Digital Commons Network^™

Urinformed Summer 2014, Urinformed

URInformed: The URI Employees' Newsletter

No abstract provided.

Urinformed Spring 2014, Urinformed

URInformed: The URI Employees' Newsletter

No abstract provided.

Lrh1 As A Driving Factor In Pancreatic Cancer Growth, Qiushi Lin, Arihiro Aihara, Waihong Chung, Yu Li, Zheping Huang, Xuesong Chen, Shaofan Weng, Rolf I. Carlson, Jack R. Wands, Xiaoqun Dong

Biomedical and Pharmaceutical Sciences Faculty Publications

Liver receptor homolog 1 (LRH1), directs the development and differentiation of embryonic pancreas, and is overexpressed in pancreatic cancer (PC). We hypothesized that LRH1 promotes PC growth. Cell proliferation and tumorigenicity in nude mice were compared between empty vector-transfected (control) and stable LRH1-overexpressed PC cell lines. The subsequent tumor burden, vasculature development, and histologic features were evaluated. LRH1 overexpression enhanced the expression of downstream target genes (cyclin D1/E1) and stimulated cell proliferation in PC cell lines. LRH1 upregulated cyclin E1 truncated T1/T2 isoforms expression which may occur through ERα–calpain1 signaling. Compared with the control, LRH1 overexpressing stable cells generated tumors …

Cranberry (Vaccinium Macrocarpon) Oligosaccharides Decrease Biofilm Formation By Uropathogenic Escherichia Coli, Jiadong Sun, Jannie P.J. Marais, Christina Khoo, Kerry L. Laplante, Rebecca M. Vejborg, Michael Givskov, Tim Tolker-Nielsen, Navindra P. Seeram, David C. Rowley

Biomedical and Pharmaceutical Sciences Faculty Publications

The preventive effects of the American cranberry (Vaccinium macrocarpon) against urinary tract infections are supported by extensive studies which have primarily focused on its phenolic constituents. Herein, a phenolic-free carbohydrate fraction (designated cranf1b-F2) was purified from cranberry fruit using ion exchange and size exclusion chromatography. MALDI-TOF-MS analysis revealed that the cranf1b-F2 constituents are predominantly oligosaccharides possessing various degrees of polymerisation and further structural analysis (by GC–MS and NMR) revealed mainly xyloglucan and arabinan residues. In antimicrobial assays, cranf1b-F2 (at 1.25 mg/mL concentration) reduced biofilm production by the uropathogenic Escherichia coli CFT073 strain by over 50% but did not …

Differential Fmo3 Gene Expression In Various Liver Injury Models Involving Hepatic Oxidative Stress In Mice, Swetha Rudraiah, Jamie E. Moscovitz, Ajay C. Donepudi, Sarah N. Campion, Angela L. Slitt, Lauren M. Aleksunes, José E. Manautou

Biomedical and Pharmaceutical Sciences Faculty Publications

Flavin-containing monooxygenase-3 (FMO3) catalyzes metabolic reactions similar to cytochrome P450 monooxygenase, however, most metabolites of FMO3 are considered non-toxic. Recent findings in our laboratory demonstrated Fmo3 gene induction following toxic acetaminophen (APAP) treatment in mice. The goal of this study was to evaluate Fmo3 gene expression in other diverse mouse models of hepatic oxidative stress and injury. Fmo3 gene regulation by Nrf2 was also investigated using Nrf2 knockout (Nrf2 KO) mice. In our studies, male C57BL/6J mice were treated with toxic doses of hepatotoxicants or underwent bile duct ligation (BDL, 10 days). Hepatotoxicants included APAP (400 mg/kg, 24–72 h), alpha-naphthyl …

Urinformed Winter 2014, Urinformed

URInformed: The URI Employees' Newsletter

No abstract provided.

Stranger Species, Rachel Burns

Electronic Theses and Dissertations

Stranger Species is a collection of interconnected personal and lyrical essays that illustrate and dissect the biological and psychological forces that drive humans to act. While essays in the collection prove the narrator's need to believe that we are animals first and human beings second and that sex and persistence to survive are proof of our animalism, essays simultaneously counter-argue that humans-our emotions, weaknesses, and consciousness-are unique to our species, separating us from the animal world. Throughout the collection, fear resonates that we do not control our desires and ultimately our lives, that biology and our deep seeded psychological inadequacies …

Technical Communicators And Writing Consultants: Identity And Expertise, Nichole Cepero

Electronic Theses and Dissertations

This paper examines the roles of technical communicators and writing center consultants in regards to their identities and the expertise that they bring to what they do. Both fields have struggled with a lack of understanding surrounding what their positions entail and more importantly how they perform in their roles. With this in mind, the goal of this paper is to analyze how the growth of each field and the variations of each position contribute to the issue of identity. Furthermore, as a result of the identity problem that faces each position, I suggest using the theory of liminality, communication …

Arabs, Berbers, Islam And Orientalism In Morocco: Historically And Culturally Contextualizing The Work Of Lalla Essaydi, Shah Mahmoud Hanifi

Selected Works

No abstract provided.

Export Controls And Economic Sanctions, John W. Boscariol, J. Patrick Briscoe, Geoffrey M. Goodale, Christopher B. Stagg, Lawrence A. Ward

The International Lawyer

No abstract provided.

Global Health, Toba Schwaber Kerson, Jessica Euna Lee

Graduate School of Social Work and Social Research Faculty Research and Scholarship

Within its 150 year history, public health has grown from a focus on local communities, to include country-wide, then international and now global perspectives. Using the United Nation’s Millennium Goals as its primary framework, this article provides an overview of global public health within the broadest possible context of the world and all of its peoples. Also provided are discussions of the global burden of disease as measured in disability-adjusted life years (DALYs), global health statistics, current health priorities and recommendations for action by social workers and other health professionals.

Full Issue

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

No abstract provided.

Some Notes On Faith And Reason, Daniel C. Peterson

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

Philosophers and theologians, believers and unbelievers, friends to faith and enemies, scientists, historians — these and many others have devoted a very great deal of time and attention for centuries to the relationship between faith and reason.

2014 Annual Report Department Of Biological Sciences, Ronald L. Frank, Chen Hou, Yue-Wern Huang, Melanie R. Mormile, Dev Niyogi, Katie Shannon, Julie A. Semon, Matthew S. Thimgan, David J. Westenberg, Terry Wilson

Biological Sciences Faculty Research & Creative Works

No abstract provided.

2014 Spring And Winter - Registration Guide, Office Of The Registrar, East Tennessee State University

Registration Resources

No abstract provided.

2014 - Etsu Fact Book, Institutional Research, East Tennessee State University

ETSU Fact Books

No abstract provided.

The New Era Of Biologic Regulation And Patenting Under The America Invents Act, David I. Rucker

Marquette Intellectual Property Law Review

None.

Mechanism For Eph-B4 Regulation Of Vein Graft Adaptation, Daniel Lu

Yale Medicine Thesis Digital Library

Introduction

Vein graft adaptation to the arterial circulation entails many changes at the cellular/molecular levels, including both cell proliferation and extracellular matrix (ECM) deposition/remodeling, resulting in thickening of the vein wall, and in excessive cases, pathological neointimal hyperplasia. Eph-B4 is a receptor tyrosine kinase and embryonic determinant of veins that, when stimulated, has been shown by our lab to decrease vein graft wall thickening. We hypothesize that among other mechanisms, Eph-B4 exerts this effect through modulating extracellular matrix production and/or degradation, and that Eph-B4 interacts directly with eNOS to mediate some of its downstream effects.

Methods

Mouse Embryonic Fibroblasts (MEFs) …

Surfactant Enhanced Delivery Of C/Ebp Homologous Protein And Angiopoietin 2 Silencing Rna To Prevent Bronchopulmonary Dysplasia In Mouse Lung, John Gregory Ramirez

Yale Medicine Thesis Digital Library

Objective. To determine if poractant alfa (Curosurf®) could serve as a viable vehicle for silencing RNA (siRNA) delivery. Specifically, we hypothesize that use of Curosurf® as an enhanced delivery vehicle for C/EBP homologous protein (CHOP) and Angiopoietin 2 (Ang2) siRNA would augment gene silencing, preventing cell death and bronchopulmonary dysplasia (BPD) in the mouse lung.

Design. Transfection efficiency of Curosurf® was compared to naked siRNA and Lipofectamine 2000®. MLE-12 cells were transfected with CHOP and Ang2 siRNA using Curosurf®, then exposed to hyperoxic conditions. Cultures were evaluated for respective protein expression and markers of cell death. Curosurf® enhanced siRNA therapy …

Assessing The Survival And Functional Outcomes Of Patients With Supraglottic Squamous Cell Carcinoma, Graeme Michael Rosenberg

Yale Medicine Thesis Digital Library

The objective of this project is to report oncologic and functional outcomes for a cohort of patients with supraglottic squamous cell carcinoma (SSCC) treated in a multidisciplinary setting including the use of transoral laser microsurgery (TLM).

A retrospective observational study at Yale New Haven Hospital, academic teaching hospital was performed. A total of 56 patients without evidence of distant metastasis at presentation treated for SSCC between January 1, 2003 and December 31, 2007 were identified. The main outcome measures include overall survival (OS), locoregional and distant recurrence, and the incidence of tracheostomy and gastrostomy tube requirement.

Of the 56 patients, …

Stress And Rest Spect/Ct Imaging For Evaluation Of Lower Extremity Perfusion: An Index For Evaluation Of Microvascular And Macrovascular Disease, Nataly Sumarriva

Yale Medicine Thesis Digital Library

STRESS AND REST SPECT/CT IMAGING FOR EVALUATION OF LOWER EXTREMITY PERFUSION. Nataly Sumarriva, Wunan Zhou, Mitchel R. Stacy, and Albert J. Sinusas. Section of Cardiology, Department of Internal Medicine, Yale University, School of Medicine, New Haven, CT.

Peripheral arterial disease (PAD) is a progressive atherosclerotic disease of the lower limbs affecting approximately 8 to 10 million Americans. Diabetic patients are twice as likely to develop PAD than are patients without diabetes mellitus (DM) and PAD progression is more rapid in DM patients. The primary goal of this study was to translate image analysis tools previously developed and validated for application …

The Genetic Basis Of Dupuytren's Disease, Gloria Sue

Yale Medicine Thesis Digital Library

Dupuytren's disease is a common heritable connective tissue disorder of poorly understood etiology. It is thought that oxidative stress pathways may play a critical role in the development of Dupuytren's disease, given the various disease associations that have been observed. We sought to sequence the mitochondrial and nuclear genomes of patients affected with Dupuytren's disease using next-generation sequencing technology to potentially identify genes of potential pathogenetic interest. Additionally, we sought to compare the genomes between diseased tissue and blood to look for potential somatic mutations in the diseased tissue. Upon sequencing and subsequent bioinformatics analysis, no differences were observed in …

Inception Cohort Study Of Workers Exposed To Toluene Diisocyanate At A Polyurethane Foam Factory, Wei Gui

Yale Medicine Thesis Digital Library

Background: Isocyanates are one of the most commonly reported causes of occupational asthma; however, the risks of developing isocyanate asthma in modern production facilities remain poorly defined. The purpose of the present investigation was to evaluate TDI exposure and respiratory health among an inception cohort of workers during their first year of employment at a new polyurethane foam production factory.

Methods: Forty-nine newly hired workers were evaluated pre-employment, 6-months, and 12-months post-employment through questionnaire, spirometry and TDI-specific serology. Airborne TDI levels were monitored by fixed-point air sampling and limited personal sampling. Qualitative surface SWYPE tests were performed to evaluate potential …

Remedies For Foreign Citizens Subjected To Outsourced Pollution: A Case Study Of American Big Oil In The Ecuadorian Amazon, Ava Azad

Florida A & M University Law Review

The term “globalization” generally carries a positive connotation, invoking images of progress and international unity. “Technology” similarly enjoys a reputation of enabling human advancement and improving sustenance, shelter, education, and overall quality of life. Both promote the development of the other and their success has become intertwined. Development of the oil industry is one newsworthy example of the coming together of technology and globalization as nations rush to discover, extract, and refine oil wherever possible and sell the fuel to their own citizens or export it to other nations. Oil is also an example of dangers generally not associated with …

Insects And Humans Share A Complex History, Aldemaro Romero Jr.

Publications and Research

No abstract provided.

2014-2015 - Quillen College Of Medicine Operating Budget (October), Budget And Financial Planning, East Tennessee State University

College of Medicine Operating Budgets and Analysis

No abstract provided.

2014-2015 - Etsu General Academic Operating Budget (October), Budget And Financial Planning, East Tennessee State University

ETSU General Academic Operating Budgets and Analysis

No abstract provided.

2014-2015 - Etsu General Academic Operating Budget (July), Budget And Financial Planning, East Tennessee State University

ETSU General Academic Operating Budgets and Analysis

No abstract provided.

Ohio Northern University Catalog, 2014-2015, Ohio Northern University

University Catalogs

No abstract provided.

How Women Became Priests In Ireland: The Development Of Women’S Ordination In The Church Of Ireland, Meagan Farrell Howe

Masters Theses

30 years ago, the Church of Ireland allowed women’s ordination as deacons, then later priests and bishops. Leading to this doctrinal and social development, the Church of Ireland wrestled with big questions on the nature of Christian ministry and women’s roles in the church. Have the Bible and church tradition always upheld male headship? Are women being called by God to serve as deacons, priests and bishops? Can groups with major theological differences reconcile and remain one church? The author introduces this historic Irish development to a United States audience with relevant lessons for social transformation, following the human drama …