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2014

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Polymer Micro- And Nanofluidic Systems For In Vitro Diagnostics: Analyzing Single Cells And Molecules, Swathi Reddy Pullagurla Jan 2014

Polymer Micro- And Nanofluidic Systems For In Vitro Diagnostics: Analyzing Single Cells And Molecules, Swathi Reddy Pullagurla

LSU Doctoral Dissertations

Polymer micro- and nanofluidic systems, with their critical dimensions, offer a potential to outperform conventional analysis techniques and diagnostic methods by enhancing speed, accuracy, sensitivity and specificity. In this work, applications of microfluidics have been demonstrated to address the existing challenges in stroke diagnosis, by mRNA expression profiling from whole blood within <20 min. A brief overview of various biomarkers for stroke diagnosis is given in chapter 1 followed by design and testing of individual microfluidic modules (chapter 2 and 3) required for the development of POC diagnostic strategy for stroke. We have designed and evaluated the performance of polymer microfluidic devices for the isolation of leukocyte subsets, known for their differential gene expression in the event of stroke. Target cells (T-cells and neutrophils) were selected from with greater purities, from 50 µl whole human blood by using affinity based capture in COC devices within a 6.6 min processing time. In addition, we have also demonstrated the ability to isolate and purify total RNA by using UV activated polycarbonate solid phase extraction platform. Polymer-based nanofluidic devices were used to study the effects of surface charge on the electrodynamic transport dynamics of target molecules. In this work, we report the fabrication of mixed-scale micro- and nanofluidic networks in poly(methylmethacrylate), PMMA, using thermal nanoimprint lithography using a resin stamp and surface modification of polymer nanoslits and nanochannels for the assessment of the associated electrokinetic parameters – surface charge density, zeta potential and electroosmotic flow. This study provided information on possible routes that can be adopted to engineer proper wall chemistry of polymer nanochannels for the enhancement or reduction of solute/wall interactions in a variety of relevant single-molecule studies.

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Evolution Of U.S. Electric Energy Regulation: From Natural Monopoly Regulation To Regulated Competition, Gary Allison Jan 2014

Evolution Of U.S. Electric Energy Regulation: From Natural Monopoly Regulation To Regulated Competition, Gary Allison

Articles, Chapters in Books and Other Contributions to Scholarly Works

No abstract provided.

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Reducing Juvenile Justice Involvement Through A Childhood Truancy Intervention, Bret James Blackmon Jan 2014

Reducing Juvenile Justice Involvement Through A Childhood Truancy Intervention, Bret James Blackmon

LSU Doctoral Dissertations

This study employed a mixed methods design to evaluate an elementary school truancy intervention in terms of reducing rates of juvenile delinquency over six years. Few (n = 11) participants became involved in the formal justice system, so the intervention’s effectiveness was measured by re-referrals for continued truancy. The regression discontinuity design was used to compare the intervention group to the comparison group. The intervention group received intensive case management and the comparison group received a warning letter. A regression discontinuity design using multivariate logistic regression indicated that the intervention did not reduce the likelihood of subsequent re-referrals, and the …

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Lopsided, Scarred, And Squint-Eyed: Ugly Women In The Work Of Southern Women Writers, Monica C. Miller Jan 2014

Lopsided, Scarred, And Squint-Eyed: Ugly Women In The Work Of Southern Women Writers, Monica C. Miller

LSU Doctoral Dissertations

The ubiquity of ugly female characters in the work of southern women calls into question what W. J. Cash termed “gyneolatry,” the worship of the beautiful white woman upon which so much of southern ideology has been based. If the South functions as an internal other for the nation, then examining this fiction’s multiplicity of ugly women illuminates the ways in which women defy not only the norms of southern gender but also those of the larger American culture, in which the southern woman often acts as a representation of the South in general. By considering ugliness as a category …

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Intersections Of Race And Class In 1830s Othello Burlesques, Laura Michelle Keigan Jan 2014

Intersections Of Race And Class In 1830s Othello Burlesques, Laura Michelle Keigan

LSU Doctoral Dissertations

In recent years, we have come to better understand how nineteenth-century burlesques critiqued and lampooned the respectable humbuggery of patent theater productions and middle-class culture. Their carnivalesque spectacle and low humor turned topsy-turvy what was falsely revered or pretentious in English society. This study, however, explores the extent to which some burlesques responded conservatively to social and legislative change, which supposedly weakened established hierarchies constituting English culture and society. My chapters examine how two burlesques of Shakespeare’s Othello—Charles M. Westmacott’s Othello, the Moor of Fleet Street (1833) and Maurice M. M. G. Dowling’s Othello Travestie (1834)—contributed to discourse surrounding debate …

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Object-Based Coastal Morphological Change Analysis Based On Lidar And Hurricane Events, Bedoor Adel Mohammad Jan 2014

Object-Based Coastal Morphological Change Analysis Based On Lidar And Hurricane Events, Bedoor Adel Mohammad

LSU Doctoral Dissertations

Storms are considered one of the rapid climatic events that have a dramatic impact on coastal morphology, hence they require further investigation and quantifying of coastal changes and responses. Light detection and ranging (LiDAR) is the most advanced technology to be widely used by researchers for coastal geomorphological studies. The purpose of this study is to apply an object-based approach using repeated LiDAR surveys to understand the short-term morphological changes that occurred on Santa Rosa Island, Florida after category 3 hurricanes Ivan (2004) and Dennis (2005), making it the first study to apply this method, as opposed to previous studies’ …

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Personality Trait Theory And Multitasking Performance: Implications For Ergonomic Design, Andrea D. Guastello, Stephen J. Guastello, Denise D. Guastello Jan 2014

Personality Trait Theory And Multitasking Performance: Implications For Ergonomic Design, Andrea D. Guastello, Stephen J. Guastello, Denise D. Guastello

Psychology Faculty Research and Publications

Although system designers usually minimise the role of individual differences in operation, personality variables could explain differences in multitasking performance. A concomitant theoretical issue is whether primary or surface personality traits do a better job of predicting performance than the Five-Factor Model (FFM) or global traits. A sample of 174 undergraduates completed the Sixteen Personality Factor Questionnaire (16PF), which was followed by a performance task. A computer-based task that measured simultaneous performance on an arithmetic task and a mental rotation task was used to measure multitasking performance; scores measured the percent accuracy. Primary traits for low emotional sensitivity and high …

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"Post Your Version Here!": Performances In/Of Online, Noncommercial, Video-To-Video Adaptations, Lyndsay Michalik Jan 2014

"Post Your Version Here!": Performances In/Of Online, Noncommercial, Video-To-Video Adaptations, Lyndsay Michalik

LSU Doctoral Dissertations

Processes of creative adaptation no longer fit traditional, culturally sanctioned forms, like commercial book-to-film adaptation, or vice versa. Meanwhile, internet users are demonstrating how noncommercial, creative text adaptation using video technology has become an everyday art form, a skill set, a form of communication, and a means of cultural commentary. Internet video adapters physically perform in their own videos and they create videos that work performatively online. Negotiating the slippery spaces between copyright, creativity, and cultural commentary, these creators adapt videos in myriad ways, and find spaces to share their adaptations online, despite (for most) a lack of financial return …

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A Study On Fairness And Latency Issues Over High Speed Networks And Data Center Networks, Lin Xue Jan 2014

A Study On Fairness And Latency Issues Over High Speed Networks And Data Center Networks, Lin Xue

LSU Doctoral Dissertations

Newly emerging computer networks, such as high speed networks and data center networks, have characteristics of high bandwidth and high burstiness which make it difficult to address issues such as fairness, queuing latency and link utilization. In this study, we first conduct extensive experimental evaluation of the performance of 10Gbps high speed networks. We found inter-protocol unfairness and larger queuing latency are two outstanding issues in high speed networks and data center networks. There have been several proposals to address fairness and latency issues at switch level via queuing schemes. These queuing schemes have been fairly successful in addressing either …

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The Dog Ate My Homework: A Qualitative Study Of Students' Views Of Their Homework Experiences, Elizabeth Yvette Stogner Jan 2014

The Dog Ate My Homework: A Qualitative Study Of Students' Views Of Their Homework Experiences, Elizabeth Yvette Stogner

LSU Doctoral Dissertations

Students’ voices are underrepresented in the professional literature and public conversations regarding homework; therefore, this study was designed to include students’ voices in future conversations. This study examined the responses of ten high school students enrolled in an eleventh grade English Language and Composition Advanced Placement (AP) class at a rural public school. The findings of this study answer the research questions: 1. What are students’ experiences with homework? 2. In what ways have these experiences shaped students’ views of homework? Over a period of 16 weeks, the researcher gathered qualitative data via students’ responses to essay writing, a questionnaire, …

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Piezoelectric Based Energy Harvesting On Low Frequency Vibrations Of Civil Infrastructures, Ye Zhang Jan 2014

Piezoelectric Based Energy Harvesting On Low Frequency Vibrations Of Civil Infrastructures, Ye Zhang

LSU Doctoral Dissertations

Piezoelectric-based energy harvesting is an efficient way to convert ambient vibration energy into usable electric energy. The piezoelectric harvester can work as a sustainable and green power source for different electric devices such as sensors and implanted medical devices. However, its application on civil infrastructures has not been fully studied yet. This dissertation aimed to study and improve the piezoelectric-based energy harvesting on civil infrastructures, especially on bridge structures. To reach the objective, a more accurate model for piezoelectric composite beams was built first, which can be adopted for the modeling of different kinds of energy harvesters. The model includes …

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The Role Of Politics And Proximity In Sea Level Rise Policy Salience: A Study Of Virginia Legislators’ Perceptions, Juita-Elena (Wie) Yusuf, Burton St. John Iii, Ivan K. Ash Jan 2014

The Role Of Politics And Proximity In Sea Level Rise Policy Salience: A Study Of Virginia Legislators’ Perceptions, Juita-Elena (Wie) Yusuf, Burton St. John Iii, Ivan K. Ash

School of Public Service Faculty Publications

The acceleration of sea level rise (SLR) has become a threat to the stability of nation-states worldwide and associated with risks to environmental sustainability, economic infrastructure, and public health. However, from both an international and U.S. perspective, there is a lack of research examining legislative decision makers’ perceptions about policies regarding SLR. This study addresses that gap by examining how politics and proximity affects Virginia state legislators’ perceptions of the saliency of SLR. A survey of these legislators reveals their perceptions of credible sources of information, SLR-related risk, and who should take the lead to address SLR. While this study …

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Novel Nanostructured Titania And Titania Nanocomposites For Photovoltaics And Photocatalysis, Xinning Luan Jan 2014

Novel Nanostructured Titania And Titania Nanocomposites For Photovoltaics And Photocatalysis, Xinning Luan

LSU Doctoral Dissertations

With the consumption of energy continually increasing around the world and the main source of this energy, fossil fuels, slowly being depleted, the need for alternate sources of energy is becoming more and more pertinent. Demand for solar energy has experienced exponential increase over the last decade. Nanostructured TiO2 has attracted significant attention due to its nontoxicity, low cost and wide applications in photovoltaics and photocatalysis. This research is focused on novel synthesis and surface modification of TiO2 nanotube arrays for applications in advanced dye-sensitized solar cells (DSSCs) and efficient photocatalysis. The first part of this work entails fast synthesis …

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The Effects Of Peripheral Nerve Impairments On Postural Control And Mobility Among People With Peripheral Neuropathy, Shuqi Zhang Jan 2014

The Effects Of Peripheral Nerve Impairments On Postural Control And Mobility Among People With Peripheral Neuropathy, Shuqi Zhang

LSU Doctoral Dissertations

Approximately 20 million Americans are suffering Peripheral Neuropathy (PN). It is estimated that the prevalence of all-cause PN is about 2.4% in the entire adult population, whereas over 8-10% in the population segment over the age of 55 (Martyn & Hughes, 1997). Peripheral Neuropathy leads to a high risk of falling, resulting from the deficits of postural control caused by the impaired peripheral nerves, especially the degenerative somatosensory system. To date, there is no effective medical treatment for the disease but pain managements. The deficits of postural control decrease the life quality of this population. The degeneration of peripheral nerves …

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Energy And Thermodynamically Based Approaches For Analysis Of Damage In Contact Problems, Afshin Babaie Aghdam Jan 2014

Energy And Thermodynamically Based Approaches For Analysis Of Damage In Contact Problems, Afshin Babaie Aghdam

LSU Doctoral Dissertations

A novel methodology for analysis of damage in contact problems in presented. Two important categories of contact damage are studied, namely crack nucleation and adhesive wear. The proposed methodology is primarily based on the laws of energy and thermodynamics, and as such offers great advantages by unifying the analysis of damage in a variety of contact configurations. Crack nucleation is the first damage type analyzed. For this purpose, the line-contact fretting configuration is chosen. A thermodynamically-based continuum damage mechanics (CDM) approach is employed. Intense stress gradients in the contact region are found to be highly influential in the crack nucleation …

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Design And Synthesis Of Pyrimidine Fused Heterocycles As Single Agents With Combination Chemotherapy Potential, Roheeth Pavana Jan 2014

Design And Synthesis Of Pyrimidine Fused Heterocycles As Single Agents With Combination Chemotherapy Potential, Roheeth Pavana

Electronic Theses and Dissertations

This dissertation describes the design, synthesis and biological evaluation of pyrimidine fused heterocycles as single agents with combination chemotherapy potential. Major limitations of cancer chemotherapy include dose limiting toxicities of clinically used agents and the development of multidrug resistance by the tumor. Agents that interfere with microtubules are important antitumor agents. Tumor angiogenic mechanisms that are vital for tumor growth and metastasis are targeted by antiangiogenic agents. Antiangiogenic agents are usually not tumoricidal but are mainly cytostatic. Combination chemotherapy with antiangiogenic and cytotoxic agents have shown significant promise and several studies with such combinations are in progress in the clinic. …

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Comparative Institutional Competency And Sovereignty In Indian Affairs, Michalyn Steele Jan 2014

Comparative Institutional Competency And Sovereignty In Indian Affairs, Michalyn Steele

Faculty Scholarship

While vigorous debate surrounds the proper scope and ambit of inherent tribal authority, there remains a critical antecedent question: whether Congress or the courts are ultimately best situated to define the contours of inherent tribal authority. In February 2013, Congress enacted controversial tribal jurisdiction provisions as part of the Violence Against Women Act reauthorization recognizing and affirming inherent tribal authority to prosecute all persons, including non-Indian offenders, for crimes of domestic violence in Indian country. This assertion by Congress of its authority to set the bounds of tribal inherent authority -- beyond where the United States Supreme Court has held …

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Sense Of Place, Place Attachment, And Rootedness In Four West Baton Rouge Parish, Louisiana Bars, John Winsor Mcewen Jan 2014

Sense Of Place, Place Attachment, And Rootedness In Four West Baton Rouge Parish, Louisiana Bars, John Winsor Mcewen

LSU Doctoral Dissertations

This dissertation explores place and the relationships that people have with place: sense of place, place attachment, and rootedness. These three concepts have each been researched and discussed on their own in journal articles, books, and book chapters, but the terms rarely appear in the same sentence let alone the same research article. In the United States, places of drink are historically linked to community and social interactions, and such establishments often possess a solid core of loyal patrons for whom going to their bar is a natural and routine part of their daily and weekly life. This research brings …

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Changes In Climate And Moisture Availability In The Antarctic Eocene, Oligocene, And Miocene: Evidence From Palynological And Stable Isotope Geochemical Analyses Of The Shaldril And Andrill Cores, Kathryn Whitney Griener Jan 2014

Changes In Climate And Moisture Availability In The Antarctic Eocene, Oligocene, And Miocene: Evidence From Palynological And Stable Isotope Geochemical Analyses Of The Shaldril And Andrill Cores, Kathryn Whitney Griener

LSU Doctoral Dissertations

Prior to the Late Eocene, the Antarctic continent experienced lush vegetation under temperate conditions. Just before the Eocene/Oligocene Boundary, the climate of the southernmost continent began to deteriorate dramatically. This cooling trend largely continued until most Antarctic vegetation disappeared, ~13.85-12.8 Ma. Classifying the nature and cause of Antarctica’s drastic climate change is essential for furthering our knowledge of Earth’s history, and also for grasping the potential effects of current and future climate shifts. Here, I present evidence from three new palynomorph-centric studies that deepen our understanding of Antarctic earth science, climate change, and of climate proxies. The first study involved …

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On Matroid And Polymatroid Connectivity, Dennis Wayne Hall Ii Jan 2014

On Matroid And Polymatroid Connectivity, Dennis Wayne Hall Ii

LSU Doctoral Dissertations

Matroids were introduced in 1935 by Hassler Whitney to provide a way to abstractly capture the dependence properties common to graphs and matrices. One important class of matroids arises by taking as objects some finite collection of one-dimensional subspaces of a vector space. If, instead, one takes as objects some finite collection of subspaces of dimensions at most k in a vector space, one gets an example of a k-polymatroid.

Connectivity is a pivotal topic of study in the endeavor to understand the structure of matroids and polymatroids. In this dissertation, we study the notion of connectivity from several …

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A Hybrid Advection Scheme For Conserving Angular Momentum On A Refined Cartesian Mesh, Zachary Duncan Byerly Jan 2014

A Hybrid Advection Scheme For Conserving Angular Momentum On A Refined Cartesian Mesh, Zachary Duncan Byerly

LSU Doctoral Dissertations

We demonstrate the capabilities of a new hybrid scheme for simulating dynamical fluid flows in which cylindrical components of the momentum are advected across a rotating Cartesian coordinate mesh. This hybrid scheme allows us to conserve angular momentum to machine precision while capitalizing on the advantages offered by a Cartesian mesh, such as mesh refinement. The work presented here focuses on measuring the real and imaginary parts of the eigenfrequency of unstable axisymmetric modes that naturally arise in massless polytropic tori having a range of different aspect ratios, and quantifying the uncertainty in these measurements. Our measured eigenfrequencies show good …

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Evaluating Alternative Techniques For Forecasting Industrial And Occupational Employment, Drew A. Varnado Jan 2014

Evaluating Alternative Techniques For Forecasting Industrial And Occupational Employment, Drew A. Varnado

LSU Doctoral Dissertations

This paper offers three different regional output-by-industry forecasting techniques (time series, Social Accounting Matrix (SAM)-based, and Computable General Equilibrium (CGE)-based) and two different occupation-by-industry matrices (national and state geographies) for use in the creation of industry/occupation employment forecasts. Estimates are compared to actual data from eight years from 2001 to 2010. OLS regressions are run to determine how well modeled employment estimates fit actual employment for the state of Louisiana. A meta-analysis style regression of the R-sqaured values on model characteristics (accounted for using Boolean dummy-variables) determines that industrial output forecasting techniques do not provide statistically different R-squared values, but …

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Queer Emplotment: Lesbian Caretaking In North American Canonical Fiction From 1980 – 2011., Penelope Gay Dane Jan 2014

Queer Emplotment: Lesbian Caretaking In North American Canonical Fiction From 1980 – 2011., Penelope Gay Dane

LSU Doctoral Dissertations

My dissertation argues that lesbian caretaking in late 20th century and early 21th century North American fiction disrupts normative temporalities while repairing damage protagonists sustain from intra-familial trauma. Aligned with queer studies’ growing interest in representations of time, my project explores this paradox of lesbian representation. How can lesbian characters be both reparative and disruptive? Lesbian characters in Alice Walker’s The Color Purple (1980); Dorothy Allison’s Bastard Out of Carolina (1992); and Louise Erdrich’s Shadow Tag (2010) are reparative as they clean up the psychological and physical damage caused male violence, sexual abuse, and neglectful mothers. Yet their caregiving disrupts …

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Methods For The Characterization Of Deep-Sea Benthic Megafauna In The Vicinity Of The Deepwater Horizon Macondo Well, Stephanie Marie Sharuga Jan 2014

Methods For The Characterization Of Deep-Sea Benthic Megafauna In The Vicinity Of The Deepwater Horizon Macondo Well, Stephanie Marie Sharuga

LSU Doctoral Dissertations

Soft-sediment benthic environments are amongst the largest marine ecosystems in the world and play important roles in many ecosystem functions. In recent years, exploitation of resources and unintentional impacts on deep-sea benthic environments has increased. The Deepwater Horizon oil spill of 2010 in the northern Gulf of Mexico (GoM) represented a prime example of this. The oil spill not only highlighted deficiencies of data and information on baseline conditions, but also represented an opportunity to learn more and develop better methods for the future. Deep-sea imaging platforms such as autonomous underwater vehicles (AUVs) and remotely operated vehicles (ROVs) have been …

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Chemistry And Application Of Pulses As Value-Added Ingredients In Processed Foods, Darryl Holliday Jan 2014

Chemistry And Application Of Pulses As Value-Added Ingredients In Processed Foods, Darryl Holliday

LSU Doctoral Dissertations

Chemical characterization of pulses allows for varying rates of water absorption, least gelation capacity, and retrogradation depending on species. Nutritionally, pulses are good sources of protein while being low in fat. Pulses deliver a readily bioavailable food form of several key minerals. Additionally, they deliver fiber. The insoluble fiber components are both natural and formed resistant starch in addition to the oligosaccharide content. Therefore, pulses can serve both a nutritional and functional role when used as a value-added ingredient. Meat patties were produced from beef and 23 different pulses at 35%, 42.5%, and 50% ratios. Each patty was tested for …

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Evolving Time Surfaces And Tracking Mixing Indicators For Flow Visualization, Farid Harhad Jan 2014

Evolving Time Surfaces And Tracking Mixing Indicators For Flow Visualization, Farid Harhad

LSU Doctoral Dissertations

The complexity of large scale computational fluid dynamic simulations (CFD) demands powerful tools to investigate the numerical results. To analyze and understand these voluminous results, we need to visualize the 3D flow field. We chose to use a visualization technique called Time Surfaces. A time surface is a set of surfaces swept by an initial seed surface for a given number of timesteps. We use a front tracking approach where the points of an in initial surface are advanced in a Lagrangian fashion. To maintain a smooth time surface, our method requires surface refinement operations that either split triangle edges, …

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Differential Examination Of Disgust In Spider, Blood-Injection, And Contamination Fear: Self-Reported And Attention-Based Assessment Of Differences, Whitney Shay Jenkins Jan 2014

Differential Examination Of Disgust In Spider, Blood-Injection, And Contamination Fear: Self-Reported And Attention-Based Assessment Of Differences, Whitney Shay Jenkins

LSU Doctoral Dissertations

Biased attention toward threat has been demonstrated across anxiety disorders as well as among nonclinical samples. While such studies have produced findings of attentional bias for fear-related or threatening stimuli, other types of emotionally laden stimuli have been ignored. This study sought to examine the experience and impact of disgust on individuals experiencing various types of anxiety, which may play a more significant role than fear in some disorders such as obsessive-compulsive disorder (OCD) and some specific phobias. Specifically, this study examined self-reported disgust and attentional bias in relation to disgust and threatening stimuli. A modified dot-probe task with pictorial …

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Mental Mapping The Transformation Of Social Space In Rio's Oldest Favela: Morro Da Providência, Jamie Lauren Worms Jan 2014

Mental Mapping The Transformation Of Social Space In Rio's Oldest Favela: Morro Da Providência, Jamie Lauren Worms

LSU Doctoral Dissertations

Amid the 2014 FIFA World Cup and the 2016 Olympic Games, strategic policy reforms at the federal, state, and municipal levels have reordered and re-purposed the social space of Rio’s favelas through the implementation of social and physical infrastructure. This research project contributes a geographical perspective to the ways in which fast-paced urbanization transforms and produces social space in Rio’s oldest favela, Morro da Providência. Based on Henri Lefebvre’s conceptual triad concerning the production of social space, this research uses mental mapping to understand the disparity between representations of conceived space and representational lived space. It also contributes to perceived …

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Robust Preconditioners For The High-Contrast Elliptic Partial Differential Equations, Zuhal Unlu Jan 2014

Robust Preconditioners For The High-Contrast Elliptic Partial Differential Equations, Zuhal Unlu

LSU Doctoral Dissertations

In this thesis, we discuss a robust preconditioner (the AGKS preconditioner) for solving linear systems arising from approximations of partial differential equations (PDEs) with high-contrast coefficients. The problems considered here include the standard second and higher order elliptic PDEs such as high-contrast diffusion equation, Stokes' equation and biharmonic-plate equation. The goal of this study is the development of robust and parallelizable preconditioners that can easily be integrated to treat large configurations. The construction of the preconditioner consists of two phases. The first one is an algebraic phase which partitions the degrees of freedom into high and low permeability regions which …

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Influence Of Aedes Aegypti Saliva On The Vertebrate Host Response To Dengue Virus, Michael Kevin Mccracken Jan 2014

Influence Of Aedes Aegypti Saliva On The Vertebrate Host Response To Dengue Virus, Michael Kevin Mccracken

LSU Doctoral Dissertations

Dengue virus (DENV) is maintained in a primarily anthroponotic cycle between humans and the mosquito, Aedes aegypti. Investigations into DENV infection of the vertebrate host generally do not account for the contribution of vector saliva, an inherent part of the mosquito-borne viral inoculum. Feeding by mosquitoes on vertebrate hosts is initiated by probing, which results in physical damage to the skin and vasculature, and the simultaneous introduction of DENV and saliva into the skin. Saliva contains many individual proteins with the potential to modulate host hemostasis and immune responses, thereby facilitating blood feeding and virus transmission. As exogenous antigens, both …

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