Digital Commons Network^™

Social Determinants Of Health And Quality Of Life Among Korean Americans With Chronic Hepatitis B, Cindy Xin Fang, Yoonjin Nam, Ann C. Klassen, Hee-Soon Juon

Department of Medical Oncology Faculty Papers

BACKGROUND: Hepatitis B virus (HBV) infection disproportionately affects Korean Americans, who often experience persistent social and structural challenges that may influence quality of life. Recent community studies showed most Korean Americans with chronic hepatitis B (CHB) were disengaged from clinical care, emphasizing the need to better understand factors affecting their well-being. This study examined associations between social determinants of health (SDOH) and physical and mental health related quality of life (HRQoL) among Korean Americans with CHB.

METHODS: A total of 365 CHB patients completed the enrollment survey. SF-12 was used to measure quality of life, calculating physical and mental components …

Mist: A Hierarchical Bayesian Framework For Detecting Differential Dna Methylation Dynamics In Single-Cell Data, Daoyu Duan, Wenjing Ma, Wen Tang, Hao Wu, Liangliang Zhang, Hao Feng

Faculty, Staff and Student Publications

Recent advancements in single-cell DNA methylation (scDNAm) sequencing technologies have enabled the profiling of epigenetic landscapes at unprecedented resolution, offering insights into cellular heterogeneity, differentiation and evolution. Trajectory inference, which orders cells along pseudotime, allows researchers to track genomics changes across continuous cell states and identify key loci exhibiting differential methylation. However, no methods currently exist to model methylation changes along pseudotime in scDNAm data. Here, we present a hierarchical Bayesian framework for scDNAm data analysis. Our method, named mist (methylation inference for single-cell along trajectory), models stage-specific biological variations, identifies genomic features with significant methylation changes along pseudotime, and …

On Message Encryption And Enhanced Security Using Protein Structure Information, Daniel Graham

Chemistry: Faculty Publications and Other Works

This is a lecture packet focused on several well-established encryption procedures. Included is a discussion of security enhancements brought about by incorporating protein structure information into the procedures.

In Vivo Hsc Gene Therapy Enables Sustained Ecd4-Ig Expression For Siv Prevention, Chang Li, Anna K Anderson, Anne-Sophie Kuhlmann, Veronica Nelson, Audrey Germond, Hongjie Wang, Aphrodite Georgakopoulou, Sucheol Gil, Jasmin Martinez-Reyes, Andrew Riker, Shruthi Shankar Raman, Jiho Kim, Philip Ng, Donna Palmer, Michael D Alpert, Nickolas Skamangas, Charles Bailey, Tianling Ou, Christine M Fennessey, Michael Farzan, Keith R Jerome, Brandon F Keele, Hans-Peter Kiem, André Lieber, John K Bui

Faculty, Staff and Students Publications

We aim to develop an in vivo hematopoietic stem cell (HSC) gene therapy approach for the prevention and control of HIV-1 infection. Toward this goal, we engineered helper-dependent adenovirus (HDAd) 6/3+ vectors to directly transduce HSCs in vivo, enabling progeny cells to secrete eCD4-Ig, a decoy protein that broadly neutralizes HIV/simian immunodeficiency virus (SIV) isolates by mimicking the primary viral receptor CD4 and coreceptors such as CCR5. In rhesus macaques, the HDAd 6/3+ platform achieved long-term expression of an enhanced eCD4-Ig variant (“eCD4-Ig-Emm06”) that retained potent neutralization efficacy in vivo. Transduced HSCs differentiated into lymphoid and myeloid lineages …

Undergraduate Research Institute Discovery 2026: Research Abstracts Booklet, Undergraduate Research Institute

Discovery Day - Prescott

No abstract provided.

Program: 2026 Featured Lecture, "Ancient Faith Meets Modern Science: Following Christ In Today’S Debates", Deborah Haarsma

Frank Pack Distinguished Christian Scholar Lecture Program

Program for the Twenty First Annual Frank Pack Distinguished Christian Scholar Lecture Program with the featured lecturer Deborah Haarsma, executive director of the International Network for Christian Higher Education and former director of BioLogos.

Investigating Corollaries Between Streptococcus Gallolyticus Subsp. Gallolyticus Virulence And Colorectal Cancer, Tyler G. Myers

Pursuit - The Journal of Undergraduate Research at The University of Tennessee

Streptococcus gallolyticus subsp. gallolyticus (Sgg) is a gram-positive, non-beta-hemolytic bacterium that belongs to the Lancefield group D of streptococcal pathogens. For the past several decades, associations between Sgg bacteremia and colorectal cancer (CRC) have been apparent, with gastroenterologists routinely recommending colonoscopies for positive cases of Sgg in either blood or stool samples. However, current research has not wholly established whether Sgg acts as a causative agent of CRC or if pre-existing cancers make the lumen of the colon more hospitable to its colonization. Regardless, Sgg has been implicated in the modulation of host inflammatory pathways and subsequent remodeling …

Noda News March 2026

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

Noda News February 2026

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

Tbi Semi-Annual Report July-December 2024, Tennessee. Bureau Of Investigation.

Annual Report

No abstract provided.

Personalized Environmental Risk Alerting Via Fusion Of Physiological, Environmental, And Contextual Data, Sumukh Shevde, Sudeep Chauhan

Defensive Publications Series

Personal health monitoring devices may detect physiological changes but can lack environmental context to determine a cause, while environmental alert systems may rely on generic, non-personalized data. Systems and methods are described that can algorithmically fuse multiple data streams. These streams can include real-time physiological data from a wearable computing device (e.g., a smart watch, fitness tracker), such as heart rate variability; hyperlocal environmental data, such as air quality or noise levels; and contextual data, such as a user's location and activity level. This fusion of data may be used to compute a personalized risk index. The index may then …

Perioperative Fluid Management In Cardiac Surgery: Contemporary Evidence And Clinical Controversies, Hussein Ali Hussein Al-Hchaimi, Hussein Alkhfaji, Majid Fakhir Al-Hamaidah, Mohammad Ali Hassan Jassim, Ammar Hoom Mahdi, Fatima Al-Sharwood, Sunder Etta

AUIQ Complementary Biological System

Perioperative fluid therapy is a cornerstone of anesthetic management in cardiac surgery, where both hypovolemia and hypervolemia are associated with increased morbidity, forming a ``U-shaped'' relationship with outcomes. This narrative review synthesizes evidence from peer-reviewed literature (2000–2024) identified via PubMed, Scopus, and the Cochrane Database, focusing on randomized trials, meta-analyses, and guidelines for adult cardiac surgery. A central debate persists regarding fluid choice. Current evidence supports the preferential use of balanced crystalloids over normal saline, as large-volume saline is linked to hyperchloremic acidosis and reduced renal perfusion. Colloids like albumin and hydroxyethyl starch (HES) offer efficient volume expansion but require …

Interdisciplinary Management Of Severe Pediatric Subglottic Stenosis: A Case Report Of Endoscopic Balloon Dilation Under Shared Airway Conditions, Margaretha Gunawan, Syahrial Marsintha Hutauruk, Fauziah Fardizza, Christopher Kapuangan, Mikhael Yosia

AUIQ Complementary Biological System

Pediatric acquired subglottic stenosis is a high-risk airway condition that requires close coordination between anesthesiology and otorhinolaryngology teams, particularly during endoscopic interventions performed under shared-airway conditions. This report describes the interdisciplinary management and anesthetic–surgical coordination in a child with severe acquired subglottic stenosis undergoing endoscopic balloon dilation, highlighting key decision points and airway management strategies. A 2-year-old boy with a history of prolonged and repeated endotracheal intubations presented with persistent dyspnea and noisy breathing, consistent with fixed extrathoracic airway obstruction. The case was reviewed in a multidisciplinary pediatric difficult-airway meeting, and operative management consisted of endoscopic airway evaluation and balloon …

Development And Evaluation Of A Folic Acid-Targeted, Ph-Responsive Superparamagnetic Nanocomposite For Selective Camptothecin Delivery In Antibacterial Applications, Musaab Mohammed Kadhim, Qasim Najim Thewaini, Sharafaldin Al-Musawi

Journal of Applied Sciences and Nanotechnology

This study addresses the critical need for improved therapeutic strategies to overcome the limitations of conventional treatments, particularly systemic toxicity and poor bioavailability of potent agents such as camptothecin (CPT). This research was designed to fabricate and characterize a superparamagnetic iron oxide nanocomposite (SPION-DEX-CPT-FA) used for the selective delivery of CPT and to evaluate its effectiveness in antibacterial applications against bacteria Escherichia coli and Klebsiella pneumoniae, Staphylococcus aureus, and Streptococcus pneumoniae from the urinary tract. Studies involving the synthesis and evaluation of nanocomposites are being considered for the targeted delivery of a particular drug. The method used a …

Formulation Of Vegetable Oils Loaded Nanoemulsions For Photoprotection Against Uvb And Uva Radiation: In Vitro Study, Kawther Ali Hussein, Randa Mohammed Dhahi

Journal of Applied Sciences and Nanotechnology

The objective of this study is the development of bio-based nanoemulsions that were derived from natural sources, including olive, coconut, red raspberry, and tomato seed oils, to produce safe and effective UV- protective agents. The nanoemulsions were produced at the nanoscale with uniform droplets by employing ultrasonic emulsification utilizing deionized water and Tween 80. According to Dynamic light scattering (DLS), the oil nanoemulsification from red raspberry exhibited the smallest droplet size of (148.5 nm), low polydispersity index of (0.218) and high zeta potential of (–35.6 mV). The spherical shape of the droplets was confirmed via Transmission electron microscopy (TEM) as …

The Student Movement Volume 110 Issue 17: Springing Forward United, Ysa Dennis, Addison Randall, Corinna Bevier, Anna Pak, Megan Constantine, Caleb Chung, Zorislav Plantak, Isa Demoraes, Moraya Truman, Melanie Webb, Nathaniel Reid, Laura Pérez

The Student Movement V. 110 (2025-2026)

ARTS & ENTERTAINMENT

To Be An Independent Artist: Mac Rapach, Ysa Dennis

Music Festival: Symphony Orchestra Showcase, Addison Randall

I Watched Every 2025 Best Picture Nominee (So You Don't Have To), Corinna Bevier

HUMANS

Bible Study Group Spotlight: "Come Let Us Reason Together", Anna Pak

Create, Communicate, Connect : A Look into the VACD, Megan Constantine

NEWS

AUSA Election Results Announced: Meet Your 2026-27 Officers, Caleb Chung

James White Library Creates New Disability Technology Room, Zorislav Plantak

University Leadership Responds to Student Concerns at Town Hall, Isa DeMoraes

IDEAS

The Monthly Cycle of Being a Woman, Moraya Truman

Maybe It …

Genetic Architecture Of The Murine Red Blood Cell Proteome Reveals Central Role Of Hemoglobin Beta Cysteine 93 In Maintaining Redox Balance., Gregory R Keele, Monika Dzieciatkowska, Ariel M Hay, Matthew Vincent, Callan O'Connor, Daniel Stephenson, Julie A Reisz, Travis Nemkov, Kirk C Hansen, Grier P Page, James C Zimring, Gary Churchill, Angelo D'Alessandro

Faculty Research 2026

Red blood cells (RBCs) transport oxygen but accumulate oxidative damage over time, reducing function in vivo and during storage, critical for transfusions. To explore the genetics of RBC resilience, we profiled proteins, metabolites, and lipids from fresh and stored RBCs from 350 genetically diverse mice. Our analysis identified over 6,000 quantitative trait loci (QTLs). Compared to other tissues, the prevalence of trans genetic effects over cis ones reflects the absence of de novo protein synthesis in anucleated RBCs. QTL hotspots at Hbb, Hba, Mon1a, and (storage-specific) Steap3 linked ferroptosis to hemolysis. Proteasome QTLs clustered at multiple loci, underscoring the importance …

Genetic Architecture Of The Murine Red Blood Cell Proteome Reveals Central Role Of Hemoglobin Beta Cysteine 93 In Maintaining Redox Balance., Gregory R Keele, Monika Dzieciatkowska, Ariel M Hay, Matthew Vincent, Callan O'Connor, Daniel Stephenson, Julie A Reisz, Travis Nemkov, Kirk C Hansen, Grier P Page, James C Zimring, Gary Churchill, Angelo D'Alessandro

Faculty Research 2026

Red blood cells (RBCs) transport oxygen but accumulate oxidative damage over time, reducing function in vivo and during storage, critical for transfusions. To explore the genetics of RBC resilience, we profiled proteins, metabolites, and lipids from fresh and stored RBCs from 350 genetically diverse mice. Our analysis identified over 6,000 quantitative trait loci (QTLs). Compared to other tissues, the prevalence of trans genetic effects over cis ones reflects the absence of de novo protein synthesis in anucleated RBCs. QTL hotspots at Hbb, Hba, Mon1a, and (storage-specific) Steap3 linked ferroptosis to hemolysis. Proteasome QTLs clustered at multiple loci, underscoring the importance …

Rural Georgia Hospital Covid-19 Virus Patient Outcomes, Susan P. Smith, Neeraj Dayama, Morgan E. House, Debra Flores, Sharon Hunt, April Dukes, Steven Gautney

Journal of the Georgia Public Health Association

Background: The Coronavirus disease 2019 (COVID-19) has led to over 1.2 million deaths in the United States. Given the staggering scale of the pandemic, rural hospitals faced heightened challenges due to limited resource availability and underlying patient characteristics.

Methods: In this context, we examined patient and hospital-related factors associated with inpatient mortality due to COVID-19. This study is a retrospective chart review of patient outcomes of patients who were hospitalized in a Southwest Georgia rural hospital with COVID-19 during the initial onset of the outbreak and over the following 23 months of the pandemic. Patient demographics, other characteristics, …

Tunable 3d-Printed Biomaterials For Perfused In Vitro Models Of The Blood-Brain Barrier, Louis Salvatore Paone

Theses and Dissertations

In vitro models have tremendous utility for improving our understanding of complex physiological and pathophysiological processes in a more controlled environment than animal models, in addition to incorporating human cells to overcome species-specific disparities. This dissertation describes innovations in biomaterial-based fabrication processes that advance in vitro models of the blood-brain barrier, providing the opportunity to evaluate the effects of cell-matrix interactions on barrier integrity, additives to reduce viscous drag of blood flow, and molecular mechanisms underlying the cellular response to amyloid beta in the context of Alzheimer’s disease. The core technology underlying this advance is a biomaterial compatible with digital …

Consumer Resilience Suppresses The Recovery Of Overgrazed Ecosystems, Nathan B. Spindel, Aaron W.E. Galloway, Julie B. Schram, Gwiisihlgaa Daniel Mcneill, Sg̱Iids Ḵung Vanessa Bellis, Niisii Guujaaw, Jaasaljuus Yakgujanaas, Ondine Pontier, Markus Thompson, Lynn C. Lee, Daniel K. Okamoto

Faculty Research, Scholarly, and Creative Activity

Many heterotroph species perish when faced with severe food limitation; others can persist, adapt, and thrive. Sea urchins are emblematic of this paradox: they can overgraze kelp forests to form barren habitats, but can then survive for decades in these nutritionally depauperate seascapes. Understanding the mechanisms enabling persistence under starvation and rapid recovery when food returns provides insights into how consumer resilience shapes ecosystem dynamics. We quantified how food abundance, quality, deprivation, and reintroduction influence bioenergetic performance in the red sea urchin (Mesocentrotus franciscanus), integrating field observations of kelp forest and barren populations with a controlled feeding experiment. We measured …

It's Getting Hot In Here: The Heated Debate On The Censorhip Of Climate Change Education And Its Violation Of State Constitutions, Lilyan Jarreau

LSU Journal of Energy Law and Resources

No abstract provided.

Ahoy, Matey! I'Ve Harnessed The Wind: Turning Ocean Air Into Renewable Wind Energy, Amber Ferguson

LSU Journal of Energy Law and Resources

No abstract provided.

Defining A Multi-Omic, Ai-Enabled Stool Screening Paradigm For Colorectal Cancer: A Consensus Framework For Clinical Translation, Arturo Loaiza-Bonilla, Yan Leyfman, Viviana Cortiana, Rhys Crawford, Shivani Modi

Einstein Health Papers

Colorectal cancer (CRC) develops through both conventional adenoma-carcinoma and serrated neoplasia pathways, yet noninvasive screening still under-detects the advanced precursor lesions that enable true cancer prevention. Stool-based screening reduces CRC mortality, but its preventive impact remains constrained by limited detection of advanced precancerous lesions (APLs), including advanced adenomas and sessile serrated lesions. Next-generation multitarget stool DNA assays (mt-sDNA; e.g., Cologuard Plus) have established high sensitivity for CRC and specificity approaching 94%, leaving improved APL detection as the principal opportunity for innovation. This review presents a consensus framework for a multi-omic stool screening paradigm that integrates host epigenetic markers (DNA methylation) …

Uncovering Hidden Features Of Copyback Viral Genomes, Sarah Pye

Arts & Sciences Graduate Student Theses and Dissertations

Copyback viral genomes (cbVGs) are truncated non-protein coding viral genomes produced when an RNA virus polymerase detaches from the replication template and resumes elongation downstream, copying back a sequence complementary to the nascent strand. cbVGs can stimulate antiviral immunity and compete for viral proteins to suppress virus replication, but technical limitations of PCR-based approaches have painted an incomplete picture of the diverse cbVG populations generated during infection. Here, we sought to improve our understanding of cbVG molecular structure by harnessing long-read RNA sequencing tools. To do this, we developed a robust and reliable pipeline to sequence and analyze native full-length …

Quality Of Life In Patients With P16+ Oropharyngeal Cancer Receiving Accelerated Radiation Therapy With Either Cisplatin Or Cetuximab In The Nrg/Rtog 1016 Randomized Controlled Trial, Jolie Ringash, Pedro A Torres-Saavedra, Maura L Gillison, Jimmy J Caudell, David J Adelstein, Paul M Harari, Erich M Sturgis, Ethan Basch, Shlomo A Koyfman, Greg A Krempl, Dukagjin M Blakaj, James Edward Bates, Thomas J Galloway, Christopher U Jones, Beth M Beadle, Jonathan Harris, Quynh-Thu Le, Sue S Yom, Benjamin Movsas

Faculty, Staff and Students Publications

Purpose: NRG/RTOG 1016 was a phase III randomized noninferiority de-escalation trial comparing cetuximab versus cisplatin, concurrent with accelerated radiation 70 Gy/6 weeks, in p16+ oropharyngeal cancer. Quality of life (QOL) was a secondary endpoint.

Methods and materials: Eligible/consenting patients among the first 400 entered completed the EORTC QLQ-C30/H&N35 at baseline, end of treatment, 3, 6, and 12 months posttreatment, to provide 90% power to detect an effect size of 0.5 in the between-arm change in QOL scores from baseline to 6 months. We report completion, responsiveness, and patterns over time across domains between arms, considering a difference of >10 points …

Ulk4 And Cdkn2a Polymorphisms Influence The Risk Of Developing Monoclonal Gammopathy Of Undetermined Significance, José Manuuel Sánchez-Maldonado, Angelica Macauda, Antonio José Cabrera-Serrano, Hauke Thomsen, Murat Güler, Rob Ter Horst, Bethany Van Guelpen, Pavel Vodicka, Stefano Landi, Subhayan Chattopadhyay, Pelin Ünal, Lucía Ruiz-Durán, Delphine Casabonne, Hartmut Goldschmidt, Istemi Serin, María Carretero-Fernández, Elena Cabezudo, Fernando Reyes-Zurita, Alyssa I. Clay-Gilmour, Et. Al.

Faculty Publications

Monoclonal gammopathy of undetermined significance (MGUS) is a necessary precursor condition to multiple myeloma (MM). Given the role of autophagy in modulating MM risk, we investigated whether genetic variation in autophagy-related genes influences susceptibility to MGUS. We analyzed the association of 34,042 common autophagy-related single nucleotide polymorphisms (SNPs) with MGUS across six independent cohorts, five from Europe and one from North America, comprising 2317 MGUS cases and 282,358 controls. We also assessed their impact on immune parameters, including absolute counts of 91 blood-derived immune cell subsets and 103 circulating immunological proteins. Meta-analysis revealed a genome-wide significant association between the ULK4 …

Brain-Engrafted Monocyte-Derived Macrophages From Blood And Skull-Bone Marrow Exhibit Distinct Properties, Siling Du, Feiya Ou, Antoine Drieu, Eric Z Xu, Yumeng Cheng, Steffen E Storck, Tornike Mamuladze, Jay Cao, Nora Abduljawad, Bishan Bhattarai, Justin Rustenhoven, Niall Mortimer, Simone Brioschi, Khai Nguyen, Patrick Fernandes Rodrigues, Igor Smirnov, Daniel Gibson, J Michael White, Wandy Beatty, David Denardo, Qingyun Li, Michael Meers, Claudia Z Han, Na Sun, Florent Ginhoux, Marina Cella, Marco Colonna, Jonathan Kipnis

The Brown Foundation: Institute of Molecular Medicine

Microglia arise from yolk sac progenitors and are thought to persist throughout life with minimal input from adult hematopoiesis. However, whether brain-engrafted monocyte-derived macrophages (MDMs) exist at homeostasis and during turnover and how they function relative to yolk-sac-derived microglia (YSMs) remain unsettled. Here, we combine lineage tracing, pharmacological microglia depletion, and multi-omics profiling to define the ontogeny, identity, and function of brain parenchymal macrophages. Despite sharing the parenchymal milieu, MDMs display transcriptional and epigenetic landscapes distinct from YSMs. Fate-mapping reveals that brain-engrafted MDMs transiently express CD206, echoing a developmental stage of microglial precursors. MDM engraftment and polarization are modulated by …

Wnt/Β -Catenin Signalling Shapes Macrophage Behaviour During Injury And Repair In The Mouse Submandibular Gland, Araz Ahmed, Suveer Sachdeva, Simon Whawell, Isabelle Miletich

Peninsula Dental School

Xerostomia, the subjective sensation of dry mouth, is a debilitating consequence of head and neck radiotherapy and autoimmune disorders such as Sjögren’s syndrome. It severely impairs oral health and quality of life by promoting mucosal ulceration, infection, malnutrition, and speech difficulties, yet effective regenerative treatments remain limited. Macrophages have recently emerged as critical regulators of salivary gland repair through their roles in coordinating inflammation, fibrosis, and epithelial regeneration; however, the molecular mechanisms governing macrophage activation and function in the injured salivary gland remain poorly defined. The Wnt/β-catenin signalling pathway is a key regulator of inflammation and tissue homeostasis across multiple …

Spartan Daily, March 11, 2026, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2026

Volume 166, Issue 21