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A Highly Adaptive And Cost Effective Second Generation Incubator (Sgi) Towards Educational, Research And Clinical Processes, Yassir H. Al-Sayagh

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Today´s rising demand for more reliable and affordable alternatives to organ transplant has led to a growing market for in vitro tissue culture systems. The main objective of tissue engineering as a whole is to employ human tissue equivalents for commercial use. The state-of-the-art processes for producing these so called tissue models are still very expensive, difficult to produce and time-consuming.

To engineer tissues, in vitro, a three-dimensional support structure commonly termed scaffold is needed. Stem cells are then added to the scaffold. In order for tissue to materialize, the scaffold and the cells must be incubated (cultured) at a …

Obesity Among Young American Indian Adults In North Dakota, Abby Omahen

All-Inclusive List of Electronic Theses and Dissertations

Obesity among American Indian young adults is a significant health problem. There is an increase in the prevalence rate of diseases associated with obesity which tend to have high medical costs and high mortality rates. Fruit and vegetable consumption, exercise, gender and education are factors which could affect obesity among American Indians. Therefore, the primary purpose of the current study was to determine if there was an association between certain factors (fruit and vegetable consumption, exercise, gender and education level) and obesity among young American Indian adults in North Dakota. The secondary purpose was to determine if there was a …

“Aho! All My Relations:” Native Identity And Its Relationship To Psychological Well-Being, Jamie Ramsey

All-Inclusive List of Electronic Theses and Dissertations

This is the first known study to examine the relationship between Native identity and psychological well-being, which is defined by Ryff in positive psychology as existential strengths. It is also the first known study to investigate the relationship between Native identity and blood quantum through quantitative measures. Overall, 199 Natives from two American Indian Centers, three Indiana powwows, and online from Facebook participated by completing the Ryff’s Scales of Psychological Well-being, Phinney’s Multigroup Ethnic Identity Measure, and demographic information. The main hypothesis was to explore whether any of the psychological well-being subscales (positive relations, autonomy, mastery of environment, self-acceptance, personal …

Culture In Solution-Focused Consultation: An Intercultural Approach*, Gale Miller

Journal of Solution Focused Practices

I develop an intercultural approach to Solution-Focused consultation in this pa­ per. The approach represents an anthropological-sociological interpretation and is written by an interested outsider to the Solution-Focused world. The analysis stresses how multicultural concerns permeate Solution-Focused consultations as practitioners and clients draw from other cultures in which they participate. Prac­titioner-client interactions are treated as negotiations that turn on participants' intercultural competencies, that is, their ability to navigate between their own cultural orientations and those of others involved in consultations. An explanation of how my intercultural perspective extends cultural themes in the Solution-Fo­cused literature is discussed and an illustration of …

Site-Specific Mutation Of The Sensor Kinase Gras In Staphylococcus Aureus Alters The Adaptive Response To Distinct Cationic Antimicrobial Peptides, Ambrose L. Cheung, Arnold S. Bayer, Michael R. Yeaman, Yan Q. Xiong, Alan J. Waring, Guido Memmi, Niles Donegan

Dartmouth Scholarship

The Staphylococcus aureus two-component regulatory system, GraRS, is involved in resistance to killing by distinct host defense cationic antimicrobial peptides (HD-CAPs). It is believed to regulate downstream target genes such as mprF and dltABCD to modify the S. aureus surface charge. However, the detailed mechanism(s) by which the histidine kinase, GraS, senses specific HD-CAPs is not well defined. Here, we studied a well-characterized clinical methicillin-resistant S. aureus (MRSA) strain (MW2), its isogenic graS deletion mutant (ΔgraS strain), a nonameric extracellular loop mutant (ΔEL strain), and four residue-specific ΔEL mutants (D37A, P39A, P39S, and D35G D37G D41G strains). The ΔgraS and …

Biochemical Characterization Of Sbip-470 And Its Role In Sa-Mediated Signaling In Plants, Danda P. Chapagai

Electronic Theses and Dissertations

Salicylic acid binding protein 2 (SABP2) is known to play a key role in Salicylic acid mediated defense pathway. SBIP-470 is SABP2 interacting protein that might be putatively involved in transfer of lipids. SBIP-470 was cloned without the signal peptide and expressed in E. coli. In vitro lipid binding assay using recombinant SBIP-470 failed to detect lipid binding. In vitro lipid transfer assay showed recombinant SBIP-470 does not transfer phospholipid. Study has shown that SBIP-470 is highly inducible upon infection with viral as well as bacterial pathogens. Induction of SBIP-470 expression upon the TMV infection most likely depends upon …

Developing Thinking In L2 Speaking: Evidence From Spatial-Temporal System In Chinese And English Learners, Pei-Ni Causarano

Linguistics ETDs

Spatial and temporal expressions cross-linguistically are metaphorical can present a difficult challenge during second language acquisition. This dissertation expands on Slobins (1996) study of 'first-language thinking in second-language speaking,' and applies linguistic relativity theory and Vygotsky's theory on thought and language to investigate how L1 thinking influences L2 speaking in Chinese native speakers learning English and English native speakers learning Chinese. It examines (a) habitual language use of spatial and temporal referents cross-linguistically and (b) dynamic changes of spatial and spatial-temporal expressions in L2 learners across proficiency levels. Some 41 CLLs and ELLs at four proficiency levels participated in this …

Dna Chemical Reaction Network Design Synthesis And Compilation, M. Leigh Fanning

Computer Science ETDs

The advantages of biomolecular computing include 1) the ability to interface with, monitor, and intelligently protect and maintain the functionality of living systems, 2) the ability to create computational devices with minimal energy needs and hazardous waste production during manufacture and lifecycle, 3) the ability to store large amounts of information for extremely long time periods, and 4) the ability to create computation analogous to human brain function. To realize these advantages over electronics, biomolecular computing is at a watershed moment in its evolution. Computing with entire molecules presents different challenges and requirements than computing just with electric charge. These …

Combating The Motivational Interference Potential Of Technological Distractions During Academic Tasks: The Role Of Academic Delay Of Gratification, Abraham E. Flanigan

College of Education and Human Sciences: Dissertations, Theses, and Student Research

The presence of technological distractions during homework and study diminishes students’ ability to self-regulate effectively, a phenomenon known as motivational interference. To date, no studies have explored the relationship between college students’ delay of gratification tendencies and motivational interference. Do students with greater delay of gratification tendencies experience less motivational interference from a potential distraction? The present study explored this question by comparing students’ academic delay of gratification tendencies with their experiences of motivational interference. Participants self-reported their delay of gratification tendencies then completed an academic task while confronted with a computer distractor. Afterward, participants self-reported their motivational interference scores. …

The Effect Of Agricultural Practices On Sugar Beet Root Aphid (Pemphigus Betae Doane) And Beneficial Epigeal Arthropods, Rudolph J. Pretorius

Department of Entomology: Dissertations, Theses, and Student Research

This study investigated the effect of several agricultural practices on the sugar beet root aphid (Pemphigus betae Doane) and beneficial epigeal natural enemies in western Nebraska sugar beet agroecosystems. Eight glyphosate-tolerant sugar beet varieties were evaluated under field conditions for their resistance to root aphids. High levels of aphid resistance were detected for some varieties. In conjunction to this, pitfall sampling was conducted to determine the beneficial epigeal natural enemy complex in the area, which could contribute to the management of both root aphids and glyphosate-resistant weeds. Ground beetles comprised an important and abundant component of this fauna, with …

Influences On Student Attitudes About U.S. Involvement In Nation-Building, Tobin C. Beck

Department of Political Science: Dissertations, Theses, and Student Research

How do college students form opinions about a complex foreign policy issue such as U.S. involvement in nation-building? My study shows that in 2012, students identifying as conservative tended to support nation-building in proportion to their perception of the strength of their own and their parents' conservatism. The association between perception of conservatism and support for nation-building was statistically significant in 2012, although there was no statistically significant overall association between student political ideology and support for U.S. involvement in nation-building. However, a relationship between conservative student perception of ideology and support for nation-building was not detected in 2011 data. …

Contextualizing Couples: Three Essays On Inequality, Stress, And Dyadic Functioning As A Longitudinal And Reciprocal Process, Deadric T. Williams

Department of Sociology: Dissertations, Theses, and Student Research

In this dissertation, I use an integrated theoretical and conceptual model that consists of several theoretical frameworks to examine the following questions: (1) is there a longitudinal and reciprocal association between parental stress/distress and dyadic functioning? (2) does the association change over time? (3) does the association vary across social contexts (e.g., marital status, race/ethnicity, and poverty)? In order to explore these questions, I use longitudinal and dyadic data from the Fragile Families and Child Well-being Study, which follows a cohort of children and their parents from birth to five years of age. Through three separate analytic studies, the results …

Carbohydrate Metabolism And The Trehalose Biosynthetic Pathway In Maize Kernels Grown In Vitro Under Sucrose Starvation Stress, Samuel W. Bledsoe

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Drought is an increasing issue that many farmers encounter especially in hot arid climates with little rainfall. High temperatures and inadequate rainfall at certain stages in crop development can have disastrous consequences to yield. In maize, drought occurring near or during the flowering stage often causes significant kernel abortion that greatly impacts potential yield. The trehalose biosynthetic pathway has recently been found to be important in plant metabolism in response to stress in higher order plants. Trehalose is currently known throughout the plant and animal kingdoms as an osmoprotectant, high energy fuel source, structural component, and involved in pathogen response. …

Development And Application Of Combined Quantum Mechanical And Molecular Mechanical Methods, Rui Lai

Department of Chemistry: Dissertations, Theses, and Student Research

Compromising of computational cost and accuracy, combined quantum mechanical and molecular mechanical (QM/MM) methods are practical methods for studying large molecular systems. The use of induced dipole polarizable force fields can significantly improve the accuracy of MM and QM/MM methods. However, induced dipole models tend to overestimate the polarization energy at short interaction distances. Damping functions can be applied to reduce the over polarization. MM-MM damping schemes have been developed to correct the overestimated polarization between MM atoms; QM-MM damping scheme has not been developed. In this thesis, a QM-MM damping scheme is developed for the damping of the MM …

The Crebh In Hepatic Lipid And Lipoprotein Metabolism: Implication For The Pathogenesis Of Hyperlipidemia And Metainflammation, Miaoyun Zhao

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

Hyperlipidemia is reemerging as an important cardiovascular disease risk factor and other metabolic disorders, such as obesity, insulin resistance and type-2 diabetes. Hepatic de novo lipogenesis is controlled by a family of the b-zip transcription factors, the sterol regulatory element-binding proteins (SREBPs), which targets downstream genes involved in free fatty acids, triglycerides and cholesterol synthesis. Regulation of SREBPs signaling is controlled by a cluster of the ER membrane-bound proteins, the insulin induced gene-1(Insig-1) and gene-2 (Insig-2) and the SCAP protein. The cAMP responsive element binding protein H (CREBH) is a recently identified member of this family. CREBH is selectively and …

Dynamic Hip Screw Fixation For Inter-Trochanteric Fractures: Determinants Of Outcomes, Adil Aijaz Shah, Santosh Kumar, Abdull Rehman

Department of Surgery Docs

bstract

OBJECTIVE:

To evaluate factors associated with revision of dynamic hip screw implant in patients undergoing the procedure for the fixation of intertrochanteric fractures.

METHODS:

The retrospective study was conducted at the Aga Khan University Hospital, Karachi, and comprised records of patients who had undergone dynamic hip screw fixation surgery between 2008 and 2012. Medical records and data for all patients were obtained from the medical records office. For all patients, the record files were systematically reviewed using a structured, pre-defined data extraction sheet. SPSS 20 was used statistical analysis.

RESULTS:

Out of 317 patients who had undergone the procedure, …

An Optimal Harvesting Strategy Of A Three Species Syn-Ecosystem With Commensalism And Stochasticity, M. N. Srinivas, A. Sabarmathi, K. S. Reddy, M. A. S. Srinivas

Applications and Applied Mathematics: An International Journal (AAM)

In this paper we have studied the stability of three typical species syn-ecosystem. The system comprises of one commensal S₁ and two hosts S₂ and S₃ . Both S₂ and S₂ benefit S₁ without getting themselves affected either positively or adversely. Further S₂ is a commensal of S₃ and S₃ is a host of both S₁ and S₂. Limited resources have been considered for all the three species in this case. The model equations of the system constitute a set of three first order non-linear ordinary differential equations. …

Cd100 Up-Regulation Induced By Interferon-Α On B Cells Is Related To Hepatitis C Virus Infection, Yu He, Yonghong Guo, Yun Zhou, Ying Zhang, Chao Fan, Guangxi Ji, Yu Wang, Zhiyuan Ma, Jianqi Lian, Chunqiu Hao, Zhi Q. Yao, Zhansheng Jia

ETSU Faculty Works

Objectives: CD100, also known as Sema4D, is a member of the semaphorin family and has important regulatory functions that promote immune cell activation and responses. The role of CD100 expression on B cells in immune regulation during chronic hepatitis C virus (HCV) infection remains unclear. Materials and Methods: We longitudinally investigated the altered expression of CD100, its receptor CD72, and other activation markers CD69 and CD86 on B cells in 20 chronic HCV-infected patients before and after treatment with pegylated interferon-alpha (Peg-IFN-α) and ribavirin (RBV) by flow cytometry. Results: The frequency of CD5+ B cells as well as the expression …

Synthesis And Characterization Of Complex Molecular Assemblies On Surfaces, Nitesh Madaan

Theses and Dissertations

The research presented in this dissertation is focused on the construction of complex molecular structures on planar gold and silicon dioxide surfaces using a variety of surface modification techniques, along with thorough surface characterization at each modification step. The dissertation is structured into six separate chapters. In Chapter 1, an introduction to the importance and implications of molecular level surface modification, commonly employed surface modification methods, and available surface characterization techniques is presented. Chapter 2 shows applications of novel methodologies for the functionalization of gold surfaces using alkane dithiol self-assembled monolayers and thiol-ene click chemistry. The resulting functionalized gold substrates …

Chaperone-Mediated Folding And Assembly Of Β-Propeller Proteins Into Cellular Signaling Complexes, Rebecca L. Plimpton

Theses and Dissertations

G protein signaling depends on the ability of the individual subunits of the G protein heterotrimer to assemble into a functional complex. Formation of the G protein βγ (Gβγ) dimer is particularly challenging because it is an obligate dimer in which the individual subunits are unstable on their own. Recent studies have revealed an intricate chaperone system that brings the Gβ and Gγ subunits together. This system includes the cytosolic chaperonin containing TCP-1 (CCT) and a co-chaperone phosducin-like protein 1 (PhLP1). Two key intermediates in the Gβγ assembly process, the Gβ-CCT and the PhLP1-Gβ-CCT complexes, were isolated and their structures …

A Study Of The American Black Bear (Ursus Americanus) In Utah: An Analysis Of The Post-Denning Activities And Bear-Human Conflict, Julie Ann Miller

Theses and Dissertations

This study examined two different aspects of black bear (Ursus americanus) ecology in Utah. First, we determined the post-denning behaviors of female black bears in order to help management agencies protect bears from human disturbances as well as set spring hunts that minimize the taking of females with dependent young. We looked at the timing of den emergence (X = 25 March), the number of days at the den site post emergence (X = 11 days), and departure (X = 8 April) for female black bears in Utah from 2011—2013. We also analyzed the effects of cohort (lone …

Measuring The Role Of Inhibition In Auditory Discrimination In Mice, Tazima Nur

Graduate Theses and Dissertations

Understanding how inhibitory neurons affect sensory information processing in the cerebral cortex is an ongoing goal of both neuroscience and statistical physics research. In this master's thesis research project, an experimental system has been designed and built for studying how auditory dynamic range depends on inhibitory neurons, based on observations of mouse behavior. In this thesis, firstly, the topic of inhibition and information processing has been introduced. Then two papers related to inhibition and dynamic range has been reviewed in detail. One of the papers is an experimental work that analyzes the affect of inhibition on dynamic range. The other …

A Comparison Of Learning In Dual Credit Introductory College Physics, Eric L. Thies

Boise State University Theses and Dissertations

Dual credit courses have been offered for over fifty years and have helped students save time and money during their college education. However, little has been done to study the quality of the dual credit courses themselves. The literature is unclear about whether students in dual credit programs learn the same material as the students enrolled in the same course at the university level.

The purpose of my study was to determine whether students in a concurrent enrollment introductory physics course achieve the same knowledge growth as university students enrolled in the same physics course. I used the Force Concept …

Jeane Kirkpatrick And Neoconservatism: The Intellectual Evolution Of A Liberal, Bianca Joy Rowlett

Graduate Theses and Dissertations

Dr. Jeane J. Kirkpatrick, a leading voice in the neoconservative movement, is best known for her articulation of the Kirkpatrick Doctrine, distinctions between authoritarian and totalitarian regimes that served as the foundation for the Reagan Administration's Latin American policies. Her prominence within the neoconservative movement, her impact on foreign affairs, and her political accomplishments in a masculine environment make her an important historical figure in recent American domestic and diplomatic history. This work explores her transition from liberal democrat to neoconservative by examining her early life and educational background, her publications and critiques of American diplomacy in the 1970s, along …

A Comparison Of Fifth Grade Mathematics Curriculum Materials, Michael E. Starks Sr.

Dissertations

In the USA, the No Child Left Behind Act of 2001 resulted in requirements placed on school districts to show student achievement in mathematics, based on measured adequate yearly progress. This caused school districts to search for standards based programs that improve mathematics learning. A quantitative multi-year study was used to compare the state-assessed achievement levels of 1,695 fifth-grade Midwestern children in the state of Missouri, who learned mathematics from two different curriculum-delivery programs, EveryDay Mathematics and EnVision Mathematics. A 2 by 2 by 8 research design was used through the choice of two elementary schools using EveryDay Mathematics and …

Book Reviews: Monographic Musings, Debbie Vaughn

Against the Grain

No abstract provided.

Bibliography For Work In Ecocriticism, Zümre Gizem Yılmaz

CLCWeb: Comparative Literature and Culture

No abstract provided.

Effective Instructional Strategies Utilized In Successful And High Performing Secondary Schools In The Southern Region Of Mississippi, Jeanifer Lynn Pearson

Dissertations

The schools in the United States have implemented measures intended to close the achievement gap for over fifty years (Solomon, 2009). The mandates handed down by the federal government cannot be altered. Therefore, schools are required to determine specific measures that increase student academic success. Prior research has demonstrated that schools can be successful if effective leadership at the district, school, and classroom level was present (Gregory, 2003; Johnson, Livingston, & Schwartz, 2000). At the classroom level, it was the leadership of the individual teacher to determine the creation of innovative techniques aimed at academic success of all students (Farr …

Utilization Of Aqueous Raft Prepared Copolymers To Improve Anticancer Drug Efficacy, Andrew Christopher Holley

Dissertations

The advent of controlled radical polymerization (CRP) techniques, along with advancements in facile conjugation chemistry, now allow synthetic tailoring of precise, polymeric architectures necessary for drug/gene delivery. Reversible addition- fragmentation chain transfer (RAFT) polymerization and its aqueous counterpart (aRAFT) afford quantitative control over key synthetic parameters including block length, microstructure, and placement of structo-pendent and structo-terminal functionality for conjugation of active agents and targeting moieties. The relevance of water-soluble and amphiphilic (co)polymers synthesized by RAFT for in vitro delivery of therapeutics in biological fluids is an especially attractive feature. In many cases, polymerization, binding, conjugation, …

Online Versus Face-To-Face Biology: A Comparison Of Student Transactional Distance, Approach To Learning, And Knowledge Outcomes, Mary Erin Riggins

Dissertations

Community colleges are among many other institutions increasing course offerings online, but there is still some concern about the quality of online learning. Educator concerns, a lack of empirical evidence on biology courses offered online, and the need for an equal opportunity for education support the need for clarification of the quality of distance education in biology, especially in the community college setting. Student attitudes, approaches to learning, and performance should all be studied in order to formulate a better evaluation of the quality and effectiveness of online courses (Svirko & Mellanby, 2008).

The purpose of this study was to …