managing forests. In doing so, REDD+ not only works to offset carbon emission levels and conserve forests and forest biodiversity, but also provides financial benefits to REDD+ participant countries, thus improving the livelihoods of local people living adjacent to forests. This program is widely regarded as the most effective and least risky …
A Hermeneutic Exploration Of And Proposed Solution To The Schism Between Researchers And Clinicians Inpsychology, Mark S. Green
A Hermeneutic Exploration Of And Proposed Solution To The Schism Between Researchers And Clinicians Inpsychology, Mark S. Green
All-Inclusive List of Electronic Theses and Dissertations
Fragmentation in the field ofPsychology has persisted throughout its history (Slife, 2000). One example of this fragmentation is the gap between researchers and clinicians (Teachman, Drabick, Hershenberg, Vivian, & Wolfe 2012). Although many attempts have been made to bridge this gap, there is still no consensus regarding its resolution. ThisDissertation provides an explanation for the gap at the philosophical level and provides a method for communicating across potentially incommensurable philosophies, based on Gadamer's (1960/1989) hermeneutic opus: Truth and Method.
Effects Of Light Brushing On Clinical Pain Intensity And Experimental Pain Sensitivity In Fibromyalgia Patients, Melissa Wassink
Effects Of Light Brushing On Clinical Pain Intensity And Experimental Pain Sensitivity In Fibromyalgia Patients, Melissa Wassink
All-Inclusive List of Electronic Theses and Dissertations
Context: The Graston Technique (GT) is an instrument-assisted soft tissue mobilization technique based on the concepts of manual therapy, which has been proven to decrease pain and disability in injured subjects. The "light brushing" stroke is proposed to desensitize the treatment area prior to more aggressive stages of the protocol. However, no studies have been conducted to assess the effectiveness of "light brushing" in subjects with chronic pain. Objective: To determine the effect that light brushing stroke has on the central and peripheral pain processing. Design: Experimental cross-sectional Setting: Experimental Pain Research Laboratory at ISU. Participants: 11 participants with Fibromyalgia …
Post-Traumatic Stress Disorder, Borderline Personality Disorder, And Disorders Of Extreme Stress, Not Otherwise Specified; A Vignette Study Exploring Va And Private Sector Clinicians' Diagnostic Perceptions, Sara B. Lacy
All-Inclusive List of Electronic Theses and Dissertations
Due to the role of trauma in the etiology of posttraumatic stress disorder (PTSD), borderline personality disorder (BPD), and disorders of extreme stress, not otherwise specified (DESNOS), and noted similar clinical pictures, it is important to explore differential diagnosis. There is evidence that gender influences the diagnosis of PTSD and BPD and of an "anchoring effect" in which disclosure of childhood trauma early versus late in a case vignette results in more diagnoses of PTSD or BPD, respectively. Additionally, as many veterans seek care within the private sector, it is important to understand possible diagnostic differences between VA and private …
Chronic Exposure To A Low Dose Of Ingested Petroleum Disrupts Corticosterone Receptor Signalling In A Tissue-Specific Manner In The House Sparrow (Passer Domesticus), Christine R. Lattin, L. Michael Romero
Chronic Exposure To A Low Dose Of Ingested Petroleum Disrupts Corticosterone Receptor Signalling In A Tissue-Specific Manner In The House Sparrow (Passer Domesticus), Christine R. Lattin, L. Michael Romero
Faculty Publications
© The Author 2014. Stress-induced concentrations of glucocorticoid hormones (including corticosterone, CORT) can be suppressed by chronic exposure to a low dose of ingested petroleum. However, endocrine-disrupting chemicals could interfere with CORT signalling beyond the disruption of hormone titres, including effects on receptors in different target tissues. In this study, we examined the effects of 6 weeks of exposure to a petroleum-laced diet (1% oil weight:food weight) on tissue mass and intracellular CORT receptors in liver, fat, muscle and kidney (metabolic tissues), spleen (an immune tissue) and testes (a reproductive tissue). In the laboratory, male house sparrows were fed either …
Role Of Adipose Tissue In The Pathogenesis And Treatment Of Metabolic Syndrome, David Sanchez-Infantes, Jacqueline M. Stephens
Role Of Adipose Tissue In The Pathogenesis And Treatment Of Metabolic Syndrome, David Sanchez-Infantes, Jacqueline M. Stephens
Faculty Publications
© Springer International Publishing Switzerland 2014. Adipocytes are highly specialized cells that play a major role in energy homeostasis in vertebrate organisms. Excess adipocyte size or number is a hallmark of obesity, which is currently a global epidemic. Obesity is not only the primary disease of fat cells, but also a major risk factor for the development of Type 2 diabetes, cardiovascular disease, hypertension, and metabolic syndrome (MetS). Today, adipocytes and adipose tissue are no longer considered passive participants in metabolic pathways. In addition to storing lipid, adipocytes are highly insulin sensitive cells that have important endocrine functions. Altering any …
Natural Selection Canalizes Expression Variation Of Environmentally Induced Plasticity-Enabling Genes, Joseph R. Shaw, Thomas H. Hampton, Benjamin L. King, Andrew Whitehead, Fernando Galvez, Robert H. Gross, Nathan Keith, Emily Notch, Dawoon Jung, Stephen P. Glaholt, Celia Y. Chen, John K. Colbourne, Bruce A. Stanton
Natural Selection Canalizes Expression Variation Of Environmentally Induced Plasticity-Enabling Genes, Joseph R. Shaw, Thomas H. Hampton, Benjamin L. King, Andrew Whitehead, Fernando Galvez, Robert H. Gross, Nathan Keith, Emily Notch, Dawoon Jung, Stephen P. Glaholt, Celia Y. Chen, John K. Colbourne, Bruce A. Stanton
Faculty Publications
© 2014 The Author. Many organisms survive fluctuating and extreme environmental conditions by manifesting multiple distinct phenotypes during adulthood by means of developmental processes that enable phenotypic plasticity. We report on the discovery of putative plasticity-enabling genes that are involved in transforming the gill of the euryhaline teleost fish, Fundulus heteroclitus, from its freshwater to its seawater gill-type, a process that alters both morphology and function. Gene expression that normally enables osmotic plasticity is inhibited by arsenic. Gene sets defined by antagonistic interactions between arsenic and salinity show reduced transcriptional variation among individual fish, suggesting unusually accurate and precise regulatory …
Combustion By-Products And Their Health Effects - Combustion Engineering And Global Health In The 21st Century: Issues And Challenges, Slawo Lomnicki, Brian Gullett, Tobias Stöger, Ian Kennedy, Jim Diaz, Tammy R. Dugas, Kurt Varner, Danielle J. Carlin, Barry Dellinger, Stephania A. Cormier
Combustion By-Products And Their Health Effects - Combustion Engineering And Global Health In The 21st Century: Issues And Challenges, Slawo Lomnicki, Brian Gullett, Tobias Stöger, Ian Kennedy, Jim Diaz, Tammy R. Dugas, Kurt Varner, Danielle J. Carlin, Barry Dellinger, Stephania A. Cormier
Faculty Publications
The 13th International Congress on Combustion By-Products and their Health Effects was held in New Orleans, Louisiana from May 15 to 18, 2013. The congress, sponsored by the Superfund Research Program, National Institute of Environmental Health Sciences, and National Science Foundation, brought together international academic and government researchers, engineers, scientists, and policymakers. With industrial growth, increased power needs and generation and coal consumption and their concomitant emissions, pernicious health effects associated with exposures to these emissions are on the rise. This congress provides a unique platform for interdisciplinary exchange and discussion of these topics. The formation, conversion, control, and health …
Deficiency Of The Two-Pore-Domain Potassium Channel Trek-1 Promotes Hyperoxia-Induced Lung Injury, Andreas Schwingshackl, Bin Teng, Patrudu Makena, Manik Ghosh, Scott E. Sinclair, Charlean Luellen, Louisa Balasz, Cynthia Rovnaghi, Robert M. Bryan, Eric E. Lloyd, Elizabeth Fitzpatrick, Jordy S. Saravia, Stephania A. Cormier, Christopher M. Waters
Deficiency Of The Two-Pore-Domain Potassium Channel Trek-1 Promotes Hyperoxia-Induced Lung Injury, Andreas Schwingshackl, Bin Teng, Patrudu Makena, Manik Ghosh, Scott E. Sinclair, Charlean Luellen, Louisa Balasz, Cynthia Rovnaghi, Robert M. Bryan, Eric E. Lloyd, Elizabeth Fitzpatrick, Jordy S. Saravia, Stephania A. Cormier, Christopher M. Waters
Faculty Publications
Copyright © 2014 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins. Objectives: We previously reported the expression of the twoporedomain K+ channel TREK-1 in lung epithelial cells and proposed a role for this channel in the regulation of alveolar epithelial cytokine secretion. In this study, we focused on investigating the role of TREK-1 in vivo in the development of hyperoxia-induced lung injury. Design: Laboratory animal experiments. Setting: University research laboratory. Subjects: Wild-type and TREK-1-deficient mice. Interventions: Mice were anesthetized and exposed to 1) room air, no mechanical ventilation, 2) 95% hyperoxia for 24 hours, and 3) …
Response Of Native Insect Communities To Invasive Plants, T. Martijn Bezemer, Jeffrey A. Harvey, James T. Cronin
Response Of Native Insect Communities To Invasive Plants, T. Martijn Bezemer, Jeffrey A. Harvey, James T. Cronin
Faculty Publications
Invasive plants can disrupt a range of trophic interactions in native communities. As a novel resource they can affect the performance of native insect herbivores and their natural enemies such as parasitoids and predators, and this can lead to host shifts of these herbivores and natural enemies. Through the release of volatile compounds, and by changing the chemical complexity of the habitat, invasive plants can also affect the behavior of native insects such as herbivores, parasitoids, and pollinators. Studies that compare insects on related native and invasive plants in invaded habitats show that the abundance of insect herbivores is often …
Relative Importance Of Host Environment, Transmission Potential And Host Phylogeny To The Structure Of Parasite Metacommunities, Tad Dallas, Steven J. Presley
Relative Importance Of Host Environment, Transmission Potential And Host Phylogeny To The Structure Of Parasite Metacommunities, Tad Dallas, Steven J. Presley
Faculty Publications
Identification of mechanisms that shape parasite community and metacommunity structures have important implications to host health, disease transmission, and the understanding of community assembly in general. Using a long-term dataset on parasites from desert rodents, we examined the relative contributions of host traits that represent important aspects of parasite environment, transmission probability between host species, and host phylogeny to the structure of a parasite metacommunity as well as for taxonomically restricted parasite metacommunities (coccidians, ectoparasites and helminths). This was done using a combination of metacommunity analysis and variance partitioning based on canonical correspondence analysis. Coccidian and ectoparasite metacommunities did not …
Iron And Zinc Binding Activity Of Escherichia Coli Topoisomerase I Homolog Yrdd, Zishuo Cheng, Guoqiang Tan, Wu Wang, Xiaolu Su, Aaron P. Landry, Jianxin Lu, Huangen Ding
Iron And Zinc Binding Activity Of Escherichia Coli Topoisomerase I Homolog Yrdd, Zishuo Cheng, Guoqiang Tan, Wu Wang, Xiaolu Su, Aaron P. Landry, Jianxin Lu, Huangen Ding
Faculty Publications
YrdD, a homolog of the C-terminal zinc-binding region of Escherichia coli topoisomerase I, is highly conserved among proteobacteria and enterobacteria. However, the function of YrdD remains elusive. Here we report that YrdD purified from E. coli cells grown in LB media contains both zinc and iron. Supplement of exogenous zinc in the medium abolishes the iron binding of YrdD in E. coli cells, indicating that iron and zinc may compete for the same metal binding sites in the protein. While the zinc-bound YrdD is able to bind single-stranded (ss) DNA and protect ssDNA from the DNase I digestion in vitro, …
Sexual Differences Of Imprinted Genes' Expression Levels, Mohammad Faisal, Hana Kim, Joomyeong Kim
Sexual Differences Of Imprinted Genes' Expression Levels, Mohammad Faisal, Hana Kim, Joomyeong Kim
Faculty Publications
In mammals, genomic imprinting has evolved as a dosage-controlling mechanism for a subset of genes that play critical roles in their unusual reproduction scheme involving viviparity and placentation. As such, many imprinted genes are highly expressed in sex-specific reproductive organs. In the current study, we sought to test whether imprinted genes are differentially expressed between the two sexes. According to the results, the expression levels of the following genes differ between the two sexes of mice: Peg3, Zim1, Igf2, H19 and Zac1. The expression levels of these imprinted genes are usually greater in males than in females. This bias is …
Thermomicrobium Carboxidum Sp. Nov., And Thermorudis Peleae Gen. Nov., Sp. Nov., Carbon Monoxide-Oxidizing Bacteria Isolated From Geothermally Heated Biofilms, C. E. King, G. M. King
Thermomicrobium Carboxidum Sp. Nov., And Thermorudis Peleae Gen. Nov., Sp. Nov., Carbon Monoxide-Oxidizing Bacteria Isolated From Geothermally Heated Biofilms, C. E. King, G. M. King
Faculty Publications
Two thermophilic, Gram-stain-positive, rod-shaped, non-spore-forming bacteria (strains KI3T and KI4T) were isolated from geothermally heated biofilms growing on a tumulus in the Kilauea Iki pit crater on the flank of Kilauea Volcano (Hawai'i, USA). Strain KI3T grew over an examined temperature range of 50-70 °C (no growth at 80 °C) and a pH range of 6.0-9.0, with optimum growth at 70 °C and pH 7.0. Strain KI4T grew at temperatures of 55-70 °C and a pH range of 5.8-8.0, with optimum growth at 65 °C and pH 6.7-7.1. The DNA G+C contents of strains KI3T and KI4T were 66.0 and …
Description Of Thermogemmatispora Carboxidivorans Sp. Nov., A Carbon-Monoxideoxidizing Member Of The Class Ktedonobacteria Isolated From A Geothermally Heated Biofilm, And Analysis Of Carbon Monoxide Oxidation By Members Of The Class Ktedonobacteria, C. E. King, G. M. King
Faculty Publications
A thermophilic, aerobic, Gram-stain-positive bacterium (strain PM5T), which formed mycelia of irregularly branched filaments and produced multiple exospores per cell, was isolated from a geothermally heated biofilm. Strain PM5T grew at 40-65 °C and pH 4.1-8.0, with optimal growth at 55 °C and pH 6.0. Phylogenetic analyses based on 16S rRNA gene sequences indicated that strain PM5T belonged to the class Ktedonobacteria, and was related most closely to Thermogemmatispora onikobensis ONI-1T (97.7 % similarity) and Thermogemmatispora foliorum ONI-5T (96.1 %). Morphological features and fatty acid profiles (major fatty acids: iso-C17: 0, iso-C19: 0 and 12,17-dimethyl C18: 0) supported the affiliation …
Urban Microbiomes And Urban Ecology: How Do Microbes In The Built Environment Affect Human Sustainability In Cities?, Gary M. King
Urban Microbiomes And Urban Ecology: How Do Microbes In The Built Environment Affect Human Sustainability In Cities?, Gary M. King
Faculty Publications
© 2014, The Microbiological Society of Korea and Springer-Verlag Berlin Heidelberg. Humans increasingly occupy cities. Globally, about 50% of the total human population lives in urban environments, and in spite of some trends for deurbanization, the transition from rural to urban life is expected to accelerate in the future, especially in developing nations and regions. The Republic of Korea, for example, has witnessed a dramatic rise in its urban population, which now accounts for nearly 90% of all residents; the increase from about 29% in 1955 has been attributed to multiple factors, but has clearly been driven by extraordinary growth …
Historical And Recent Processes Shaping The Geographic Range Of A Rocky Intertidal Gastropod: Phylogeography, Ecology, And Habitat Availability, Phillip B. Fenberg, Karine Posbic, Michael E. Hellberg
Historical And Recent Processes Shaping The Geographic Range Of A Rocky Intertidal Gastropod: Phylogeography, Ecology, And Habitat Availability, Phillip B. Fenberg, Karine Posbic, Michael E. Hellberg
Faculty Publications
Factors shaping the geographic range of a species can be identified when phylogeographic patterns are combined with data on contemporary and historical geographic distribution, range-wide abundance, habitat/food availability, and through comparisons with codistributed taxa. Here, we evaluate range dynamism and phylogeography of the rocky intertidal gastropod Mexacanthina lugubris lugubris across its geographic range - the Pacific coast of the Baja peninsula and southern California. We sequenced mitochondrial DNA (CO1) from ten populations and compliment these data with museum records, habitat availability and range-wide field surveys of the distribution and abundance of M. l. lugubris and its primary prey (the barnacle …
Genetic Species Delineation Among Branching Caribbean Porites Corals, C. Prada, M. B. De Biasse, J. E. Neigel, B. Yednock, J. L. Stake, Z. H. Forsman, I. B. Baums, M. E. Hellberg
Genetic Species Delineation Among Branching Caribbean Porites Corals, C. Prada, M. B. De Biasse, J. E. Neigel, B. Yednock, J. L. Stake, Z. H. Forsman, I. B. Baums, M. E. Hellberg
Faculty Publications
© 2014, Springer-Verlag Berlin Heidelberg. Coral species are difficult to discern because of their morphological plasticity, long generation times, and slow rates of mitochondrial DNA evolution. Among Caribbean representatives of the genus Porites are three named species (P. divaricata, P. furcata, and P. porites) with branching colony morphologies whose validity as genetically isolated species has been debated. We present sequence data from the mitochondrial control region, nuclear ITS, and nine single-copy nuclear loci for the Caribbean Porites and a related eastern Pacific species. mtDNA sequences were nearly invariant among the three branching species and their crustose sister P. branneri, and …
Cryptic Diversity Hides Host And Habitat Specialization In A Gorgonian-Algal Symbiosis, Carlos Prada, Shelby E. Mcilroy, Diana M. Beltrán, Daniel J. Valint, Scott A. Ford, Michael E. Hellberg, Mary Alice Coffroth
Cryptic Diversity Hides Host And Habitat Specialization In A Gorgonian-Algal Symbiosis, Carlos Prada, Shelby E. Mcilroy, Diana M. Beltrán, Daniel J. Valint, Scott A. Ford, Michael E. Hellberg, Mary Alice Coffroth
Faculty Publications
Shallow water anthozoans, the major builders of modern coral reefs, enhance their metabolic and calcification rates with algal symbionts. Controversy exists over whether these anthozoan-algae associations are flexible over the lifetimes of individual hosts, promoting acclimative plasticity, or are closely linked, such that hosts and symbionts co-evolve across generations. Given the diversity of algal symbionts and the morphological plasticity of many host species, cryptic variation within either partner could potentially confound studies of anthozoan-algal associations. Here, we used ribosomal, organelle and nuclear sequences, along with microsatellite variation, to study the relationship between lineages of a common Caribbean gorgonian and its …
Optimized Inhibitors Of Soluble Epoxide Hydrolase Improve In Vitro Target Residence Time And In Vivo Efficacy, Kin Sing Stephen Lee, Jun Yan Liu, Karen M. Wagner, Svetlana Pakhomova, Hua Dong, Christophe Morisseau, Samuel H. Fu, Jun Yang, Peng Wang, Arzu Ulu, Christina A. Mate, Long V. Nguyen, Sung Hee Hwang, Matthew L. Edin, Alexandria A. Mara, Heike Wulff, Marcia E. Newcomer, Darryl C. Zeldin, Bruce D. Hammock
Optimized Inhibitors Of Soluble Epoxide Hydrolase Improve In Vitro Target Residence Time And In Vivo Efficacy, Kin Sing Stephen Lee, Jun Yan Liu, Karen M. Wagner, Svetlana Pakhomova, Hua Dong, Christophe Morisseau, Samuel H. Fu, Jun Yang, Peng Wang, Arzu Ulu, Christina A. Mate, Long V. Nguyen, Sung Hee Hwang, Matthew L. Edin, Alexandria A. Mara, Heike Wulff, Marcia E. Newcomer, Darryl C. Zeldin, Bruce D. Hammock
Faculty Publications
Diabetes is affecting the life of millions of people. A large proportion of diabetic patients suffer from severe complications such as neuropathic pain, and current treatments for these complications have deleterious side effects. Thus, alternate therapeutic strategies are needed. Recently, the elevation of epoxy-fatty acids through inhibition of soluble epoxide hydrolase (sEH) was shown to reduce diabetic neuropathic pain in rodents. In this report, we describe a series of newly synthesized sEH inhibitors with at least 5-fold higher potency and doubled residence time inside both the human and rodent sEH enzyme than previously reported inhibitors. These inhibitors also have better …
Phylogeny, Classification, And Fruit Evolution Of The Species-Rich Neotropical Bellflowers (Campanulaceae: Lobelioideae), Laura P. Lagomarsino, Alexandre Antonelli, Nathan Muchhala, Allan Timmermann, Sarah Mathews, Charles C. Davis
Phylogeny, Classification, And Fruit Evolution Of The Species-Rich Neotropical Bellflowers (Campanulaceae: Lobelioideae), Laura P. Lagomarsino, Alexandre Antonelli, Nathan Muchhala, Allan Timmermann, Sarah Mathews, Charles C. Davis
Faculty Publications
© 2014 Botanical Society of America. Premise of the study: The species-rich Neotropical genera Centropogon, Burmeistera, and Siphocampylus represent more than half of the ∼1200 species in the subfamily Lobelioideae (Campanulaceae). They exhibit remarkable morphological variation in floral morphology and habit. Limited taxon sampling and phylogenetic resolution, however, obscures our understanding of relationships between and within these genera and underscores our uncertainty of the systematic value of fruit type as a major diagnostic character.Methods: We inferred a phylogeny from five plastid DNA regions (rpl32-trnL, ndhF-rpl32, rps16-trnK, trnG-trnG-trns, rbcL) using maximum-likelihood and Bayesian inference. Ancestral character reconstructions were applied to infer …
Pleading Patterns And The Role Of Litigation As A Driver Of Federal Climate Change Legislation, Juscelino F. Colares, Kosta Ristovski
Pleading Patterns And The Role Of Litigation As A Driver Of Federal Climate Change Legislation, Juscelino F. Colares, Kosta Ristovski
Faculty Publications
Based on a variant of the Elliott-Ackerman-Millian theory that variable, potentially inconsistent and costly litigation outcomes induce industry to seek federal preemptive legislation to reign in such costs, we collect data on climate change-related litigation to determine whether litigation might motivate major greenhouse gas emitters to accept a preemptive, though possibly carbon-restricting, legislative compromise. We conduct a spectral cluster analysis on 178 initial federal and state judicial filings to reveal the most relevant groupings among climate change-related suits and their underlying pleading patterns. Besides exposing the general content and structure of climate change-related filings, this study identifies major specific pleading …