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Development Of A Molecular Method For Detecting The Causative Agent Of Swimmer's Itch (Trichobilharzia) In Freshwater Ecosystems, Heidi Mcmaster

UNLV Theses, Dissertations, Professional Papers, and Capstones

Cercarial dermatitis, commonly known as swimmer's itch, is caused by penetration of larvae of the schistosome,Trichobilharzia, into the dermis and epidermis layers of the skin. Symptoms are characterized by painful swelling and itching at the site of penetration. The normal hosts for the life cycle of the schistosome are aquatic birds and aquatic snails. The most frequently used method of detection forTrichobilharziais microscopy. With increases in the occurrence of cercarial dermatitis outbreaks in freshwater in the Southwestern United States, it is becoming increasingly important to develop and standardize a molecular method for rapid detection that can assist health professionals and …

Determinants Of Head And Neck Cancer Survival In Nevada For 1995-2008, Xiao Q. Li

UNLV Theses, Dissertations, Professional Papers, and Capstones

Head and neck cancer (HNC), also known as oral cavity and pharyngeal cancer, comprises a group of cancers that arise in the head or neck region, such as the nasal cavity, sinuses, lips, mouth, salivary glands, and pharynx. Use of tobacco, alcohol, or a combination of the two, are major risk factors for head and neck cancer. Approximately 75% of oral cancers are attributable to smoking and/or alcohol consumption. More recently, the human papilloma virus (HPV) has also been associated with the development of head and neck cancer.

The objective of the present study is to investigate head and neck …

Sex In The Brain: The Relationship Between Event Related Potentials And Subjective Sexual Arousal, Taylor Lynn Oliver

UNLV Theses, Dissertations, Professional Papers, and Capstones

Research investigating the relationship between subjective sexual arousal and physiological arousal has focused primarily on measures of genital arousal and has yielded only modest concordance rates between genital and subjective sexual arousal in men, and low concordance rates in women. One of the nagging confounds in the literature, however, has been the fact that different assessment methods are necessitated by men and women's differing genital physiology (i.e., vaginal photoplethysmography in women and penile plethysmography in men). This study sought to investigate the relationship between subjective sexual arousal and a different type of physical arousal (brain activation) that could be measured …

Wisc-Iv Profiles In Children With Attention Deficit Hyperactivity Disorder And Comorbid Learning Disabilities, Elyse Parke

UNLV Theses, Dissertations, Professional Papers, and Capstones

Attention Deficit Hyperactivity Disorder (ADHD) and learning disabilities (LD), including Reading Disorder (RD), Disorder of Written Expression (DWE), and Developmental Coordination Disorder (DCD) all co-occur at high rates. Previous research indicates increased neurocognitive impairment in ADHD with the presence of comorbid diagnoses. However, few direct comparisons between intellectual profiles of children with one or multiple ADHD and LD diagnoses are available, specifically for the Wechsler Intelligence Scale Fourth Edition (WISC-IV), despite its frequent and historical use with this population. Profile analysis may contribute insights into spared and impaired abilities. Therefore, the present study addressed these matters by comparing WISC-IV profiles …

Investigating The Physical Properties And Runoff Treatment Capability Of Pervious Concrete Containing Granular Activated Carbon, Mark Elias Elkouz

UNLV Theses, Dissertations, Professional Papers, and Capstones

A current environmental concern is that of urban stormwater runoff, which can carry a multitude of contaminants and could threaten or impair surface waters. Pervious concrete (PC) is a type of concrete with significant void spaces that can facilitate infiltration and lead to less runoff. The EPA cites previous research to show that pervious pavement structures reduce such contaminants as metals and total suspended solids. Since Granular Activated Carbon (GAC) is a well-known contaminant adsorbent, the purpose of this research was to determine if PC with added GAC would result in improved runoff treatment, while still maintaining its material properties. …

Design And Analysis Of Hydrogen Powered Actuator Integrating Metal Hydride Storage System, Md Mainul Hossain Bhuiya

UNLV Theses, Dissertations, Professional Papers, and Capstones

The multi-fold purposes of this dissertation consists of construction, simulation and validation of a model describing hydrogen sorption kinetics in metal hydride. The project involves a comprehensive review of engineering applications involving metal hydrides and furthermore, design and investigation of a thermo-kinetically driven actuation system integrating metal hydrides for compact and soft robotic actuation. This will also shed some light on the feasibility of designing a damping system integrating metal hydride. Firstly, a mathematical model along with comprehensive simulation strategy of hydrogen absorption and desorption processes in porous metal hydride compacts was developed. A two dimensional axisymmetric model was built …

The Relationship Among School Playground Design And Conditions And Physical Activity Levels In Children, Ipuna Estavillo Black

UNLV Theses, Dissertations, Professional Papers, and Capstones

Almost 20% of children aged 6 to 11 years are obese in the United States, tripling over the last ten years. The rise in childhood obesity challenges nurses in their efforts to improve community health and sustainability. A decrease in physical activity (PA) levels has been associated with an increase in obesity. Schools have been identified as a primary setting to provide children adequate amounts of daily PA, and nurses working in the area of child health promotion can work with schools to provide opportunities for children to increase PA levels. The playground is one environment where children can increase …

Cognitive Differences Between High And Low Responders Of A Tier Ii Reading Intervention, Jillian Cohen

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study evaluated a population of young students with potential reading disabilities who participated in a large western school district's Reading Skills Development project from October 2012 to May 2013. The following questions were addressed: Are there cognitive differences between students who respond well to an intense Tier II reading intervention and those who make little progress? If so, which cognitive skills best discriminate between high and low responders? De-identified data was collected from 171 struggling readers in 1st through 3rd grade who participated in the Reading Skills project. After controlling for English proficiency level, high and low responders were …

Scalable, Solar Powered Membrane-Based Water Purification Systems For Community Development In Developing Countries, Yung Wong

Doctoral Dissertations and Master's Theses

This manuscript style thesis presents a community development model developed at Embry-Riddle Aeronautical University (ERAU) to deliver sustainable water purification systems and originate a companion micro-business to sell excess clean water in communities in Haiti. Since 2010, students and faculty from ERAU have partnered with strategic partners to not only provide clean water to their in-country operations but also provide an opportunity for economic growth through a clean water selling micro-business. Water, sanitation, and hygiene (WASH) training is also implemented to aid in community buy-in. Lessons learned from the history of foreign aid to developing countries is taken into account …

Stacking Of A Stearoyl-Acp Thioesterase With A Dual-Silenced Palmitoyl-Acp Thioesterase And Δ12 Fatty Acid Desaturase In Transgenic Soybean, Hyunwoo Park, George L. Graef, Yixiang Xu, Patrick Tenopir, Thomas E. Clemente

Department of Agronomy and Horticulture: Faculty Publications

Soybean (Glycine max (L.) Merr) is valued for both its protein and oil, whose seed is composed of 40% and 20% of each component, respectively. Given its high percentage of polyunsaturated fatty acids, linoleic acid and linolenic acid, soybean oil oxidative stability is relatively poor. Historically food processors have employed a partial hydrogenation process to soybean oil as a means to improve both the oxidative stability and functionality in end-use applications. However, the hydrogenation process leads to the formation of trans-fats, which are associated with negative cardiovascular health. As a means to circumvent the need for the hydrogenation process, genetic …

Olfactory Identification, Detection Thresholds, And Sensitivity In Kidney Disease Patients, Joseph Wesley Jones

Masters Theses and Doctoral Dissertations

While there is evidence for a decline in olfactory identification scores for patients with Kidney Disease, there are contradictory results for detection thresholds. Some results indicate higher thresholds while others found similar thresholds or elevated thresholds for one odorant, but not others. The current study evaluated the olfactory abilities with participants diagnosed with Kidney Disease for numerous odorants. No significant differences were found in olfactory identification, detection thresholds, or sensitivity compared to healthy controls. Despite the non-significant results, there did appear a trend of poorer olfactory abilities in Kidney Disease participants. The differences in olfactory performance also varied from odorant …

Myocyte-Specific Overexpression Of Stromal Cell-Derived Factor 1 Facilitates Cardiac Regeneration And Improves Myocardial Function After Infarction In Mice., Detlef Ernst-Rudolf Obal

Electronic Theses and Dissertations

Background: Interruption of cardiac stromal cell-derived factor 1 (SDF1)-CXCR4 axis by chronic AMD3100 administration increased myocardial injury after permanent coronary artery ligation, demonstrating the important role of this chemokine in cardiac regeneration. Hypothesis: Cardiomyocyte-specific conditional overexpression of SDF prevents heart failure after permanent coronary ligation and facilitates cardiac regeneration. Methods and Results: Tetracycline-controlled, a-myosine heavy chain promoter directed overexpression of cardiac SDF resulted in a significant increase of SDF expression (SDF: 8.1 ng / g protein) compared with littermate WT mice (0.02 ng / g protein) four weeks after doxycycline withdrawal. SDF overexpression increased AKT and casein kinase 1 levels …

Applications Of Gis Analyses And Ecological Approaches To Paleolithic Sites In Portugal., Christopher M. Sims

Electronic Theses and Dissertations

Developments in landscape approaches to archaeological research have been greatly advanced by the use of geospatial technologies. Despite this boon, certain questions remain where the spatial distributions of archaeological material are complicated by other factors. Geomorphic processes significantly hinder site survivability and visibility, and complicate fieldwork. Such is the case for Paleolithic archaeological sites in Portugal, where the current landscape has been drastically altered since Paleolithic human occupation at the Last Glacial Maximum. The challenge to landscape-scale approaches is to provide a bridge between long-term environmental factors and smaller-scale evidence for human-ecosystem interaction. This requires that adaptations be made to …

Preventive Effect Of Non-Mitogenic Acidic Fibroblast Growth Factor On Diabetes-Induced Testicular Cell Death., Melissa Skibba 1990-

Electronic Theses and Dissertations

Fibroblast growth factor (FGF)-1 was found to protect the heart from oxidative damage, but clinically its long-term use was restricted for its undesirable proliferating activity on cells. Thus a cluster of amino acids responsible for the proliferation were deleted in the native FGF-1 to create a non-mitogenic FGF-1 (nmFGF-1). To assess whether nmFGF-1 protects male germ cells from diabetes-induced apoptotic death, the study employed a murine model of diabetes using multiple low-doses of streptozotocin, followed by nmFGF-1 treatment for 6 months. Diabetic mice showed a decrease in testicular weight and an increase in apoptotic cell death. Treatment with nmFGF-1 alleviated …

Live In The Moment: The Essence Of Life, Ta-Wen Huang

Theses

I have thought about the essence of human life ever since I witnessed the impermanence of people's lives through a near-death experience I had when I was nineteen years old. Life is a given amount of time, space, and memory, and every person, event, and object in the universe is stored up in time, space, and memory. These three factors combine to create the unique experience, character, and life of each individual person.

A number of experts from different fields, as well as international celebrities, have publicly expressed various thoughts on life. However, most of their theories are explained with …

Crosslinking Albumin For Drug Release From Spray Dried Particles., Ishita Jain

Electronic Theses and Dissertations

In space, astronauts are exposed to a large doses of ionizing radiation which can cause various health problems. The drug delivery of antioxidants and anti-inflammatory substances is a promising countermeasure for the harmful cellular effects of radiation exposure. Curcumin is a polyphenol derived from the rhizome of the turmeric plant that has strong antioxidant capabilities. The therapeutic potential of this radical scavenging drug is limited by poor uptake in the body due to its insolubility in water, rapid metabolism by the intestinal mucosa and liver, and quick excretion. Drug delivery vehicles can be used to enhance the bioavailability of curcumin. …

Early Detection And Control Of Potential Pandemics., Shengpeng Jin

Electronic Theses and Dissertations

Over the centuries, human beings have been inflicted with a variety of contagious diseases, resulting in tens of millions of respiratory illnesses and deaths worldwide. Early detection of disease spread facilitates timely responses that can greatly reduce its impact on a population. Therefore, this early information is a major public health objective and is crucial for policy makers and public health officials responsible for protecting the public from the spread of contagious diseases. Current indicators of the spread of contagious outbreaks lag behind its actual spread, leaving no time for a planned response. The studies of Christakis et al. in …

Development Of A Light-Powered Microstructure : Enhancing Thermal Actuation With Near-Infrared Absorbent Gold Nanoparticles., Thomas Matthew Lucas

Electronic Theses and Dissertations

Development of microscale actuating technologies has considerably added to the toolset for interacting with natural components at the cellular level. Small-scale actuators and switches have potential in areas such as microscale pumping and particle manipulation. Thermal actuation has been used with asymmetric geometry to create large deflections with high force relative to electrostatically driven systems. However, many thermally based techniques require a physical connection for power and operate outside the temperature range conducive for biological studies and medical applications. The work presented here describes the design of an out-of-plane bistable switch that responds to near-infrared light with wavelength-specific response. In …

Drivers Of Spatial And Temporal Variation In Soybean Yield And Irrigation Requirements In The Western Us Corn Belt, Patricio Grassini, Jessica A. Torrion, Kenneth Cassman, Haishun Yang, James Specht

Department of Agronomy and Horticulture: Faculty Publications

Both rainfed and irrigated soybean production are important in Nebraska (western US Corn Belt), accounting for a respective 48 and 52% of the state’s soybean production of 7 Mt on a respective 55 and 45% share of the state soybean area of 1.9 Mha. To date, no assessment of factors that may account for regional and inter-annual variation in yield and irrigation amount has been performed. To accomplish that objective, we evaluated a database containing on-farm field yields and total irrigation amount used in those fields. These data have been collected annually from ca. 1000 soybean fields in six regions …

Three-Dimensional Modeling Of The Human Jaw/Teeth Using Optics And Statistics., Aly Saber Abdelrahim

Electronic Theses and Dissertations

Object modeling is a fundamental problem in engineering, involving talents from computer-aided design, computational geometry, computer vision and advanced manufacturing. The process of object modeling takes three stages: sensing, representation, and analysis. Various sensors may be used to capture information about objects; optical cameras and laser scanners are common with rigid objects, while X-ray, CT and MRI are common with biological organs. These sensors may provide a direct or an indirect inference about the object, requiring a geometric representation in the computer that is suitable for subsequent usage. Geometric representations that are compact, i.e., capture the main features of the …

Housing First, Neighborhood Second? : The Role Of Housing And Neighborhood Characteristics On Residential Stability In Two Housing First Projects., Carey D. Addison

Electronic Theses and Dissertations

This study examined the impacts of neighborhood and housing type on housing stability for formerly homeless individuals participating in Housing First projects in Louisville, Kentucky, and Cincinnati, Ohio. Both projects operate similarly except that the Louisville project has only scattered-site housing while the Cincinnati project has both project-based and scattered-site housing. The first chapter presents five key research questions that frame the study. Chapter 2 reviews literature on homelessness and policies to address this urban problem with a specific emphasis on Housing First. Chapter 3 proposes qualitative and quantitative methods for answering the proposed research questions. Chapter 4 summarizes findings …

Markers And Mechanisms Of Metabolic Aging., Peter Dziewornu Ahiawodzi

Electronic Theses and Dissertations

Oxidative stress has been implicated in aging and age-related diseases. Using three distinct studies, this dissertation examines associations between lifestyle factors and oxidative stress, and their effects on advanced glycation end products, telomere length, and type II diabetes. Carboxymethyl-lysine (CML), an advanced glycation end-product, has been linked to oxidative stress, cardiovascular and other age-related diseases. The first study investigates the association between sleep disordered breathing (SDB), a source of oxidative stress, and CML. 1002 participants with sleep data from the Cardiovascular Health Study (CHS) were analyzed. SDB was not significantly associated with CML, but after stratification by gender and hemoglobin …

The Role Of Pesticides In Non-Alcoholic Fatty Liver Disease (Nafld)., Laila Al-Eryani 1986-

Electronic Theses and Dissertations

NAFLD, the most common form of liver disease worldwide, is caused by various factors including industrial chemicals and pesticides exposure. Annually, 5.2 billion pounds of pesticides are used worldwide and can contribute to liver disease, but their role is modestly studied. We hypothesize that pesticides contaminating food supply can worsen diet-induced steatosis via xenobiotic receptor activation. Two human and two rodent databases were utilized and 85% of the 330 chemicals identified associated with NAFLD were pesticides. Eight were selected for evaluating hepatic receptor activation in vitro. The majority including DDT activated hPXR/CAR and mPXR. DDT (100 mg/kg) was studied in …

Forecasting Seasonal Hydrologic Response In Major River Basins., A. M. Tanvir Hossain Bhuiyan

Electronic Theses and Dissertations

Seasonal precipitation variation due to natural climate variation influences stream flow and the apparent frequency and severity of extreme hydrological conditions such as flood and drought. To study hydrologic response and understand the occurrence of extreme hydrological events, the relevant forcing variables must be identified. This study attempts to assess and quantify the historical occurrence and context of extreme hydrologic flow events and quantify the relation between relevant climate variables. Once identified, the flow data and climate variables are evaluated to identify the primary relationship indicators of hydrologic extreme event occurrence. Existing studies focus on developing basin-scale forecasting techniques based …

Neutrophils Alter Epithelial Response To Porphyromonas Gingivalis In A Gingival Crevice Model., Jessica Lynn Bondy-Carey 1987-

Electronic Theses and Dissertations

A gingival crevice model (epithelial cell-Porphyromonas gingivalis-neutrophil) was established and used to profile gingipain, matrix metalloproteinase (MMP), MMP mediators [neutrophil gelatinase-associated lipocalin (NGAL) and tissue inhibitor of metalloproteinases 1 (TIMP-1)] and cytokine networks. Smoking is the primary environmental risk factor for periodontitis. Therefore, the influence of cigarette smoke extract (CSE) was also monitored in the same model. Porphyromonas gingivalis alone induced low levels of interleukin-1b and interleukin-8 from epithelial cells, but high levels of both cytokines were produced on the addition of neutrophils. Exposure to CSE (100 and 1000 ng mL1 nicotine equivalency) significantly compromised P. gingivalis-induced cytokine secretion (both …

Samantha’S Dilemma: A Look Into A Life With Ai, Thomas Bojarski

Theses

In this paper, I propose a thought experiment, “Samantha’s Dilemma,” which captures the complexity of determining whether moral considerations can be attributed to artificial intelligence (AI). Deciding whether or not we attribute autonomous freedom to artificial beings lays the foundation, not only for our relationships with AI, but with any ‘intelligent’ species we encounter in the future. By analyzing several core arguments regarding the treatment of artificial beings, I will show that abandoning our predominant self-serving tendencies and choosing not to limit the potentiality of autonomous AI is not only the safest course of action, but also the morally correct …

Use Of Alkali Metal Salts To Prepare High Purity Single-Walled Carbon Nanotube Solutions And Thin Films, Rakan F. Ashour

Theses

Single-walled carbon nanotubes (SWCNTs) display interesting electronic and optical properties desired for many advanced thin film applications, such as transparent conductive electrodes or thin-film transistors. Large-scale production of SWCNTs generally results in polydispersed mixtures of nanotube structures. Since SWCNT electronic character (conducting or semiconducting nature) depends on the nanotube structure, application performance is being held back by this inability to discretely control SWCNT synthesis. Although a number of post-production techniques are able to separate SWCNTs based on electronic character, diameter, or chirality, most still suffer from the disadvantage of high costs of materials, equipment, or labor intensity to be relevant …

Mobilizing Modernist Magazines : Peter Sloterdijk And The Transatlantic Review., Daniel Lee Conrad

Electronic Theses and Dissertations

Many early examinations of “little magazines,” or avant-garde modernist publications, tend to focus on the biographical narratives of their editors or center their discussion on early versions of canonical works in order to develop a greater understanding of the body of work itself. Works like Bernard Poli’s Ford Madox Ford and the Transatlantic Review follow this biographical model, and while well researched and informative, Poli's study strictly focuses on the role Ford played in the publication; in doing so, it limits what can be said about the review’s project to the local editorial level. This thesis, by contrast, seeks to …

Sa-4-1bbl As A Platform To Develop Adjuvant Systems For Prophylactic And Therapeutic Vaccines., Gunes Dinc 1984-

Electronic Theses and Dissertations

Vaccines against infectious diseases are one of the most critical accomplishments in modern medicine. Despite significant progress in vaccinology, there is still a dire need for developing vaccines against various acute and chronic infections and cancer. In general, vaccines are categorized as prophylactic, given to healthy individuals to prevent disease, and therapeutic, administered to people who already have disease. As such, the nature, quality, and quantity of immune responses required for the efficacy of these two types vaccines are different. Prophylactic vaccines against infectious diseases primarily rely on the generation of neutralizing high titers of antibody for their efficacy. These …

Development Of Srade Tool And Analysis Of Quality Scores Of The Reads Of Next-Generation Sequencing Data, Chaitanya Krishna Kotha

Theses

Capillary Electrophoresis (CE) based on Sanger sequencing has given the ability to extract and explain the genetic information among any given biological system. Even though it brought about a major breakthrough in the field of biology, it had limitations like speed, throughput, scaling and resolution that paved the way for the invention of new technology named as Next-Generation Sequencing (NGS). With the invention of NGS technology, there has been a lot of insight into the genomes, transcriptomes and epigenomes of many of the species on earth. As time passed by, a lot of information has been generated using the NGS …