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Dietary Behaviors And Nutrition Intervention Preferences Of Breast Cancer Survivors, Sherry A. Stokes

All Theses

Breast cancer is the most commonly diagnosed cancer among women and there are expected to be 1,665,540 new cases diagnosed in 2014. Advancements in early detection, have greatly improved treatment outcomes for the majority of these patients and the 5-year survival rate is 89.2%. The newly emerging field of survivorship care is an attempt to meet the unique needs of this expanding population. Research has demonstrated that an unhealthy body weight is an important modifiable risk factor for the recurrence of breast cancer. This study used an electronic version of the Block 2005 to collect dietary information on 30 breast …

Glutaredoxin 2 (Grx2) Gene Deletion Induces Early Onset Of Age-Dependent Cataracts In Mice, Hongli Wu, Yibo Yu, Larry David, Ye-Shih Ho, Marjorie . F. Lou

School of Veterinary and Biomedical Sciences: Faculty Publications

Glutaredoxin 2 (Grx2) is an isozyme of glutaredoxin1 (thioltransferase) present in the mitochondria and nucleus with disulfide reductase and peroxidase activities, and it controls thiol/ disulfide balance in cells. In this study, we investigated whether Grx2 gene deletion could induce faster age-related cataract formation and elucidated the biochemical changes effected by Grx2 gene deletion that may contribute to lens opacity. Slit lamp was used to examine the lenses in Grx2 knock-out (KO) mice and age-matched wild-type (WT) mice ages 1 to 16 months. In the Grx2 null mice, the lens nuclear opacity began at 5 months, 3 months sooner than …

Comparative Genomics Reveals Insights Into Avian Genome Evolution And Adaptation, Guojie Zhang, Cai Li, Qiye Li, Bo Li, Dennis M. Larkin, Chul Lee, Jay F. Storz, Agostinho Antunes, Matthew J. Greenwold, Robert W. Meredith, Anders Ödeen, Jie Cui, Qi Zhou, Luohao Xu, Hailin Pan, Zongji Wang, Lijun Jin, Pei Zhang, Haofu Hu, Wei Yang, Jiang Hu, Jin Xiao, Zhikai Yang, Yang Liu, Qiaolin Xie, Hao Yu, Jinmin Lian, Ping Wen, Fang Zhang, Hui Li, Yongli Zeng, Zijun Xiong, Shiping Liu, Long Zhou, Zhiyong Huang, Na An, Jie Wang, Quimei Zheng, Yingqi Xiong, Guangbiao Wang, Bo Wang, Jingjing Wang, Yu Fan, Rute R. Da Fonseca, Alonzo Alfaro-Núñez, Mikkel Schubert, Ludovic Orlando, Tobias Mourier, Jason T. Howard, Ganeshkumar Ganapathy, Andreas Pfenning, Osceola Whitney, Miriam V. Rivas, Erina Hara, Julia Smith, Marta Farré, Jitendra Narayan, Gancho Slavov, Michael N. Romanov, Rui Borges, João Paulo Machado, Imran Khan, Mark S. Springer, John Gatesy, Federico G. Hoffmann, Juan C. Opazo, Olle Håstad, Roger H. Sawyer, Heebal Kim, Kyu-Won Kim, Hyeon Jeong Kim, Seoae Cho, Ning Li, Yinhua Huang, Michael W. Bruford, Xiangjiang Zhan, Andrew Dixon, Mads F. Bertelsen, Elizabeth Derryberry, Wesley Warren, Richard K. Wilson, Shengbin Li, David A. Ray, Richard E. Green, Stephen J. O'Brien, Darren Griffin, Warren E. Johnson, David Haussler, Oliver A. Ryder, Eske Willerslev, Gary R. Graves, Per Alström, Jon Fjeldså, David P. Mindell, Scott V. Edwards, Edward L. Braun, Carsten Rahbek, David W. Burt, Peter Houde, Yong Zhang, Huanming Yang, Jian Wang, Avian Genome Consortium, Erich D. Jarvis, M. Thomas P. Gilbert, Jun Wang

Jay F. Storz Publications

Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across many research fields. We explored bird macroevolution using full genomes from 48 avian species representing all major extant clades. The avian genome is principally characterized by its constrained size, which predominantly arose because of lineage-specific erosion of repetitive elements, large segmental deletions, and gene loss. Avian genomes furthermore show a remarkably high degree of evolutionary stasis at the levels of nucleotide sequence, gene synteny, and chromosomal structure. Despite this pattern of conservation, we detected many non-neutral evolutionary changes in protein-coding genes and noncoding regions. These analyses …

Zoonoses In The Arabian Peninsula, Ulrich Wernery

Saudi Medical Journal

The human population is rising and will soon reach 9 billion people. In parallel, the demand for animal protein is increasing and with it is the threat of zoonotic diseases. We must therefore be on our guard. The close association of people with animals promotes the opportunity for zoonotic infections and real danger may arise when animals are imported with no health background. Therefore, it is essential to implement strict import controls, and establish efficient quarantine facilities. Many viral, bacterial, and zoonotic diseases have been diagnosed on the Arabian Peninsula, either by isolating the pathogens or through serological surveys. Most …

Production Of Recombinant Streptokinase From Streptococcus Pyogenes Isolate And Its Potential For Thrombolytic Therapy, Abdullah S. Assiri, Basiouny A. El-Gamal, Elsayed E. Hafez, Mohamed A. Haidara

Saudi Medical Journal

OBJECTIVES: To produce an effective recombinant streptokinase (rSK) from pathogenic Streptococcus pyogenes isolate in yeast, and evaluate its potential for thrombolytic therapy. METHODS: This study was conducted from November 2012 to December 2013 at King Khalid University, Abha, Kingdom of Saudi Arabia (KSA). Throat swabs collected from 45 pharyngitis patients in Asser Central Hospital, Abha, KSA were used to isolate Streptococcus pyogenes. The bacterial DNA was used for amplification of the streptokinase gene (1200 bp). The gene was cloned and in vitro transcribed in an eukaryotic expression vector that was transformed into yeast Pichia pastoris SMD1168, and the rSK protein …

Histopathological Features Of Breast Cancer In Al-Madinah Region Of Saudi Arabia, Abdulkader Albasri, Akbar S. Hussainy, Ibrahim Sundkji, Ahmed Alhujaily

Saudi Medical Journal

OBJECTIVES: To observe the frequency of breast cancer among Saudi patients and to highlight the age variations and features of advanced cancer. METHODS: A retrospective study of breast cancer biopsies from all Saudi patients performed between January 2006 and December 2013 in King Fahad Hospital, Al-Madinah, Kingdom of Saudi Arabia. All the available demographic and tumor related data was analyzed. RESULTS: Of 1005 breast tissues reviewed, 982 specimens were from female, and 23 from male patients. In females, 398 specimens (40.5%) were diagnosed as malignant. Invasive ductal carcinoma (IDC) (85.2%) was most common, followed by ductal carcinoma in situ (8%), …

Molecular Mechanisms Of Anti-Hyperglycemic Effects Of Costus Speciosus Extract In Streptozotocin-Induced Diabetic Rats, Haytham A. Ali, Omar A. Almaghrabi, Mohamed E. Afifi

Saudi Medical Journal

OBJECTIVES: To investigate the mechanisms of the anti-hyperglycemic effect of Costus speciosus (C. speciosus) root ethanolic extracts (CSREt) by assessing its action on insulin synthesis and glucose catabolic enzyme gene expression and activities in streptozotocin (STZ) diabetic rats. METHODS: This study was carried out at the Biochemical Laboratory, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt between July and August 2013. Sixty male albino rats (120 +/- 20 g weight, and 6 months old) were used and divided into 6 groups (n=10). Two groups served as diabetic and nondiabetic controls. Four groups of STZ diabetic animals were given oral C. …

Long-Acting Antituberculous Therapeutic Nanoparticles Target Macrophage Endosomes, Benson J. Edagwa, Dongwei Guo, Pavan Puligujja, Han Chen, Joellyn Mcmillan, Xinming Liu, Howard Gendelman, Prabagaran Narayanasamy

Nebraska Center for Biotechnology: Faculty and Staff Publications

Eradication of Mycobacterium tuberculosis (MTB) infection requires daily administration of combinations of rifampin (RIF), isoniazid [isonicotinylhydrazine (INH)], pyrazinamide, and ethambutol, among other drug therapies. To facilitate and optimize MTB therapeutic selections, a mononuclear phagocyte (MP; monocyte, macrophage, and dendritic cell)-targeted drug delivery strategy was developed. Long-acting nanoformulations of RIF and an INH derivative, pentenyl- INH (INHP), were prepared, and their physicochemical properties were evaluated. This included the evaluation of MP particle uptake and retention, cell viability, and antimicrobial efficacy. Drug levels reached 6 μg/106 cells in human monocyte-derived macrophages (MDMs) for nanoparticle treatments compared with 0.1 μg/106 cells for native …

Borderline Personality Disorder And Self-Conscious Emotions In Response To Adult Unwanted Sexual Experiences, Michelle Schoenleber, Kim L. Gratz, Terri Messman-Moore, David Dilillo

Department of Psychology: Faculty Publications

Borderline personality disorder (BPD) is associated with a proneness to unpleasant self-conscious emotions (SCE). Given that BPD is also associated with heightened rates of SCE-eliciting events (including unwanted sexual experiences), research examining the factors influencing SCE in response to these events is needed. This study examined associations between BPD pathology and SCE in response to adult unwanted sexual experiences among 303 community women. Extent of sharing about and perceived personal responsibility for the event were examined as moderators of the association between BPD and current event-related SCE. Both self-reported BPD symptom severity in the full sample and interview-based measures of …

Speed Kills: Ineffective Avian Escape Responses To Oncoming Vehicles, Travis L. Devault, Bradley F. Blackwell, Thomas W. Seamans, Steven L. Lima, Esteban Fernandez-Juricic

United States Department of Agriculture Wildlife Services: Staff Publications

Animal–vehicle collisions cause high levels of vertebrate mortality worldwide, and what goes wrong when animals fail to escape and ultimately collide with vehicles is notwell understood.We investigated alert and escape behaviours of captive brown-headed cowbirds (Molothrus ater) in response to virtual vehicle approaches of different sizes and at speeds ranging from 60 to 360 km h^-1. Alert and flight initiation distances remained similar across vehicle speeds, and accordingly, alert and flight initiation times decreased at higher vehicle speeds. Thus, avoidance behaviours in cowbirds appeared to be based on distance rather than time available for escape, particularly …

Gender Differences In Narcissism: A Meta-Analytic Review, Emily Grijalva, Daniel A. Newman, Louis Tay, M. Brent Donnellan, Peter D. Harms, Richard W. Robins, Taiyi Yan

P. D. Harms Publications

Despite the widely held belief that men are more narcissistic than women, there has been no systematic review to establish the magnitude, variability across measures and settings, and stability over time of this gender difference. Drawing on the biosocial approach to social role theory, a meta-analysis performed for Study 1 found that men tended to be more narcissistic than women (d = .26; k = 355 studies; N = 470,846). This gender difference remained stable in U.S. college student cohorts over time (from 1990 to 2013) and across different age groups. Study 1 also investigated gender differences in three …

The (Un) Desirability Of Happiness: Pathogen Threats Predict Differences In The Value Of Happiness, Sharon Li Hua Koh

Dissertations and Theses Collection (Open Access)

People in some parts of the world find positive emotions more desirable than others. What accounts for this variability? We predicted that happiness would be valued less under conditions where the behaviors that happiness promotes would be less beneficial. We analyzed international survey data and United Nations voting records and found that happiness was valued relatively less in environments that had been historically pathogen-rich. Using a series of experimental studies, we showed that people who were experimentally primed by the threat of pathogens judged happiness in others less favorably and found happiness less appropriate. Our findings contribute to research on …

Is Postpartum Depression A Disease Of Modern Civilization?, Jennifer Hahn-Holbrook, Martie Haselton

Psychology Faculty Articles and Research

Access to calorie-dense foods, medicine, and other comforts has made modern humans healthier than our prehistoric ancestors in many respects. However, the epidemics of obesity, diabetes, and cardiovascular disease suggest that there are also drawbacks to modern living. Here, we address the question of whether the dramatic cultural changes that have occurred over the past century have inflated rates of postpartum depression, adding postpartum depression to the list of diseases of modern civilization. We review evidence from cross-cultural, epidemiological, and experimental studies documenting associations between postpartum depression and modern patterns of early weaning, diets deficient in essential fatty acids, low …

Montclair Magazine (Fall/Winter 2014), Montclair State University

Montclair: The magazine of Montclair State University

No abstract provided.

Empirical Demonstration Of Environmental Sensing In Catalytic Rna: Evolution Of Interpretive Behavior At The Origins Of Life, Niles Lehman, Tess Bernhard, Brian C. Larson, Andrew J.N. Robinson, Christopher C.B. Southgate

Chemistry Faculty Publications and Presentations

Background: The origins of life on the Earth required chemical entities to interact with their environments in ways that could respond to natural selection. The concept of interpretation, where biotic entities use signs in their environment as proxy for the existence of other items of selective value in their environment, has been proposed on theoretical grounds to be relevant to the origins and early evolution of life. However this concept has not been demonstrated empirically.

Results: Here, we present data that certain catalytic RNA sequences have properties that would enable interpretation of divalent cation levels in their environment. …

Rrh Library Newsletter, December 2014, Libraries At Rochester Regional Health

Rochester Regional Health authored publications and proceedings

Newsletter sections include: Frostbite; Reminder -- MD Consult to retire in 2014; Rename the Library Newsletter

The Predicts Database: A Global Database Of How Local Terrestrial Biodiversity Responds To Human Impacts, Lawrence N. Hudson, Tim Newbold, Sara Contu, Samantha L.L. Hill, Igor Lysenko, Adriana De Palma, Helen R.P. Phillips, Rebecca A. Senior, Dominic J. Bennett, Hollie Booth, Argyrios Choimes, David L.P. Correia, Julie Day, Susy Echeverría-Londoño, Morgan Garon, Michelle L.K. Harrison, Daniel J. Ingram, Martin Jung, Victoria Kemp, Lucinda Kirkpatrick, Callum D. Martin, Yuan Pan, Hannah J. White, Job Aben, Stefan Abrahamczyk, Gilbert B. Adum, Virginia Aguilar-Barquero, Marcelo A. Aizen, Marc Ancrenaz, Enrique Arbeláez-Cortés, Inge Armbrecht, Badrul Azhar, Christopher A. Williams

Geography

Biodiversity continues to decline in the face of increasing anthropogenic pressures such as habitat destruction, exploitation, pollution and introduction of alien species. Existing global databases of species' threat status or population time series are dominated by charismatic species. The collation of datasets with broad taxonomic and biogeographic extents, and that support computation of a range of biodiversity indicators, is necessary to enable better understanding of historical declines and to project - and avert - future declines. We describe and assess a new database of more than 1.6 million samples from 78 countries representing over 28,000 species, collated from existing spatial …

How Do Middle School Core Content Area Teachers In A Title 1 School Use Cooperative Learning In The Context Of High Accountability For Student Proficiency: A Multiple Case Study, Martha Cunigan-Wells

Dissertations

This action research case study describes how content area teachers in a middle school with low reading achievement levels utilize cooperative learning and curriculum integration (with a focus on the integration of literacy skills and thinking skills) in their content area given the current context of accountability for student mastery of tested core content outcomes. The participants were four urban middle school teachers from the core areas of science, social studies, mathematics, and language arts who had varying levels of training and experience with cooperative learning and curriculum integration. Data sources included audio-recorded pre-conferences, video-taped classroom observations, audio-recorded post-conferences, and …

A Monte Carlo Study Of The Optimal Rank Order Relationship With Criterion Scores, Hongyan Cui

Dissertations

Appropriate scoring methods for tests should be based on theories of the construct domains of such tests (Messick, 1989). This is called structural fidelity (Loevinger, 1957), a necessary but not sufficient condition for construct validity (Keith & Kranzler, 1999). A situation reaction test (SRT) consists of items with alternatives to be ranked according to subjects’ best judgment. Traditional rank scoring methods assume unidimensionality, implying one scoring key for each item – a single external criterion. This is not appropriate when items elicit multidimensional responses determined by subjects’ best judgments based on possibly multiple internal criteria. The purpose of this study …

An Examination Of How Feminist Perspectives And Generational Differences Lnfluence The Leadership Practices Of Women Administrators In Higher Education, Marlene Kowalski-Braun

Dissertations

This study explored how feminist perspectives and generational differences influence the leadership practice of women administrators in higher education, specifically, how they lead and create institutional change. It examined the experiences of seven women who identified as feminists, who were part of Generation X, and who were at the mid-level, aspiring to senior-level, or in senior-level positions.

Phenomenology was the qualitative methodology used in this study to uncover how these women made meaning of their feminist and generational identities. The approach was grounded in feminist methodology and utilized feminist standpoint theory to legitimize women as “knowers.” It drew on a …

Multiple Osteochondromas In A 16th–19th Century Individual From Setúbal (Portugal), Nathalie Antunes-Ferreira, Eugénia Cunha, Carina Marques

Anthropology Faculty Publications

An archaeological survey at the church of Nossa Senhora da Anunciada (Setúbal, Portugal) uncovered the remains of 92 individuals. Historical and archaeological data suggest that the inhumations occurred between 1531 and 1839. The present work reports the pathological features of a mature male individual exhibiting multiple osseous bony projections and bone deformity, mainly affecting the metaphyseal and adjacent diaphyseal regions of the long bones. The macroscopic and the radiological analyses of the lesions suggest multiple osteochondromas as the most probable diagnosis. This is the first archaeological case of this disease known on the Portuguese territory and in southern Europe.

Gender Differences In Neighborhood Walking In Older Adults, N. A. Gallagher, P. J. Clarke, Kimberlee A. Gretebeck

College of Nursing Faculty Research and Publications

Objective: This study examined mobility, self-efficacy, outcome expectations, neighborhood (density, destinations, and design), and neighborhood walking in older men (n = 106, 60-99 years, M = 76.78, SD = 8.12) and women (n = 216, 60-99 years, M = 75.81, SD = 8.46).

Method/Results: In hierarchical regression, the variables explained 32% of the variance in neighborhood walking in men (p < .001) and 27% of the variance in women (p < .01). Self-efficacy (β = .49, p < .01), density (β= .22, p < .05), and design (β= .21, p = .05) were associated with walking in men. Significant design characteristics included sidewalks (β= .25, p < .05) and crime (β= .36, p < .01). In women, self-efficacy (β= .48, p < .001) and destinations (β= .15, p < .05) were associated with walking. Walking was associated with self-efficacy for walking despite individual barriers in women (β= .38, p < .001) and neighborhood barriers in men (β= .30, p < .05).

Conclusion: Walking interventions targeting older women should incorporate local destinations. In older …

A Fish Farmer’S Role In Sustainable Aquaculture: An Overview Of Philippine Aquaculture, Janice A. Ragaza, Jonni Fay C. Teves

Biology Faculty Publications

The expansion of Philippine aquaculture is essential to addressing poverty and food insecurity in the midst of a seemingly irreversible decline in national capture fisheries. Concomitant with its rise, however, are compounding environmental problems caused by climate change, lackluster governance and irresponsible farming practices. It is equally important to ensure aquaculture sustainability so that fish demand from a rapidly growing population is continually met and that fish farmers’ socioeconomic well-being is secured. As such, programs have been developed that aim to enjoin the government and private sectors with fishing communities to realize this goal.

Development Of Models For The Study Of The Molecular Mechanisms Of Host Restriction And Adaptation Of Hantaviruses., Ryan Carroll Mcallister 1988-

Electronic Theses and Dissertations

Hantaviruses, family Bunyaviridae, are present throughout the globe in a variety of mouse, rat, mole, vole, shrew, or bat species. Hantaviruses persist for the lifetime of the animal reservoir, while causing no signs or symptoms of disease. Only the rodent-borne hantaviruses cause disease in humans. In contrast, a “spillover” infection of a hantavirus into a nonreservoir rodent species results in an asymptomatic acute infection. We and others in the field are interested in understanding the biology of these virus-host interactions and mechanisms that underlie these three very different outcomes. The second chapter of my thesis focused on probing the intrahost …

Study Of Novel Nanoparticle Transport And Drug Release For Cancer Treatment., Christopher Gene England 1988-

Electronic Theses and Dissertations

Nano-scale particles sized 10—400 nm administered systemically preferentially extravasate from tumor vasculature due to the enhanced permeability and retention effect. Therapeutic success remains elusive, however, because of inhomogeneous particle distribution within tumor tissue. Insufficient tumor vascularization limits particle transport and also results in avascular hypoxic regions with non-proliferating cells, which can regenerate tissue after nanoparticle-delivered cytotoxicity or thermal ablation. In this study, gold nanoparticles were functionalized with phosphatidylcholine (two-layer) or phosphatidylcholine and HDL (three-layer) in the formation of “layered” nanoparticles. The diffusivity of both two- and three layered colloidal gold nanoparticles and silica gold nanoshells were examined in 3D cell …

Enzyme Kinetics : 6-Phosphofructo-2-Kinase/2,6-Bisphosphatase., Jennifer Clark

Electronic Theses and Dissertations

Altered energy metabolism is an established hallmark of cancer cells. Fructose-2,6-bisphosphate is an allosteric activator of glycolysis and its concentration in a cell is dictated by the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4) family of bifunctional enzymes. The PFKFB family of enzymes are characterized by their different kinase: bisphosphatase activities and were originally determined to be tissue-specific. More recent data however suggest that multiple isoforms are co-expressed in both normal and neoplastic tissues. PFKFB4 is highly expressed in human cancer, strongly induced by hypoxia, and required for the survival of cancer cells. However, it remains unclear whether the kinase or phosphatase activity of human …

Avoidance In Disordered Eating : The Roles Of Overvaluation Of Weight And Shape And Repetitive Thinking., Anne Christine Bjerg

Electronic Theses and Dissertations

Disordered eating is associated with several negative outcomes and often lead to diagnosable eating disorders. The coping strategies used by those with disordered eating may contribute to such consequences. Past research has found experiential avoidance to be common among those with disordered eating to escape uncomfortable internal experiences. The current study suggested that repetitive thinking and overvaluation of weight and shape are two such mechanisms by which avoidance of negative core beliefs, in particular, is achieved. It was hypothesized that eating disorder symptoms, negative core beliefs, experiential avoidance, overvaluation of weight and shape and repetitive thinking would all be positively …

Graduate Students Who Are Part-Time Workers : How Does Occupational Stress And Gender Role Affect Job Satisfaction?, Megan Church-Nally

Electronic Theses and Dissertations

Job satisfaction and occupational stress have consistently been examined in professionals for decades due to its link to turnover and reduced productivity. Similar concepts have been investigated in undergraduate students, but there is paucity of research of attrition in graduate students. This gap persists despite estimates that 50% of graduate students fail to graduate (Cassuto, 2013). Such attrition is not due to deficiency in academic skills, as Carroll, Ng, and Birch (2009) reported that personal reasons were cited more than academic concerns for attrition. The purpose of this dissertation was to address this job satisfaction and occupational stress gap with …

Classification Of Clinical Outcomes Using High-Throughput And Clinical Informatics., Alexander Carswell Cambon

Electronic Theses and Dissertations

It is widely recognized that many cancer therapies are effective only for a subset of patients. However clinical studies are most often powered to detect an overall treatment effect. To address this issue, classification methods are increasingly being used to predict a subset of patients which respond differently to treatment. This study begins with a brief history of classification methods with an emphasis on applications involving melanoma. Nonparametric methods suitable for predicting subsets of patients responding differently to treatment are then reviewed. Each method has different ways of incorporating continuous, categorical, clinical and high-throughput covariates. For nonparametric and parametric methods, …

Evaluating The Effects Of Aroclor 1260 In Non-Alcoholic Fatty Liver Disease : The Role Of Xenobiotic Receptors., Banrida Wahlang

Electronic Theses and Dissertations

Polychlorinated biphenyls (PCBs) are persistent environmental toxicants, present in 100% of US adults and dose-dependently associated with nonalcoholic fatty liver disease (NAFLD) in epidemiologic studies. PCBs are predicted to interact with receptors previously implicated in xenobiotic/energy metabolism and NAFLD. These receptors include the aryl hydrocarbon receptor (AhR), pregnane xenobiotic receptor (PXR), constitutive androstane receptor (CAR), peroxisome proliferator-activated receptors (PPARs), liver-X-receptor and farnesoid-X-receptor. This study evaluated the hepatic effects of the PCB mixture, Aroclor 1260, whose composition mimics human bioaccumulation patterns, in a mouse model of diet-induced obesity. Male C57Bl/6J mice were fed a control or 42% high fat diet (HFD) …