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2014

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Sedimentation And Barnacle Recruitment And Growth In A Shallow Coastal Lagoon Of South Texas, John Jack Gray Jan 2014

Sedimentation And Barnacle Recruitment And Growth In A Shallow Coastal Lagoon Of South Texas, John Jack Gray

Theses and Dissertations - UTB/UTPA

According to the United States Environmental Protection Agency, one of this nation’s greatest concerns to the receiving waters of an aquatic system is the impairment of water quality due to sediment transport. Thus, an aquatic system whose receiving waters are subject to unrestrained sediment transport from a spoil bank, which is an unstabilized depository for sediment acquired during a dredge, should be a concern. In this study an attempt was made to assess sedimentation and its effect on the life cycle of sessile aquatic life over a year. South Bay was chosen for the study site because it is adjacent …


Design And Synthesis Of Pyrimidine Fused Heterocycles As Single Agents With Combination Chemotherapy Potential, Roheeth Pavana Jan 2014

Design And Synthesis Of Pyrimidine Fused Heterocycles As Single Agents With Combination Chemotherapy Potential, Roheeth Pavana

Electronic Theses and Dissertations

This dissertation describes the design, synthesis and biological evaluation of pyrimidine fused heterocycles as single agents with combination chemotherapy potential. Major limitations of cancer chemotherapy include dose limiting toxicities of clinically used agents and the development of multidrug resistance by the tumor. Agents that interfere with microtubules are important antitumor agents. Tumor angiogenic mechanisms that are vital for tumor growth and metastasis are targeted by antiangiogenic agents. Antiangiogenic agents are usually not tumoricidal but are mainly cytostatic. Combination chemotherapy with antiangiogenic and cytotoxic agents have shown significant promise and several studies with such combinations are in progress in the clinic. …