Digital Commons Network^™

Letter To The Editor, Sally G. Hoskins, Kristy L. Kenyon

Publications and Research

No abstract provided.

Safety Of Infliximab In Children With Ibd: The Experience Of An Academic Center In Wv, Michael Northcutt Md, Awni Al-Subu Md, Brooke Bella Rn, Yoram Elitsur Md

Biochemistry and Microbiology

BACKGROUND: The immune-modulating drug, infliximab, is approved for Inflammatory Bowel Disease (IBD) treatment in children. Chronic therapy with infliximab is associated with the development of early and delayed infusion reactions. We reviewed our experience with infliximab treatment and its side effects in a cohort of children diagnosed with IBD who were treated in our clinic.

METHODS: A retrospective analysis of all IBD children treated with infliximab in our center from 2006-2011 was performed. The demographic, chronological and clinical data were recorded. The infliximab infusion was given at 5mg/ kg according to a standard protocol after pre-treatment with low dose …

Preventing Falls With Vitamin D, Franklin D. Shuler Md, Phd, Thomas Schlierf, Matthew Wingate

Orthopaedics

Falls are the number one cause for injury-related morbidity and mortality in West Virginia’s seniors. Multiple independent variables contribute to the risk of a fall: previous falls, alterations in balance and vision, impairments in gait and strength, and medications most highly correlate with the risk for a fall. Vitamin D supplementation is emerging as an easy, safe and well-tolerated fall reduction/prevention strategy due to the beneficial effects on the musculoskeletal system with improvements in strength, function and navigational abilities. From meta-analysis data, maximal fall reduction benefit in seniors is achieved when correcting vitamin D deficiency and when using adjunctive calcium …

College Of Arts And Sciences E-News Issue 13: May 2014, College Of Arts And Sciences

College of Arts and Sciences news

• CAS News
• lnterdisciplinary freshwater science and sustain ability degree offered
• Dean and department chair named outstanding administrators
• Department of Gender and Women's Studies receives Bronco Pride Advocacy Award
• CAS employees Make a Difference
• Faculty Feature
• Dr. Wafa Hassan earns STARTALK grant
• Alumni Profiles
• After 14 years in foster care, Amanda Shelton '14 graduates with highest undergraduate honor
• Bradford Shovlin '03, new executive chef at Iron Horse Hotel
• Student Story
• WMU students lobby in Lansing

Progression Magazine, 2014 Spring, Coastal Carolina University

Progression Magazine

Magazine of the College of Science at Coastal Carolina University.

The Genus Palaeagapetus Ulmer (Trichoptera, Hydroptilidae, Ptilocolepinae) In North America, Tomiko Ito, Robert W. Wisseman, John C. Morse, Murray H. Colbo, John S. Weaver Iii

Publications

The genus Palaeagapetus Ulmer (Trichoptera, Hydroptilidae, Ptilocolepinae) is revised in North America. Descriptions of the western species, P. nearcticus Banks 1938, are provided with the first descriptions of the female, pupa, larva, egg and case and with notes on food, habitat and annual life cycle. The male and female of the eastern species, P. celsus Ross 1936, are described or redescribed with some ecological notes. Distributions of the two species are summarized.

In Vitro Validation Of Patient-Specific Hemodynamic Simulations In Coronary Aneurysms Caused By Kawasaki Disease, Ethan Kung, Andrew M. Kahn, Jane C. Burns, Alison Marsden

Publications

To perform experimental validation of computational fluid dynamics (CFD) applied to patient specific coronary aneurysm anatomy of Kawasaki disease. We quantified hemodynamics in a patient-specific coronary artery aneurysm physical phantom under physiologic rest and exercise flow conditions. Using phase contrast MRI (PCMRI), we acquired 3-component flow velocity at two slice locations in the aneurysms. We then performed numerical simulations with the same geometry and inflow conditions, and performed qualitative and quantitative comparisons of velocities between experimental measurements and simulation results. We observed excellent qualitative agreement in flow pattern features. The quantitative spatially and temporally varying differences in velocity between PCMRI …

The Neural Correlates Of Regulating Positive And Negative Emotions In Medication-Free Major Depression, Steven G. Greening, Elizabeth A. Osuch, Peter C. Williamson, Derek G. V. Mitchell

Anatomy and Cell Biology Publications

Depressive cognitive schemas play an important role in the emergence and persistence of major depressive disorder (MDD). The current study adapted emotion regulation techniques to reflect elements of cognitive behavioural therapy (CBT) and related psychotherapies to delineate neurocognitive abnormalities associated with modulating the negative cognitive style in MDD. Nineteen non-medicated patients with MDD and 19 matched controls reduced negative or enhanced positive feelings elicited by emotional scenes while undergoing functional magnetic resonance imaging. Although both groups showed significant emotion regulation success as measured by subjective ratings of affect, the controls were significantly better at modulating both negative and positive emotion. …

Sagestep News, Spring 2014, No. 24, Sagestep

Newsletters

Seasonal newsletter of SageSTEP.

Diverse Gastropod Hosts Of Angiostrongylus Cantonensis, The Rat Lungworm, Globally And With A Focus On The Hawaiian Islands, Jaynee Kim, Kenneth Hayes, Norine Norine W Yeung, Robert Cowie

Department of Biology Faculty Publications

Eosinophilic meningitis caused by the parasitic nematode Angiostrongylus cantonensis is an emerging infectious disease with recent outbreaks primarily in tropical and subtropical locations around the world, including Hawaii. Humans contract the disease primarily through ingestion of infected gastropods, the intermediate hosts of Angiostrongylus cantonensis. Effective prevention of the disease and control of the spread of the parasite require a thorough understanding of the parasite's hosts, including their distributions, as well as the human and environmental factors that contribute to transmission. The aim of this study was to screen a large cross section of gastropod species throughout the main Hawaiian Islands …

Investigating Antibiotic Resistance Levels Of Salmonella Internalized In Lettuce Leaves, Jason B. Thomas

McNair Scholars Research Journal

Contamination of food crops by the human pathogen Salmonella is a food safety threat worldwide. Though using treated wastewater for irrigation is a sustainable practice, it may introduce trace levels of Salmonella that may contaminate food crops. Salmonella could develop resistance to antibiotics present in wastewater. The overall goal of the project is to increase the understanding of the public health risk associated with the use of treated wastewater to irrigate food crops. The objective of this particular study is to determine the antibiotic resistance level of Salmonella internalized in lettuce leaves. In this experiment, thirty-six plants of the lettuce …

The Rational Agent Or The Relational Agent: Moving From Freedom To Justice In Migration Systems Ethics, Tisha Rajendra

Theology: Faculty Publications and Other Works

Most accounts of immigration ethics implicitly rely upon neoclassical migration theory, which understands migration as the result of poverty and unemployment in sending countries. This paper argues that neoclassical migration theory assumes an account of the human person as solely an autonomous rational agent which then leads to ethics of migration which overemphasize freedom and self-determination. This tendency to assume that migration works as neoclassical migration theory describes is shared by political philosophers, such as Joseph Carens, Michael Walzer, and David Miller. This paper argues that all three philosophers incorrectly frame migration as a contest between the freedom of the …

Evolution Of The Un-Wed Mother, Carol Jean Obergfell

Senior Theses

According to the National Vital Statistics System, since the 1980’s, there has been a dramatic increase of unmarried pregnancies, close to an 80% increase. Drawing predominantly on historical information, and interviews with a multi-generational group of unmarried mothers, my research will show that although there are socio-economic factors which contribute to this phenomenon, the overwhelming factor is the increase in individualism, and that over the decades, unmarried women have evolved. With the release of societal pressures that once deemed them “fallen women” they no longer feel that they have to be married in order to provide a good life for …

On The Electrostatic Properties Of Homodimeric Proteins, Brandon Campbell, Marharyta Petukh, Emil Alexov, Chuan Li

Publications

A large fraction of proteins function as homodimers, but it is not always clear why the dimerization is important for functionality since frequently each monomer possesses a distinctive active site. Recent work (PLoS Computational Biology, 9(2), e1002924) indicates that homodimerization may be important for forming an electrostatic funnel in the spermine synthase homodimer which guides changed substrates toward the active centers. This prompted us to investigate the electrostatic properties of a large set of homodimeric proteins and resulted in an observation that in a vast majority of the cases the dimerization indeed results in specific electrostatic features, although not necessarily …

An Exploration Of The Factors That Motivate Gifted And Talented Black Males To Engage In Science, Technology, Engineering And Mathematics In A Gifted, Residential Community, Adrienne L. Coleman

Publications & Research

This study was an exploration of the factors that motivated gifted and talented Black males to engage in science, technology, engineering and mathematics (STEM). The specific problem addressed was the lack of motivation among Black males to become gifted and talented learners engaged in STEM. Thus, the purpose of this study was to examine the factors that motivate gifted and talented Black males to engage in STEM at the Illinois Mathematics and Science Academy (IMSA), a residential academy for gifted/talented students. Qualitative methodology was used to interview focus groups of 20 gifted and talented Black males who currently attended IMSA …

Biology And Control Of Rice False Smut Caused By Ustilaginoidea Virens (Teleomorph Villosiclava Virens), Andrew Clayton Jecmen

Graduate Theses and Dissertations

Rice false smut (FS), a disease caused by Ustilaginoidea virens (Cke.) Takahashi (1896), was first reported in northeastern Arkansas counties in 1997. The first objective of this research was to establish a collection of U. virens isolates from geographically diverse regions of Arkansas. Three U. virens isolates and chlamydospores from `Templeton' and `Clearfield-151' rice cultivars were used to determine the effects of temperature and pH on mycelial growth and germination. A nested-PCR protocol and histological methods were used to determine if U. virens infects and colonizes rice seedlings and spikelets on panicles. The sensitivity of three U. virens isolates was …

Relationship Between 1,3-Dichloropropene And Nitrogen Fertility In Cotton In The Presence Of Root-Knot And Reniform Nematodes, Amanda Michelle Greer

Graduate Theses and Dissertations

The use of soil fumigation for nematode management in cotton (Gossypium hirsutum) has become increasingly popular in recent years in the absence of effective resistant cultivars. While soil fumigation is relatively expensive, lint yields have consistently been improved to make this practice profitable in fields with severe nematode pressure. Growers in southern Arkansas have observed changes in cotton growth patterns when severely infested fields are fumigated. The most noticeable change has been excessive (rank) growth resulting in an increased need for growth regulators, especially where the nitrogen fertilization exceeds standard recommendations. Field studies were conducted between 2007 and 2010 to …

A Study Of Ciliary Beating In Chlamydomonas, Xin Li

Renée Crown University Honors Thesis Projects - All

The goal of this research is to understand how a unicellular green alga, Chlamydomonas-reinhardtii, responds to red light (670nm) and sound waves, by monitoring the beating frequency of its two cilia, which control cell motility. Ciliary beating frequency (BF) is proportional to the production of ATP, mainly generated by photosynthesis. A photosynthesis inhibitor, 3-(3-, 4-dichlorophenyl)-1, 1-dimethylurea (DCMU) decreases ATP production by photosynthesis. I used DCMU as a tool to analyze the red light effect on BF.

In the process of studying the effect of red light, I unexpectedly discovered experimental conditions for unstable ciliary beating (as shown in the video). …

Seat Hunt, Nathan Kiehn

The Prairie Light Review

No abstract provided.

Evolving Mentoring Into E-Mentoring For Future Applications And Improvement, Andrew James Wood

Counselor Education Capstones

Since electronic communications do not necessarily have time or distance constraints, a mentoring program utilizing this communication style could reach a greater number and variety of mentors for students. Mentoring can have a large impact on students in a world where who you know is key to reaching educational and career goals. The benefits and barriers to such a program must first be assessed in order to ascertain the efficacy of ementoring. Upon review of relevant literature, these benefits and barriers were discussed and many suggestions for implementing e-mentoring programs were found.

Chronic Beryllium Disease: Revealing The Role Of Beryllium Ion And Small Peptides Binding To Hla-Dp2, Marharyta Petukh, Bohua Wu, Shannon Stefl, Nick Smith, David Hyde-Volpe, Li Wang, Emil Alexov

Publications

Chronic Beryllium (Be) Disease (CBD) is a granulomatous disorder that predominantly affects the lung. The CBD is caused by Be exposure of individuals carrying the HLA-DP2 protein of the major histocompatibility complex class II (MHCII). While the involvement of Be in the development of CBD is obvious and the binding site and the sequence of Be and peptide binding were recently experimentally revealed [1], the interplay between induced conformational changes and the changes of the peptide binding affinity in presence of Be were not investigated. Here we carry out in silico modeling and predict the Be binding to be within …

Computational And Experimental Approaches To Reveal The Effects Of Single Nucleotide Polymorphisms With Respect To Disease Diagnostics, Tugba G. Kucukkal, Ye Yang, Susan C. Chapman, Weiguo Cao, Emil Alexov

Publications

DNA mutations are the cause of many human diseases and they are the reason for natural differences among individuals by affecting the structure, function, interactions, and other properties of DNA and expressed proteins. The ability to predict whether a given mutation is disease-causing or harmless is of great importance for the early detection of patients with a high risk of developing a particular disease and would pave the way for personalized medicine and diagnostics. Here we review existing methods and techniques to study and predict the effects of DNA mutations from three different perspectives: in silico, in vitro and …

Exploring The Utility Of The Children’S Kitchen Task Assessment For Use With Six-Year-Olds, Vanessa Mae Clemente Carzon, Charisa Justine Kelly, Alexandra Maria Rodriguez

Dissertations, Masters Theses, Capstones, and Culminating Projects

Objective The Children’s Kitchen Task Assessment (CKTA) is an ecologically valid assessment that was designed to assess executive functioning skills in children age 7-10. Currently there is a lack of ecologically valid assessments that test executive functioning in children under seven years of age. For this reason, this study explored the utility of the CKTA for use with six-year-olds.

Methods This study used an exploratory, qualitative, case study design to facilitate its implementation and used quantitative data to make qualitative inferences about the results. Children were given the CKTA and the Wechsler Intelligence Scale for Children (WISC-IV Digit Span), a …

Misunderstandings Of Tolerance And The Path Of Mercy, Karin Heller

Theology Faculty Scholarship

Contribution to a study seminar organized by the Lateran University, Rome, May 2014, in preparation for the Synod on Marriage and the Family convened by Pope Francis.

Phthalates And Phthalate Alternatives: Effects On Proliferative And Estrogenic Target Genes In Ishikawa Cells, Ranjani Sundar '15, Ping Yin, Serdar E. Bulun

Student Publications & Research

Phthalates are used as plasticizers in many of the products found in medical, household, and industrial applications. Much research has not been completed on the effects of these phthalates as potential endocrine disrupting chemicals (EDCs). As these chemicals are ingested, the mechanism by which they affect the reproductive system is largely unknown. The purpose of this study was to observe how 2 phthalates, Di-n-butyl phthalate (DBP) and Diisononyl phthalate (DINP), and 2 phthalate alternatives, Dioctyl terephthalate (DOTP) and BHT (butylated hydroxytoluene)affect uterine cells in comparison to a vehicle treatment and 17β-Estradiol treatment. Changes in expression of mRNA were observed using …

The Effect Of Small Molecule 390 On Cxcr4 Receptors, Selam B. Zenebe-Gete '14, Shruti R. Topudurti '14, Shum Andrew, Richard J. Miller

Student Publications & Research

CXCR4 is the chemokine receptor which aids in chemotaxis of stem cells, such as those in the bone marrow or the brain. SDF-1 is the natural ligand for the CXCR4 receptor. Similarities between novel molecule 390 synthesized by the Miller Lab and SDF-1 make this novel small molecule a possible agonist of the CXCR4 receptor. To determine whether 390 is an agonist to the CXCR4 receptor, we transfected cells with CXCR4 and exposed them to no agonist [vehicle control], SDF-1, or varying concentrations of our agonist drug. Next, we took calcium images using the dye fura-2, which indicates changes in …

Avs Corner, May 2014, Kathy Still, Johanna Johnson, Allison Millican, Megan Kelley, Michelle Brauneis, Tina Rowland

AVS Corner

No abstract provided.

Annual Report Honors Program And Visiting Scholars Committee 2013-2014, University Of Rhode Island Faculty Senate

Faculty Senate Committee Reports and Appendices

No abstract provided.

The Capitalist Kitchen: Chemicals, Food Safety, And Public Awareness, Shannon Dehoff

3690: A Journal of First-Year Student Research Writing

Overview: Capitalism is a system based on individual rights with the principles of laissez-faire and the free market. In a capitalist economy, one has the individual right to succeed or fail. One is supposed to have the right to rise from poverty to riches, if they possess the skills and willpower to do so. While Ayn Rand’s notion of capitalism persuades one to believe it is a system of justice, corporate greed and political persuasion have taken a functional system and corrupted it. The system is rampant with insatiable hunger for more wealth, and the principles of capitalism allow for …

The Inclusion Of Lgbtq Yal In The Curriculum: Can It Foster Acceptance?, Alysha Mercendetti

3690: A Journal of First-Year Student Research Writing

Overview: Acceptance, whether it be by friends, family, teachers, or peers, is crucial for any teen. Finding acceptance can be significantly more difficult for a teen going through the coming out process or maybe one that has already done so but is still not feeling completely okay in his or her own skin. Along with the fact that the world is highly a heteronormative one, society holds extremely shortsighted views and lacks knowledge on the subject of lesbian, gay, bisexual, transgender, or questioning sexualities, and this ultimately plays a huge role in why LGBTQ teens are either too afraid to …