Digital Commons Network^™

Finding Success In Elementary Science Across Socioeconomic Boundaries, Jill K. Hettinger

Boise State University Theses and Dissertations

Elementary science education provides a platform for intellectual development, building a foundation of scientific literacy and a first entry point into interest in Science, Technology, Engineering, and Mathematics (STEM) fields. A significant body of research on elementary science education clearly defines what high-quality science education should look like at the elementary level. However, there is little understood about how to implement high-quality science instruction effectively within a school system. Prior research indicates that this problem is further compounded in low socioeconomic elementary schools by a lack of resources, time, and high teacher mobility. I used descriptive research to identify the …

Tgfβr2 Is A Major Target Of Mir-93 In Nasopharyngeal Carcinoma Aggressiveness, X Lyu, W Fang, L Cai, H Zheng, Et Al

School of Biomedical Sciences

BACKGROUND: MiR-17-92 cluster and its paralogues have emerged as crucial regulators of many oncogenes and tumor suppressors. Transforming growth factor-β receptor II (TGFβR2), as an important tumor suppressor, is involved in various cancer types. However, it is in cancer that only two miRNAs of this cluster and its paralogues have been reported so far to regulate TGFβR2. MiR-93 is oncogenic, but its targetome in cancer has not been fully defined. The role of miR-93 in nasopharyngeal carcinoma (NPC) still remains largely unknown. METHODS: We firstly evaluated the clinical signature of TGFβR2 down-regulation in clinical samples, and next used a miRNA …

A Spatially Resolved Pressure-Based Approach To Evaluate Combined Effects Of Human Activities And Management In Marine Ecosystems, F Goodsir, Hj Bloomfield, Ad Judd, Et Al

School of Biological and Marine Sciences

Our oceans are heavily utilized by a wide variety of human activities that exert pressures which negatively impact marine ecosystems, occasionally leading to unsustainable rates of exploitation. A linkage framework approach can be used to make independent associations between sectors, activities, and the pressures they introduce. However, in reality, many different sectors and their associated activities overlap in time and space, potentially changing the severity of their impact as pressures combine, and undermine the efforts of environmental managers to mitigate the harmful effects of those activities. Here, we present a spatially resolved approach to assess the potential for combined effects …

Lawyers And Sawyers: Venetian Forest Law And The Conquest Of Terraferma (1350-1476), Michael S. Beaudoin

Boise State University Theses and Dissertations

Throughout the fourteenth and fifteenth centuries, Venice played a direct role in shaping the future of Northeastern Italy. The standing scholarship views Venetian involvement on the mainland as either an abandonment of the city’s maritime tradition or as a buffer zone against rival powers, like Milan. Venice’s western mainland empire, Terraferma, provided Venice with many commercial products that the Eastern Mediterranean did not. One mainland product, timber, was a central focus of Venetian expansion into Terraferma and has thus far been neglected by historians. This thesis argues that the Venetian Republic manipulated mainland legal traditions in order to obtain …

Caepidr: A Computational Approach To Efficient Peptide Influenced Drug Repurposing, Thomas Francis Long

Boise State University Theses and Dissertations

Since the discovery of the molecular basis of disease, numerous studies have reported a correlation between the activity of specific protein receptors the progression of disease. As a result, drug development has become dependent on the study of protein receptor activities. The relative inexpense of computing hardware has made computational methods an important supplementary tool for receptor modeling. This work details an open source software tool that is capable of both efficiently screening large peptide mutant libraries and enabling 3D conformer-based searches over local molecular databases.

A Computational Approach to Efficient Peptide Influenced Drug Repurposing (CAEPIDR) has been developed to …

Ciliates Of Sagebrush-Steppe Soils Of Southwestern Idaho: Species Richness And Its Relationship To Changed Soil Variables After Wildfire Events, Laura G. Wendell

Boise State University Theses and Dissertations

I conducted a pilot study to examine species richness of terrestrial ciliates associated with big sagebrush habitat (Artemisia tridentata) in southwestern Idaho, USA. As wildland fires are a naturally occurring disturbance in this area, soil variables associated with these fires (% C, % N, pH, soil texture, and % clay) were measured at three sites, both in burned and unburned areas. These soil characteristics were compared to corresponding ciliate diversity and ratios of r-selected colpodeans to K-selected polyhymenophorans (C/P) in non-flooded Petri dish preparations. A total of 85 ciliate taxa were observed across the three sites, including …

Aminoglycoside-Induced Otoneurotoxicity: Analysis Of Inner Hair Cell Synaptic Plasticity Following Drug Exposure, Matthew M. Abernathy

Dissertations

Aminoglycoside antibiotics are powerful drugs for combating bacterial infections, but are limited in use due to their ototoxicity. This class of drug targets the auditory hair cells of the cochlea, causing cell death, which leads to a decline in auditory function. In spite of much research aimed at revealing a mechanism of damage, there are no co-therapies available to diminish the ototoxic liability of aminoglycosides. Existing research does show that there may be a neurodegenerative process that contributes to the observed toxicity. In an effort towards clarifying present understanding of issue, this dissertation project was conducted to characterize the neurodegenerative …

Probing The Unfolding And The Stability Of The Last Four Metal Binding Domains Of Wilson Disease Protein Using Circular Dichroism And Novel Spectroscopic Techniques, Ibtesam Yaseen Alja’Afreh

Dissertations

Wilson disease protein is a copper-transporting P_1B type ATPase. It has large N-terminal copper binding domain which is composed of six homologous sub-domains. Each of these six domains is ~72 residues and connected to one another by linking regions of various lengths. They all possess similar ferrodoxin fold, and metal-binding motif, MXCXXC.

The need of having six metal binding domains and the manner in which they are communicating with each other is not well understood. To better understand how the last four metal binding domains function, I pursued a detailed biophysical characterization of these domains. Using molecular biology I …

The Relationship Between Racial Ambiguity And Self-Concept In Multiracial Lndividuals, James R. Jobe

Dissertations

The present study examined the relationship between racial ambiguity and self-concept in multiracial individuals. Research as to the experiences of multiracial people is limited both in frequency and in scope. As multiracial individuals continue to grow in number, understanding their unique experiences will become more important to social scientists (e.g., psychologists, anthropologists, sociologists) across disciplines. The current study examined two hypotheses and explored a series of additional relationships. The theoretical framework that was utilized for this study was Symbolic Interaction Theory. This theory provided an effective way to understand how people use and make meaning of their surrounding social contexts …

Lntegration Of Conventional Lithography And Printing Processes As A Key Enabling Technology For Printed And Flexible Sensing Systems, Binu Baby Narakathu

Dissertations

Sensors, which are used ubiquitously in a wide variety of applications, are revolutionizing the already ever-changing world we live in by providing real-time information about our surroundings. This dissertation focuses on the integration of conventional photolithography and printing processes as a key enabling technology for printed and flexible sensing systems.

Initially, an efficient opto-electrochemical sensing system, for the dual detection of heavy metal compounds was successfully developed. A novel microfluidic flow cell, with a reservoir volume of 25 μl, was designed and fabricated using acrylic. An electrochemical sensor with gold (Au) interdigitated electrodes (IDE) on a glass substrate was photolithographically …

The Neurobehavioral Consequences Of Gestational And Chronic Atrazine Exposure In Male And Female Sprague Dawley Rats, Jennifer L. Walters

Dissertations

The adverse health risks of exposure to the herbicide, atrazine, in humans are not fully understood. Although numerous studies have demonstrated atrazine to be an endocrine disrupter, the neurobehavioral consequences of atrazine exposure have not been thoroughly examined. The aim of this study was to investigate the effects of environmentally-relevant levels

of gestational followed by continued chronic atrazine exposure on motor function, learning and memory, anxiety, and striatal dopamine content in rodents. Pregnant Sprague Dawley rats were treated by gavage with 100 µg/kg atrazine (ATZ low), 10 me/kg atrazine (ATZ high), or vehicle on

gestational day l through postnatal day …

Ultrafast Interfacial Electron Transfer Across Molecule-Tio2 Nanocomposites: Towards Solar Cells And Two Photon Absorption, Edwin Mghanga

Dissertations

Interfacial charge transfer (ICT) across the molecule-TiO2 nanoparticle interface has gained enormous research attention for applications in dye sensitized solar cells (DSSC), photo-catalysis, water splitting and nonlinear optics. DSSCs are promising clean alternative energy sources. However, current DSSCs suffer from lower efficiencies and higher cost. Better understanding of the ICT processes in DSSCs can help solve these problems. We have used two strategies to understand ICT in the context of DSSCs. Firstly, we used a computationally validated anchor group, acetylacetonate (acac) to bind molecules to the semiconductor surface and facilitate charge separation. Secondly, we used natural dye sensitizers, …

Magnetic Nickel Nanoparticles: Synthesis, Environmental Lmplications And Potential Role As Drug Carriers, Setare Tahmasebi Nick

Dissertations

The design and synthesis of well-defined magnetic particles with nanoscale dimensions is opening new avenues in understanding their fundamental chemical and physical properties. Our work describes a novel facile procedure for the synthesis of homogenous isotropic and anisotropic magnetic nickel nanoparticles. These nanoparticles were produced using a wet-chemical process and characterized by transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), selected-area electron diffraction (SAED), powder x-ray diffraction (XRD), energy dispersive spectroscopy (EDS) and thermogravimetric analysis (TGA). Magnetic measurements were acquired using a superconducting quantum interference device (SQUID) magnetometer. While there is significant interest in using magnetic nanoparticles for biological …

Traffic Noise Decreases Body Condition And Stopover Efficiency Of Migrating Songbirds, Heidi Elise Ware

Boise State University Theses and Dissertations

Numerous studies document impacts of roads on wildlife, and suggest traffic noise as a primary cause of population declines near roads. For migratory birds faced with increasingly human-altered habitats, noise may pose a serious threat. Using an array of speakers, we applied traffic noise to a roadless landscape, directly testing the effect of noise alone on an entire songbird community. Focusing on individuals that stayed despite the noise, we demonstrate that songbirds show a near halving of ability to gain body condition when exposed to traffic noise during migratory stopover. This marked degradation in stopover efficiency may help explain dramatic …

Assessing Net Returns To Blueberry Production Using A Decision Support Tool, Sokha Sok

Graduate Theses and Dissertations

The purpose of this study was to develop and assess the profitability of four highbush blueberry farming systems in the south: organic field production, conventional field production, organic high tunnel production and conventional high tunnel production. Four baseline budget scenarios, one for each system, are developed for a 15 year production period. The results suggest that under expected production and price conditions for Northwest Arkansas, while all four production systems generated positive present value of net returns, the conventional field production produced the highest present value of net returns across the 15 years. The breakeven years of production were 7 …

Use Of Complementary Therapies By Individuals With Or At Risk For Cardiovascular Disease And Diabetes: Results Of The 2007 National Health Interview Survey, Katrina Michelle Embrey

Dissertations, Theses and Capstone Projects (Full IR Collection)

Costly, debilitating and largely preventable, cardiovascular disease (CVD) and diabetes mellitus (DM) place a heavy disease burden of high morbidity, mortality, and rising health care costs on people of the United States. With mortality reports from the two diseases of over 600,000 per year and costs in excess of $176 billion, identifying alternatives to traditional models of care must be considered. Complementary and alternative medicine (CAM) therefore becomes a viable option for prevention and treatment. Using secondary data analysis of the 2007 National Health Interview Survey, the aim of the current study was to determine whether CAM use was associated …

Impact Of Character Development And Empowerment Program On Grit And Resilience Growth In Early And Middle Adolescents, Mimi Gamel

Dissertations, Theses and Capstone Projects (Full IR Collection)

The results from the study have shown that the 7 Mindsets: Ultimate Life Summit program has a positive impact on the perception of students’ growth in both grit and resilience. Participants’ growth was shown through the use of the Grit Scale and the Resilience Scale of Children and Adolescents (RSCA) scale. This study is purposeful and timely. It examines the non-cognitive side of education – grit and resilience development in adolescents in an era when adolescents are struggling emotionally at school and at home. The study included forty-five students between the ages of ten and eighteen from ten different countries. …

Parallel Adaptation Of Cd4 In Siv-Endemic Gorilla And Pan Lineages, Katie E. Brown

Biological Sciences

The simian immunodeficiency virus (SIV) is homologous to the human immunodeficiency virus (HIV), and naturally infects chimpanzees and gorillas in the wild. Some African primate species appear to have evolved resistance to SIV, in that the virus no longer is found in the species or, if infected, individuals within the species show no serious symptoms of simian AIDS (SAIDS). In contrast, Asian primate species do not appear to naturally harbor SIV and, like humans, often progress to AIDS following infection. CD4 is the primary T cell receptor that SIV/HIV interacts with to infect host T cells. Domain 1 (D1) of …

Metamorphosis Of Limulus Polyphemus Trilobite Larvae: Role Of Chemical And Structural Cues, Competency, And The Cost Of Delayed Metamorphosis, Stephanie Marie Kronstadt

Theses and Dissertations

Many marine and estuarine arthropods exhibit complex life cycles that include planktonic larval stages and benthic juvenile and adult phases. Chemical and structural cues associated with juvenile habitats often induce settlement and metamorphosis, thereby shortening the duration of the larval phase. These cues can trigger metamorphosis only after larvae reach competency, or developmental maturity. The point at which larvae reach this competency period and the ability to retain competency is highly species specific. Once competency is attained, a decrease in the time to metamorphosis (TTM) can decrease dispersal potential but may increase the chance of settling in a suitable habitat. …

Numerical Simulations Of In Vitro Nanoparticle Toxicity – The Case Of Poly(Amido Amine) Dendrimers., Marcus Maher, Pratap Naha, Sourav Prasanna Mukherjee, Hugh Byrne

Articles

A phenomenological rate equation model is constructed to numerically simulate nanoparticle uptake and subsequent cellular response. Polyamidoamine dendrimers (generations 4-6) are modelled and the temporal evolution of the intracellular cascade of; increased levels of reactive oxygen species, intracellular antioxidant species, caspase activation, mitochondrial membrane potential decay, tumour necrosis factor and interleukin generation is simulated, based on experimental observations.

The dose and generation dependence of several of these response factors are seen to well represent experimental observations at a range of time points. The model indicates that variations between responses of different cell-lines, including murine macrophages, human keratinocytes and colon cells, …

The Interaction Of Aeolian And Fluvial Processes In Dry Washes On The Colorado Plateau, Usa, Beau Jensen Walker

Theses and Dissertations

In the past decade there has been a call for integrated studies that examine the interaction of fluvial and aeolian processes (Belnap et al., 2011; Bullard and Livingstone, 2002). In this study, we examined the role of land-use, weather, and soil type on the flux of aeolian material into dry washes on the Colorado Plateau in central Utah, USA, and western Colorado, USA. Our goal was to quantify the impact of individual deposition and erosion events by correlating weather and land-use data with a combination of measurement methods including dust collection via dust traps, GPS surveying, and close-range photogrammetry. Our …

Studies Of Phou In Escherichia Coli: Metal Binding, Dimerization,Protein/Protein Interactions, And A Signaling Complex Model, Stewart G. Gardner

Theses and Dissertations

Phosphate is an essential nutrient for all forms of life. Escherichia coli has a PhoR/PhoB two component regulatory system that controls the expression of various genes whose products allow the cell to thrive in low phosphate environments. The signaling mechanism of the PhoR/PhoB system has been studied and the phosphorylation cascade that controls gene expression is well understood. What is still unknown is how PhoR senses the phosphate level of the environment. The PstS, PstC, PstA, PstB, and PhoU proteins play a role in this signal sensing. This work confirms the hypothesis that the PstSCAB complex senses the environmental phosphate …

Fabrication, Characterization, Optimization And Application Development Of Novel Thin-Layer Chromatography Plates, Supriya Singh Kanyal

Theses and Dissertations

This dissertation describes advances in the microfabrication of thin layer chromatography (TLC) plates. These plates are prepared by the patterning of carbon nanotube (CNT) forests on substrates, followed by their infiltration with an inorganic material. This document is divided into ten sections or chapters. Chapter 1 reviews the basics of conventional TLC technology. This technology has not changed substantially in decades. This chapter also mentions some of the downsides of the conventional approach, which include unwanted interactions of the binder in the plates with the analytes, relatively slow development times, and only moderately high efficiencies. Chapter 2 focuses primarily on …

Variation In Resource Utilization And Cost Of Reproduction For Two Burying Beetle Species, Peter J. Meyers

Theses and Dissertations

The cost of reproduction hypothesis suggests that allocation into current reproduction constrains future reproduction. How organisms accrue reproductive costs may differ between species and with varying levels of resource quality. Burying beetles are model organisms for testing for the cost of reproduction because of their unique natural history; beetles utilize small vertebrate carcasses for reproduction and they and their offspring feed exclusively on these discrete resources. Burying beetles also can utilize a large range of carcass sizes for reproduction. We tested for the cost of reproduction in two species of burying beetles, Nicrophorus marginatus and Nicrophorus guttula found in Central …

Alcohol Modulation Of Dopamine Release, Nathan Dan Schilaty

Theses and Dissertations

The mesolimbic dopamine (DA) system projects from the ventral tegmental area (VTA) to structures associated with the limbic system, primarily the nucleus accumbens (NAc). This system has been implicated in the rewarding effects of drugs of abuse. Many drugs of abuse act in the VTA, the NAc, or both. Dopamine neurons in the VTA that project to the NAc, and the GABA neurons that inhibit DA neurons locally in the VTA or project to the NAc, play an important role in mediating addiction to various drugs of abuse, in particular alcohol. There is a growing body of evidence of co-dependence …

Simultaneous Determination Of Multiple Actinide Elements In A Variety Of Soils Utilizing A Standardized Sequential Extraction Protocol, Sherry Alina Faye

UNLV Theses, Dissertations, Professional Papers, and Capstones

To obtain a better understanding of the mobility of actinide element contaminants in the environment, the association of the contaminants with specific host phases of soils and sediments must be investigated. This investigation is most commonly conducted using sequential extraction techniques that employ the selective dissolution of soil phases with increasingly aggressive chemical treatment. Though several sequential extraction studies exist in literature, conclusions cannot be made by direct comparison of data due to the lack of uniformity in the protocols used. This work aims to continue development of a standard sequential extraction protocol and expanding its capabilities to include the …

Designing A Process To Reliably Split Extracted Teeth To Access The Dental Root Canal, Happy Singh Ghag

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction

Mesenchymal stem cell (MSC) research is a contemporary topic in modern healthcare. These cells have the ability to divide and generate progeny, which then become committed to specific and distinctive end-stage phenotypes, such as cartilage or bone (Caplan 1991). MSCs have been isolated from a variety of tissues such as the umbilical cord, bone marrow, adipose tissue (Ding, Shyu & Lin 2011) and dental pulp (Takeda et al 2008). Although dental pulp is a viable source for MSCs, peer reviewed research has given limited attention to its retrieval process through intentional tooth splitting of extracted teeth. The purpose of …

Socio-Economic And Cultural Determinants Of Health Care Services Utilization In Ghana, Vickita Akosua Antwiwaa Harvey

UNLV Theses, Dissertations, Professional Papers, and Capstones

The study examines the relationship between socio-economic and cultural determinants of health care service utilization in Ghana using Ghana Demographic and Health Survey (GDHS) 2008 data collected by Ghana Statistical Service (GSS) in which a two-stage sample design was used. The first stage involved a systematic sampling, with probability proportional to size, of 412 clusters using the 2000 Ghana Population and Housing Census as the sampling frame. At the second stage, systematic samples of 30 households from each cluster were selected, making a total of 12,360 sampled households. According to the GSS, data were not collected in some of the …

Who Or What Should I Be Like? The Self-Assessment Of Sexual Desire, Caroline Maykut

UNLV Theses, Dissertations, Professional Papers, and Capstones

The construct of sexual desire has been notoriously difficult to capture and measure, in part as a function of questionable methods of sexual desire assessment. Due to problems finding an accurate, objective marker of sexual desire, research has relied on self-report. One notable difficulty with self-reported desire assessment is the lack of information on the context in which these assessments are made. The only available data focuses on relative assessment of sexual desire within couples, and ignores broader social and cultural contexts. The present study investigated men and women's perception of sexual desire discrepancies between themselves and other people and …

The Presentation Of Childhood Parental Divorce In Adulthood: A Retrospective Phenomenological Study, Sheala Catherine Morrison

UNLV Theses, Dissertations, Professional Papers, and Capstones

There has been a wealth of research aimed at developing an understanding of the way in which the experience of divorce impacts children. However, adult children of divorce have been widely underrepresented in this literature, much of which is outdated being at least ten years old. With shifting societal attitudes and the transformation of the family system since the 1990's it is crucial that the research is updated in order to stay up on the way children and families are impacted in today's society. The purpose of this study was to hear directly from adults who experienced their parents' divorce …