Digital Commons Network^™

Capacity Building In Stakeholders Around Detroit Riverfish Consumption Advisory Issues, Donna R. Kashian, Ann E. Krause, Larissa Sano, Branda Nowell, Ken G. Drouillard

Environmental Science and Geology Faculty Research Publications

The Detroit River is an international water body that has several fish consumption advisories for contaminants that affect human health and economic revenue for the USA and Canada. Despite the importance of these advisories, little progress has been made in developing effective management strategies or coordinating monitoring, research, and policy efforts between the 2 nations. We engaged 44 stakeholder organizations to in- crease community capacity on these issues for the Detroit River. We assessed capacity with key informant interviews and a network survey. Our analysis identified weak ties in information sharing and collaboration between countries. We used this information to …

Factors Influencing Breast Cancer Screening In Low-Income African Americans In Tennessee, Kushal Patel, Mohamed Kanu, Jianguo Liu, Brea Bond, Elizabeth Brown, Elizabeth Williams, Rosemary Theriot, Stephanie Bailey, Maureen Sanderson, Margaret Hargreaves

Public Health, Health Administration, and Health Sciences Faculty Research

This study examined demographic and lifestyle factors that influenced decisions and obstacles to being screened for breast cancer in low-income African Americans in three urban Tennessee cities. As part of the Meharry Community Networks Program (CNP) needs assessment, a 123-item community survey was administered to assess demographic characteristics, health care access and utilization, and screening practices for various cancers in low-income African Americans. For this study, only African American women 40 years and older (n = 334) were selected from the Meharry CNP community survey database. There were several predictors of breast cancer screening such as marital status and having …

Responding To A Forest Catastrophe: The Emergence Of New Governance Arrangements In Southern California, Brian Peterson, Adam Wellstead

Department of Social Sciences Publications

The San Bernardino National Forest in southern California experienced an unprecedented bark beetle outbreak in the early 2000s. The outbreak, coupled with a looming threat of catastrophic wildfire, droughts, changing forest management priorities, and a legacy of poor forest management practices coalesced to create a challenge that existing institutions and management agencies could not address. In response, an interagency collaborative effort, the Mountain Area Taskforce (MAST), was initiated. Based on key informant interviews, this paper details how this new governance organization emerged and how it effectively addressed a landscape scale forest challenge. Forest governance analyses often focus attention on macroscales, …

Dynamic Association Of Mortality Hazard With Body Shape, Nir Y. Krakauer, Jesse C. Krakauer

Publications and Research

Background A Body Shape Index (ABSI) had been derived from a study of the United States National Health and Nutrition Examination Survey (NHANES) 1999–2004 mortality data to quantify the risk associated with abdominal obesity (as indicated by a wide waist relative to height and body mass index). A national survey with longer follow-up, the British Health and Lifestyle Survey (HALS), provides another opportunity to assess the predictive power for mortality of ABSI. HALS also includes repeat observations, allowing estimation of the implications of changes in ABSI. Methods and Findings We evaluate ABSI z score relative to population normals as a …

February 20, 2014, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Insights Into The Development And Evolution Of Exaggerated Traits Using De Novo Transcriptomes Of Two Species Of Horned Scarab Beetles, Ian A. Warren, J. Cristobal Vera, Annika Johns, Robert Zinna, James H. Marden, Douglas J. Emlen, Ian Dworkin, Laura C. Lavine

Biological Sciences Faculty Publications

Scarab beetles exhibit an astonishing variety of rigid exo-skeletal outgrowths, known as ‘‘horns’’. These traits are often sexually dimorphic and vary dramatically across species in size, shape, location, and allometry with body size. In many species, the horn exhibits disproportionate growth resulting in an exaggerated allometric relationship with body size, as compared to other traits, such as wings, that grow proportionately with body size. Depending on the species, the smallest males either do not produce a horn at all, or they produce a disproportionately small horn for their body size. While the diversity of horn shapes and their behavioural ecology …

Curricular Affairs Committee Report #512, University Of Rhode Island Faculty Senate

Faculty Senate Committee Reports and Appendices

No abstract provided.

As Majors Are Pathways In New Heritage College Of Osteopathic Medicine Eap, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Global Analysis Of Lysine Acetylation Suggests The Involvement Of Protein Acetylation In Diverse Biological Processes In Rice (Oryza Sativa)., Babi Ramesh Reddy Nallamilli, Mariola J. Edelmann, Xiaoxian Zhong, Feng Tan, Hana Mujahid, Jian Zhang, Bindu Nanduri, Zhaohua Peng

CALS Publications

Lysine acetylation is a reversible, dynamic protein modification regulated by lysine acetyltransferases and deacetylases. Recent advances in high-throughput proteomics have greatly contributed to the success of global analysis of lysine acetylation. A large number of proteins of diverse biological functions have been shown to be acetylated in several reports in human cells, E.coli, and dicot plants. However, the extent of lysine acetylation in non-histone proteins remains largely unknown in monocots, particularly in the cereal crops. Here we report the mass spectrometric examination of lysine acetylation in rice (Oryza sativa). We identified 60 lysine acetylated sites on 44 proteins of diverse …

The Influence Of Early Childhood Program Participation On Academic Achievement At The Elementary Level, Gina Marie Villani

Seton Hall University Dissertations and Theses (ETDs)

The purpose of this study was to examine the influence of early childhood program participation on academic achievement by grade 3. This case study utilized a quantitative approach to data collection. For purposes of this research, one P-12 school district in central New Jersey was studied to look at the influence of early childhood program participation on academic achievement as measured by the NJ ASK 3. A quantitative approach to this research was used to remove opinions and perceptions from the data collection. Quantitative data was collected through demographic information and NJ ASK 3 results for students who participated in …

The Role Of Prototype Learning In Hierarchical Models Of Vision, Michael David Thomure

Dissertations and Theses

I conduct a study of learning in HMAX-like models, which are hierarchical models of visual processing in biological vision systems. Such models compute a new representation for an image based on the similarity of image sub-parts to a number of specific patterns, called prototypes. Despite being a central piece of the overall model, the issue of choosing the best prototypes for a given task is still an open problem. I study this problem, and consider the best way to increase task performance while decreasing the computational costs of the model. This work broadens our understanding of HMAX and related hierarchical …

Be On The Lookout Amphibians Crossing The Road, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Targeting Iga Antibody Responses To Mucosal Tissues Through Chemokine Receptor Manipulation, Eric Wilson

Journal of Undergraduate Research

Proper functioning of cells of the immune system is highly dependent on their efficient accumulation to tissues where infection may occur. These cells migrate throughout the body to sites of possible infection via arteries and blood vessels, much like commuters travel to their places of employment via highways and city streets. Just as commuters must take the appropriate off-ramps to get to their desired destination and then enter their work place, white blood cells must also exit the blood vessels of the body at appropriate locations and enter their destination tissues to effectively protect the host from infection.

Optically Significant Particle Sizes In Seawater, Emlyn J. Davies, David Mckee, David Bowers, George W. Graham, W. Alex M. Nimmo-Smith

School of Biological and Marine Sciences

Small particles (<10 μm) are often considered to play the dominant role in controlling scattering and absorption due to their relatively large numbers, which are typically found in the ocean. Here we present an approach for quantifying the size range of particles that contribute significantly to bulk inherent optical properties. We present a numerical assessment of the variability in optically significant particle sizes for simplistic populations that conform to the assumptions of homogeneous, spherical particles, and power-law size distributions. We use numerical predictions from Mie theory to suggest minimum and maximum particle sizes required for accurate predictions and observations of ocean optics for different particle size distributions (PSDs). When considering observed ranges of PSDs, our predictions suggest the need for measurements of optical properties and particles to capture information from particle sizes between diameters of 0.05-2000 μm in order to properly constrain relationships between particles and their associated optical properties. Natural particle populations in the ocean may present more complex PSDs that could be analyzed using the method presented here to establish optically significant size classes.

Creating Student-¬‐Experts In Hydroecology, Richard Gill

Journal of Undergraduate Research

The National Research Council, in its report on how people learn, identified key differences between novices and experts (Bransford et al. 2000; Donovan and Bransford 2005). One of the grand challenges of education is to shepherd students through the process of becoming experts. Mentored research experiences are a critical component of this process as students “grow in skills and increase in responsibility” (Mentoring Principle #3) and participate in projects that “extend well beyond the routine” and “[develop] of new concepts of learning” (Mentoring Principle #5). Bransford et al. (2000) emphasized that developing into an expert requires, among other things, (1) …

C. Elegans Cep-1/P53 And Bec-1 Are Involved In Dna Repair, Sandy Hoffman, Daniel Martin, Alicia Meléndez, Jill Bargonetti

Publications and Research

p53 is a transcription factor that regulates the response to cellular stress. Mammalian p53 functions as a tumor suppressor. The C. elegans p53, cep-1, regulates DNA-damage induced germline cell death by activating the transcription of egl-1 and ced-13. We used the C. elegans model to investigate how, in the whole animal, different forms of DNA damage can induce p53-dependent versus p53-independent cell death and DNA repair. DNA damage was induced by ultraviolet type C (UVC) radiation, or 10-decarbamoyl mitomycin C (DMC, an agent known to induce mammalian p53-independent cell death). Wild-type or cep-1 loss-of-function mutant animals were assayed for germline …

Pfkfb3 Regulates Oxidative Stress Homeostasis Via Its S-Glutathionylation In Cancer, Minsuh Seo, Yong Hwan Lee

Faculty Publications

Whereas moderately increased cellular oxidative stress is supportive for cancerous growth of cells, excessive levels of reactive oxygen species (ROS) are detrimental to their growth and survival. We demonstrated that high ROS levels, via increased oxidized glutathione (GSSG), induce isoform-specific S-glutathionylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) at residue Cys206, which is located near the entrance to the 6-phosphofructo-2-kinase catalytic pocket. Upon this ROS-dependent, reversible, covalent modification, a marked decrease in its catalytic ability to synthesize fructose-2,6-bisphosphate (Fru-2,6-P2), the key glycolysis allosteric activator, was observed. This event was coupled to a decrease in glycolytic flux and an increase in glucose metabolic flux …

A Randomized Trial Of Bevacizumab For Newly Diagnosed Glioblastoma., Mark R Gilbert, James J Dignam, Terri S Armstrong, Jeffrey S Wefel, Deborah T Blumenthal, Michael A Vogelbaum, Howard Colman, Arnab Chakravarti, Stephanie Pugh, Minhee Won, Robert Jeraj, Paul D Brown, Kurt A Jaeckle, David Schiff, Volker W Stieber, David G Brachman, Maria Werner-Wasik, Ivo W Tremont-Lukats, Erik P Sulman, Kenneth D Aldape, Walter J Curran, Minesh P Mehta

Department of Radiation Oncology Faculty Papers

BACKGROUND: Concurrent treatment with temozolomide and radiotherapy followed by maintenance temozolomide is the standard of care for patients with newly diagnosed glioblastoma. Bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor A, is currently approved for recurrent glioblastoma. Whether the addition of bevacizumab would improve survival among patients with newly diagnosed glioblastoma is not known.

METHODS: In this randomized, double-blind, placebo-controlled trial, we treated adults who had centrally confirmed glioblastoma with radiotherapy (60 Gy) and daily temozolomide. Treatment with bevacizumab or placebo began during week 4 of radiotherapy and was continued for up to 12 cycles of maintenance chemotherapy. …

Panther - February 2014 - Vol. Xciv No. 13, Prairie View A&M University

PV Panther Newspapers

No abstract provided.

State V. Orellana-Castro Appellant's Brief Dckt. 41358

Not Reported

No abstract provided.

The Alestle - Vol. 66 No. 22 - 02/20/2014, Southern Illinois University Edwardsville

The Alestle

Vol. 66 No. 22

A Modified Generalized Fisher Method For Combining Probabilities From Dependent Tests., Hongying Dai, J Steven Leeder, Yuehua Cui

Manuscripts, Articles, Book Chapters and Other Papers

Rapid developments in molecular technology have yielded a large amount of high throughput genetic data to understand the mechanism for complex traits. The increase of genetic variants requires hundreds and thousands of statistical tests to be performed simultaneously in analysis, which poses a challenge to control the overall Type I error rate. Combining p-values from multiple hypothesis testing has shown promise for aggregating effects in high-dimensional genetic data analysis. Several p-value combining methods have been developed and applied to genetic data; see Dai et al. (2012b) for a comprehensive review. However, there is a lack of investigations conducted for dependent …

Structure And Composition Of Old-Growth And Unmanaged Second-Growth Riparian Forests At Redwood National Park, Usa, Christopher R. Keyes, Emily K. Teraoka

Forest Management Faculty Publications

Restoration of second-growth riparian stands has become an important issue for managers of redwood (Sequoia sempervirens [D. Don] Endl.) forest reserves. Identifying differences between old-growth and second-growth forest vegetation is a necessary step in evaluating restoration needs and targets. The objective of this study was to characterize and contrast vegetation structure and composition in old-growth and unmanaged second-growth riparian forests in adjacent, geomorphologically similar watersheds at Redwood National Park. In the old-growth, redwood was the dominant overstory species in terms of stem density, basal area, and importance values. Second-growth was dominated by red alder (Alnus rubra Bong.), …

The East Texan, 2014-02-20, Texas A&M University-Commerce

All Issues

A color copy of The East Texan, a student newspaper published at Texas A&M University-Commerce.

Nuclear Receptor 4a3 (Nr4a3) Regulates Murine Mast Cell Responses And Granule Content, Gianni Garcia-Faroldi, Fabio R. Melo, Dennis Bruemmer, Orla M Conneely, Gunnar Pejler, Anders Lundequist

Internal Medicine Faculty Publications

Nuclear receptor 4a3 (Nr4a3) is a transcription factor implicated in various settings such as vascular biology and inflammation. We have recently shown that mast cells dramatically upregulate Nuclear receptor 4a3 upon activation, and here we investigated the functional impact of Nuclear receptor 4a3 on mast cell responses. We show that Nuclear receptor 4a3 is involved in the regulation of cytokine/chemokine secretion in mast cells following activation via the high affinity IgE receptor. Moreover, Nuclear receptor 4a3 negatively affects the transcript and protein levels of mast cell tryptase as well as the mast cell’s responsiveness to allergen. Together, these findings identify …

Luna Tunes, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Identifying The Effect Of Open Access On Citations Using A Panel Of Science Journals, Mark J. Mccabe, Christopher M. Snyder

Dartmouth Scholarship

An open‐access journal allows free online access to its articles, obtaining revenue from fees charged to submitting authors or from institutional support. Using panel data on science journals, we are able to circumvent problems plaguing previous studies of the impact of open access on citations. In contrast to the huge effects found in these previous studies, we find a more modest effect: moving from paid to open access increases cites by 8% on average in our sample. The benefit is concentrated among top‐ranked journals. In fact, open access causes a statistically significant reduction in cites to the bottom‐ranked journals in …

The Montclarion, February 20, 2014, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

The Colby Echo (2014-02-20), Colby College

The Colby Echo

Published by the students of Colby College since 1877, The Colby Echo is the weekly, editorially independent student-run newspaper of Colby College in Waterville, Maine. Published monthly, 1877-1886; semi-monthly, 1886-1897; and weekly, during the academic year, 1898-present.

Faculty Senate Meeting Minutes February 20, 2014, University Of Rhode Island Faculty Senate

Faculty Senate Meeting Minutes

No abstract provided.