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A Safety Mnemonic For Pediatric Oncology Patients: Knowledge, Confidence And Skills Accuracy During Simulation, Luanne Linnard-Palmer, Barbara Ganley

Collected Faculty Scholarship

Cancer is the second leading cause of death in the United States, surpassed only by heart disease [1]. Approximately 1.6 million Americans will receive treatment for a variety of cancers annually [2]. This increase in oncology nursing care opportunities highlights the need to ensure that nurses have the skills, knowledge, and tools that allow them to safely provide care. Because Undergraduate nursing education often does not provide in-depth coverage of the principles of safe oncology nursing care required for children or adults, this study addressed protocols used when caring for chemotherapy pediatric patients using a chemotherapy mnemonic. The purpose of …

Weekly News Digest 01/15/2014, Jenna Ray

Weekly Bulletin Archive

In this issue:

● Campus to Take Part in MLK Day of Service

● Speaking in Tongues to Perform at Morris

● Biology Faculty Receive Grant In Aid Awards

● Bart Finzel Featured in Mpls.St.Paul Magazine

Founders Keepers Newsletter 2014-01-15, Niu Libraries

University Libraries Archives

No abstract provided.

Seasonal Mesophotic Coral Bleaching Of Stylophora Pistillata In The Northern Red Sea, Orit Nir, David F. Gruber, Eli Shemesh, Eliezra Glasser, Dan Tchernov

Publications and Research

Coral bleaching occurs when environmental stress induces breakdown of the coral-algae symbiosis and the host initiates algae expulsion. Two types of coral bleaching had been thoroughly discussed in the scientific literature; the first is primarily associated with mass coral bleaching events; the second is a seasonal loss of algae and/or pigments. Here, we describe a phenomenon that has been witnessed for repeated summers in the mesophotic zone (40–63 m) in the northern Red Sea: seasonal bleaching and recovery of several hermatypic coral species. In this study, we followed the recurring bleaching process of the common coral Stylophora pistillata. Bleaching occurred …

Synthesis And Characterization Of New Gd3+-Containing Complexes As Potential Targeted Contrast Agents For Magnetic Resonance Imaging, Sashiprabha Manjari Vithanarachchi

Wayne State University Dissertations

The focus of the research described in this thesis is the study of chemistry relevant to target-specific contrast agents for magnetic resonance imaging (MRI). MRI is a widely used technique in diagnostic medicine and biomedical research to obtain anatomical and physiological details of soft tissues. Contrast agents are used to enhance the contrast of MR images by causing changes to the chemical environment of water molecules. Clinically approved GdIII-containing contrast agents for MRI are non-specific, and consequently, have limited utility. Target-specific contrast agents represent one way to circumvent this limitation. In the research described in this thesis, myelin and Β-amyloid …

Biochemical And Cellular Studies Of Human Msh2 Atpase Domain Mutants Support The Molecular Switch Model Of Mismatch Repair In Vivo, Graham D. Brown

Doctoral Dissertations

Lynch syndrome is the most common form of hereditary colorectal cancer. It is caused by genetic mutations in the DNA mismatch repair (MMR) pathway. The MMR pathway is a cellular mechanism for repairing nucleotide mismatches that arise during DNA replication. Generally, MSH2-MSH6 heterodimers bind mismatches then are themselves bound by a second mismatch repair heterodimer, MLH1-PMS2. This complex regulates an exonuclease, Exo1, to remove the mismatch-containing DNA that is re-synthesized and sealed by DNA polymerase δ and DNA ligase. There are multiple models to explain the specific MMR molecular mechanism including the molecular switch model. In this model, mismatch binding …

Physics Colloquium | How Cosmic Collisions Shape The Universe, Jan 15, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

The Daily Egyptian, January 15, 2014, Daily Egyptian Staff

January 2014

No abstract provided.

Our Impressive Immune System: More Than A Defense, Alan L. Gillen, Jason Conrad

Faculty Publications and Presentations

Most likely the immune system was put into place in the original human body design. We know from Exodus 20:11 and other verses that God completed His work of creation in six days. Therefore, the human body and its functional parts, including the components of the immune system, must have been part of the original creation. God said that all He had made was very good (Genesis 1:31). Since there were no pathogens (germs), parasites, or diseases prior the Edenic Fall and subsequent Curse, the immune system may have functioned differently in that world unmarred by sin and death.

The …

Volume 51, Number 22: January 15, 2014, University Of North Dakota

University Letter Archive

No abstract provided.

Identification Of Quantitative Trait Loci (Qtl) Underlying Protein, Oil, And Five Major Fatty Acids’ Contents In Soybean, M Akond, Shiming Liu, Melanie Boney, Stella K. Kantartzi, David A. Lightfoot, Nacer Bellaloui, Khalid Meksem, My Abdelmajid Kassem

Articles

Improved seed composition in soybean [Glycine max (L.) Merr.] for protein and oil quality is one of the major goals of soybean breeders. A group of genes that act as quantitative traits with their effects can alter protein, oil, palmitic, stearic, oleic, linoleic, and linolenic acids percentage in soybean seeds. The objective of this study was to identify Quantitative Trait Loci (QTL) controlling protein, oil, and fatty acids content in a set of F5:8 RILs de-rived from a cross between lines, ‘MD 96-5722’ and ‘Spencer’ using 5376 Single Nucleotide Polymorphism (SNP) markers from the Illumina Infinium SoySNP6K BeadChip array. QTL …

Emu Today, January 15, 2014, Eastern Michigan University

EMU Today

No abstract provided.

Management For Mountain Pine Beetle Outbreak Suppression: Does Relevant Science Support Current Policy?, Diana Six, Eric Biber, Elisabeth Long

Ecosystem and Conservation Sciences Faculty Publications

While the use of timber harvests is generally accepted as an effective approach to controlling bark beetles during outbreaks, in reality there has been a dearth of monitoring to assess outcomes, and failures are often not reported. Additionally, few studies have focused on how these treatments affect forest structure and function over the long term, or our forests’ ability to adapt to climate change. Despite this, there is a widespread belief in the policy arena that timber harvesting is an effective and necessary tool to address beetle infestations. That belief has led to numerous proposals for, and enactment of, significant …

Measurement Of Hydrodynamic Force Generation By Swimming Dolphins Using Bubble Dpiv, Frank E. Fish, Paul Legac, Terrie M. Williams, Timothy Wei

Biology Faculty Publications

No abstract provided.

A Social Ecological Approach: Understanding The Factors Associated With Hiv Risk In Fishing Communities In Lake Victoria, Uganda., Paola Chanes-Mora

Master's Theses

Uganda has an estimated 1.4 million Human Immunodeficiency Virus (HIV) -positive adults (United Nations Program on HIV/AIDS [UNAIDS], 2011). The initial cases of acquired immune deficiency syndrome (AIDS) in Uganda were identified in fishing villages on the shores of Lake Victoria in 1985 (Serwadda et al., 1985). Fishing villages continue to remain at high risk of HIV transmission (United Nations Program on HIV/AIDS [UNAIDS], 2012). Evidence suggests that the HIV- prevalence rates among fishermen and commercial sex workers (CSWs) in the Wakiso District are more than 20 percent (Alex, Michael, & Nordin, 2011). The purpose of this study was to …

Identification Of A Developmental Gene Expression Signature, Including Hox Genes, For The Normal Human Colonic Crypt Stem Cell Niche: Overexpression Of The Signature Parallels Stem Cell Overpopulation During Colon Tumorigenesis., Seema Bhatlekar, Sankar Addya, Moreh Salunek, Christopher R Orr, Saul Surrey, Steven E. Mckenzie, Jeremy Z Fields, Bruce M Boman

Kimmel Cancer Center Faculty Papers

Our goal was to identify a unique gene expression signature for human colonic stem cells (SCs). Accordingly, we determined the gene expression pattern for a known SC-enriched region--the crypt bottom. Colonic crypts and isolated crypt subsections (top, middle, and bottom) were purified from fresh, normal, human, surgical specimens. We then used an innovative strategy that used two-color microarrays (∼18,500 genes) to compare gene expression in the crypt bottom with expression in the other crypt subsections (middle or top). Array results were validated by PCR and immunostaining. About 25% of genes analyzed were expressed in crypts: 88 preferentially in the bottom, …

The Guardian, January 15, 2014, Wright State University Student Body

The Guardian Student Newspaper

Twelve page issue of The Guardian, the official student-run newspaper for Wright State University. The Guardian has been published regularly since March of 1965.

A Phenomenological Study Of The Experiences Of Higher Education Students With Disabilities, Allen J. Heindel

USF Tampa Graduate Theses and Dissertations

Distance education has the potential to offer a meaningful alternative for students with disabilities. Colleges and universities have opportunities to provide quality online courses to students with disabilities; yet data show these students may often choose to discontinue higher education pursuits. Little is currently known about how students with disabilities experience the distance learning environment or how institutions of higher education. This phenomenological study focuses on the quality of the learning experiences and learner satisfaction of students with disabilities in distance education courses.

The purpose of this study is to investigate 1) how online learning is experienced by students with …

Military Uses Of Outer Space: Legal Limitations, Contemporary Perspectives, Isavella Maria Vasilogeorgi

Journal of Space Law

No abstract provided.

Multiscale Geometric Modeling Of Macromolecules I: Cartesian Representation, Kelin Xia, Xin Feng, Zhan Chen, Yiying Tong, Guo-Wei Wei

Mathematical Sciences: Faculty Publications

This paper focuses on the geometric modeling and computational algorithm development of biomolecular structures from two data sources: Protein Data Bank (PDB) and Electron Microscopy Data Bank (EMDB) in the Eulerian (or Cartesian) representation. Molecular surface (MS) contains non-smooth geometric singularities, such as cusps, tips and self-intersecting facets, which often lead to computational instabilities in molecular simulations, and violate the physical principle of surface free energy minimization. Variational multiscale surface definitions are proposed based on geometric flows and solvation analysis of biomolecular systems. Our approach leads to geometric and potential driven Laplace–Beltrami flows for biomolecular surface evolution and formation. The …

The Murray Ledger And Times, January 15, 2014, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

The Cytotoxic Effect Of 2-Acylated-1,4-Naphthohydroquinones On Leukemia/Lymphoma Cells, Diego A. Pedroza, Fernando De Leon, Armando Varela-Ramirez, Carolina Lerma, Renato J. Aguilera, Shizue Mito

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Here, we tested seven 2-acylated-1,4-hydronaphthoquinones for their cytotoxic effects on a panel of cancer lymphoma/leukemia cells and compared to a non-cancer origin cell line. Several naphthohydroquinones exhibited selective cytotoxic effects on lymphoma/leukemia cells with lowest activity on non-cancer cells. The mode of cell death induced by an acylated naphthohydroquinone, which has a long alkyl chain, was found to be via apoptosis. Furthermore, the naphthohydroquinone provoked mitochondria depolarization and activation of its downstream effector, caspase-3, thus implicating the intrinsic apoptotic pathway as its mechanism to exert cell death.

Minutes, Arts & Sciences Professional Standards Committee Meeting, Tuesday, January 14, 2014, Arts & Sciences Professional Standards Committee

Professional Standards Committee Minutes

No abstract provided.

The Utah Statesman, January 14, 2014, Utah State University

The Utah Statesman

Weekly student newspaper for Utah State University in Logan.

Early-Life Seizures In Predisposing Neuronal Preconditioning: A Critical Review, Linda Friedman, Shirley Hu

NYMC Faculty Publications

Although seizures are known to be harmful, recent evidence indicates that they can also lead to adaptations that protect neurons from further insult. For example, a history of two episodes of status epilepticus during a critical period of early development can prolong the time period of resistance to hippocampal injury during the postnatal period. Neonatal seizures may lead to this neuroprotection via a preconditioning mechanism that could be attributed to attenuation of Ca(2+) currents, reduction of inflammation, and induction of survival signaling pathways. Understanding mechanisms underlying neuroprotective preconditioning may elucidate new therapeutic targets and improve outcomes and quality of life …

Tetrakis-Quaternary Ammonium Salts And Methods For Modulating Neuronal Nicotinic Acteylcholine Receptors, Peter A. Crooks, Linda P. Dwoskin, Zhnefa Zhang, Marharyta Pivavarchyk

Pharmaceutical Sciences Faculty Patents

Provided are tetrakis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.

Religion, Partisanship, And Attitudes Toward Science Policy, Ted G. Jelen, Linda A. Lockett

Political Science Faculty Research

We examine issues involving science which have been contested in recent public debate. These “contested science” issues include human evolution, stem-cell research, and climate change. We find that few respondents evince consistently skeptical attitudes toward science issues, and that religious variables are generally strong predictors of attitudes toward individual issues. Furthermore, and contrary to analyses of elite discourse, partisan identification is not generally predictive of attitudes toward contested scientific issues.

Religion, Partisanship, And Attitudes Towards Science Policy, Ted G. Jelen, Linda A. Lockett

Political Science Faculty Research

We examine issues involving science which have been contested in recent public debate. These “contested science” issues include human evolution, stem-cell research, and climate change. We find that few respondents evince consistently skeptical attitudes toward science issues, and that religious variables are generally strong predictors of attitudes toward individual issues. Furthermore, and contrary to analyses of elite discourse, partisan identification is not generally predictive of attitudes toward contested scientific issues.

Academic Senate - Agenda, 1/14/2014, Academic Senate

Academic Senate Agendas

No abstract provided.

Ranbp9 Overexpression Accelerates Loss Of Pre And Postsynaptic Proteins In The Apδe9 Transgenic Mouse Brain, Hongjie Wang, Ruizhi Wang, Shaohua Xu, Madepalli Krishnappa Lakshmana

Biomedical Engineering and Sciences Faculty Publications

There is now compelling evidence that the neurodegenerative process in Alzheimer's disease (AD) begins in synapses. Loss of synaptic proteins and functional synapses in the amyloid precursor protein (APP) transgenic mouse models of AD is well established. However, what is the earliest age at which such loss of synapses occurs, and whether known markers of AD progression accelerate functional deficits is completely unknown. We previously showed that RanBP9 overexpression leads to robustly increased amyloid β peptide (Aβ) generation leading to enhanced amyloid plaque burden in a mouse model of AD. In this study we compared synaptic protein levels among four …