Digital Commons Network^™

Evolution Of Splicing Regulatory Networks In Drosophila, C. Joel Mcmanus, Jodi Eipper-Mains, Brenton R. Graveley

UCHC Articles - Research

The proteome expanding effects of alternative pre-mRNA splicing have had a profound impact on eukaryotic evolution. The events that create this diversity can be placed into four major classes: exon skipping, intron retention, alternative 5′ splice sites, and alternative 3′ splice sites. Although the regulatory mechanisms and evolutionary pressures among alternative splicing classes clearly differ, how these differences affect the evolution of splicing regulation remains poorly characterized. We used RNA-seq to investigate splicing differences in D. simulans, D. sechellia, and three strains of D. melanogaster. Regulation of exon skipping and tandem alternative 3′ splice sites (NAGNAGs) were …

Modeling The Use Of Programming Languages: A Very Simple Approach, J. C. Chimal-Egu?A, A. Chavez-Valle

Applied Mathematics & Information Sciences

In this paper a very simple model for the dynamics of two programming languages is presented. Considering two programming languages X and Y respectively, it is possible to explain in relation to time the obsolescence of some programming languages and the future trend of those most used. Also, it is possible to quantify the level of popularity or decadence by using a parameter related with the use of language.With the aid of the model it is possible to predict future trends of languages, something very important when we have to take some decisions related to the investment in education related …

2014 Spring Graduate Commencement, Lindenwood University

Commencement Programs

Lindenwood University Commencement program.

Leader-Follower Unity: A Grounded Theory Based On Perceptions Of Leadership And Followership Experts In The United States, Evgenia Prilipko

Theses & Dissertations

Leaders and followers are equally important for organizational success and development. While leadership training is widely available, very few training sessions and courses are offered on cultivating follower skills. It is essential to educate and transform individuals to become effective followers. This study identifies the most important characteristics to be exhibited by individuals in the follower role as perceived by followership and leadership experts in the United States. The theoretical framework used for this study is 12 follower attributes proposed by Antelo, Henderson, and St. Clair (2010). Seven scholars were interviewed: Ira Chaleff, Dr. Joanne Ciulla, Dr. Gene Dixon, Dr. …

Self-Esteem Of Boys During The Transition From A Single-Sex Middle School To A Coeducational High School, Patrick Atkerson

Theses & Dissertations

The purpose of this qualitative case study was to examine how men who attended a single-sex elementary and middle school as a boy describe their experiences following their transition to coeducational high schools and how the participants perceived those experiences influenced their global self-esteem during the first years in high school. Two questions guided the research. 1) What changes, if any, did the men in this study perceive in their global self-esteem, as measured by the Rosenberg Self-Esteem Scale after their transition from a single-sex middle school to a coeducational high school? 2) If there were changes to the levels …

Foresight Benchmark Data 2012-2013, Paul J. Speaker

Faculty & Staff Scholarship

Project FORESIGHT is a business-guided self-evaluation of forensic science laboratories across the globe. The participating laboratories represent local, regional, state, and national agencies. Economics, accounting, finance, and forensic faculty provide assistance, guidance, and analysis. Laboratories participating in Project FORESIGHT have developed standardized definitions for metrics to evaluate work processes, linking financial information to work tasks, and functions. Laboratory managers can then assess resource allocations, efficiencies, and value of services—the mission of Project FORESIGHT is to measure, preserve what works, and change what does not.

The benchmark data for the 2012-2013 performance period includes laboratory submissions for a variety of fiscal …

Los Baños Times, Vol. 34, No. 4, College Of Development Communication, University Of The Philippines Los Baños

Los Baños Times

No abstract provided.

Testing And Data Recovery Excavations At 11 Native American Archeological Sites Along The U.S. Highway 271 Mount Pleasant Relief Route, Titus County, Texas Volume Ii, Ross C. Fields, Virginia L. Hatfield, Damon Burden, Eloise Frances Gadus, Michael C. Wilder, Karl W. Kibler

Index of Texas Archaeology: Open Access Gray Literature from the Lone Star State

Register of Historic Places and State Antiquities Landmark testing of 11 prehistoric sites that will be impacted by construction of the proposed U.S. Highway 271 relief route around Mount Pleasant in Titus County, Texas. The work was done in 2005 for the Texas Department of Transportation’s Environmental Affairs Division under Contract No. 575XXSA006, Work Authorization No. 57501SA006. This research design provides support for a scope of work for testing, prepared as a separate document. The primary relevant historic context for future work on this project is The Development of Agriculture in Northeast Texas Before a.d. 1600 (Kenmotsu and Perttula 1993). …

Bright Ideas Awards Ceremony, Sfa Faculty

Bright Ideas Conference

Agenda for BIC awards luncheon.

Measuring "Problems Of Human Behavior": The Eugenic Origins Of Yale's Institute Of Psychology, 1921-1929, John Doyle

Kaplan Senior Essay Prize for Use of Library Special Collections

The Institute of Psychology at Yale was established in 1924 to study what its founders perceived as “problems of human behavior.” The Institute was Yale President James Angell’s first major step towards making the University a pre-eminent center for psychological research in the 1920s and 1930s. Endowed for a five-year term by the Laura Spelman Rockefeller Memorial Fund, the Institute brought three distinguished faculty to Yale: comparative psychologist Robert M. Yerkes, anthropologist Clark D. Wissler, and psychologist Raymond Dodge. While the Institute has been briefly cited in the historical literature as a precursor to the larger Institute of Human Relations …

Cyanide Toxicokinetics: The Behavior Of Cyanide, Thiocyanate And 2-Amino-2-Thiazoline-4-Carboxylic Acid In Multiple Animal Models, Raj K. Bhandari, Robert P. Oda, Ilona Petrikovics, David E. Thompson, Matthew Brenner, Sari B. Mahon, Vikhyat S. Bebarta, Gary A. Rockwood, Brian A. Logue

Chemistry and Biochemistry Faculty Publications

Cyanide causes toxic effects by inhibiting cytochrome c oxidase, resulting in cellular hypoxia and cytotoxic anoxia, and can eventually lead to death. Cyanide exposure can be verified by direct analysis of cyanide concentrations or analyzing its metabolites, including thiocyanate (SCN⁻) and 2-amino-2-thiazoline-4-carboxylic acid (ATCA) in blood. To determine the behavior of these markers following cyanide exposure, a toxicokinetics study was performed in three animal models: (i) rats (250–300 g), (ii) rabbits (3.5–4.2 kg) and (iii) swine (47–54 kg). Cyanide reached a maximum in blood and declined rapidly in each animal model as it was absorbed, distributed, metabolized and …

Interannual Variations And Trends In Global Land Surface Phenology Derived From Enhanced Vegetation Index During 1982–2010, Xiaoyang Zhang, Bin Tan, Yunyue Yu

GSCE Faculty Publications

Land surface phenology is widely retrieved from satellite observations at regional and global scales, and its long-term record has been demonstrated to be a valuable tool for reconstructing past climate variations, monitoring the dynamics of terrestrial ecosystems in response to climate impacts, and predicting biological responses to future climate scenarios. This study detected global land surface phenology from the advanced very high resolution radiometer (AVHRR) and the Moderate Resolution Imaging Spectroradiometer (MODIS) data from 1982 to 2010. Based on daily enhanced vegetation index at a spatial resolution of 0.05 degrees, we simulated the seasonal vegetative trajectory for each individual pixel …

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.

Scholarworks Statistics - May 2014, Scholarworks

ScholarWorks Reports

For the month of May 2014, ScholarWorks recorded a total of 54,694 full-text downloads and 12,297 page views.

Mapping The Social Sciences Landscape: A Way Forward, David A. Pendlebury

Library Events

The use of bibliometric data for the analysis of research performance in the social sciences presents significant challenges, especially in some fields whose publication patterns differ markedly from the sciences. For example, the book literature is a more important vehicle for scholarly communication in many social sciences fields than it is in the sciences and, therefore, should not be excluded from examination. A brief review of this and other issues will be presented as well as those that affect attempts to map research activity in the social sciences. Mapping the specialty and higher-level structure of scholarly research and detecting changes …

No One Cried For Help: The Integration Of Groupthink Into Modern Rape Culture, Jourdin Hermann

Themis: Research Journal of Justice Studies and Forensic Science

Rape symbolizes lost innocence. Many young females increasingly endure sexual violence at the hands of multiple male assailants. Despite the common coupling of group dynamics and rapes, little evidence proposes Irving Janis’s theory of groupthink as one plausible explanation. This paper argues that the two concepts are related; groupthink needs to hold a more prominent position within the sexual violence literature. A case in the small town of Steubenville, Ohio provides the backdrop for investigating how groupthink impacts instances of gang rapes. Integration of the scholarly literature available on groupthink and sexual violence establishes the basis of this research. Janis’s …

Dna Typing Compatibility With A One Step Saliva Screening Test, Nicole Roda, Steven B. Lee, Brooke Barloewen, Tahnee Mehmet

Themis: Research Journal of Justice Studies and Forensic Science

Screening a substrate for bodily fluids is an extremely important step for locating areas that may contain DNA. Several different methods have been developed for saliva (1). The Phadebas® Forensic Press (PFP) test is a presumptive saliva test that utilizes a preloaded paper that will react with the enzyme amylase, a component of saliva (2-5). Because of its ability to screen for amylase while simultaneously locating stains, the PFP may prove to be an effective, rapid method for screening. However it is important to assess whether the PFP introduces any inhibitors (7) to downstream processing such as PCR amplification. Based …

Neuroimaging And Eyewitness Testimony, Madysen Gardner

Themis: Research Journal of Justice Studies and Forensic Science

This paper will explore how breakthroughs in neuroscience, specifically neuroimaging, can be used to validate eyewitness testimony. Though the use of direct evidence is decreasing, due to findings of numerous wrongful convictions that were based on eyewitness testimonies, it is still an element of many criminal trials today. Cross-examination is used to validate eyewitness testimony because memories are fallible. Cross-examination can successfully determine if a witness is telling the truth, but it cannot determine if a memory is true. This has resulted in juries convicting individuals based on questionable eyewitness testimony. Neuroscientists have found that neuroimaging methods, such as functional …

Academic Affairs Division Newsletter, May 2014, San Jose State University

Academic Affairs Division Newsletter

No abstract provided.

St. John Fisher In Galway, Tim Madigan

Verbum

In lieu of an abstract, below is the essay's first paragraph.

"I am sending this article to Verbum from my apartment in Galway, Ireland, overlooking the beautiful Corrib River. Tomorrow I head to Dublin to celebrate the long St. Patrick’s Day weekend. I am over in Ireland for the Spring semester with nine intrepid St. John Fisher College students: Catherine Cunningham, Aidan Evans, Chelsea Marshall, Maggie Martin, Erin Mosher, André Remillard, Katlin Shippy, Brittany Sidari, and Sierra Stuckey. Together with 10 students from Hobart & William Smith Colleges, we have all traveled throughout the island, experiencing Ireland in all its …

Full Issue, No Author

Verbum

This is the full issue of Volume 11, Issue 2 of Verbum, published in Spring 2014 by the REST Club at St. John Fisher College. Articles from this issue are available as separate PDFs at http://fisherpub.sjfc.edu/verbum/vol11/iss2/

Remote Sensing Of Freshwater Bacterial Populations Using Spectral Analysis Of Satellite Imagery, John J. Crean, Steven Maisto, J. A. Concha, N. Raqueño, J. R. Schott, Maryann Herman, Fernando Ontiveros

Undergraduate External Publications

Remote sensing of bacterial populations in small and large bodies of water can significantly enhance our ability to understand fresh water ecosystems and monitor water quality. Although the identification of individual species is still unfeasible, the detection of certain bacterial groups and the likelihood of occurrence would be very valuable. Spectral analysis of satellite imagery is currently used to determine water parameters like temperature, turbidity, phytoplankton and dissolved organic matter. In order to establish a correlation between some of these parameters and the presence of microorganisms, we collected water samples from several locations in the Lake Ontario Rochester Embayment and …

Targeting Therapy To The Neuromuscular Junction: Proof Of Concept, Linda L. Kusner, Namita Satija, Georgiana Cheng, Henry J. Kaminski

Pharmacology and Physiology Faculty Publications

Introduction: The site of pathology in myasthenia gravis (MG) is the neuromuscular junction (NMJ). Our goal was to determine the ability to direct complement inhibition to the NMJ.

Methods: A single-chain antibody directed against the alpha subunit of the acetylcholine receptor was synthesized (scFv-35) and coupled to decay-accelerating factor (DAF, scFv-35-DAF). scFv-35-DAF was tested in a passive model of experimentally acquired MG.

Results: Administration of scFv-35-DAF to mice deficient in intrinsic complement inhibitors produced no weakness despite confirmation of its localization to the NMJ and no evidence of tissue destruction related to complement activation. Rats with experimentally …

Evidence That Bdnf Regulates Heart Rate By A Mechanism Involving Increased Brainstem Parasympathetic Neuron Excitability, Ruqian Wan, Letitia A. Weigand, Ryan Bateman, Kathleen Griffioen, David Mendelowitz, Mark P. Mattson

Pharmacology and Physiology Faculty Publications

Autonomic control of heart rate is mediated by cardioinhibitory parasympathetic cholinergic neurons located in the brainstem and stimulatory sympathetic noradrenergic neurons. During embryonic development the survival and cholinergic phenotype of brainstem autonomic neurons is promoted by brain-derived neurotrophic factor (BDNF). We now provide evidence that BDNF regulates heart rate by a mechanism involving increased brainstem cardioinhibitory parasympathetic activity. Mice with a BDNF haploinsufficiency exhibit elevated resting heart rate, and infusion of BDNF intracerebroventricularly reduces heart rate in both wild-type and BDNF+/− mice. The atropine-induced elevation of heart rate is diminished in BDNF+/− mice and is restored by BDNF infusion, whereas …

Paying For Prescribed Drugs In Medicaid: Current Policy And Upcoming Changes, Brian K. Bruen, Katherine Young

Health Policy and Management Issue Briefs

Since the early 2000s, state Medicaid programs have made concerted efforts to control the cost of prescription drug spending. One crucial aspect in doing so is using a pharmacy reimbursement methodology that best reflects actual drug costs. Currently, states set pharmacy reimbursement policy within broad federal guidelines, resulting in a complex mix of reimbursement rules. Many states use list prices to set reimbursement levels, and these list prices increasingly have been criticized as not accurately reflecting the cost of the drug. Specifically, there are concerns that some benchmarks lead to inflated reimbursement levels. As a result, the federal government has …

Manganese-Containing Prussian Blue Nanoparticles For Imaging Of Pediatric Brain Tumors, Matthieu F. Dumont, Sridevi Yadavilli, Raymond Sze, Javad Nazarian, Rohan Fernandes

Radiology Faculty Publications

Pediatric brain tumors (PBTs) are a leading cause of death in children. For an improved prognosis in patients with PBTs, there is a critical need to develop molecularly-specific imaging agents to monitor disease progression and response to treatment. In this paper, we describe manganese-containing Prussian blue nanoparticles as agents for molecular magnetic resonance imaging (MRI) and fluorescence-based imaging of PBTs. Our core-shell nanoparticles consist of a core lattice structure that incorporates and retains paramagnetic Mn²⁺ ions, and generates MRI contrast (both negative and positive). The biofunctionalized shell is comprised of fluorescent avidin, which serves the dual purpose of enabling …

Investigating The Dynamics Of Bystander Behavior In Child Sexual Abuse Incidents, Charles Leonard

Master’s Theses and Projects

It is well known that child sexual abuse is a long standing problem in society. Much has been researched concerning the pedophile and other child molesters who choose to sexually exploit minors. Too often the victims of these crimes have been abused over a protracted period—sometimes years. Even more disturbing is the discovery that the abuse was noticed, even witnessed by others who choose not to intervene. Many people have looked the other way, denied what has occurred, or simply refused to become involved in stopping child molesters. This exploratory research examines what bystanders choose to do once they recognize …

Faculty Achievements, May 2014, Otterbein University

Faculty Achievement Reports

No abstract provided.

University Of Minnesota, Morris 2014 Commencement, University Relations

UMM Commencement

The University of Minnesota, Morris's Fifty-First Commencement Saturday, May 10, 2014 1:30 p.m., Campus Mall

Validation Of Satellite Rainfall Products For Western Uganda., Jeremy E. Diem, Joel N. Hartter, Sadie J. Ryan, Michael W. Palace

Geography

Central equatorial Africa is deficient in long-term, ground-based measurements of rainfall; therefore, the aim of this study is to assess the accuracy of three high-resolution, satellite-based rainfall products in western Uganda for the 2001–10 period. The three products are African Rainfall Climatology, version 2 (ARC2); African Rainfall Estimation Algorithm, version 2 (RFE2); and 3B42 from the Tropical Rainfall Measuring Mission, version 7 (i.e., 3B42v7). Daily rainfall totals from six gauges were used to assess the accuracy of satellite-based rainfall estimates of rainfall days, daily rainfall totals, 10-day rainfall totals, monthly rainfall totals, and seasonal rainfall totals. The northern stations had …